{"id":"https://openalex.org/W2102878627","doi":"https://doi.org/10.4049/jimmunol.173.2.855","title":"FTY720-Enhanced T Cell Homing Is Dependent on CCR2, CCR5, CCR7, and CXCR4: Evidence for Distinct Chemokine Compartments","display_name":"FTY720-Enhanced T Cell Homing Is Dependent on CCR2, CCR5, CCR7, and CXCR4: Evidence for Distinct Chemokine Compartments","publication_year":2004,"publication_date":"2004-07-01","ids":{"openalex":"https://openalex.org/W2102878627","doi":"https://doi.org/10.4049/jimmunol.173.2.855","mag":"2102878627","pmid":"https://pubmed.ncbi.nlm.nih.gov/15240672"},"language":"en","primary_location":{"id":"doi:10.4049/jimmunol.173.2.855","doi":"https://doi.org/10.4049/jimmunol.173.2.855","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.173.2.855","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/173/2/855/1187952/855.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://journals.aai.org/jimmunol/article-pdf/173/2/855/1187952/855.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085283718","display_name":"Adam Charles Yopp","orcid":"https://orcid.org/0000-0002-5887-5315","observed_orcids":["https://orcid.org/0000-0002-5887-5315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adam C Yopp","raw_affiliation_strings":["Carl C. Icahn Center for Gene Therapy and Molecular Medicine , New York, NY 10029","*Carl C. Icahn Center for Gene Therapy and Molecular Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carl C. Icahn Center for Gene Therapy and Molecular Medicine , New York, NY 10029","institution_ids":[]},{"raw_affiliation_string":"*Carl C. Icahn Center for Gene Therapy and Molecular Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Shuang Fu","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Shuang Fu","raw_affiliation_strings":["Carl C. Icahn Center for Gene Therapy and Molecular Medicine , New York, NY 10029","*Carl C. Icahn Center for Gene Therapy and Molecular Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carl C. Icahn Center for Gene Therapy and Molecular Medicine , New York, NY 10029","institution_ids":[]},{"raw_affiliation_string":"*Carl C. Icahn Center for Gene Therapy and Molecular Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110551733","display_name":"Shaun Honig","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shaun M Honig","raw_affiliation_strings":["Carl C. Icahn Center for Gene Therapy and Molecular Medicine , New York, NY 10029","*Carl C. Icahn Center for Gene Therapy and Molecular Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carl C. Icahn Center for Gene Therapy and Molecular Medicine , New York, NY 10029","institution_ids":[]},{"raw_affiliation_string":"*Carl C. Icahn Center for Gene Therapy and Molecular Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090527726","display_name":"Gwendalyn J. Randolph","orcid":"https://orcid.org/0000-0001-9045-1195","observed_orcids":["https://orcid.org/0000-0001-9045-1195"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gwendalyn J Randolph","raw_affiliation_strings":["Carl C. Icahn Center for Gene Therapy and Molecular Medicine , New York, NY 10029","*Carl C. Icahn Center for Gene Therapy and Molecular Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carl C. Icahn Center for Gene Therapy and Molecular Medicine , New York, NY 10029","institution_ids":[]},{"raw_affiliation_string":"*Carl C. Icahn Center for Gene Therapy and Molecular Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039048669","display_name":"Yaozhong Ding","orcid":"https://orcid.org/0000-0003-3684-8217","observed_orcids":["https://orcid.org/0000-0003-3684-8217"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Yaozhong Ding","raw_affiliation_strings":["Carl C. Icahn Center for Gene Therapy and Molecular Medicine , New York, NY 10029","*Carl C. Icahn Center for Gene Therapy and Molecular Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carl C. Icahn Center for Gene Therapy and Molecular Medicine , New York, NY 10029","institution_ids":[]},{"raw_affiliation_string":"*Carl C. Icahn Center for Gene Therapy and Molecular Medicine, and","institution_ids":[]}]},{"author_position":"middle","author":{"id":null,"display_name":"Nancy R Krieger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nancy R Krieger","raw_affiliation_strings":["Carl C. Icahn Center for Gene Therapy and Molecular Medicine , New York, NY 10029","\u2020 Recanti/Miller Transplantation Institute, Mount Sinai School of Medicine, New York, NY 10029","*Carl C. Icahn Center for Gene Therapy and Molecular Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carl C. Icahn Center for Gene Therapy and Molecular Medicine , New York, NY 10029","institution_ids":[]},{"raw_affiliation_string":"\u2020 Recanti/Miller Transplantation Institute, Mount Sinai School of Medicine, New York, NY 10029","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"*Carl C. Icahn Center for Gene Therapy and Molecular Medicine, and","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5061721392","display_name":"Jonathan S. Bromberg","orcid":"https://orcid.org/0000-0002-1407-8795","observed_orcids":["https://orcid.org/0000-0002-1407-8795"]},"institutions":[{"id":"https://openalex.org/I98704320","display_name":"Icahn School of Medicine at Mount Sinai","ror":"https://ror.org/04a9tmd77","country_code":"US","type":"education","lineage":["https://openalex.org/I1320796813","https://openalex.org/I98704320"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan S Bromberg","raw_affiliation_strings":["Carl C. Icahn Center for Gene Therapy and Molecular Medicine , New York, NY 10029","\u2020 Recanti/Miller Transplantation Institute, Mount Sinai School of Medicine, New York, NY 10029","*Carl C. Icahn Center for Gene Therapy and Molecular Medicine, and"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carl C. Icahn Center for Gene Therapy and Molecular Medicine , New York, NY 10029","institution_ids":[]},{"raw_affiliation_string":"\u2020 Recanti/Miller Transplantation Institute, Mount Sinai School of Medicine, New York, NY 10029","institution_ids":["https://openalex.org/I98704320"]},{"raw_affiliation_string":"*Carl C. Icahn Center for Gene Therapy and Molecular Medicine, and","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5039048669"],"corresponding_institution_ids":[],"apc_list":{"value":3500,"currency":"USD","value_usd":3500},"apc_paid":null,"fwci":4.3181,"has_fulltext":true,"cited_by_count":74,"citation_normalized_percentile":{"value":0.94955997,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":98},"biblio":{"volume":"173","issue":"2","first_page":"855","last_page":"865"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11532","display_name":"Chemokine receptors and signaling","score":0.9199000000953674,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11308","display_name":"Sphingolipid Metabolism and Signaling","score":0.05220000073313713,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11157","display_name":"Chronic Lymphocytic Leukemia Research","score":0.002199999988079071,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/fingolimod","display_name":"fingolimod","score":0.9589999914169312},{"id":"https://openalex.org/keywords/t-cell-homing","display_name":"T cell homing","score":0.8539999723434448},{"id":"https://openalex.org/keywords/chemokine-receptors","display_name":"chemokine receptors","score":0.8259999752044678},{"id":"https://openalex.org/keywords/ccr2","display_name":"CCR2","score":0.949999988079071},{"id":"https://openalex.org/keywords/ccr5","display_name":"CCR5","score":0.996999979019165},{"id":"https://openalex.org/keywords/ccr7","display_name":"CCR7","score":1.0},{"id":"https://openalex.org/keywords/cxcr4","display_name":"CXCR4","score":1.0},{"id":"https://openalex.org/keywords/sphingosine-1-phosphate-receptor","display_name":"sphingosine-1-phosphate receptor","score":0.8330000042915344},{"id":"https://openalex.org/keywords/mcp-1","display_name":"MCP-1","score":0.7009999752044678},{"id":"https://openalex.org/keywords/thymic-egress","display_name":"thymic egress","score":0.7279999852180481},{"id":"https://openalex.org/keywords/lymph-node-homing","display_name":"lymph node homing","score":0.8399999737739563},{"id":"https://openalex.org/keywords/multidrug-transporter","display_name":"multidrug transporter","score":0.6769999861717224},{"id":"https://openalex.org/keywords/p-glycoprotein","display_name":"P-glycoprotein","score":0.8830000162124634},{"id":"https://openalex.org/keywords/abcb5","display_name":"ABCB5","score":0.6779999732971191},{"id":"https://openalex.org/keywords/5-lipoxygenase","display_name":"5-lipoxygenase","score":0.9940000176429749}],"concepts":[{"id":"https://openalex.org/C151872237","wikidata":"https://www.wikidata.org/wiki/Q1410759","display_name":"Homing (biology)","level":2,"score":0.7337923645973206},{"id":"https://openalex.org/C12823836","wikidata":"https://www.wikidata.org/wiki/Q24720618","display_name":"Chemokine receptor","level":4,"score":0.7290024757385254},{"id":"https://openalex.org/C127801297","wikidata":"https://www.wikidata.org/wiki/Q17907809","display_name":"C-C chemokine receptor type 7","level":5,"score":0.7042801380157471},{"id":"https://openalex.org/C129470790","wikidata":"https://www.wikidata.org/wiki/Q415718","display_name":"CXCR4","level":4,"score":0.5624790191650391},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5561481714248657},{"id":"https://openalex.org/C206615009","wikidata":"https://www.wikidata.org/wiki/Q4035572","display_name":"CCR2","level":5,"score":0.5361080169677734},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.5271615386009216},{"id":"https://openalex.org/C129013479","wikidata":"https://www.wikidata.org/wiki/Q21111916","display_name":"CCR1","level":5,"score":0.44814276695251465},{"id":"https://openalex.org/C31179232","wikidata":"https://www.wikidata.org/wiki/Q14911549","display_name":"CX3CR1","level":5,"score":0.43029510974884033},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3742583394050598},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.32992681860923767},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.32544374465942383},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.07529380917549133},{"id":"https://openalex.org/C18903297","wikidata":"https://www.wikidata.org/wiki/Q7150","display_name":"Ecology","level":1,"score":0.05049136281013489}],"mesh":[{"descriptor_ui":"D000068876","descriptor_name":"Fingolimod Hydrochloride","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001094","descriptor_name":"Arachidonate 5-Lipoxygenase","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D007166","descriptor_name":"Immunosuppressive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011409","descriptor_name":"Propylene Glycols","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D013110","descriptor_name":"Sphingosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D018077","descriptor_name":"Receptors, Leukotriene","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019707","descriptor_name":"Receptors, Chemokine","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019713","descriptor_name":"Receptors, CCR5","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D019718","descriptor_name":"Receptors, CXCR4","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D043562","descriptor_name":"Receptors, G-Protein-Coupled","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D049312","descriptor_name":"Receptors, Lysophospholipid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054390","descriptor_name":"Receptors, CCR2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054400","descriptor_name":"Receptors, CCR7","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.4049/jimmunol.173.2.855","doi":"https://doi.org/10.4049/jimmunol.173.2.855","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.173.2.855","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/173/2/855/1187952/855.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},{"id":"pmid:15240672","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15240672","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of immunology (Baltimore, Md. : 1950)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.4049/jimmunol.173.2.855","doi":"https://doi.org/10.4049/jimmunol.173.2.855","is_oa":true,"landing_page_url":"https://doi.org/10.4049/jimmunol.173.2.855","pdf_url":"https://journals.aai.org/jimmunol/article-pdf/173/2/855/1187952/855.pdf","source":{"id":"https://openalex.org/S38008053","display_name":"The Journal of Immunology","issn_l":"0022-1767","issn":["0022-1767","1550-6606"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4320800377","host_organization_name":"American Association of Immunologists","host_organization_lineage":["https://openalex.org/P4320800377"],"host_organization_lineage_names":["American Association of Immunologists"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G4592967061","display_name":"Migration and Trafficking in Tolerance 10/07","funder_award_id":"R01AI041428","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2102878627.pdf","grobid_xml":"https://content.openalex.org/works/W2102878627.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W36254779","https://openalex.org/W1485925178","https://openalex.org/W1500954694","https://openalex.org/W1524570470","https://openalex.org/W1530656249","https://openalex.org/W1609653960","https://openalex.org/W1654241956","https://openalex.org/W1967994686","https://openalex.org/W1981480494","https://openalex.org/W1981651039","https://openalex.org/W1983092575","https://openalex.org/W1987090231","https://openalex.org/W1992400390","https://openalex.org/W2006985918","https://openalex.org/W2022157262","https://openalex.org/W2022905629","https://openalex.org/W2025122749","https://openalex.org/W2029897954","https://openalex.org/W2036017974","https://openalex.org/W2036071939","https://openalex.org/W2036852690","https://openalex.org/W2038725731","https://openalex.org/W2041159500","https://openalex.org/W2043112660","https://openalex.org/W2045326880","https://openalex.org/W2065456444","https://openalex.org/W2081487051","https://openalex.org/W2083318970","https://openalex.org/W2090456065","https://openalex.org/W2092216228","https://openalex.org/W2094115571","https://openalex.org/W2095136469","https://openalex.org/W2105192692","https://openalex.org/W2108813293","https://openalex.org/W2114926817","https://openalex.org/W2117342688","https://openalex.org/W2119992148","https://openalex.org/W2127141798","https://openalex.org/W2127553530","https://openalex.org/W2132579946","https://openalex.org/W2133368465","https://openalex.org/W2137428636","https://openalex.org/W2137636472","https://openalex.org/W2142361972","https://openalex.org/W2148077696","https://openalex.org/W2150295492","https://openalex.org/W2151215047","https://openalex.org/W2154089780","https://openalex.org/W2165704853","https://openalex.org/W2166588660","https://openalex.org/W2292480560","https://openalex.org/W2317145780","https://openalex.org/W2340807252","https://openalex.org/W4239544480"],"related_works":["https://openalex.org/W2049990323","https://openalex.org/W2127141798","https://openalex.org/W7099829946","https://openalex.org/W2119992148","https://openalex.org/W1937674947","https://openalex.org/W2091208988","https://openalex.org/W2036017974","https://openalex.org/W3151154777","https://openalex.org/W7096226309","https://openalex.org/W2172204101"],"abstract_inverted_index":{"FTY720":[0,38,61,82,118,121],"stimulates":[1,41],"CCR7-driven":[2],"T":[3,44,87,107,114,151,172],"cell":[4,45,108,115,152,173],"homing":[5],"to":[6,47,51],"peripheral":[7,92,149],"lymph":[8],"nodes":[9],"(LN)":[10],"by":[11],"direct":[12],"activation":[13,66],"of":[14,22,54,67,81,86,157,181],"sphingosine":[15,169],"1-phosphate":[16,170],"receptors,":[17],"along":[18],"with":[19],"the":[20,68,90,178],"participation":[21],"multidrug":[23,69],"transporters,":[24,70],"5-lipoxygenase,":[25],"and":[26,59,72,74,95,99,112,137,148,168],"G":[27],"protein-coupled":[28],"receptors":[29],"for":[30,105,126,129,134,139],"chemokines.":[31],"In":[32,78],"this":[33],"study,":[34],"we":[35],"demonstrate":[36],"that":[37,166],"also":[39],"directly":[40],"in":[42,89,110],"vitro":[43],"chemotaxis":[46],"CCR2-CCL2,":[48],"but":[49,132,142],"not":[50,133,143],"a":[52,124],"variety":[53],"other":[55],"chemokines,":[56],"including":[57],"CCR5-CCL3/4/5":[58],"CXCR4-CXCL12.":[60],"influences":[62],"CCR2-CCL2-driven":[63],"migration":[64,85,174],"through":[65,75],"Abcb1":[71],"Abcc1,":[73],"5-lipoxygenase":[76],"activity.":[77],"vivo":[79],"administration":[80,122],"induces":[83],"chemokine-dependent":[84],"cells":[88],"thymus,":[91],"blood,":[93],"LN,":[94],"spleen.":[96],"The":[97],"CCR7":[98],"CCR2":[100],"chemokine":[101,182],"ligands":[102,128],"are":[103,154,175],"required":[104],"both":[106,155],"sequestration":[109],"LN":[111,130,144],"thymic":[113,135,140],"egress":[116,153],"following":[117],"administration.":[119],"Furthermore,":[120],"uncovers":[123],"requirement":[125],"CXCR4":[127],"homing,":[131],"egress,":[136,141],"CCR5":[138],"homing.":[145],"FTY720-driven":[146],"splenic":[147],"blood":[150],"independent":[156],"CCR2,":[158],"CCR5,":[159],"CCR7,":[160],"or":[161],"CXCR4.":[162],"These":[163],"results":[164],"indicate":[165],"FTY720-":[167],"receptor-stimulated":[171],"dependent":[176],"on":[177],"restricted":[179],"usage":[180],"receptor-ligand":[183],"pairs":[184],"within":[185],"discrete":[186],"anatomic":[187],"compartments.":[188]},"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":6},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
