{"id":"https://openalex.org/W2102858085","doi":"https://doi.org/10.1128/mcb.00379-10","title":"MeCP2 Binds Cooperatively to Its Substrate and Competes with Histone H1 for Chromatin Binding Sites","display_name":"MeCP2 Binds Cooperatively to Its Substrate and Competes with Histone H1 for Chromatin Binding Sites","publication_year":2010,"publication_date":"2010-08-03","ids":{"openalex":"https://openalex.org/W2102858085","doi":"https://doi.org/10.1128/mcb.00379-10","mag":"2102858085","pmid":"https://pubmed.ncbi.nlm.nih.gov/20679481","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2950531"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.00379-10","doi":"https://doi.org/10.1128/mcb.00379-10","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.00379-10","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2950531/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5055261141","display_name":"Rajarshi P. Ghosh","orcid":"https://orcid.org/0000-0002-0020-6194","observed_orcids":["https://orcid.org/0000-0002-0020-6194","https://orcid.org/0000-0003-2348-6333"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rajarshi P. Ghosh","raw_affiliation_strings":["Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, Massachusetts 01003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, Massachusetts 01003","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053540822","display_name":"Rachel A. Horowitz-Scherer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel A. Horowitz-Scherer","raw_affiliation_strings":["Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033373220","display_name":"Nikitina Tv","orcid":"https://orcid.org/0000-0002-4230-6855","observed_orcids":["https://orcid.org/0000-0002-4230-6855"]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tatiana Nikitina","raw_affiliation_strings":["Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003","institution_ids":["https://openalex.org/I24603500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110809906","display_name":"Luda S. Shlyakhtenko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I59130452","display_name":"University of Nebraska Medical Center","ror":"https://ror.org/00thqtb16","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I59130452"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Luda S. Shlyakhtenko","raw_affiliation_strings":["Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmaceutical Sciences, University of Nebraska Medical Center, Omaha, Nebraska 68198","institution_ids":["https://openalex.org/I59130452"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111866704","display_name":"Christopher L. F. Woodcock","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I24603500","display_name":"University of Massachusetts Amherst","ror":"https://ror.org/0072zz521","country_code":"US","type":"education","lineage":["https://openalex.org/I24603500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Christopher L. Woodcock","raw_affiliation_strings":["Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003","Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, Massachusetts 01003","2 Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"Program in Molecular and Cellular Biology, University of Massachusetts, Amherst, Massachusetts 01003","institution_ids":["https://openalex.org/I24603500"]},{"raw_affiliation_string":"2 Department of Biology, University of Massachusetts, Amherst, Massachusetts 01003","institution_ids":["https://openalex.org/I24603500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111866704"],"corresponding_institution_ids":["https://openalex.org/I24603500"],"apc_list":null,"apc_paid":null,"fwci":12.6453,"has_fulltext":false,"cited_by_count":150,"citation_normalized_percentile":{"value":0.99265045,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"30","issue":"19","first_page":"4656","last_page":"4670"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11772","display_name":"Genetics and Neurodevelopmental Disorders","score":0.9185000061988831,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.05920000001788139,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.014999999664723873,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mecp2","display_name":"MeCP2","score":0.9959999918937683},{"id":"https://openalex.org/keywords/rett-syndrome","display_name":"Rett syndrome","score":0.9670000076293945},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.7689999938011169},{"id":"https://openalex.org/keywords/cooperative-dna-binding","display_name":"cooperative DNA binding","score":0.7829999923706055},{"id":"https://openalex.org/keywords/histone-h1","display_name":"histone H1","score":0.8669999837875366},{"id":"https://openalex.org/keywords/chromatin-binding","display_name":"chromatin binding","score":0.7670000195503235},{"id":"https://openalex.org/keywords/30-nm-chromatin-fiber","display_name":"30 nm chromatin fiber","score":0.9020000100135803},{"id":"https://openalex.org/keywords/dna-length-dependence","display_name":"DNA length dependence","score":0.5730000138282776},{"id":"https://openalex.org/keywords/protein-dimerization","display_name":"protein dimerization","score":0.7049999833106995},{"id":"https://openalex.org/keywords/chromatin-condensation","display_name":"chromatin condensation","score":0.6610000133514404}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7502015829086304},{"id":"https://openalex.org/C83640560","wikidata":"https://www.wikidata.org/wiki/Q180951","display_name":"Chromatin","level":3,"score":0.6529339551925659},{"id":"https://openalex.org/C84772758","wikidata":"https://www.wikidata.org/wiki/Q271794","display_name":"Nucleosome","level":4,"score":0.6509523391723633},{"id":"https://openalex.org/C2778863441","wikidata":"https://www.wikidata.org/wiki/Q18028997","display_name":"MECP2","level":4,"score":0.6096194982528687},{"id":"https://openalex.org/C64927066","wikidata":"https://www.wikidata.org/wiki/Q36293","display_name":"Histone","level":3,"score":0.47698265314102173},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4179849624633789},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.40097957849502563},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.3629875183105469},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.34293892979621887},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.15393590927124023},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.05646142363548279}],"mesh":[{"descriptor_ui":"D000077209","descriptor_name":"Decitabine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001374","descriptor_name":"Azacitidine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001665","descriptor_name":"Binding Sites","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001667","descriptor_name":"Binding, Competitive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002843","descriptor_name":"Chromatin","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005454","descriptor_name":"Fluorescence Polarization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006657","descriptor_name":"Histones","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008854","descriptor_name":"Microscopy, Electron","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008856","descriptor_name":"Microscopy, Fluorescence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009154","descriptor_name":"Mutation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009707","descriptor_name":"Nucleosomes","qualifier_ui":"Q000648","qualifier_name":"ultrastructure","is_major_topic":false},{"descriptor_ui":"D011485","descriptor_name":"Protein Binding","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018625","descriptor_name":"Microscopy, Atomic Force","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019175","descriptor_name":"DNA Methylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D020856","descriptor_name":"AT Rich Sequence","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D041702","descriptor_name":"BALB 3T3 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D049452","descriptor_name":"Green Fluorescent Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051783","descriptor_name":"Methyl-CpG-Binding Protein 2","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051783","descriptor_name":"Methyl-CpG-Binding Protein 2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051783","descriptor_name":"Methyl-CpG-Binding Protein 2","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D055503","descriptor_name":"Protein Multimerization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1128/mcb.00379-10","doi":"https://doi.org/10.1128/mcb.00379-10","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.00379-10","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmid:20679481","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20679481","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2950531","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2950531/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2950531","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC2950531/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1723430804","display_name":"Role of MeCP2 as a Chromatin Architectural Protein","funder_award_id":"R01GM070897","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320308928","display_name":"University of Delaware","ror":"https://ror.org/01sbq1a82"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":72,"referenced_works":["https://openalex.org/W131822264","https://openalex.org/W597159688","https://openalex.org/W1520946154","https://openalex.org/W1559742681","https://openalex.org/W1568313174","https://openalex.org/W1572088192","https://openalex.org/W1632044028","https://openalex.org/W1635552303","https://openalex.org/W1890119853","https://openalex.org/W1967154908","https://openalex.org/W1970149098","https://openalex.org/W1971284874","https://openalex.org/W1975317507","https://openalex.org/W1978107331","https://openalex.org/W1981831332","https://openalex.org/W1981977553","https://openalex.org/W1993137394","https://openalex.org/W1995470989","https://openalex.org/W1997641930","https://openalex.org/W2000073535","https://openalex.org/W2000342325","https://openalex.org/W2001936578","https://openalex.org/W2005641629","https://openalex.org/W2008753573","https://openalex.org/W2009143215","https://openalex.org/W2017178787","https://openalex.org/W2017314177","https://openalex.org/W2018771202","https://openalex.org/W2018947009","https://openalex.org/W2025919590","https://openalex.org/W2029331780","https://openalex.org/W2030023744","https://openalex.org/W2032151283","https://openalex.org/W2032660941","https://openalex.org/W2033162367","https://openalex.org/W2035090622","https://openalex.org/W2038151035","https://openalex.org/W2042269850","https://openalex.org/W2043676713","https://openalex.org/W2044107593","https://openalex.org/W2047422719","https://openalex.org/W2049545055","https://openalex.org/W2052842503","https://openalex.org/W2059305083","https://openalex.org/W2061764188","https://openalex.org/W2062514148","https://openalex.org/W2067004457","https://openalex.org/W2067267228","https://openalex.org/W2068266901","https://openalex.org/W2071730442","https://openalex.org/W2074302707","https://openalex.org/W2075334136","https://openalex.org/W2086485143","https://openalex.org/W2087782080","https://openalex.org/W2089191944","https://openalex.org/W2097321367","https://openalex.org/W2097778167","https://openalex.org/W2099351601","https://openalex.org/W2103620614","https://openalex.org/W2103743266","https://openalex.org/W2111592257","https://openalex.org/W2113377321","https://openalex.org/W2116119112","https://openalex.org/W2121003260","https://openalex.org/W2121417064","https://openalex.org/W2123979543","https://openalex.org/W2144792857","https://openalex.org/W2145379834","https://openalex.org/W2163449711","https://openalex.org/W2166633156","https://openalex.org/W2167388443","https://openalex.org/W2172197806"],"related_works":["https://openalex.org/W7163568738","https://openalex.org/W2116119112","https://openalex.org/W2102289595","https://openalex.org/W6977622649","https://openalex.org/W7020028848","https://openalex.org/W4319940262","https://openalex.org/W7212319431","https://openalex.org/W2000073535","https://openalex.org/W2504075081","https://openalex.org/W4401728711"],"abstract_inverted_index":{"Sporadic":[0],"mutations":[1],"in":[2,17,73,99,111,114,117,142,174,179],"the":[3,18,26,41,100,122,180],"hMeCP2":[4],"gene,":[5],"coding":[6],"for":[7,133,155,161],"a":[8,30],"protein":[9],"that":[10,53,120,167],"preferentially":[11],"binds":[12,109],"symmetrically":[13],"methylated":[14],"CpGs,":[15],"result":[16],"severe":[19,104],"neurological":[20],"disorder":[21],"Rett":[22],"syndrome":[23],"(RTT).":[24],"In":[25,136],"present":[27],"work,":[28],"employing":[29],"wide":[31],"range":[32],"of":[33,44,147,182],"experimental":[34],"approaches,":[35],"we":[36],"shed":[37],"new":[38],"light":[39],"on":[40],"many":[42],"levels":[43],"MeCP2":[45,62,69,107,149,158,171],"interaction":[46],"with":[47,81,86],"DNA":[48,66,78],"and":[49,89,102,130,141,150,159,172],"chromatin.":[50],"We":[51],"show":[52],"strong":[54,153],"methylation-independent":[55],"as":[56,58],"well":[57],"methylation-dependent":[59],"binding":[60,76,83,96,139,146,163,169],"by":[61,65,91,127,170],"is":[63,70,79,97],"influenced":[64],"length.":[67],"Although":[68],"strictly":[71],"monomeric":[72],"solution,":[74],"its":[75],"to":[77],"cooperative,":[80],"dimeric":[82],"strongly":[84],"correlated":[85],"methylation":[87],"density,":[88],"strengthened":[90],"nearby":[92],"A/T":[93],"repeats.":[94],"Dimeric":[95],"abolished":[98],"F155S":[101],"R294X":[103],"RTT":[105],"mutants.":[106],"also":[108],"chromatin":[110,138,168],"vitro,":[112],"resulting":[113],"compaction-related":[115],"changes":[116],"nucleosome":[118,145],"architecture":[119],"resemble":[121],"classical":[123],"zigzag":[124],"motif":[125],"induced":[126],"histone":[128],"H1":[129,151,160,173],"considered":[131],"important":[132],"30-nm-fiber":[134],"formation.":[135],"vivo":[137,175],"kinetics":[140],"vitro":[143],"steady-state":[144],"both":[148],"provide":[152],"evidence":[154],"competition":[156],"between":[157],"common":[162],"sites.":[164],"This":[165],"suggests":[166],"should":[176],"be":[177],"viewed":[178],"context":[181],"competitive":[183],"multifactorial":[184],"regulation.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":11},{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":13},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":11},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":16},{"year":2012,"cited_by_count":9}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
