{"id":"https://openalex.org/W2102889328","doi":null,"title":"Evaluation of the effects of hydroalcoholic extract of Berberis vulgaris root on the activity of liver enzymes in male hypercholesterolemic rats.","display_name":"Evaluation of the effects of hydroalcoholic extract of Berberis vulgaris root on the activity of liver enzymes in male hypercholesterolemic rats.","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2102889328","mag":"2102889328","pmid":"https://pubmed.ncbi.nlm.nih.gov/25050245","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4075670"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:3073127","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4075670","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4075670","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091465699","display_name":"Soheila Taheri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I133903919","display_name":"Arak University of Medical Sciences","ror":"https://ror.org/056mgfb42","country_code":"IR","type":"education","lineage":["https://openalex.org/I133903919"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Soheila Taheri","raw_affiliation_strings":["Department of Physiology, Arak University of Medical Sciences, Arak, I. R. Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Arak University of Medical Sciences, Arak, I. R. Iran","institution_ids":["https://openalex.org/I133903919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100691029","display_name":"Ali Zarei","orcid":"https://orcid.org/0000-0002-2405-691X","observed_orcids":["https://orcid.org/0000-0002-2405-691X"]},"institutions":[{"id":"https://openalex.org/I4210159640","display_name":"Islamic Azad University, Damghan Branch","ror":"https://ror.org/05a2cfm07","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I4210159640"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Ali Zarei","raw_affiliation_strings":["Islamic Azad University of Damghan, Damghan, I. R. Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Islamic Azad University of Damghan, Damghan, I. R. Iran","institution_ids":["https://openalex.org/I4210159640"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068851774","display_name":"Saeed Changizi\u2010Ashtiyani","orcid":"https://orcid.org/0000-0001-9781-5553","observed_orcids":["https://orcid.org/0000-0001-9781-5553"]},"institutions":[{"id":"https://openalex.org/I133903919","display_name":"Arak University of Medical Sciences","ror":"https://ror.org/056mgfb42","country_code":"IR","type":"education","lineage":["https://openalex.org/I133903919"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Saeed Changizi Ashtiyani","raw_affiliation_strings":["Department of Physiology, Arak University of Medical Sciences, Arak, I. R. Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Physiology, Arak University of Medical Sciences, Arak, I. R. Iran","institution_ids":["https://openalex.org/I133903919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101823098","display_name":"Azam Rezaei Farimani","orcid":"https://orcid.org/0000-0002-7853-2993","observed_orcids":["https://orcid.org/0000-0002-7853-2993"]},"institutions":[{"id":"https://openalex.org/I4210146840","display_name":"Islamic Azad University of Arsanjan","ror":"https://ror.org/05fbv2v73","country_code":"IR","type":"education","lineage":["https://openalex.org/I110525433","https://openalex.org/I4210146840"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Azam Rezaei","raw_affiliation_strings":["Islamic Azad University of Arsanjan, Arsanjan , I. R. Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Islamic Azad University of Arsanjan, Arsanjan , I. R. Iran","institution_ids":["https://openalex.org/I4210146840"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051190027","display_name":"Saeed Zaheiri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55547365","display_name":"Payame Noor University","ror":"https://ror.org/031699d98","country_code":"IR","type":"education","lineage":["https://openalex.org/I55547365"]}],"countries":["IR"],"is_corresponding":false,"raw_author_name":"Saeed Zaheiri","raw_affiliation_strings":["Department of Biology, Payame Noor University of Abadeh, Abadeh , I. R. Iran"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Payame Noor University of Abadeh, Abadeh , I. R. Iran","institution_ids":["https://openalex.org/I55547365"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.7241,"has_fulltext":false,"cited_by_count":37,"citation_normalized_percentile":{"value":0.82536479,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"2","issue":"3","first_page":"153","last_page":"61"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12059","display_name":"Berberine and alkaloids research","score":0.9458000063896179,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13828","display_name":"Natural Products and Biological Research","score":0.03999999910593033,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/berberis-vulgaris","display_name":"Berberis vulgaris","score":0.9959999918937683},{"id":"https://openalex.org/keywords/root-extract","display_name":"root extract","score":0.7689999938011169},{"id":"https://openalex.org/keywords/hydroalcoholic-extract","display_name":"hydroalcoholic extract","score":0.8569999933242798},{"id":"https://openalex.org/keywords/hypercholesterolemia","display_name":"hypercholesterolemia","score":0.9760000109672546},{"id":"https://openalex.org/keywords/hyperlipidemia","display_name":"hyperlipidemia","score":0.9710000157356262},{"id":"https://openalex.org/keywords/fatty-diet","display_name":"fatty diet","score":0.7870000004768372},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.9639999866485596},{"id":"https://openalex.org/keywords/alanine-aminotransferase","display_name":"alanine aminotransferase","score":0.9549999833106995},{"id":"https://openalex.org/keywords/alkaline-phosphatase","display_name":"alkaline phosphatase","score":0.9750000238418579},{"id":"https://openalex.org/keywords/aspartate-aminotransferase","display_name":"aspartate aminotransferase","score":0.9990000128746033},{"id":"https://openalex.org/keywords/atorvastatin","display_name":"atorvastatin","score":0.9399999976158142},{"id":"https://openalex.org/keywords/antioxidant-activity","display_name":"antioxidant activity","score":0.7329999804496765},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.8259999752044678},{"id":"https://openalex.org/keywords/rats","display_name":"rats","score":0.335999995470047}],"concepts":[{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.6958121657371521},{"id":"https://openalex.org/C2779091943","wikidata":"https://www.wikidata.org/wiki/Q1079120","display_name":"Hyperlipidemia","level":3,"score":0.677832305431366},{"id":"https://openalex.org/C2779679107","wikidata":"https://www.wikidata.org/wiki/Q412474","display_name":"Aspartate transaminase","level":4,"score":0.6616914868354797},{"id":"https://openalex.org/C2778606649","wikidata":"https://www.wikidata.org/wiki/Q305481","display_name":"Alanine transaminase","level":2,"score":0.6200839281082153},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.5858149528503418},{"id":"https://openalex.org/C2777482532","wikidata":"https://www.wikidata.org/wiki/Q668093","display_name":"Atorvastatin","level":2,"score":0.5599856972694397},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.5344687104225159},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.45305341482162476},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.4388253688812256},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.431610643863678},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.398353636264801},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.37789955735206604},{"id":"https://openalex.org/C31903555","wikidata":"https://www.wikidata.org/wiki/Q1637030","display_name":"Food science","level":1,"score":0.33023279905319214},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3157275319099426},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.2767762541770935},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.21243968605995178},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"pmh:oai:europepmc.org:3073127","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4075670","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4075670","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4075670","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Avicenna J Phytomed","raw_type":"Text"},{"id":"pmid:25050245","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25050245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Avicenna journal of phytomedicine","raw_type":"Journal Article"},{"id":"pmh:oai:doaj.org/article:1390ee1902d446fe91dc2c873c05027d","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/1390ee1902d446fe91dc2c873c05027d","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Avicenna Journal of Phytomedicine, Vol 2, Iss 3, Pp 153-161 (2012)","raw_type":"article"},{"id":"mag:2102889328","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25050245","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3073127","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4075670","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W1595611683","https://openalex.org/W1792250632","https://openalex.org/W1991109718","https://openalex.org/W2001301735","https://openalex.org/W2008313230","https://openalex.org/W2009430120","https://openalex.org/W2015656731","https://openalex.org/W2029790721","https://openalex.org/W2030882694","https://openalex.org/W2057353165","https://openalex.org/W2068426713","https://openalex.org/W2069038722","https://openalex.org/W2072966392","https://openalex.org/W2080084246","https://openalex.org/W2128230963","https://openalex.org/W2138396117","https://openalex.org/W2142879854","https://openalex.org/W2150615446","https://openalex.org/W2157847667","https://openalex.org/W2163129455","https://openalex.org/W2169759546","https://openalex.org/W2185481271","https://openalex.org/W2197332903","https://openalex.org/W2219907588","https://openalex.org/W2226985137","https://openalex.org/W2227578523","https://openalex.org/W2230271892","https://openalex.org/W2268665680","https://openalex.org/W2282705587","https://openalex.org/W2300883430","https://openalex.org/W2301783731","https://openalex.org/W2377459357","https://openalex.org/W2395301700"],"related_works":["https://openalex.org/W2461601848","https://openalex.org/W2408103807","https://openalex.org/W2908534604","https://openalex.org/W3002472096","https://openalex.org/W2580265917","https://openalex.org/W2120952434","https://openalex.org/W1910719696","https://openalex.org/W4405759544","https://openalex.org/W2108597791","https://openalex.org/W2276081590"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Hyperlipidemia":[1],"can":[2,246],"cause":[3],"a":[4,75,83,94,127,248],"variety":[5],"of":[6,40,46,68,101,133,144,161,169,226,238,243,255],"diseases":[7],"such":[8],"as":[9,198,200],"atherosclerosis,":[10],"diabetes,":[11],"and":[12,63,78,97,111,141,173,231],"fatty":[13,84,95,128,185],"liver":[14,20,47,239],"which":[15],"is":[16],"followed":[17],"by":[18,116],"increased":[19,187],"enzymes.":[21],"Since":[22],"Berberis":[23],"vulgaris":[24,103,196,228],"(B.":[25],"vulgaris)":[26],"root":[27,229],"possesses":[28],"antioxidant":[29,224],"properties,":[30],"the":[31,38,44,79,87,98,131,142,145,162,167,179,191,202,223,236,241,253],"present":[32],"study":[33],"was":[34],"conducted":[35],"to":[36,65],"investigate":[37],"effect":[39],"its":[41,232],"extract":[42,100,197,230,242],"on":[43,234],"activity":[45,237],"enzymes":[48,177,207],"in":[49,178,190,201,216],"rats.":[50],"MATERIALS":[51],"AND":[52],"METHODS:":[53],"In":[54],"this":[55,134,244],"experimental":[56,91],"study,":[57],"sixty":[58],"Wistar":[59],"rats":[60],"were":[61,139,148,151,214],"selected":[62],"allocated":[64],"six":[66],"groups":[67,89,92,193],"ten":[69],"each.":[70],"The":[71,159],"control":[72],"group":[73,81,181,203],"received":[74,82,93,184],"normal":[76],"diet":[77,85,96],"sham":[80,180],"while":[86],"other":[88],"including":[90],"alcoholic":[99],"B.":[102,195,227],"at":[104],"minimum":[105],"(75":[106],"mg/kg),":[107,110],"moderate":[108],"(150":[109],"maximum":[112],"(300":[113],"mg/kg)":[114],"doses":[115],"intraperitoneal":[117],"injection":[118],"(i.p.)":[119],"or":[120],"oral":[121],"atorvastatin":[122],"(10":[123],"mg":[124],"/kg)":[125],"with":[126],"diet.":[129],"At":[130],"end":[132],"21-day":[135],"period,":[136],"blood":[137],"samples":[138],"drawn":[140],"levels":[143,168],"intended":[146],"factors":[147],"measured.":[149],"Data":[150],"analyzed":[152],"using":[153],"SPSS":[154],"software":[155],"version":[156],"11.5.":[157],"RESULTS:":[158],"comparison":[160],"obtained":[163],"results":[164],"showed":[165],"that":[166,182],"alanine":[170],"transaminase":[171,218],"(ALT)":[172],"alkaline":[174],"phosphatase":[175],"(ALP)":[176],"only":[183],"food":[186],"(p\u22640.05),":[188],"whereas":[189],"treatment":[192],"receiving":[194,204],"well":[199],"Atorvastatin,":[205],"these":[206],"significantly":[208],"decreased;":[209],"however,":[210],"no":[211],"significant":[212],"changes":[213],"observed":[215],"aspartate":[217],"(AST)":[219],"levels.":[220],"CONCLUSION:":[221],"Noticing":[222],"properties":[225],"effects":[233],"reducing":[235],"enzymes,":[240],"plant":[245],"be":[247],"good":[249],"choice":[250],"for":[251],"improving":[252],"function":[254],"liver.":[256]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":3},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}