{"id":"https://openalex.org/W2102878689","doi":"https://doi.org/10.1080/15412550701601274","title":"Computed Tomography Phenotypes in Severe, Early-Onset Chronic Obstructive Pulmonary Disease","display_name":"Computed Tomography Phenotypes in Severe, Early-Onset Chronic Obstructive Pulmonary Disease","publication_year":2007,"publication_date":"2007-01-01","ids":{"openalex":"https://openalex.org/W2102878689","doi":"https://doi.org/10.1080/15412550701601274","mag":"2102878689","pmid":"https://pubmed.ncbi.nlm.nih.gov/18027160"},"language":"en","primary_location":{"id":"doi:10.1080/15412550701601274","doi":"https://doi.org/10.1080/15412550701601274","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15412550701601274","pdf_url":null,"source":{"id":"https://openalex.org/S15387528","display_name":"COPD Journal of Chronic Obstructive Pulmonary Disease","issn_l":"1541-2555","issn":["1541-2555","1541-2563"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059655447","display_name":"Craig P. Hersh","orcid":"https://orcid.org/0000-0002-1342-4334","observed_orcids":["https://orcid.org/0000-0002-1342-4334"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Craig P. Hersh","raw_affiliation_strings":["Channing Laboratory, Brigham and Women's Hospital, Boston, MA 02115, USA. craig.hersh@channing.harvard.edu","Channing Laboratory, Boston, MA, 02115, USA","Harvard Medical School, Boston, MA, 02115, USA","Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Laboratory, Brigham and Women's Hospital, Boston, MA 02115, USA. craig.hersh@channing.harvard.edu","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Channing Laboratory, Boston, MA, 02115, USA","institution_ids":[]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012618305","display_name":"Francine L. Jacobson","orcid":"https://orcid.org/0000-0002-0716-2198","observed_orcids":["https://orcid.org/0000-0002-0716-2198"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Francine L. Jacobson","raw_affiliation_strings":["Thoracic Radiology Division, Department of Radiology, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA","Harvard Medical School, Boston, MA, 02115, USA","Thoracic Radiology Division, Department of Radiology, Brigham and Women's Hospital, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Radiology Division, Department of Radiology, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Thoracic Radiology Division, Department of Radiology, Brigham and Women's Hospital, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044949497","display_name":"Ritu R. Gill","orcid":"https://orcid.org/0000-0001-8119-8407","observed_orcids":["https://orcid.org/0000-0001-8119-8407"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ritu Gill","raw_affiliation_strings":["Thoracic Radiology Division, Department of Radiology, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA","Harvard Medical School, Boston, MA, 02115, USA","Thoracic Radiology Division, Department of Radiology, Brigham and Women's Hospital, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Thoracic Radiology Division, Department of Radiology, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Thoracic Radiology Division, Department of Radiology, Brigham and Women's Hospital, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5035524361","display_name":"Edwin K. Silverman","orcid":"https://orcid.org/0000-0002-3641-3822","observed_orcids":["https://orcid.org/0000-0002-3641-3822"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Edwin K. Silverman","raw_affiliation_strings":["Channing Laboratory, Boston, MA, 02115, USA; Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA","Channing Laboratory, Boston, MA, 02115, USA","Harvard Medical School, Boston, MA, 02115, USA","Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Channing Laboratory, Boston, MA, 02115, USA; Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA; Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Channing Laboratory, Boston, MA, 02115, USA","institution_ids":[]},{"raw_affiliation_string":"Harvard Medical School, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I136199984"]},{"raw_affiliation_string":"Pulmonary and Critical Care Division, Department of Medicine, Brigham and Women's Hospital, Boston, MA, 02115, USA","institution_ids":["https://openalex.org/I1283280774"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2650,"currency":"USD","value_usd":2650},"apc_paid":null,"fwci":2.5933,"has_fulltext":false,"cited_by_count":43,"citation_normalized_percentile":{"value":0.89611971,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"4","issue":"4","first_page":"331","last_page":"337"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10665","display_name":"Cystic Fibrosis Research Advances","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.925000011920929},{"id":"https://openalex.org/keywords/early-onset-copd","display_name":"early-onset COPD","score":0.9340000152587891},{"id":"https://openalex.org/keywords/emphysema-severity","display_name":"emphysema severity","score":0.9440000057220459},{"id":"https://openalex.org/keywords/airflow-obstruction","display_name":"airflow obstruction","score":0.6510000228881836},{"id":"https://openalex.org/keywords/bronchodilator-response","display_name":"bronchodilator response","score":0.9919999837875366},{"id":"https://openalex.org/keywords/asthma","display_name":"asthma","score":0.6230000257492065},{"id":"https://openalex.org/keywords/serum-ige","display_name":"serum IgE","score":0.9700000286102295},{"id":"https://openalex.org/keywords/genetic-susceptibility","display_name":"genetic susceptibility","score":0.7129999995231628},{"id":"https://openalex.org/keywords/siblings","display_name":"siblings","score":0.33399999141693115},{"id":"https://openalex.org/keywords/phenotyping","display_name":"phenotyping","score":0.3240000009536743}],"concepts":[{"id":"https://openalex.org/C2992779976","wikidata":"https://www.wikidata.org/wiki/Q3286546","display_name":"Pulmonary disease","level":2,"score":0.8295185565948486},{"id":"https://openalex.org/C544519230","wikidata":"https://www.wikidata.org/wiki/Q32566","display_name":"Computed tomography","level":2,"score":0.6712914705276489},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6347038745880127},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5878444314002991},{"id":"https://openalex.org/C3020646490","wikidata":"https://www.wikidata.org/wiki/Q25203551","display_name":"Clinical phenotype","level":4,"score":0.46177375316619873},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4481632709503174},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.41989371180534363},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.32384371757507324},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.10549616813659668},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0809430181980133},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005500","descriptor_name":"Follow-Up Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":false},{"descriptor_ui":"D011656","descriptor_name":"Pulmonary Emphysema","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012189","descriptor_name":"Retrospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014057","descriptor_name":"Tomography, X-Ray Computed","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":true},{"descriptor_ui":"D020022","descriptor_name":"Genetic Predisposition to Disease","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035781","descriptor_name":"Siblings","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1080/15412550701601274","doi":"https://doi.org/10.1080/15412550701601274","is_oa":false,"landing_page_url":"https://doi.org/10.1080/15412550701601274","pdf_url":null,"source":{"id":"https://openalex.org/S15387528","display_name":"COPD Journal of Chronic Obstructive Pulmonary Disease","issn_l":"1541-2555","issn":["1541-2555","1541-2563"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-70","russia-white-list-3","vabb-shw"],"host_organization":"https://openalex.org/P4310320449","host_organization_name":"Informa","host_organization_lineage":["https://openalex.org/P4310320449"],"host_organization_lineage_names":["Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"COPD: Journal of Chronic Obstructive Pulmonary Disease","raw_type":"journal-article"},{"id":"pmid:18027160","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/18027160","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"COPD","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9922999739646912}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1797602459","display_name":"Fine Mapping of a COPD Locus on Chromosome 19q","funder_award_id":"K08HL080242","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G436166612","display_name":"Genetics of COPD in NETT","funder_award_id":"R01HL071393","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4731985522","display_name":null,"funder_award_id":"HL71393","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4755940723","display_name":"Fine Mapping of COPD Susceptibility Genes","funder_award_id":"R01HL075478","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4899389735","display_name":null,"funder_award_id":"HL080242","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5332233980","display_name":null,"funder_award_id":"HL075478","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6255367236","display_name":null,"funder_award_id":"HL68926","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G7359959296","display_name":"Genetic Modifiers of Alpha 1-Antitrypsin Deficiency","funder_award_id":"R01HL068926","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":26,"referenced_works":["https://openalex.org/W108255485","https://openalex.org/W1492075988","https://openalex.org/W1552880417","https://openalex.org/W1843924911","https://openalex.org/W1866342749","https://openalex.org/W1965640848","https://openalex.org/W1977238523","https://openalex.org/W2026825842","https://openalex.org/W2045616259","https://openalex.org/W2061574596","https://openalex.org/W2062407252","https://openalex.org/W2075125370","https://openalex.org/W2085118879","https://openalex.org/W2101787490","https://openalex.org/W2108641738","https://openalex.org/W2112183064","https://openalex.org/W2127951128","https://openalex.org/W2134977695","https://openalex.org/W2150816988","https://openalex.org/W2161484765","https://openalex.org/W2161848454","https://openalex.org/W2171506107","https://openalex.org/W2185440705","https://openalex.org/W2604596332","https://openalex.org/W2605650619","https://openalex.org/W4249200669"],"related_works":["https://openalex.org/W3199158867","https://openalex.org/W2289003509","https://openalex.org/W2766926873","https://openalex.org/W2328987612","https://openalex.org/W7135761182","https://openalex.org/W2911802159","https://openalex.org/W4387268643","https://openalex.org/W3133948055","https://openalex.org/W2172103070","https://openalex.org/W2894285957"],"abstract_inverted_index":{"Subjects":[0],"with":[1,24,237,242],"severe":[2,25,145,157],"chronic":[3],"obstructive":[4],"pulmonary":[5],"disease":[6],"(COPD)":[7],"may":[8],"have":[9,28,38],"marked":[10],"differences":[11],"in":[12,43,66,96],"emphysema":[13,117,132,140,153,166],"severity":[14,118],"on":[15,93],"chest":[16,29,36,55,76,90,112,126,226],"computed":[17],"tomography":[18],"(CT)":[19],"scans.":[20],"Although":[21],"many":[22],"patients":[23],"COPD":[26,71,100,215],"will":[27],"CTs":[30,37],"performed":[31,58],"during":[32],"their":[33],"clinical":[34,60,225],"care,":[35],"not":[39],"been":[40],"widely":[41],"included":[42],"epidemiologic":[44,68],"and":[45,72,108,200],"genetic":[46,219],"studies":[47],"of":[48,70,85,124,139,152,165,177,196,211,213],"COPD.":[49,88,245],"We":[50],"sought":[51],"to":[52,73,82,110,144,221,232],"determine":[53,74],"whether":[54,75],"CT":[56,77,91,127,227],"scans":[57,78,92,128],"for":[59,131],"indications":[61],"can":[62,79],"provide":[63],"useful":[64],"data":[65],"an":[67,234],"study":[69],"be":[80],"used":[81],"define":[83],"subtypes":[84],"severe,":[86,243],"early-onset":[87,214,244],"Clinical":[89],"91":[94,125],"probands":[95,216],"the":[97,222],"Boston":[98],"Early-Onset":[99],"Study":[101],"were":[102,129,230],"retrospectively":[103],"reviewed":[104],"by":[105],"2":[106,111],"pulmonologists":[107],"1":[109],"radiologists,":[113],"using":[114],"a":[115,136,181,193,201,218],"semi-quantitative":[116],"score,":[119],"ranging":[120],"from":[121,142],"0-24.":[122],"88":[123],"suitable":[130],"analysis.":[133],"There":[134],"was":[135],"wide":[137],"range":[138],"severity,":[141],"mild":[143],"(1.3-23.7).":[146],"Emphysema-predominant":[147],"subjects":[148,162,179,190,241],"(upper":[149],"3":[150],"quartiles":[151],"scores)":[154],"had":[155,180,192],"more":[156],"airflow":[158],"obstruction":[159],"than":[160],"airway-predominant":[161,178,235],"(lowest":[163],"quartile":[164],"scores):":[167],"FEV(1)":[168],"17.4%":[169],"vs.":[170,186],"22.4%":[171],"predicted,":[172],"p=0.009.":[173],"A":[174],"higher":[175,194,204],"percentage":[176],"positive":[182],"bronchodilator":[183],"response":[184],"(28.6%":[185],"6.7%,":[187],"p=0.009).":[188],"Airway-predominant":[189],"also":[191],"frequency":[195],"physician-diagnosed":[197],"asthma":[198],"(p=0.04)":[199],"trend":[202],"towards":[203],"serum":[205],"immunoglobulin":[206],"E":[207],"levels":[208],"(p=0.09).":[209],"Analysis":[210],"siblings":[212],"suggested":[217],"contribution":[220],"subgroups.":[223],"Using":[224],"scans,":[228],"we":[229],"able":[231],"identify":[233],"subgroup":[236],"asthma-like":[238],"features":[239],"among":[240]},"counts_by_year":[{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
