{"id":"https://openalex.org/W2102867860","doi":"https://doi.org/10.1371/journal.pone.0033299","title":"Both TLR2 and TRIF Contribute to Interferon-\u03b2 Production during Listeria Infection","display_name":"Both TLR2 and TRIF Contribute to Interferon-\u03b2 Production during Listeria Infection","publication_year":2012,"publication_date":"2012-03-14","ids":{"openalex":"https://openalex.org/W2102867860","doi":"https://doi.org/10.1371/journal.pone.0033299","mag":"2102867860","pmid":"https://pubmed.ncbi.nlm.nih.gov/22432012","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3303824"},"language":"en","primary_location":{"id":"doi:10.1371/journal.pone.0033299","doi":"https://doi.org/10.1371/journal.pone.0033299","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0033299","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0033299&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0033299&type=printable","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"Camille Aubry","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I204730241","https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Camille Aubry","raw_affiliation_strings":["Institut Pasteur, Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Paris, France","INRA, USC2020, Paris, France","Inserm, U604, Paris, France","Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Cellule Pasteur, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institut Pasteur, Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Paris, France","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"INRA, USC2020, Paris, France","institution_ids":["https://openalex.org/I4387154544"]},{"raw_affiliation_string":"Inserm, U604, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Cellule Pasteur, Paris, France","institution_ids":["https://openalex.org/I4210091437","https://openalex.org/I4387154366"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090465353","display_name":"Sin\u00e9ad C. Corr","orcid":"https://orcid.org/0000-0001-9930-5039","observed_orcids":["https://orcid.org/0000-0001-9930-5039"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Sin\u00e9ad C. Corr","raw_affiliation_strings":["School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001120940","display_name":"Sebastian Wienerroither","orcid":"https://orcid.org/0000-0002-9284-7123","observed_orcids":["https://orcid.org/0000-0002-9284-7123"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I2802916955","display_name":"Max Perutz Labs","ror":"https://ror.org/05cz70a34","country_code":"AT","type":"facility","lineage":["https://openalex.org/I129774422","https://openalex.org/I2802916955"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Sebastian Wienerroither","raw_affiliation_strings":["Max F. Perutz Laboratories, Department of Genetics, Microbiology and Immunobiology, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max F. Perutz Laboratories, Department of Genetics, Microbiology and Immunobiology, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I2802916955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003330017","display_name":"C\u00e9line Goulard","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"C\u00e9line Goulard","raw_affiliation_strings":["INRA, USC2020, Paris, France","Inserm, U604, Paris, France","Institut Pasteur, Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRA, USC2020, Paris, France","institution_ids":["https://openalex.org/I4387154544"]},{"raw_affiliation_string":"Inserm, U604, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut Pasteur, Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000498716","display_name":"Ruth H. Jones","orcid":"https://orcid.org/0000-0001-5811-8827","observed_orcids":["https://orcid.org/0000-0001-5811-8827"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Ruth Jones","raw_affiliation_strings":["School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011905223","display_name":"Amanda Mercedes Jamieson","orcid":"https://orcid.org/0000-0002-5781-9231","observed_orcids":["https://orcid.org/0000-0002-5781-9231"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I2802916955","display_name":"Max Perutz Labs","ror":"https://ror.org/05cz70a34","country_code":"AT","type":"facility","lineage":["https://openalex.org/I129774422","https://openalex.org/I2802916955"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Amanda M. Jamieson","raw_affiliation_strings":["Max F. Perutz Laboratories, Department of Genetics, Microbiology and Immunobiology, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max F. Perutz Laboratories, Department of Genetics, Microbiology and Immunobiology, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I2802916955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042463876","display_name":"Thomas Decker","orcid":"https://orcid.org/0000-0001-9683-0620","observed_orcids":["https://orcid.org/0000-0001-9683-0620"]},"institutions":[{"id":"https://openalex.org/I129774422","display_name":"University of Vienna","ror":"https://ror.org/03prydq77","country_code":"AT","type":"education","lineage":["https://openalex.org/I129774422"]},{"id":"https://openalex.org/I2802916955","display_name":"Max Perutz Labs","ror":"https://ror.org/05cz70a34","country_code":"AT","type":"facility","lineage":["https://openalex.org/I129774422","https://openalex.org/I2802916955"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Thomas Decker","raw_affiliation_strings":["Max F. Perutz Laboratories, Department of Genetics, Microbiology and Immunobiology, University of Vienna, Vienna, Austria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Max F. Perutz Laboratories, Department of Genetics, Microbiology and Immunobiology, University of Vienna, Vienna, Austria","institution_ids":["https://openalex.org/I129774422","https://openalex.org/I2802916955"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065688806","display_name":"Luke A.J. O'Neill","orcid":"https://orcid.org/0000-0002-4333-2748","observed_orcids":["https://orcid.org/0000-0002-4333-2748","https://orcid.org/0009-0001-8312-138X"]},"institutions":[{"id":"https://openalex.org/I205274468","display_name":"Trinity College Dublin","ror":"https://ror.org/02tyrky19","country_code":"IE","type":"education","lineage":["https://openalex.org/I205274468"]}],"countries":["IE"],"is_corresponding":false,"raw_author_name":"Luke A. J. O'Neill","raw_affiliation_strings":["School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College Dublin, Ireland","institution_ids":["https://openalex.org/I205274468"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064566554","display_name":"Olivier Dussurget","orcid":"https://orcid.org/0000-0001-9924-0837","observed_orcids":["https://orcid.org/0000-0001-9924-0837"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I4210091437","display_name":"Sorbonne Paris Cit\u00e9","ror":"https://ror.org/001z21q04","country_code":"FR","type":"other","lineage":["https://openalex.org/I204730241","https://openalex.org/I4210091437"]},{"id":"https://openalex.org/I4387154366","display_name":"Universit\u00e9 Paris Diderot","ror":"https://ror.org/02n7qrg46","country_code":"FR","type":"education","lineage":["https://openalex.org/I204730241","https://openalex.org/I4387154366"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Olivier Dussurget","raw_affiliation_strings":["INRA, USC2020, Paris, France","Inserm, U604, Paris, France","Institut Pasteur, Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Paris, France","Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Cellule Pasteur, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRA, USC2020, Paris, France","institution_ids":["https://openalex.org/I4387154544"]},{"raw_affiliation_string":"Inserm, U604, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut Pasteur, Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Paris, France","institution_ids":["https://openalex.org/I157536573"]},{"raw_affiliation_string":"Universit\u00e9 Paris Diderot, Sorbonne Paris Cit\u00e9, Cellule Pasteur, Paris, France","institution_ids":["https://openalex.org/I4210091437","https://openalex.org/I4387154366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5105977350","display_name":"Pascale Cossart","orcid":"https://orcid.org/0000-0001-8871-6780","observed_orcids":["https://orcid.org/0000-0001-8871-6780"]},"institutions":[{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I157536573","display_name":"Institut Pasteur","ror":"https://ror.org/0495fxg12","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I157536573"]},{"id":"https://openalex.org/I4387154544","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83","country_code":"FR","type":"government","lineage":["https://openalex.org/I4210088668","https://openalex.org/I4387154544"]}],"countries":["FR"],"is_corresponding":true,"raw_author_name":"Pascale Cossart","raw_affiliation_strings":["INRA, USC2020, Paris, France","Inserm, U604, Paris, France","Institut Pasteur, Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Paris, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"INRA, USC2020, Paris, France","institution_ids":["https://openalex.org/I4387154544"]},{"raw_affiliation_string":"Inserm, U604, Paris, France","institution_ids":["https://openalex.org/I154526488"]},{"raw_affiliation_string":"Institut Pasteur, Unit\u00e9 des Interactions Bact\u00e9ries-Cellules, Paris, France","institution_ids":["https://openalex.org/I157536573"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5064566554","https://openalex.org/A5105977350"],"corresponding_institution_ids":["https://openalex.org/I154526488","https://openalex.org/I157536573","https://openalex.org/I4210091437","https://openalex.org/I4387154366","https://openalex.org/I4387154544"],"apc_list":{"value":2382,"currency":"USD","value_usd":2382},"apc_paid":{"value":2382,"currency":"USD","value_usd":2382},"fwci":2.8586,"has_fulltext":true,"cited_by_count":63,"citation_normalized_percentile":{"value":0.90763745,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"7","issue":"3","first_page":"e33299","last_page":"e33299"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.7734000086784363,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.22179999947547913,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/interferon-beta","display_name":"interferon-beta","score":0.8799999952316284},{"id":"https://openalex.org/keywords/tlr2","display_name":"TLR2","score":0.9319999814033508},{"id":"https://openalex.org/keywords/trif","display_name":"TRIF","score":1.0},{"id":"https://openalex.org/keywords/listeria-monocytogenes","display_name":"Listeria monocytogenes","score":0.9860000014305115},{"id":"https://openalex.org/keywords/irf3","display_name":"IRF3","score":0.9890000224113464},{"id":"https://openalex.org/keywords/irf7","display_name":"IRF7","score":1.0},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.890999972820282},{"id":"https://openalex.org/keywords/innate-immunity","display_name":"innate immunity","score":0.6729999780654907},{"id":"https://openalex.org/keywords/bacterial-internalization","display_name":"bacterial internalization","score":0.8220000267028809},{"id":"https://openalex.org/keywords/peritoneal-macrophages","display_name":"peritoneal macrophages","score":0.8659999966621399},{"id":"https://openalex.org/keywords/bone-marrow-derived-macrophages","display_name":"bone marrow-derived macrophages","score":0.8320000171661377},{"id":"https://openalex.org/keywords/pro-inflammatory-macrophages","display_name":"inflammatory macrophages","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C43929388","wikidata":"https://www.wikidata.org/wiki/Q4050587","display_name":"TRIF","level":5,"score":0.9319338798522949},{"id":"https://openalex.org/C2780209191","wikidata":"https://www.wikidata.org/wiki/Q14914339","display_name":"IRF3","level":4,"score":0.8009478449821472},{"id":"https://openalex.org/C2781236682","wikidata":"https://www.wikidata.org/wiki/Q410015","display_name":"TLR2","level":4,"score":0.6710172295570374},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6418247222900391},{"id":"https://openalex.org/C2781350384","wikidata":"https://www.wikidata.org/wiki/Q292015","display_name":"Listeria monocytogenes","level":3,"score":0.6401957273483276},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.6220746636390686},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.6077814102172852},{"id":"https://openalex.org/C2776634448","wikidata":"https://www.wikidata.org/wiki/Q206920","display_name":"Peptidoglycan","level":3,"score":0.4692525863647461},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.43962541222572327},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3237506151199341},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.26539045572280884},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.23764470219612122},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.23107731342315674},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.15815860033035278},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09139996767044067},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08880367875099182}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001854","descriptor_name":"Bone Marrow Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004705","descriptor_name":"Endocytosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008088","descriptor_name":"Listeriosis","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008088","descriptor_name":"Listeriosis","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D008088","descriptor_name":"Listeriosis","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009696","descriptor_name":"Nucleic Acids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016328","descriptor_name":"NF-kappa B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016899","descriptor_name":"Interferon-beta","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017472","descriptor_name":"Receptors, Interleukin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D017737","descriptor_name":"Macrophages, Peritoneal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D033942","descriptor_name":"Adaptor Proteins, Vesicular Transport","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042541","descriptor_name":"Intracellular Space","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":false},{"descriptor_ui":"D050838","descriptor_name":"Interferon Regulatory Factor-3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050839","descriptor_name":"Interferon Regulatory Factor-7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051195","descriptor_name":"Toll-Like Receptor 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051196","descriptor_name":"Toll-Like Receptor 3","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051197","descriptor_name":"Toll-Like Receptor 4","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":10,"locations":[{"id":"doi:10.1371/journal.pone.0033299","doi":"https://doi.org/10.1371/journal.pone.0033299","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0033299","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0033299&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},{"id":"pmid:22432012","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22432012","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PloS one","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3303824","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3303824/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS One","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.349.3330","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.349.3330","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/18/70/PLoS_One_2012_Mar_14_7(3)_e33299.tar.gz","raw_type":"text"},{"id":"pmh:http://www.rian.ie/95786/","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/2262/66880","pdf_url":null,"source":{"id":"https://openalex.org/S4306400033","display_name":"Arrow@dit (Dublin Institute of Technology)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210144925","host_organization_name":"Technological University Dublin","host_organization_lineage":["https://openalex.org/I4210144925"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Aubry C, Corr SC, Wienerroither S, Goulard C, Jones R, Jamieson AM, Decker T, O'Neill LA, Dussurget O, Cossart P, Both TLR2 and TRIF contribute to interferon-? production during Listeria infection., PloS one, 7, 3, 2012, e33299","raw_type":"Journal article"},{"id":"pmh:info:fedora/oai:univie.ac.at:o:597990","doi":null,"is_oa":true,"landing_page_url":"https://phaidra.univie.ac.at/o:597990","pdf_url":null,"source":{"id":"https://openalex.org/S4306401993","display_name":"Phaidra (Universit\u00e4t Wien)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I129774422","host_organization_name":"University of Vienna","host_organization_lineage":["https://openalex.org/I129774422"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ISSN:1932-6203","raw_type":"article"},{"id":"pmh:oai:HAL:hal-02650491v1","doi":null,"is_oa":true,"landing_page_url":"https://hal.inrae.fr/hal-02650491","pdf_url":null,"source":{"id":"https://openalex.org/S4306402512","display_name":"HAL","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4405252976","host_organization_name":"Centre pour la Communication Scientifique Directe","host_organization_lineage":["https://openalex.org/I4405252976"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, 2012, 7 (3), pp.285-290. ⟨10.1371/journal.pone.0033299⟩","raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:doaj.org/article:06afff3580454afc85a16f3ed1ac712f","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/06afff3580454afc85a16f3ed1ac712f","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PLoS ONE, Vol 7, Iss 3, p e33299 (2012)","raw_type":"article"},{"id":"pmh:oai:figshare.com:article/127589","doi":null,"is_oa":true,"landing_page_url":"https://figshare.com/articles/dataset/Both_TLR2_and_TRIF_Contribute_to_Interferon_Production_during_Listeria_Infection/127589","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Dataset"},{"id":"pmh:oai:tara.tcd.ie:2262/66880","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2262/66880","pdf_url":null,"source":{"id":"https://openalex.org/S4306400387","display_name":"Trinity's Access to Research Output (TARA) (Trinity College Dublin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I205274468","host_organization_name":"Trinity College Dublin","host_organization_lineage":["https://openalex.org/I205274468"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1371/journal.pone.0033299","doi":"https://doi.org/10.1371/journal.pone.0033299","is_oa":true,"landing_page_url":"https://doi.org/10.1371/journal.pone.0033299","pdf_url":"https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0033299&type=printable","source":{"id":"https://openalex.org/S202381698","display_name":"PLoS ONE","issn_l":"1932-6203","issn":["1932-6203"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","doaj","dongbi-c","doyens","erih-plus","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315706","host_organization_name":"Public Library of Science","host_organization_lineage":["https://openalex.org/P4310315706"],"host_organization_lineage_names":["Public Library of Science"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PLoS ONE","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4600894321","display_name":"Understanding the infection by the bacterium Listeria monocytogenes as a way to address key issues in biology","funder_award_id":"233348","funder_id":"https://openalex.org/F4320338352","funder_display_name":"FP7 Ideas: European Research Council"}],"funders":[{"id":"https://openalex.org/F4320306082","display_name":"Howard Hughes Medical Institute","ror":"https://ror.org/006w34k90"},{"id":"https://openalex.org/F4320320842","display_name":"Irish Research Council for Science, Engineering and Technology","ror":null},{"id":"https://openalex.org/F4320320847","display_name":"Science Foundation Ireland","ror":"https://ror.org/0271asj38"},{"id":"https://openalex.org/F4320320893","display_name":"Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale","ror":"https://ror.org/02vjkv261"},{"id":"https://openalex.org/F4320321056","display_name":"Irish Research Council","ror":"https://ror.org/051xex213"},{"id":"https://openalex.org/F4320323910","display_name":"Institut National de la Recherche Agronomique","ror":"https://ror.org/01x3gbx83"},{"id":"https://openalex.org/F4320338352","display_name":"FP7 Ideas: European Research Council","ror":"https://ror.org/0472cxd90"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2102867860.pdf","grobid_xml":"https://content.openalex.org/works/W2102867860.grobid-xml"},"referenced_works_count":44,"referenced_works":["https://openalex.org/W1543052543","https://openalex.org/W1569685664","https://openalex.org/W1673881514","https://openalex.org/W1963504987","https://openalex.org/W1964141567","https://openalex.org/W1968718809","https://openalex.org/W1987609001","https://openalex.org/W1993347488","https://openalex.org/W1993832002","https://openalex.org/W2006928776","https://openalex.org/W2012319233","https://openalex.org/W2023853099","https://openalex.org/W2025381177","https://openalex.org/W2029361361","https://openalex.org/W2031269216","https://openalex.org/W2031801904","https://openalex.org/W2035752210","https://openalex.org/W2039390702","https://openalex.org/W2041345682","https://openalex.org/W2052566477","https://openalex.org/W2055456092","https://openalex.org/W2058127453","https://openalex.org/W2063125566","https://openalex.org/W2065423690","https://openalex.org/W2077648685","https://openalex.org/W2082889122","https://openalex.org/W2095807050","https://openalex.org/W2098188064","https://openalex.org/W2102550380","https://openalex.org/W2106248075","https://openalex.org/W2109491705","https://openalex.org/W2115366652","https://openalex.org/W2116803339","https://openalex.org/W2118621168","https://openalex.org/W2124530155","https://openalex.org/W2127863596","https://openalex.org/W2130421043","https://openalex.org/W2131617804","https://openalex.org/W2137701173","https://openalex.org/W2150058561","https://openalex.org/W2150736048","https://openalex.org/W2166257949","https://openalex.org/W2167121999","https://openalex.org/W4246645317"],"related_works":["https://openalex.org/W7096213627","https://openalex.org/W1569685664","https://openalex.org/W2076001499","https://openalex.org/W2149779118","https://openalex.org/W1928690870","https://openalex.org/W2142433291","https://openalex.org/W2068337199","https://openalex.org/W138840601","https://openalex.org/W2161832384","https://openalex.org/W2113757071"],"abstract_inverted_index":{"Synthesis":[0],"of":[1,29,54,61,76,90,94,142,151,163],"interferon-\u03b2":[2],"(IFN-\u03b2)":[3],"is":[4,66],"an":[5],"innate":[6],"response":[7],"to":[8,37,68,80,113,160,177,182],"cytoplasmic":[9],"infection":[10,53],"with":[11,57],"bacterial":[12,87],"pathogens.":[13],"Our":[14],"recent":[15],"studies":[16],"showed":[17],"that":[18,170],"Listeria":[19],"monocytogenes":[20],"limits":[21],"immune":[22],"detection":[23],"and":[24,86,102,107,126,153,167],"IFN-\u03b2":[25,48,82,91,165,183],"synthesis":[26],"via":[27],"deacetylation":[28],"its":[30,70],"peptidoglycan,":[31],"which":[32,65],"renders":[33],"the":[34,46,52,74,81,95,103,131,148,161,164],"bacterium":[35],"resistant":[36],"lysozyme":[38],"degradation.":[39],"Here,":[40],"we":[41],"examined":[42],"signaling":[43,78],"requirements":[44],"for":[45],"massive":[47],"production":[49],"resulting":[50],"from":[51,130],"murine":[55],"macrophages":[56,128],"a":[58,114],"mutant":[59],"strain":[60],"L.":[62,119],"monocytogenes,":[63],"\u0394pgdA,":[64],"unable":[67],"modify":[69],"peptidoglycan.":[71],"We":[72],"report":[73],"identification":[75],"unconventional":[77],"pathways":[79,110],"gene,":[83],"requiring":[84],"TLR2":[85,152],"internalization.":[88],"Induction":[89],"was":[92],"independent":[93],"Mal/TIRAP":[96],"adaptor":[97],"protein":[98],"but":[99,134],"required":[100],"TRIF":[101,154],"transcription":[104],"factors":[105],"IRF3":[106],"IRF7.":[108],"These":[109],"were":[111],"stimulated":[112],"lesser":[115],"degree":[116],"by":[117],"wild-type":[118],"monocytogenes.":[120],"They":[121],"operated":[122],"in":[123,136,147,168],"both":[124],"resident":[125],"inflammatory":[127],"derived":[129],"peritoneal":[132],"cavity,":[133],"not":[135],"bone":[137],"marrow-derived":[138],"macrophages.":[139],"The":[140],"novelty":[141],"our":[143],"findings":[144],"thus":[145],"lies":[146],"first":[149],"description":[150],"as":[155],"two":[156],"critical":[157],"components":[158],"leading":[159],"induction":[162],"gene":[166,184],"uncovering":[169],"individual":[171],"macrophage":[172],"populations":[173],"adopt":[174],"different":[175],"strategies":[176],"link":[178],"pathogen":[179],"recognition":[180],"signals":[181],"expression.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":4},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":5},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":5},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}