{"id":"https://openalex.org/W2102881136","doi":"https://doi.org/10.1684/ecn.2012.0302","title":"Quantitative mRNA expression of genes involved in angiogenesis, coagulation and inflammation in multiforme glioblastoma tumoral tissue versus peritumoral brain tissue: lack of correlation with clinical data","display_name":"Quantitative mRNA expression of genes involved in angiogenesis, coagulation and inflammation in multiforme glioblastoma tumoral tissue versus peritumoral brain tissue: lack of correlation with clinical data","publication_year":2012,"publication_date":"2012-06-01","ids":{"openalex":"https://openalex.org/W2102881136","doi":"https://doi.org/10.1684/ecn.2012.0302","mag":"2102881136","pmid":"https://pubmed.ncbi.nlm.nih.gov/22591734"},"language":"en","primary_location":{"id":"doi:10.1684/ecn.2012.0302","doi":"https://doi.org/10.1684/ecn.2012.0302","is_oa":false,"landing_page_url":"https://doi.org/10.1684/ecn.2012.0302","pdf_url":null,"source":{"id":"https://openalex.org/S121125150","display_name":"European Cytokine Network","issn_l":"1148-5493","issn":["1148-5493","1952-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320125","host_organization_name":"John Libbey Eurotext","host_organization_lineage":["https://openalex.org/P4310320125"],"host_organization_lineage_names":["John Libbey Eurotext"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Cytokine Network","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064374408","display_name":"Ioana Berindan\u2010Neagoe","orcid":"https://orcid.org/0000-0001-5828-1325","observed_orcids":["https://orcid.org/0000-0001-5828-1325"]},"institutions":[{"id":"https://openalex.org/I4210100616","display_name":"Institute of Oncology Prof. Dr. Ion Chiricuta","ror":"https://ror.org/00nrbsf87","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210100616"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Ioana Berindan-Neagoe","raw_affiliation_strings":["Cancer Institute I. Chiricuta, Cluj-Napoca, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute I. Chiricuta, Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I4210100616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089194275","display_name":"Roxana Chiorean","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I208470662","display_name":"Iuliu Ha\u021bieganu University of Medicine and Pharmacy","ror":"https://ror.org/051h0cw83","country_code":"RO","type":"education","lineage":["https://openalex.org/I208470662"]},{"id":"https://openalex.org/I4210100616","display_name":"Institute of Oncology Prof. Dr. Ion Chiricuta","ror":"https://ror.org/00nrbsf87","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210100616"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Roxana Chiorean","raw_affiliation_strings":["Cancer Institute \u201cI. Chiricuta\u201d, Cluj-Napoca,Romania, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, Cluj-Napoca, Romania, Clinical Universitary Hospital of Dermatovenereology, Cluj-Napoca, Romania, Clinical Universitary Emergency Hospital, Department of Neurosurgery, Cluj-Napoca, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute \u201cI. Chiricuta\u201d, Cluj-Napoca,Romania, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, Cluj-Napoca, Romania, Clinical Universitary Hospital of Dermatovenereology, Cluj-Napoca, Romania, Clinical Universitary Emergency Hospital, Department of Neurosurgery, Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I208470662","https://openalex.org/I4210100616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043162309","display_name":"Cornelia Braicu","orcid":"https://orcid.org/0000-0002-3055-4747","observed_orcids":["https://orcid.org/0000-0002-3055-4747"]},"institutions":[{"id":"https://openalex.org/I208470662","display_name":"Iuliu Ha\u021bieganu University of Medicine and Pharmacy","ror":"https://ror.org/051h0cw83","country_code":"RO","type":"education","lineage":["https://openalex.org/I208470662"]},{"id":"https://openalex.org/I4210100616","display_name":"Institute of Oncology Prof. Dr. Ion Chiricuta","ror":"https://ror.org/00nrbsf87","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210100616"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Cornelia Braicu","raw_affiliation_strings":["Cancer Institute \u201cI. Chiricuta\u201d, Cluj-Napoca,Romania, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, Cluj-Napoca, Romania, Clinical Universitary Hospital of Dermatovenereology, Cluj-Napoca, Romania, Clinical Universitary Emergency Hospital, Department of Neurosurgery, Cluj-Napoca, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute \u201cI. Chiricuta\u201d, Cluj-Napoca,Romania, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, Cluj-Napoca, Romania, Clinical Universitary Hospital of Dermatovenereology, Cluj-Napoca, Romania, Clinical Universitary Emergency Hospital, Department of Neurosurgery, Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I208470662","https://openalex.org/I4210100616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086827328","display_name":"Ioan \u015etefan Florian","orcid":"https://orcid.org/0000-0001-7127-0946","observed_orcids":["https://orcid.org/0000-0001-7127-0946"]},"institutions":[{"id":"https://openalex.org/I208470662","display_name":"Iuliu Ha\u021bieganu University of Medicine and Pharmacy","ror":"https://ror.org/051h0cw83","country_code":"RO","type":"education","lineage":["https://openalex.org/I208470662"]},{"id":"https://openalex.org/I4210100616","display_name":"Institute of Oncology Prof. Dr. Ion Chiricuta","ror":"https://ror.org/00nrbsf87","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210100616"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Ioan Stefan Florian","raw_affiliation_strings":["Cancer Institute \u201cI. Chiricuta\u201d, Cluj-Napoca,Romania, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, Cluj-Napoca, Romania, Clinical Universitary Hospital of Dermatovenereology, Cluj-Napoca, Romania, Clinical Universitary Emergency Hospital, Department of Neurosurgery, Cluj-Napoca, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute \u201cI. Chiricuta\u201d, Cluj-Napoca,Romania, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, Cluj-Napoca, Romania, Clinical Universitary Hospital of Dermatovenereology, Cluj-Napoca, Romania, Clinical Universitary Emergency Hospital, Department of Neurosurgery, Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I208470662","https://openalex.org/I4210100616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012253016","display_name":"Daniel\u2010Corneliu Leucuta","orcid":"https://orcid.org/0000-0003-4218-8622","observed_orcids":["https://orcid.org/0000-0003-4218-8622"]},"institutions":[{"id":"https://openalex.org/I208470662","display_name":"Iuliu Ha\u021bieganu University of Medicine and Pharmacy","ror":"https://ror.org/051h0cw83","country_code":"RO","type":"education","lineage":["https://openalex.org/I208470662"]},{"id":"https://openalex.org/I4210100616","display_name":"Institute of Oncology Prof. Dr. Ion Chiricuta","ror":"https://ror.org/00nrbsf87","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210100616"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Daniel Leucuta","raw_affiliation_strings":["Cancer Institute \u201cI. Chiricuta\u201d, Cluj-Napoca,Romania, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, Cluj-Napoca, Romania, Clinical Universitary Hospital of Dermatovenereology, Cluj-Napoca, Romania, Clinical Universitary Emergency Hospital, Department of Neurosurgery, Cluj-Napoca, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute \u201cI. Chiricuta\u201d, Cluj-Napoca,Romania, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, Cluj-Napoca, Romania, Clinical Universitary Hospital of Dermatovenereology, Cluj-Napoca, Romania, Clinical Universitary Emergency Hospital, Department of Neurosurgery, Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I208470662","https://openalex.org/I4210100616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102893877","display_name":"Doini\u0163a Cri\u015fan","orcid":"https://orcid.org/0000-0003-4414-7410","observed_orcids":["https://orcid.org/0000-0003-4414-7410"]},"institutions":[{"id":"https://openalex.org/I208470662","display_name":"Iuliu Ha\u021bieganu University of Medicine and Pharmacy","ror":"https://ror.org/051h0cw83","country_code":"RO","type":"education","lineage":["https://openalex.org/I208470662"]},{"id":"https://openalex.org/I4210100616","display_name":"Institute of Oncology Prof. Dr. Ion Chiricuta","ror":"https://ror.org/00nrbsf87","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210100616"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Doinita Crisan","raw_affiliation_strings":["Cancer Institute \u201cI. Chiricuta\u201d, Cluj-Napoca,Romania, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, Cluj-Napoca, Romania, Clinical Universitary Hospital of Dermatovenereology, Cluj-Napoca, Romania, Clinical Universitary Emergency Hospital, Department of Neurosurgery, Cluj-Napoca, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute \u201cI. Chiricuta\u201d, Cluj-Napoca,Romania, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, Cluj-Napoca, Romania, Clinical Universitary Hospital of Dermatovenereology, Cluj-Napoca, Romania, Clinical Universitary Emergency Hospital, Department of Neurosurgery, Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I208470662","https://openalex.org/I4210100616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011899583","display_name":"Adriana Cocis","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I208470662","display_name":"Iuliu Ha\u021bieganu University of Medicine and Pharmacy","ror":"https://ror.org/051h0cw83","country_code":"RO","type":"education","lineage":["https://openalex.org/I208470662"]},{"id":"https://openalex.org/I4210100616","display_name":"Institute of Oncology Prof. Dr. Ion Chiricuta","ror":"https://ror.org/00nrbsf87","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210100616"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Adriana Cocis","raw_affiliation_strings":["Cancer Institute \u201cI. Chiricuta\u201d, Cluj-Napoca,Romania, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, Cluj-Napoca, Romania, Clinical Universitary Hospital of Dermatovenereology, Cluj-Napoca, Romania, Clinical Universitary Emergency Hospital, Department of Neurosurgery, Cluj-Napoca, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute \u201cI. Chiricuta\u201d, Cluj-Napoca,Romania, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, Cluj-Napoca, Romania, Clinical Universitary Hospital of Dermatovenereology, Cluj-Napoca, Romania, Clinical Universitary Emergency Hospital, Department of Neurosurgery, Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I208470662","https://openalex.org/I4210100616"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027897849","display_name":"Ovidiu B\u0103l\u0103cescu","orcid":"https://orcid.org/0000-0003-0253-7103","observed_orcids":["https://orcid.org/0000-0003-0253-7103"]},"institutions":[{"id":"https://openalex.org/I208470662","display_name":"Iuliu Ha\u021bieganu University of Medicine and Pharmacy","ror":"https://ror.org/051h0cw83","country_code":"RO","type":"education","lineage":["https://openalex.org/I208470662"]},{"id":"https://openalex.org/I4210100616","display_name":"Institute of Oncology Prof. Dr. Ion Chiricuta","ror":"https://ror.org/00nrbsf87","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210100616"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Ovidiu Balacescu","raw_affiliation_strings":["Cancer Institute \u201cI. Chiricuta\u201d, Cluj-Napoca,Romania, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, Cluj-Napoca, Romania, Clinical Universitary Hospital of Dermatovenereology, Cluj-Napoca, Romania, Clinical Universitary Emergency Hospital, Department of Neurosurgery, Cluj-Napoca, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute \u201cI. Chiricuta\u201d, Cluj-Napoca,Romania, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, Cluj-Napoca, Romania, Clinical Universitary Hospital of Dermatovenereology, Cluj-Napoca, Romania, Clinical Universitary Emergency Hospital, Department of Neurosurgery, Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I208470662","https://openalex.org/I4210100616"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105405703","display_name":"Alexandru Irimie","orcid":"https://orcid.org/0000-0002-7812-5204","observed_orcids":["https://orcid.org/0000-0002-7812-5204"]},"institutions":[{"id":"https://openalex.org/I208470662","display_name":"Iuliu Ha\u021bieganu University of Medicine and Pharmacy","ror":"https://ror.org/051h0cw83","country_code":"RO","type":"education","lineage":["https://openalex.org/I208470662"]},{"id":"https://openalex.org/I4210100616","display_name":"Institute of Oncology Prof. Dr. Ion Chiricuta","ror":"https://ror.org/00nrbsf87","country_code":"RO","type":"facility","lineage":["https://openalex.org/I4210100616"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Alexandru Irimie","raw_affiliation_strings":["Cancer Institute \u201cI. Chiricuta\u201d, Cluj-Napoca,Romania, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, Cluj-Napoca, Romania, Clinical Universitary Hospital of Dermatovenereology, Cluj-Napoca, Romania, Clinical Universitary Emergency Hospital, Department of Neurosurgery, Cluj-Napoca, Romania"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Institute \u201cI. Chiricuta\u201d, Cluj-Napoca,Romania, University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d, Cluj-Napoca, Romania, Clinical Universitary Hospital of Dermatovenereology, Cluj-Napoca, Romania, Clinical Universitary Emergency Hospital, Department of Neurosurgery, Cluj-Napoca, Romania","institution_ids":["https://openalex.org/I208470662","https://openalex.org/I4210100616"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.2524,"has_fulltext":false,"cited_by_count":19,"citation_normalized_percentile":{"value":0.79168493,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"23","issue":"2","first_page":"45","last_page":"55"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10129","display_name":"Glioma Diagnosis and Treatment","score":0.7675999999046326,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.22709999978542328,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13779","display_name":"Cancer Mechanisms and Therapy","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/glioblastoma","display_name":"glioblastoma","score":1.0},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.777999997138977},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.8519999980926514},{"id":"https://openalex.org/keywords/platelet-derived-growth-factor","display_name":"platelet-derived growth factor","score":0.9940000176429749},{"id":"https://openalex.org/keywords/endothelial-protein-c-receptor","display_name":"endothelial protein C receptor","score":0.9039999842643738},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9639999866485596},{"id":"https://openalex.org/keywords/icam-1","display_name":"ICAM-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/connective-tissue-growth-factor","display_name":"connective tissue growth factor","score":0.9929999709129333},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.7620000243186951},{"id":"https://openalex.org/keywords/blood-coagulation","display_name":"coagulation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.9950000047683716},{"id":"https://openalex.org/keywords/endothelial-hyperplasia","display_name":"endothelial hyperplasia","score":0.9300000071525574},{"id":"https://openalex.org/keywords/coagulative-necrosis","display_name":"coagulative necrosis","score":0.8669999837875366},{"id":"https://openalex.org/keywords/ischemic-necrosis","display_name":"ischemic necrosis","score":0.9729999899864197},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.5640000104904175}],"concepts":[{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.8390952348709106},{"id":"https://openalex.org/C2780631158","wikidata":"https://www.wikidata.org/wiki/Q14907752","display_name":"CTGF","level":4,"score":0.7275145649909973},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5946581363677979},{"id":"https://openalex.org/C2778271429","wikidata":"https://www.wikidata.org/wiki/Q1281049","display_name":"Neovascularization","level":3,"score":0.5512243509292603},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.5160326957702637},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.5098985433578491},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.5083076357841492},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4366002380847931},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.41412442922592163},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3533868193626404},{"id":"https://openalex.org/C2775960820","wikidata":"https://www.wikidata.org/wiki/Q408378","display_name":"Growth factor","level":3,"score":0.18769723176956177},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12793508172035217},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.0665343701839447},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000074283","descriptor_name":"Endothelial Protein C Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074283","descriptor_name":"Endothelial Protein C Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000074283","descriptor_name":"Endothelial Protein C Receptor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001777","descriptor_name":"Blood Coagulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001932","descriptor_name":"Brain Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005909","descriptor_name":"Glioblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009389","descriptor_name":"Neovascularization, Pathologic","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010982","descriptor_name":"Platelet-Derived Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011956","descriptor_name":"Receptors, Cell Surface","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018799","descriptor_name":"Intercellular Adhesion Molecule-1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048069","descriptor_name":"Tumor Necrosis Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D048069","descriptor_name":"Tumor Necrosis Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D048069","descriptor_name":"Tumor Necrosis Factors","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D048069","descriptor_name":"Tumor Necrosis Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048069","descriptor_name":"Tumor Necrosis Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048069","descriptor_name":"Tumor Necrosis Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055513","descriptor_name":"Connective Tissue Growth Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D055513","descriptor_name":"Connective Tissue Growth Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D055513","descriptor_name":"Connective Tissue Growth Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D055513","descriptor_name":"Connective Tissue Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055513","descriptor_name":"Connective Tissue Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055513","descriptor_name":"Connective Tissue Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1684/ecn.2012.0302","doi":"https://doi.org/10.1684/ecn.2012.0302","is_oa":false,"landing_page_url":"https://doi.org/10.1684/ecn.2012.0302","pdf_url":null,"source":{"id":"https://openalex.org/S121125150","display_name":"European Cytokine Network","issn_l":"1148-5493","issn":["1148-5493","1952-4005"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","doyens","jufo-1","ki-jl-1","medline","norway-1"],"host_organization":"https://openalex.org/P4310320125","host_organization_name":"John Libbey Eurotext","host_organization_lineage":["https://openalex.org/P4310320125"],"host_organization_lineage_names":["John Libbey Eurotext"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Cytokine Network","raw_type":"journal-article"},{"id":"pmid:22591734","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22591734","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European cytokine network","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"sustainable_development_goals_aurora":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.75}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2104752154","https://openalex.org/W2414879916","https://openalex.org/W2460667757","https://openalex.org/W2051449188","https://openalex.org/W73242545","https://openalex.org/W2114498041","https://openalex.org/W1946062636","https://openalex.org/W13443198","https://openalex.org/W2146672236","https://openalex.org/W53666519"],"abstract_inverted_index":{"Glioblastoma":[0],"multiforme":[1],"is":[2,18,57],"a":[3,19,80,92],"very":[4],"aggressive":[5],"brain":[6,106,169,216],"tumor.":[7],"Angiogenesis,":[8],"the":[9,74,117,138,142,149,177],"formation":[10],"of":[11,31,43,63,68,79,82,94,102,119,154,176,200],"new":[12],"blood":[13],"vessels":[14],"from":[15],"pre-existing":[16],"ones,":[17],"process":[20,33],"that":[21],"plays":[22],"an":[23,50],"essential":[24],"role":[25,52],"in":[26,53,76,86,123,162,208,212],"cancer":[27],"development.":[28],"The":[29,66,89,218],"evolution":[30],"this":[32],"depends":[34],"upon":[35],"several":[36],"proangiogenic":[37],"factors":[38],"as":[39,41],"well":[40],"inhibitors":[42],"angiogenesis.":[44,88],"Coagulation":[45],"and":[46,104,130,157,179,188,190,203,223,230,244],"inflammation":[47],"also":[48],"play":[49],"important":[51],"tumorigenesis.":[54],"Their":[55],"expression":[56,118,133,222,243],"controlled":[58],"by":[59,136],"over-":[60],"or":[61],"under-expression":[62],"certain":[64],"genes.":[65],"objective":[67],"our":[69],"study":[70,90],"was":[71,134,206,233],"to":[72,115],"evaluate":[73,116],"expression,":[75],"tissue":[77,107,144,211],"samples,":[78],"set":[81],"six":[83,120],"genes":[84,121,159,181,192,205],"involved":[85,122],"tumoral":[87,103,143,164,210],"concerned":[91],"group":[93],"14":[95],"patients":[96],"with":[97,145,167,214],"pathologically-confirmed":[98],"glioblastoma":[99,163,209],"multiforme.":[100],"Samples":[101],"peritumoral":[105,150,168,215],"were":[108,160,172,239],"taken":[109],"during":[110],"surgery.":[111],"We":[112],"used":[113],"RT-PCR":[114],"angiogenesis:":[124],"VEGF,":[125,155],"PDGF,":[126],"EPCR,":[127],"TNF,":[128],"ICAM-1":[129,158,191],"CTGF.":[131],"Gene":[132],"calculated":[135],"comparing":[137],"values":[139],"obtained":[140,147],"for":[141,148],"those":[146],"tissue.":[151,217],"Increased":[152],"transcription":[153,175],"PDGF":[156,189],"observed":[161,173,207,240],"tissues":[165],"compared":[166],"tissues.":[170],"Correlations":[171],"between":[174,220,241],"CTGF":[178],"TNF":[180,204],"(rho":[182,193],"=":[183,186,194,197],"0.54,":[184,195],"p-value":[185,196],"0.05)":[187],"0.05).":[198],"Under-expression":[199],"CTGF,":[201],"EPCR":[202],"comparison":[213],"association":[219],"gene":[221,242],"histopathological":[224],"results":[225],"(endothelial":[226],"hyperplasia,":[227],"coagulation":[228],"necrosis":[229],"ischemic":[231],"necrosis)":[232],"evaluated.":[234],"No":[235],"statistically":[236],"significant":[237],"associations":[238],"survival":[245],"rates.":[246]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2}],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2025-10-10T00:00:00"}