{"id":"https://openalex.org/W2102906337","doi":"https://doi.org/10.1158/1541-7786.mcr-11-0300","title":"Role of Neurofilament Light Polypeptide in Head and Neck Cancer Chemoresistance","display_name":"Role of Neurofilament Light Polypeptide in Head and Neck Cancer Chemoresistance","publication_year":2012,"publication_date":"2012-01-14","ids":{"openalex":"https://openalex.org/W2102906337","doi":"https://doi.org/10.1158/1541-7786.mcr-11-0300","mag":"2102906337","pmid":"https://pubmed.ncbi.nlm.nih.gov/22246235"},"language":"en","primary_location":{"id":"doi:10.1158/1541-7786.mcr-11-0300","doi":"https://doi.org/10.1158/1541-7786.mcr-11-0300","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-11-0300","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087991582","display_name":"Baishen Chen","orcid":"https://orcid.org/0009-0001-2164-7036","observed_orcids":["https://orcid.org/0009-0001-2164-7036"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210088873","display_name":"Third Affiliated Hospital of Southern Medical University","ror":"https://ror.org/0050r1b65","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088873"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Baishen Chen","raw_affiliation_strings":["Authors' Affiliations:\u20081Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana; 2Department of Surgery, Memorial Hospital, Sun Yat-Sen University School of Medicine, Guangzhou, P. R. China; 3Department of Thoracic Surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou, P.R.China; 4Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland; and 5Department of Cellular and Integrative Physiology and Indiana University Simon Cancer Center, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana; 2Department of Surgery, Memorial Hospital, Sun Yat-Sen University School of Medicine, Guangzhou, P. R. China; 3Department of Thoracic Surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou, P.R.China; 4Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland; and 5Department of Cellular and Integrative Physiology and Indiana University Simon Cancer Center, Indianapolis, Indiana","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I157773358","https://openalex.org/I4210088873","https://openalex.org/I4210097354","https://openalex.org/I4210119109","https://openalex.org/I4390039317","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100774575","display_name":"Ju Chen","orcid":"https://orcid.org/0000-0001-8711-4294","observed_orcids":["https://orcid.org/0000-0001-8711-4294"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210088873","display_name":"Third Affiliated Hospital of Southern Medical University","ror":"https://ror.org/0050r1b65","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088873"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Ju Chen","raw_affiliation_strings":["Authors' Affiliations:\u20081Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana; 2Department of Surgery, Memorial Hospital, Sun Yat-Sen University School of Medicine, Guangzhou, P. R. China; 3Department of Thoracic Surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou, P.R.China; 4Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland; and 5Department of Cellular and Integrative Physiology and Indiana University Simon Cancer Center, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana; 2Department of Surgery, Memorial Hospital, Sun Yat-Sen University School of Medicine, Guangzhou, P. R. China; 3Department of Thoracic Surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou, P.R.China; 4Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland; and 5Department of Cellular and Integrative Physiology and Indiana University Simon Cancer Center, Indianapolis, Indiana","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I157773358","https://openalex.org/I4210088873","https://openalex.org/I4210097354","https://openalex.org/I4210119109","https://openalex.org/I4390039317","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063009124","display_name":"Michael Garrett House","orcid":"https://orcid.org/0000-0002-1676-8124","observed_orcids":["https://orcid.org/0000-0002-1676-8124"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210088873","display_name":"Third Affiliated Hospital of Southern Medical University","ror":"https://ror.org/0050r1b65","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088873"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Michael G. House","raw_affiliation_strings":["Authors' Affiliations:\u20081Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana; 2Department of Surgery, Memorial Hospital, Sun Yat-Sen University School of Medicine, Guangzhou, P. R. China; 3Department of Thoracic Surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou, P.R.China; 4Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland; and 5Department of Cellular and Integrative Physiology and Indiana University Simon Cancer Center, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana; 2Department of Surgery, Memorial Hospital, Sun Yat-Sen University School of Medicine, Guangzhou, P. R. China; 3Department of Thoracic Surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou, P.R.China; 4Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland; and 5Department of Cellular and Integrative Physiology and Indiana University Simon Cancer Center, Indianapolis, Indiana","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I157773358","https://openalex.org/I4210088873","https://openalex.org/I4210097354","https://openalex.org/I4210119109","https://openalex.org/I4390039317","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110823521","display_name":"Kevin J. Cullen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210088873","display_name":"Third Affiliated Hospital of Southern Medical University","ror":"https://ror.org/0050r1b65","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088873"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Kevin J. Cullen","raw_affiliation_strings":["Authors' Affiliations:\u20081Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana; 2Department of Surgery, Memorial Hospital, Sun Yat-Sen University School of Medicine, Guangzhou, P. R. China; 3Department of Thoracic Surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou, P.R.China; 4Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland; and 5Department of Cellular and Integrative Physiology and Indiana University Simon Cancer Center, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana; 2Department of Surgery, Memorial Hospital, Sun Yat-Sen University School of Medicine, Guangzhou, P. R. China; 3Department of Thoracic Surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou, P.R.China; 4Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland; and 5Department of Cellular and Integrative Physiology and Indiana University Simon Cancer Center, Indianapolis, Indiana","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I157773358","https://openalex.org/I4210088873","https://openalex.org/I4210097354","https://openalex.org/I4210119109","https://openalex.org/I4390039317","https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061888144","display_name":"Kenneth P. Nephew","orcid":"https://orcid.org/0000-0003-2192-1346","observed_orcids":["https://orcid.org/0000-0003-2192-1346"]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210088873","display_name":"Third Affiliated Hospital of Southern Medical University","ror":"https://ror.org/0050r1b65","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088873"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Kenneth P. Nephew","raw_affiliation_strings":["Authors' Affiliations:\u20081Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana; 2Department of Surgery, Memorial Hospital, Sun Yat-Sen University School of Medicine, Guangzhou, P. R. China; 3Department of Thoracic Surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou, P.R.China; 4Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland; and 5Department of Cellular and Integrative Physiology and Indiana University Simon Cancer Center, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana; 2Department of Surgery, Memorial Hospital, Sun Yat-Sen University School of Medicine, Guangzhou, P. R. China; 3Department of Thoracic Surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou, P.R.China; 4Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland; and 5Department of Cellular and Integrative Physiology and Indiana University Simon Cancer Center, Indianapolis, Indiana","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I157773358","https://openalex.org/I4210088873","https://openalex.org/I4210097354","https://openalex.org/I4210119109","https://openalex.org/I4390039317","https://openalex.org/I4394709130"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5114045443","display_name":"Zhongmin Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I126744593","display_name":"University of Maryland, Baltimore","ror":"https://ror.org/04rq5mt64","country_code":"US","type":"education","lineage":["https://openalex.org/I126744593"]},{"id":"https://openalex.org/I157773358","display_name":"Sun Yat-sen University","ror":"https://ror.org/0064kty71","country_code":"CN","type":"education","lineage":["https://openalex.org/I157773358"]},{"id":"https://openalex.org/I4210088873","display_name":"Third Affiliated Hospital of Southern Medical University","ror":"https://ror.org/0050r1b65","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210088873"]},{"id":"https://openalex.org/I4210097354","display_name":"Sun Yat-sen Memorial Hospital","ror":"https://ror.org/01px77p81","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097354"]},{"id":"https://openalex.org/I4210119109","display_name":"Indiana University Bloomington","ror":"https://ror.org/02k40bc56","country_code":"US","type":"education","lineage":["https://openalex.org/I4210119109","https://openalex.org/I592451"]},{"id":"https://openalex.org/I4390039317","display_name":"University of Maryland Marlene and Stewart Greenebaum Comprehensive Cancer Center","ror":"https://ror.org/01vft3j45","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I14285509","https://openalex.org/I4390039317"]},{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["CN","US"],"is_corresponding":false,"raw_author_name":"Zhongmin Guo","raw_affiliation_strings":["Authors' Affiliations:\u20081Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana; 2Department of Surgery, Memorial Hospital, Sun Yat-Sen University School of Medicine, Guangzhou, P. R. China; 3Department of Thoracic Surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou, P.R.China; 4Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland; and 5Department of Cellular and Integrative Physiology and Indiana University Simon Cancer Center, Indianapolis, Indiana"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Authors' Affiliations:\u20081Medical Sciences Program, Indiana University School of Medicine, Bloomington, Indiana; 2Department of Surgery, Memorial Hospital, Sun Yat-Sen University School of Medicine, Guangzhou, P. R. China; 3Department of Thoracic Surgery, the Third Affiliated Hospital of Southern Medical University, Guangzhou, P.R.China; 4Marlene and Stewart Greenebaum Cancer Center, University of Maryland School of Medicine, Baltimore, Maryland; and 5Department of Cellular and Integrative Physiology and Indiana University Simon Cancer Center, Indianapolis, Indiana","institution_ids":["https://openalex.org/I126744593","https://openalex.org/I157773358","https://openalex.org/I4210088873","https://openalex.org/I4210097354","https://openalex.org/I4210119109","https://openalex.org/I4390039317","https://openalex.org/I4394709130"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":7,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":3.4227,"has_fulltext":false,"cited_by_count":27,"citation_normalized_percentile":{"value":0.91755627,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"10","issue":"3","first_page":"305","last_page":"315"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10307","display_name":"Head and Neck Cancer Studies","score":0.9301999807357788,"subfield":{"id":"https://openalex.org/subfields/2733","display_name":"Otorhinolaryngology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.04859999939799309,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10163","display_name":"Metal complexes synthesis and properties","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/head-and-neck-cancer","display_name":"head and neck cancer","score":0.8830000162124634},{"id":"https://openalex.org/keywords/cisplatin-resistance","display_name":"cisplatin resistance","score":0.9769999980926514},{"id":"https://openalex.org/keywords/chemoresistance","display_name":"chemoresistance","score":0.8799999952316284},{"id":"https://openalex.org/keywords/promoter-hypermethylation","display_name":"promoter hypermethylation","score":0.9319999814033508},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tsc1","display_name":"TSC1","score":0.8040000200271606},{"id":"https://openalex.org/keywords/mtor-signaling","display_name":"mTOR signaling","score":0.9610000252723694},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.8399999737739563},{"id":"https://openalex.org/keywords/gene-knockdown","display_name":"gene knockdown","score":0.4309999942779541}],"concepts":[{"id":"https://openalex.org/C3018411727","wikidata":"https://www.wikidata.org/wiki/Q3867488","display_name":"Head and neck","level":2,"score":0.6557800769805908},{"id":"https://openalex.org/C2776530083","wikidata":"https://www.wikidata.org/wiki/Q1783924","display_name":"Head and neck cancer","level":3,"score":0.6120728254318237},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5716869831085205},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.5628390312194824},{"id":"https://openalex.org/C2994463257","wikidata":"https://www.wikidata.org/wiki/Q233309","display_name":"Brain cancer","level":3,"score":0.47362229228019714},{"id":"https://openalex.org/C157207234","wikidata":"https://www.wikidata.org/wiki/Q962115","display_name":"Neurofilament","level":3,"score":0.4469420909881592},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37610000371932983},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34562838077545166},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2550588846206665},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.22722643613815308},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.1652916967868805},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.06269174814224243}],"mesh":[{"descriptor_ui":"D000077004","descriptor_name":"Tuberous Sclerosis Complex 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002945","descriptor_name":"Cisplatin","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006258","descriptor_name":"Head and Neck Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010455","descriptor_name":"Peptides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D016019","descriptor_name":"Survival Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016900","descriptor_name":"Neurofilament Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016900","descriptor_name":"Neurofilament Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D019008","descriptor_name":"Drug Resistance, Neoplasm","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020868","descriptor_name":"Gene Silencing","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D025521","descriptor_name":"Tumor Suppressor Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D058570","descriptor_name":"TOR Serine-Threonine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1158/1541-7786.mcr-11-0300","doi":"https://doi.org/10.1158/1541-7786.mcr-11-0300","is_oa":false,"landing_page_url":"https://doi.org/10.1158/1541-7786.mcr-11-0300","pdf_url":null,"source":{"id":"https://openalex.org/S192067876","display_name":"Molecular Cancer Research","issn_l":"1541-7786","issn":["1541-7786","1557-3125"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320273","host_organization_name":"American Association for Cancer Research","host_organization_lineage":["https://openalex.org/P4310320273"],"host_organization_lineage_names":["American Association for Cancer Research"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Cancer Research","raw_type":"journal-article"},{"id":"pmid:22246235","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22246235","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular cancer research : MCR","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.7799999713897705}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4941813046","display_name":"Interrogating Epigenetic Changes in Cancer Genomes","funder_award_id":"U54CA113001","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":54,"referenced_works":["https://openalex.org/W1587842942","https://openalex.org/W1601126644","https://openalex.org/W1982303634","https://openalex.org/W1996857140","https://openalex.org/W2013177587","https://openalex.org/W2016782531","https://openalex.org/W2020319882","https://openalex.org/W2028045352","https://openalex.org/W2028952215","https://openalex.org/W2034687480","https://openalex.org/W2035503420","https://openalex.org/W2035595951","https://openalex.org/W2037572151","https://openalex.org/W2038212243","https://openalex.org/W2042512744","https://openalex.org/W2045293701","https://openalex.org/W2047243813","https://openalex.org/W2048332228","https://openalex.org/W2051808614","https://openalex.org/W2064661688","https://openalex.org/W2070661301","https://openalex.org/W2090260075","https://openalex.org/W2091572722","https://openalex.org/W2093380524","https://openalex.org/W2095717162","https://openalex.org/W2097908686","https://openalex.org/W2102179098","https://openalex.org/W2103540939","https://openalex.org/W2104027245","https://openalex.org/W2109898875","https://openalex.org/W2110298732","https://openalex.org/W2117741956","https://openalex.org/W2124293825","https://openalex.org/W2128142253","https://openalex.org/W2129737973","https://openalex.org/W2130177169","https://openalex.org/W2133171927","https://openalex.org/W2134044586","https://openalex.org/W2134739993","https://openalex.org/W2143116661","https://openalex.org/W2152794932","https://openalex.org/W2153607816","https://openalex.org/W2158685104","https://openalex.org/W2160872988","https://openalex.org/W2163802618","https://openalex.org/W2163999275","https://openalex.org/W2167012615","https://openalex.org/W2460306028","https://openalex.org/W6635200458","https://openalex.org/W6649485272","https://openalex.org/W6676449885","https://openalex.org/W6677394090","https://openalex.org/W6682282270","https://openalex.org/W6718554968"],"related_works":["https://openalex.org/W2012770246","https://openalex.org/W2906853171","https://openalex.org/W2017458264","https://openalex.org/W1992366236","https://openalex.org/W2144204897","https://openalex.org/W4385407717","https://openalex.org/W2970653411","https://openalex.org/W2241401228","https://openalex.org/W7117483352","https://openalex.org/W2016155274"],"abstract_inverted_index":{"Resistance":[0],"to":[1,44,66,119,164,179,203,219],"cisplatin-based":[2,45,120,145],"chemotherapy":[3,46,121],"is":[4,215,234],"responsible":[5],"for":[6,141,223,238],"therapeutic":[7],"failure":[8],"of":[9,16,50,58,69,148,174,195,206,248],"many":[10],"common":[11],"human":[12],"cancers":[13],"including":[14],"cancer":[15],"head":[17],"and":[18,85,89,96,134,138,169,199,209,241,251],"neck":[19],"(HNC).":[20],"Mechanisms":[21],"underlying":[22],"cisplatin":[23,212],"resistance":[24,43,65,118,163],"remain":[25],"unclear.":[26],"In":[27,166],"this":[28],"study,":[29],"we":[30],"identified":[31],"neurofilament":[32],"light":[33],"polypeptide":[34],"(NEFL)":[35],"as":[36,79],"a":[37,192,221,235,244],"novel":[38,236],"hypermethylated":[39],"gene":[40],"associated":[41,116,185],"with":[42,63,92,103,117,144,186,255],"in":[47,76,100,152,225,253],"HNC.":[48,256],"Analysis":[49],"14":[51],"HNC":[52,104,226,239],"cell":[53,77,156],"lines":[54,78],"revealed":[55],"that":[56,231],"downregulation":[57,201],"NEFL":[59,70,94,112,149,175,183,200,224,232],"expression":[60,173],"significantly":[61,176],"correlated":[62,91],"increased":[64,159,177],"cisplatin.":[67,165],"Hypermethylation":[68],"promoter":[71,113],"CpG":[72],"islands":[73],"was":[74,115],"observed":[75],"examined":[80],"by":[81,109,150],"bisulfite":[82],"DNA":[83],"sequencing":[84],"methylation-specific":[86],"PCR":[87],"(MSP)":[88],"tightly":[90],"reduced":[93],"mRNA":[95],"protein":[97],"expression.":[98],"Furthermore,":[99,182],"patient":[101],"samples":[102],"(n":[105],"=":[106,132],"51)":[107],"analyzed":[108],"quantitative":[110],"MSP,":[111],"hypermethylation":[114],"[relative":[122],"risk":[123],"(RR),":[124],"3.045;":[125],"95%":[126],"confidence":[127],"interval":[128],"(CI),":[129],"1.459-6.355;":[130],"P":[131],"0.007]":[133],"predicted":[135],"diminished":[136],"overall":[137],"disease-free":[139],"survival":[140,252],"patients":[142,254],"treated":[143],"chemotherapy.":[146],"Knockdown":[147],"siRNA":[151],"the":[153,180,196,216],"highly":[154],"cisplatin-sensitive":[155],"line":[157],"PCI13":[158],"(P":[160],"<":[161],"0.01)":[162],"cisplatin-resistant":[167],"O11":[168],"SCC25cp":[170],"cells,":[171],"restored":[172],"sensitivity":[178],"drug.":[181],"physically":[184],"tuberous":[187],"sclerosis":[188],"complex":[189],"1":[190],"(TSC1),":[191],"known":[193],"inhibitor":[194],"mTOR":[197,207],"pathway,":[198],"led":[202],"functional":[204],"activation":[205],"pathway":[208],"consequentially":[210],"conferred":[211],"resistance.":[213],"This":[214],"first":[217],"study":[218],"show":[220],"role":[222],"chemoresistance.":[227],"Our":[228],"findings":[229],"suggest":[230],"methylation":[233],"mechanism":[237],"chemoresistance":[240],"may":[242],"represent":[243],"candidate":[245],"biomarker":[246],"predictive":[247],"chemotherapeutic":[249],"response":[250]},"counts_by_year":[{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":1},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":4},{"year":2013,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
