{"id":"https://openalex.org/W2102906124","doi":null,"title":"PTBP-dependent PSD-95 and CamKII\u03b1 alternative splicing in the lens.","display_name":"PTBP-dependent PSD-95 and CamKII\u03b1 alternative splicing in the lens.","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2102906124","mag":"2102906124","pmid":"https://pubmed.ncbi.nlm.nih.gov/25540577","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4265770"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3240865","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4265770","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4265770","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109132905","display_name":"Peter H. Frederikse","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Frederikse","raw_affiliation_strings":["Department of Oral Biology, Rutgers SDM, Newark, NJ ; Department of Pharmacology & Physiology, Rutgers BHS"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, Rutgers SDM, Newark, NJ ; Department of Pharmacology & Physiology, Rutgers BHS","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5050677213","display_name":"Anoop Nandanoor","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anoop Nandanoor","raw_affiliation_strings":["Department of Oral Biology, Rutgers SDM, Newark, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, Rutgers SDM, Newark, NJ","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108594389","display_name":"Chinnaswamy Kasinathan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Chinnaswamy Kasinathan","raw_affiliation_strings":["Department of Oral Biology, Rutgers SDM, Newark, NJ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oral Biology, Rutgers SDM, Newark, NJ","institution_ids":["https://openalex.org/I102322142"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I102322142"],"apc_list":null,"apc_paid":null,"fwci":0.4405,"has_fulltext":false,"cited_by_count":6,"citation_normalized_percentile":{"value":0.55582828,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"20","issue":null,"first_page":"1660","last_page":"7"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10604","display_name":"RNA Research and Splicing","score":0.975600004196167,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.01269999984651804,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11480","display_name":"Connexins and lens biology","score":0.006300000008195639,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psd-95","display_name":"PSD-95","score":0.9100000262260437},{"id":"https://openalex.org/keywords/camkiialpha","display_name":"CaMKII\u03b1","score":0.9810000061988831},{"id":"https://openalex.org/keywords/alternative-splicing","display_name":"alternative splicing","score":0.996999979019165},{"id":"https://openalex.org/keywords/lens-fiber-cells","display_name":"lens fiber cells","score":0.9779999852180481},{"id":"https://openalex.org/keywords/mir-124","display_name":"miR-124","score":0.8309999704360962},{"id":"https://openalex.org/keywords/nonsense-mediated-mrna-decay","display_name":"nonsense-mediated mRNA decay","score":0.7829999923706055},{"id":"https://openalex.org/keywords/glutamate-receptors","display_name":"glutamate receptors","score":0.9020000100135803},{"id":"https://openalex.org/keywords/gaba-receptors","display_name":"GABA receptors","score":0.9340000152587891},{"id":"https://openalex.org/keywords/lens-regeneration","display_name":"lens regeneration","score":0.7979999780654907},{"id":"https://openalex.org/keywords/exon-18","display_name":"exon 18","score":0.7129999995231628}],"concepts":[{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5886302590370178},{"id":"https://openalex.org/C194583182","wikidata":"https://www.wikidata.org/wiki/Q21114084","display_name":"Alternative splicing","level":4,"score":0.5720045566558838},{"id":"https://openalex.org/C187541742","wikidata":"https://www.wikidata.org/wiki/Q4374336","display_name":"Postsynaptic density","level":4,"score":0.5416557788848877},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5239946246147156},{"id":"https://openalex.org/C160268369","wikidata":"https://www.wikidata.org/wiki/Q295251","display_name":"AMPA receptor","level":4,"score":0.4837198555469513},{"id":"https://openalex.org/C197341189","wikidata":"https://www.wikidata.org/wiki/Q863533","display_name":"Postsynaptic potential","level":3,"score":0.34056979417800903},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.33601289987564087},{"id":"https://openalex.org/C61174792","wikidata":"https://www.wikidata.org/wiki/Q420510","display_name":"Glutamate receptor","level":3,"score":0.3062850534915924},{"id":"https://openalex.org/C36823959","wikidata":"https://www.wikidata.org/wiki/Q373027","display_name":"Exon","level":3,"score":0.292285293340683},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.27630990743637085},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2578630745410919},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.1546093225479126}],"mesh":[{"descriptor_ui":"D000076122","descriptor_name":"Disks Large Homolog 4 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D007908","descriptor_name":"Lens, Crystalline","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008565","descriptor_name":"Membrane Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D008807","descriptor_name":"Mice, Inbred BALB C","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011817","descriptor_name":"Rabbits","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014018","descriptor_name":"Tissue Distribution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015870","descriptor_name":"Gene Expression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017398","descriptor_name":"Alternative Splicing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018076","descriptor_name":"DNA, Complementary","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019084","descriptor_name":"Fluorescent Antibody Technique, Indirect","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020133","descriptor_name":"Reverse Transcriptase Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D038941","descriptor_name":"Polypyrimidine Tract-Binding Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051528","descriptor_name":"Guanylate Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051528","descriptor_name":"Guanylate Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D054732","descriptor_name":"Calcium-Calmodulin-Dependent Protein Kinase Type 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:3240865","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4265770","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmid:25540577","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25540577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular vision","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4265770","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC4265770/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Vis","raw_type":"Text"},{"id":"mag:2102906124","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25540577","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3240865","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4265770","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G128509666","display_name":"Alzheimer disease biomarkers in lens","funder_award_id":"R01EY015855","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1483685331","https://openalex.org/W1551663317","https://openalex.org/W1569092853","https://openalex.org/W1597198747","https://openalex.org/W1963537939","https://openalex.org/W1976041850","https://openalex.org/W1978337436","https://openalex.org/W1980728857","https://openalex.org/W1990822683","https://openalex.org/W1998328961","https://openalex.org/W2001183296","https://openalex.org/W2001547716","https://openalex.org/W2001720542","https://openalex.org/W2013895647","https://openalex.org/W2021712527","https://openalex.org/W2026441189","https://openalex.org/W2029568863","https://openalex.org/W2031953192","https://openalex.org/W2038874091","https://openalex.org/W2047819814","https://openalex.org/W2049788085","https://openalex.org/W2052624503","https://openalex.org/W2052698368","https://openalex.org/W2056429179","https://openalex.org/W2059031716","https://openalex.org/W2065567075","https://openalex.org/W2080336978","https://openalex.org/W2080592158","https://openalex.org/W2085739680","https://openalex.org/W2086121847","https://openalex.org/W2096642853","https://openalex.org/W2097907196","https://openalex.org/W2099299356","https://openalex.org/W2100013751","https://openalex.org/W2105366549","https://openalex.org/W2117293520","https://openalex.org/W2126440176","https://openalex.org/W2129923922","https://openalex.org/W2135321046","https://openalex.org/W2148256023","https://openalex.org/W2150393383","https://openalex.org/W2158643993","https://openalex.org/W2161272397","https://openalex.org/W2341832919","https://openalex.org/W2421471272"],"related_works":["https://openalex.org/W2105366549","https://openalex.org/W2129923922","https://openalex.org/W7097116442","https://openalex.org/W7100799561","https://openalex.org/W2052698368","https://openalex.org/W2026441189","https://openalex.org/W2341832919","https://openalex.org/W2585952154","https://openalex.org/W2001720542","https://openalex.org/W2735482961"],"abstract_inverted_index":{"PURPOSE:":[0],"Parallels":[1],"described":[2],"between":[3],"neurons":[4,48],"and":[5,26,68,75,85,92,107,113,123,126,136,145,163,186,210,215,227,246,258,271,288],"lens":[6,54,165,234,261,299],"fiber":[7,203,235],"cells":[8],"include":[9],"detailed":[10],"similarities":[11],"in":[12,23,31,52,130,161,194,255,263,277,297],"sub-cellular":[13],"structures":[14,30],"that":[15,42,70,243,303],"increasingly":[16],"show":[17],"shared":[18,312],"expression":[19,112,144],"of":[20,28,36,39,118,120,176,191,269,282,290,294,306],"genes":[21,41],"involved":[22],"the":[24,53,79,116,131,152,195,223,298,307,314],"construction":[25],"function":[27],"these":[29,40,248],"neurons.":[32],"Intriguingly,":[33],"associated":[34],"modes":[35],"molecular":[37,122,295],"regulation":[38,296],"had":[43],"been":[44,50],"thought":[45],"to":[46,96,141,182],"distinguish":[47],"have":[49],"identified":[51,232],"as":[55],"well.":[56],"Both":[57],"elongated":[58],"cell":[59,124,204,236],"types":[60],"form":[61],"membrane":[62],"protrusions":[63],"with":[64,78,90,207,266,313],"similar":[65],"size,":[66],"shape,":[67],"spacing":[69],"exclude":[71],"microtubules,":[72],"contain":[73],"F-actin,":[74],"are":[76,311],"coated":[77],"clathrin/AP-2":[80],"adaptor.":[81],"Lenses":[82],"express":[83],"glutamate":[84,214],"gamma-aminobutyric":[86],"acid":[87,212],"(GABA)":[88],"receptors":[89],"signaling":[91],"channel":[93],"proteins":[94],"shown":[95],"act":[97],"together":[98],"at":[99,202,233],"neuronal":[100,121],"membranes.":[101,237],"Postsynaptic":[102],"density":[103],"protein":[104,109,143,157,172,199,287],"95":[105],"(PSD-95)":[106],"Ca(2+)/calmodulin-dependent":[108],"kinase":[110],"(CaMKII\u03b1)":[111],"functions":[114],"illustrate":[115],"integration":[117],"aspects":[119,305],"biology":[125],"were":[127,139,230],"investigated":[128],"here":[129],"lens.":[132,196,315],"METHODS:":[133],"Immunofluorescence,":[134],"immunoblot,":[135],"RT-PCR":[137],"methods":[138],"used":[140],"assess":[142],"alternative":[146,174,189],"transcript":[147],"splicing.":[148],"RESULTS:":[149],"We":[150],"showed":[151,187],"essential":[153],"dendritic":[154,284],"spine":[155,285],"scaffold":[156,286],"PSD-95":[158,166,198],"is":[159,241,252],"expressed":[160,242,254],"lenses":[162,257],"demonstrated":[164],"transcripts":[167,193],"undergo":[168],"polypyrimidine":[169],"tract":[170],"binding":[171],"(PTBP)-dependent":[173],"splicing":[175,190,249,276],"its":[177,291],"pivotal":[178],"exon":[179,274],"18":[180],"required":[181],"avoid":[183],"nonsense-mediated":[184],"decay,":[185],"PTBP-dependent":[188,272],"CaMKII\u03b1":[192],"The":[197],"was":[200],"observed":[201],"membranes":[205],"overlapping":[206],"N-methyl-D-aspartate":[208],"(NMDA)":[209],"\u03b1-amino-3-hydroxy-5-methyl-4-isoxazolepropionic":[211],"(AMPA)":[213],"GABA":[216],"receptor":[217],"proteins,":[218],"tyrosine":[219],"phosphatase":[220],"STEP,":[221],"CaMKII\u03b1,":[222],"Ca(V)1.3":[224],"calcium":[225],"channel,":[226],"clathrin,":[228],"which":[229],"previously":[231],"During":[238],"neurogenesis,":[239],"miR-124":[240,251],"suppresses":[244],"PTBP1":[245],"promotes":[247],"events.":[250],"also":[253],"mammalian":[256],"upregulated":[259],"during":[260],"regeneration":[262],"amphibians,":[264],"consistent":[265],"previous":[267],"demonstrations":[268],"PTBP1,2":[270],"PTBP2":[273],"10":[275],"rodent":[278],"lenses.":[279],"CONCLUSIONS:":[280],"Findings":[281],"this":[283],"conservation":[289],"key":[292,304],"mode":[293],"provides":[300],"further":[301],"evidence":[302],"neuron":[308],"morphogenetic":[309],"program":[310]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2015,"cited_by_count":3}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
