{"id":"https://openalex.org/W2102920107","doi":"https://doi.org/10.1080/10408440902837959","title":"Derivation of inhalation toxicity reference values for propylene oxide using mode of action analysis: Example of a threshold carcinogen","display_name":"Derivation of inhalation toxicity reference values for propylene oxide using mode of action analysis: Example of a threshold carcinogen","publication_year":2009,"publication_date":"2009-03-27","ids":{"openalex":"https://openalex.org/W2102920107","doi":"https://doi.org/10.1080/10408440902837959","mag":"2102920107","pmid":"https://pubmed.ncbi.nlm.nih.gov/19545197"},"language":"en","primary_location":{"id":"doi:10.1080/10408440902837959","doi":"https://doi.org/10.1080/10408440902837959","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10408440902837959","pdf_url":null,"source":{"id":"https://openalex.org/S78069630","display_name":"Critical Reviews in Toxicology","issn_l":"0045-6446","issn":["0045-6446","1040-8444","1547-6898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Toxicology","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5013772689","display_name":"Lisa M. Sweeney","orcid":"https://orcid.org/0000-0002-4672-7358","observed_orcids":["https://orcid.org/0000-0002-4672-7358"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Lisa M. Sweeney","raw_affiliation_strings":["The Sapphire Group, Inc., 2661 Commons Blvd., Second Floor, Dayton, OH 45431, USA. LMS29@case.edu","The Sapphire Group, Inc., Dayton, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Sapphire Group, Inc., 2661 Commons Blvd., Second Floor, Dayton, OH 45431, USA. LMS29@case.edu","institution_ids":[]},{"raw_affiliation_string":"The Sapphire Group, Inc., Dayton, Ohio, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108459030","display_name":"Christopher R. Kirman","orcid":"https://orcid.org/0000-0002-5362-9254","observed_orcids":["https://orcid.org/0000-0002-5362-9254"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christopher R. Kirman","raw_affiliation_strings":["The Sapphire Group, Inc., Beachwood, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Sapphire Group, Inc., Beachwood, Ohio, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091472273","display_name":"Richard J. Albertini","orcid":"https://orcid.org/0000-0002-9827-854X","observed_orcids":["https://orcid.org/0000-0002-9827-854X"]},"institutions":[{"id":"https://openalex.org/I111236770","display_name":"University of Vermont","ror":"https://ror.org/0155zta11","country_code":"US","type":"education","lineage":["https://openalex.org/I111236770"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard J. Albertini","raw_affiliation_strings":["University of Vermont, Burlington, Vermont, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Vermont, Burlington, Vermont, USA","institution_ids":["https://openalex.org/I111236770"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029174596","display_name":"Yu\u2010Mei Tan","orcid":"https://orcid.org/0000-0002-8553-9288","observed_orcids":["https://orcid.org/0000-0002-8553-9288"]},"institutions":[{"id":"https://openalex.org/I4210093870","display_name":"The Hamner Institutes for Health Sciences","ror":"https://ror.org/00jjvav84","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210093870"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yu-Mei Tan","raw_affiliation_strings":["The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA","institution_ids":["https://openalex.org/I4210093870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002591537","display_name":"Harvey J. Clewell III M.A.","orcid":"https://orcid.org/0000-0002-2253-9045","observed_orcids":["https://orcid.org/0000-0002-2253-9045"]},"institutions":[{"id":"https://openalex.org/I4210093870","display_name":"The Hamner Institutes for Health Sciences","ror":"https://ror.org/00jjvav84","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210093870"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Harvey J. Clewell","raw_affiliation_strings":["The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Hamner Institutes for Health Sciences, Research Triangle Park, North Carolina, USA","institution_ids":["https://openalex.org/I4210093870"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068357698","display_name":"Johannes Georg Filser","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Johannes G. Filser","raw_affiliation_strings":["Institute of Toxicology, Helmholtz Zentrum, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Toxicology, Helmholtz Zentrum, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109127235","display_name":"Gy\u00f6rgy Andr\u00e1s Csan\u00e1dy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Gy\u00f6rgy Csan\u00e1dy","raw_affiliation_strings":["Institute of Toxicology, Helmholtz Zentrum, M\u00fcnchen, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Toxicology, Helmholtz Zentrum, M\u00fcnchen, Germany","institution_ids":["https://openalex.org/I3018134672"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051491025","display_name":"Lynn H. Pottenger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133143","display_name":"Dow Chemical (United States)","ror":"https://ror.org/032hx4q18","country_code":"US","type":"company","lineage":["https://openalex.org/I4210133143"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lynn H. Pottenger","raw_affiliation_strings":["The Dow Chemical Company, Midland, Michigan, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Dow Chemical Company, Midland, Michigan, USA","institution_ids":["https://openalex.org/I4210133143"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003573049","display_name":"Marcy I. Banton","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcy I. Banton","raw_affiliation_strings":["LyondellBasell Industries, Rotterdam, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"LyondellBasell Industries, Rotterdam, The Netherlands","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108571422","display_name":"Cynthia Graham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165638839","display_name":"Huntsman (United States)","ror":"https://ror.org/02d814r78","country_code":"US","type":"company","lineage":["https://openalex.org/I165638839"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cynthia J. Graham","raw_affiliation_strings":["Huntsman Corporation, The Woodlands, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Corporation, The Woodlands, Texas, USA","institution_ids":["https://openalex.org/I165638839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003202726","display_name":"Larry S. Andrews","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Larry S. Andrews","raw_affiliation_strings":["Rohm & Haas Company, Spring House, Pennsylvania, USA","Rohm and Haas Company, Spring House , Pennsylvania, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Rohm & Haas Company, Spring House, Pennsylvania, USA","institution_ids":[]},{"raw_affiliation_string":"Rohm and Haas Company, Spring House , Pennsylvania, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089419911","display_name":"Raymond J. Papciak","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165638839","display_name":"Huntsman (United States)","ror":"https://ror.org/02d814r78","country_code":"US","type":"company","lineage":["https://openalex.org/I165638839"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond J. Papciak","raw_affiliation_strings":["Huntsman Corporation, The Woodlands, Texas, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Huntsman Corporation, The Woodlands, Texas, USA","institution_ids":["https://openalex.org/I165638839"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038393989","display_name":"Michael L. Gargas","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael L. Gargas","raw_affiliation_strings":["The Sapphire Group, Inc., Dayton, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Sapphire Group, Inc., Dayton, Ohio, USA","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5013772689"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0681,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.09502262,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":97},"biblio":{"volume":"39","issue":"6","first_page":"462","last_page":"486"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13840","display_name":"Chemical Safety and Risk Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1504","display_name":"Chemical Health and Safety"},"field":{"id":"https://openalex.org/fields/15","display_name":"Chemical Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T13165","display_name":"Agricultural safety and regulations","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/propylene-oxide","display_name":"propylene oxide","score":1.0},{"id":"https://openalex.org/keywords/inhalation-toxicity","display_name":"inhalation toxicity","score":0.902999997138977},{"id":"https://openalex.org/keywords/mechanism-of-action","display_name":"mechanism of action","score":0.7900000214576721},{"id":"https://openalex.org/keywords/nasal-tumors","display_name":"nasal tumors","score":0.6909999847412109},{"id":"https://openalex.org/keywords/glutathione-depletion","display_name":"glutathione depletion","score":0.7319999933242798},{"id":"https://openalex.org/keywords/uncertainty-factors","display_name":"uncertainty factors","score":0.7889999747276306},{"id":"https://openalex.org/keywords/occupational-exposure","display_name":"occupational exposure","score":0.5009999871253967},{"id":"https://openalex.org/keywords/rodent-carcinogenesis","display_name":"rodent carcinogenesis","score":0.621999979019165}],"concepts":[{"id":"https://openalex.org/C114246631","wikidata":"https://www.wikidata.org/wiki/Q187661","display_name":"Carcinogen","level":2,"score":0.832578182220459},{"id":"https://openalex.org/C2778959862","wikidata":"https://www.wikidata.org/wiki/Q1009245","display_name":"Genotoxicity","level":3,"score":0.7629001140594482},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.7082078456878662},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.6824327707290649},{"id":"https://openalex.org/C121587506","wikidata":"https://www.wikidata.org/wiki/Q6888113","display_name":"Mode of action","level":2,"score":0.6591941118240356},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.61436527967453},{"id":"https://openalex.org/C2779777708","wikidata":"https://www.wikidata.org/wiki/Q6033622","display_name":"Inhalation exposure","level":3,"score":0.6054145097732544},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.5761579871177673},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5271085500717163},{"id":"https://openalex.org/C143425029","wikidata":"https://www.wikidata.org/wiki/Q5205747","display_name":"DNA damage","level":3,"score":0.5078402161598206},{"id":"https://openalex.org/C51671895","wikidata":"https://www.wikidata.org/wiki/Q17153670","display_name":"Reference dose","level":3,"score":0.44315749406814575},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.44073817133903503},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.4270566999912262},{"id":"https://openalex.org/C42407357","wikidata":"https://www.wikidata.org/wiki/Q521","display_name":"Physiology","level":1,"score":0.3631379306316376},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2989504933357239},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26558631658554077},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.26254352927207947},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.2131475806236267},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.20013979077339172},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.19669628143310547},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.17550769448280334},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.14876529574394226},{"id":"https://openalex.org/C38652104","wikidata":"https://www.wikidata.org/wiki/Q3510521","display_name":"Computer security","level":1,"score":0.0},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.0},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.0},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002273","descriptor_name":"Carcinogens","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004781","descriptor_name":"Environmental Exposure","qualifier_ui":"Q000592","qualifier_name":"standards","is_major_topic":false},{"descriptor_ui":"D004852","descriptor_name":"Epoxy Compounds","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D004852","descriptor_name":"Epoxy Compounds","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004852","descriptor_name":"Epoxy Compounds","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012016","descriptor_name":"Reference Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020711","descriptor_name":"Threshold Limit Values","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1080/10408440902837959","doi":"https://doi.org/10.1080/10408440902837959","is_oa":false,"landing_page_url":"https://doi.org/10.1080/10408440902837959","pdf_url":null,"source":{"id":"https://openalex.org/S78069630","display_name":"Critical Reviews in Toxicology","issn_l":"0045-6446","issn":["0045-6446","1040-8444","1547-6898"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical Reviews in Toxicology","raw_type":"journal-article"},{"id":"pmid:19545197","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19545197","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Critical reviews in toxicology","raw_type":"Journal Article"},{"id":"pmh:oai:mediatum.ub.tum.de:node/1100294","doi":null,"is_oa":false,"landing_page_url":"https://mediatum.ub.tum.de/1100294","pdf_url":null,"source":{"id":"https://openalex.org/S4306400453","display_name":"mediaTUM \u2013 the media and publications repository of the Technical University Munich (Technical University Munich)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I62916508","host_organization_name":"Technical University of Munich","host_organization_lineage":["https://openalex.org/I62916508"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"article"},{"id":"pmh:oai:opus-zb.helmholtz-muenchen.de:1055","doi":null,"is_oa":false,"landing_page_url":"https://push-zb.helmholtz-muenchen.de/frontdoor.php?source_opus=1055","pdf_url":null,"source":{"id":"https://openalex.org/S4377196115","display_name":"Site cant be reached","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Crit. Rev. Toxicol. 39, 462-486 (2009)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":65,"referenced_works":["https://openalex.org/W2009580","https://openalex.org/W1568390176","https://openalex.org/W1748993273","https://openalex.org/W1842309689","https://openalex.org/W1848098399","https://openalex.org/W1908327267","https://openalex.org/W1965862485","https://openalex.org/W1968739847","https://openalex.org/W1969463358","https://openalex.org/W1971879939","https://openalex.org/W1978167598","https://openalex.org/W1978646476","https://openalex.org/W1979332506","https://openalex.org/W1979753791","https://openalex.org/W1985091316","https://openalex.org/W1986297273","https://openalex.org/W1986420231","https://openalex.org/W1990480904","https://openalex.org/W1993313826","https://openalex.org/W1994588577","https://openalex.org/W1996262374","https://openalex.org/W1996369211","https://openalex.org/W2004842367","https://openalex.org/W2007472894","https://openalex.org/W2019199848","https://openalex.org/W2023111300","https://openalex.org/W2025331873","https://openalex.org/W2026342193","https://openalex.org/W2029537954","https://openalex.org/W2041189385","https://openalex.org/W2043426707","https://openalex.org/W2045182627","https://openalex.org/W2047724233","https://openalex.org/W2048918508","https://openalex.org/W2052945291","https://openalex.org/W2054844212","https://openalex.org/W2071152734","https://openalex.org/W2071760336","https://openalex.org/W2078382033","https://openalex.org/W2081536044","https://openalex.org/W2083818175","https://openalex.org/W2087865482","https://openalex.org/W2088579287","https://openalex.org/W2093810119","https://openalex.org/W2093887459","https://openalex.org/W2095550112","https://openalex.org/W2102211513","https://openalex.org/W2103622212","https://openalex.org/W2106337037","https://openalex.org/W2116309785","https://openalex.org/W2120933051","https://openalex.org/W2121417474","https://openalex.org/W2121683869","https://openalex.org/W2143032276","https://openalex.org/W2146976723","https://openalex.org/W2155491988","https://openalex.org/W2158899370","https://openalex.org/W2159165567","https://openalex.org/W2165131862","https://openalex.org/W2184630694","https://openalex.org/W2185129731","https://openalex.org/W2324948660","https://openalex.org/W4229791719","https://openalex.org/W4285719527","https://openalex.org/W4301011369"],"related_works":["https://openalex.org/W1986444757","https://openalex.org/W2043426707","https://openalex.org/W2170901847","https://openalex.org/W2081536044","https://openalex.org/W4299432530","https://openalex.org/W2103622212","https://openalex.org/W2047724233","https://openalex.org/W4300142390","https://openalex.org/W2083818175","https://openalex.org/W1971879939"],"abstract_inverted_index":{"Propylene":[0],"oxide":[1],"(PO)":[2],"is":[3,50,110],"an":[4],"important":[5],"industrial":[6],"chemical":[7],"used":[8],"primarily":[9],"in":[10,19,89,108,133,152,201],"the":[11,42,104,146,160,172,195],"synthesis":[12],"of":[13,25,44,70,106,124,197],"other":[14],"compounds.":[15],"Inhalation":[16],"carcinogenesis":[17],"studies":[18,135],"rodents,":[20],"with":[21],"no-observed-adverse-effect":[22],"levels":[23],"(NOAELs)":[24],"100":[26],"and":[27,74,81,91,136,162,174,180],"200":[28],"ppm,":[29,191],"have":[30],"revealed":[31],"that":[32,53,77,98],"chronic,":[33],"high":[34],"exposure":[35],"to":[36,59,86],"PO":[37,60,71,102,125],"can":[38],"induce":[39],"tumors":[40,131],"at":[41,103],"site":[43,105],"contact.":[45],"Despite":[46],"these":[47],"characteristics,":[48],"there":[49],"no":[51],"evidence":[52,94],"typical":[54],"environmental":[55],"or":[56],"occupational":[57],"exposures":[58],"constitute":[61],"a":[62,113,149],"health":[63],"risk":[64,155],"for":[65,120],"humans.":[66],"The":[67,140,166],"nongenotoxic":[68],"effects":[69,123,200],"(glutathione":[72],"depletion":[73],"cell":[75],"proliferation)":[76],"augment":[78],"its":[79],"DNA-reactive":[80],"non-DNA-reactive":[82],"genotoxicity":[83],"are":[84],"expected":[85],"be":[87],"similar":[88,186],"humans":[90],"rodents.":[92],"Available":[93],"on":[95,129,145,194],"mode-of-action":[96],"suggests":[97],"cancer":[99],"induction":[100],"by":[101,112],"contact":[107],"rodents":[109],"characterized":[111],"practical":[114],"threshold.":[115],"Human":[116],"toxicity":[117],"reference":[118,168,188],"values":[119,169,177],"potential":[121],"carcinogenic":[122],"were":[126,178],"derived":[127,170,193],"based":[128],"nasal":[130,199],"identified":[132],"rodent":[134],"specified":[137],"uncertainty":[138],"factors.":[139],"95%":[141],"lower":[142],"confidence":[143],"limit":[144],"dose":[147],"producing":[148],"10%":[150],"increase":[151],"additional":[153],"tumor":[154],"(LED10)":[156],"was":[157,192],"calculated":[158],"using":[159],"rat":[161,173],"mouse":[163,175],"data":[164],"sets.":[165],"human":[167],"from":[171],"LED10":[176],"0.7":[179],"0.5":[181],"ppm":[182],"PO,":[183],"respectively.":[184],"A":[185],"noncancer":[187],"value,":[189],"0.4":[190],"basis":[196],"non-neoplastic":[198],"rats.":[202]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
