{"id":"https://openalex.org/W2102896945","doi":"https://doi.org/10.1111/j.1399-6576.1983.tb01947.x","title":"Intestinal Vascular Responses to Dopamine During Fentanyl\u2010Nitrous Oxide Anaesthesia, Supplemented with Dixyrazin","display_name":"Intestinal Vascular Responses to Dopamine During Fentanyl\u2010Nitrous Oxide Anaesthesia, Supplemented with Dixyrazin","publication_year":1983,"publication_date":"1983-06-01","ids":{"openalex":"https://openalex.org/W2102896945","doi":"https://doi.org/10.1111/j.1399-6576.1983.tb01947.x","mag":"2102896945","pmid":"https://pubmed.ncbi.nlm.nih.gov/6880586"},"language":"en","primary_location":{"id":"doi:10.1111/j.1399-6576.1983.tb01947.x","doi":"https://doi.org/10.1111/j.1399-6576.1983.tb01947.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-6576.1983.tb01947.x","pdf_url":null,"source":{"id":"https://openalex.org/S177321322","display_name":"Acta Anaesthesiologica Scandinavica","issn_l":"0001-5172","issn":["0001-5172","1399-6576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Anaesthesiologica Scandinavica","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5109553396","display_name":"B. Biber","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":true,"raw_author_name":"B. Biber","raw_affiliation_strings":["Departments of Anaesthesia and Physiology, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anaesthesia and Physiology, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019709705","display_name":"Jan Martner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"J. Martner","raw_affiliation_strings":["Departments of Anaesthesia and Physiology, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anaesthesia and Physiology, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033001505","display_name":"Holger Nilsson","orcid":"https://orcid.org/0000-0003-2350-7157","observed_orcids":["https://orcid.org/0000-0003-2350-7157"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"H. Nilsson","raw_affiliation_strings":["Departments of Anaesthesia and Physiology, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anaesthesia and Physiology, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019249193","display_name":"S. Redfors","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"S. Redfors","raw_affiliation_strings":["Departments of Anaesthesia and Physiology, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anaesthesia and Physiology, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007674070","display_name":"Henrik Sj\u00f6vall","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"H. Sj\u00f6wall","raw_affiliation_strings":["Departments of Anaesthesia and Physiology, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anaesthesia and Physiology, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5021353667","display_name":"Ola Wins\u00f6","orcid":"https://orcid.org/0000-0001-5473-1878","observed_orcids":["https://orcid.org/0000-0001-5473-1878"]},"institutions":[{"id":"https://openalex.org/I881427289","display_name":"University of Gothenburg","ror":"https://ror.org/01tm6cn81","country_code":"SE","type":"education","lineage":["https://openalex.org/I881427289"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"O. Wins\u00f6","raw_affiliation_strings":["Departments of Anaesthesia and Physiology, University of Gothenburg, Gothenburg, Sweden"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Anaesthesia and Physiology, University of Gothenburg, Gothenburg, Sweden","institution_ids":["https://openalex.org/I881427289"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5109553396"],"corresponding_institution_ids":["https://openalex.org/I881427289"],"apc_list":{"value":4430,"currency":"USD","value_usd":4430},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":2,"citation_normalized_percentile":{"value":0.21822813,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"27","issue":"3","first_page":"255","last_page":"261"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.44359999895095825,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10436","display_name":"Anesthesia and Sedative Agents","score":0.44359999895095825,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11700","display_name":"Hemodynamic Monitoring and Therapy","score":0.2538999915122986,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10189","display_name":"Anesthesia and Pain Management","score":0.08529999852180481,"subfield":{"id":"https://openalex.org/subfields/2703","display_name":"Anesthesiology and Pain Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dopamine","display_name":"dopamine","score":0.8899999856948853},{"id":"https://openalex.org/keywords/intestinal-blood-flow","display_name":"intestinal blood flow","score":0.7519999742507935},{"id":"https://openalex.org/keywords/vasodilator-response","display_name":"vasodilator response","score":0.7630000114440918},{"id":"https://openalex.org/keywords/renal-vasoconstriction","display_name":"renal vasoconstriction","score":0.8769999742507935},{"id":"https://openalex.org/keywords/mesenteric-resistance-vessels","display_name":"mesenteric resistance vessels","score":0.9359999895095825},{"id":"https://openalex.org/keywords/alpha-adrenergic-stimulation","display_name":"alpha-adrenergic stimulation","score":0.8610000014305115},{"id":"https://openalex.org/keywords/cats","display_name":"cats","score":0.4399999976158142}],"concepts":[{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7463277578353882},{"id":"https://openalex.org/C2779961880","wikidata":"https://www.wikidata.org/wiki/Q1067506","display_name":"Vasoconstriction","level":2,"score":0.7149289846420288},{"id":"https://openalex.org/C2776725644","wikidata":"https://www.wikidata.org/wiki/Q594365","display_name":"Chloralose","level":3,"score":0.6688688397407532},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6633691191673279},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5858587026596069},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5693731307983398},{"id":"https://openalex.org/C2781072394","wikidata":"https://www.wikidata.org/wiki/Q407541","display_name":"Fentanyl","level":2,"score":0.5171288847923279},{"id":"https://openalex.org/C142225936","wikidata":"https://www.wikidata.org/wiki/Q1129139","display_name":"Renal blood flow","level":3,"score":0.46885666251182556},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.46012425422668457},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.39375627040863037},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.3917108476161957},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3340514302253723},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3266910910606384}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002415","descriptor_name":"Cats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002698","descriptor_name":"Chloralose","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D004357","descriptor_name":"Drug Synergism","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005283","descriptor_name":"Fentanyl","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007421","descriptor_name":"Intestine, Small","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008638","descriptor_name":"Mesenteric Arteries","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D009609","descriptor_name":"Nitrous Oxide","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":false},{"descriptor_ui":"D010640","descriptor_name":"Phenothiazines","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D012039","descriptor_name":"Regional Blood Flow","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D014664","descriptor_name":"Vasodilation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D066298","descriptor_name":"In Vitro Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1399-6576.1983.tb01947.x","doi":"https://doi.org/10.1111/j.1399-6576.1983.tb01947.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1399-6576.1983.tb01947.x","pdf_url":null,"source":{"id":"https://openalex.org/S177321322","display_name":"Acta Anaesthesiologica Scandinavica","issn_l":"0001-5172","issn":["0001-5172","1399-6576"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta Anaesthesiologica Scandinavica","raw_type":"journal-article"},{"id":"pmid:6880586","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6880586","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Acta anaesthesiologica Scandinavica","raw_type":"Comparative Study"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":40,"referenced_works":["https://openalex.org/W275832574","https://openalex.org/W313903468","https://openalex.org/W348971113","https://openalex.org/W1495589657","https://openalex.org/W1966186243","https://openalex.org/W1969646326","https://openalex.org/W1970445852","https://openalex.org/W1975551184","https://openalex.org/W1983239920","https://openalex.org/W1990655387","https://openalex.org/W1992908489","https://openalex.org/W2013472748","https://openalex.org/W2029768262","https://openalex.org/W2030279594","https://openalex.org/W2035977209","https://openalex.org/W2039425578","https://openalex.org/W2047054489","https://openalex.org/W2077262204","https://openalex.org/W2078332173","https://openalex.org/W2081152205","https://openalex.org/W2089966669","https://openalex.org/W2131466521","https://openalex.org/W2139785932","https://openalex.org/W2167241860","https://openalex.org/W2244783795","https://openalex.org/W2250122627","https://openalex.org/W2275396273","https://openalex.org/W2337747281","https://openalex.org/W2394517609","https://openalex.org/W2395173766","https://openalex.org/W2409255659","https://openalex.org/W2410523159","https://openalex.org/W2411125903","https://openalex.org/W2414687501","https://openalex.org/W2417465981","https://openalex.org/W2421295873","https://openalex.org/W2425329482","https://openalex.org/W2437743883","https://openalex.org/W2473098081","https://openalex.org/W4298100022"],"related_works":["https://openalex.org/W2134236388","https://openalex.org/W2017941960","https://openalex.org/W2013472748","https://openalex.org/W319238867","https://openalex.org/W2035266294","https://openalex.org/W1990655387","https://openalex.org/W2254986032","https://openalex.org/W2397691658","https://openalex.org/W2054607605","https://openalex.org/W2048782513"],"abstract_inverted_index":{"Intestinal":[0],"haemodynamics":[1],"in":[2,12,30,86],"response":[3,66,141,181],"to":[4,131,142,174],"continuous":[5],"i.v.":[6,125,143],"administration":[7],"of":[8,23,124],"dopamine":[9,32,61,102,117,144],"were":[10,93],"investigated":[11],"cats":[13],"anaesthetized":[14],"with":[15,19],"fentanyl-nitrous":[16,133],"oxide":[17,134],"either":[18],"or":[20],"without":[21],"supplement":[22],"dixyrazin.":[24],"A":[25],"dose-dependent":[26,172],"vasodilatation":[27],"was":[28,49,55,98,114,151,182],"observed":[29],"the":[31,42,59,64,132,138,146,168],"dose":[33],"range":[34],"2.5-35":[35],"micrograms":[36,72,106,155],".":[37,39,73,75,107,109,129,156,158],"kg-1":[38,74,108,157],"min-1":[40],"and":[41,90,145],"subsequent":[43],"maximal":[44,147],"intestinal":[45,53,139],"blood":[46,96,148],"flow":[47,97,149],"increase":[48,150],"121%.":[50],"No":[51],"net":[52],"vasoconstriction":[54,113,188],"evident":[56,115],"even":[57],"at":[58,70,101,153],"largest":[60],"doses,":[62],"although":[63],"vascular":[65],"reached":[67],"a":[68,171],"plateau":[69],"17.5":[71],"min-1.":[76,159],"Control":[77],"experiments":[78,162],"during":[79],"chloralose":[80],"anaesthesia":[81,135],"gave":[82],"similar":[83],"results.":[84],"Changes":[85],"mean":[87],"arterial":[88],"pressure":[89],"heart":[91],"rate":[92],"small.":[94],"Renal":[95],"virtually":[99],"unchanged":[100],"doses":[103,118,179],"below":[104],"10":[105],"min-1,":[110],"while":[111],"renal":[112],"following":[116],"above":[119],"that":[120],"level.":[121],"The":[122],"addition":[123],"dixyrazin":[126],"(0.15-0.30":[127],"mg":[128],"kg-1)":[130],"substantially":[136],"potentiated":[137],"vasodilator":[140],"183%":[152],"10-15":[154],"In":[160],"vitro":[161],"using":[163],"mesenteric":[164],"resistance":[165],"vessels":[166],"from":[167],"rat":[169],"demonstrated":[170],"relaxation":[173],"dopamine.":[175],"At":[176],"very":[177],"large":[178],"this":[180],"counteracted,":[183],"but":[184],"not":[185],"reversed":[186],"into":[187],"by":[189],"dopamine-induced":[190],"alpha-adrenergic":[191],"stimulation.":[192]},"counts_by_year":[],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}