{"id":"https://openalex.org/W2102820448","doi":null,"title":"Biotechnological Applications of Artificial Microtissues","display_name":"Biotechnological Applications of Artificial Microtissues","publication_year":2009,"publication_date":"2009-05-22","ids":{"openalex":"https://openalex.org/W2102820448","mag":"2102820448"},"language":"en","primary_location":{"id":"mag:2102820448","doi":null,"is_oa":false,"landing_page_url":"https://ddd.uab.cat/pub/tesis/2009/tdx-0216110-161351/cdb1de1.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039849017","display_name":"Carlota D\u00edaz S\u00e1nchez-Bustamante","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Carlota D\u00edaz S\u00e1nchez-Bustamante","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5039849017"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.7925000190734863,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.7925000190734863,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.08529999852180481,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11190","display_name":"3D Printing in Biomedical Research","score":0.06830000132322311,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":0.6940000057220459},{"id":"https://openalex.org/keywords/fosb","display_name":"FosB","score":0.9359999895095825},{"id":"https://openalex.org/keywords/cardiomyocyte-differentiation","display_name":"cardiomyocyte differentiation","score":0.5849999785423279},{"id":"https://openalex.org/keywords/cardiac-regeneration","display_name":"cardiac regeneration","score":0.8019999861717224},{"id":"https://openalex.org/keywords/adipose-tissue-differentiation","display_name":"adipose tissue differentiation","score":0.7020000219345093},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.7319999933242798},{"id":"https://openalex.org/keywords/osteoporosis","display_name":"osteoporosis","score":0.8100000023841858},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.4189999997615814},{"id":"https://openalex.org/keywords/tissue-engineering","display_name":"tissue engineering","score":0.5870000123977661},{"id":"https://openalex.org/keywords/therapeutic-protein-production","display_name":"therapeutic protein production","score":0.7710000276565552},{"id":"https://openalex.org/keywords/cellular-reprogramming","display_name":"cellular reprogramming","score":0.4819999933242798},{"id":"https://openalex.org/keywords/3d-cell-culture","display_name":"3D cell culture","score":0.7170000076293945}],"concepts":[{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.4779248833656311},{"id":"https://openalex.org/C15708023","wikidata":"https://www.wikidata.org/wiki/Q80083","display_name":"Humanities","level":1,"score":0.4562864899635315},{"id":"https://openalex.org/C121332964","wikidata":"https://www.wikidata.org/wiki/Q413","display_name":"Physics","level":0,"score":0.36763447523117065},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2932558059692383},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.14070433378219604}],"mesh":[],"locations_count":1,"locations":[{"id":"mag:2102820448","doi":null,"is_oa":false,"landing_page_url":"https://ddd.uab.cat/pub/tesis/2009/tdx-0216110-161351/cdb1de1.pdf","pdf_url":null,"source":{"id":"https://openalex.org/S4306531624","display_name":"TDX (Tesis Doctorals en Xarxa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"TDX (Tesis Doctorals en Xarxa)","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":317,"referenced_works":["https://openalex.org/W19330912","https://openalex.org/W47689339","https://openalex.org/W69719363","https://openalex.org/W137616578","https://openalex.org/W985799322","https://openalex.org/W996832073","https://openalex.org/W1481565655","https://openalex.org/W1488252766","https://openalex.org/W1509401342","https://openalex.org/W1518819083","https://openalex.org/W1524345526","https://openalex.org/W1541555963","https://openalex.org/W1574631190","https://openalex.org/W1577871794","https://openalex.org/W1587712169","https://openalex.org/W1595083713","https://openalex.org/W1599501164","https://openalex.org/W1603508604","https://openalex.org/W1607413909","https://openalex.org/W1631449371","https://openalex.org/W1645799104","https://openalex.org/W1663371441","https://openalex.org/W1688307469","https://openalex.org/W1701172542","https://openalex.org/W1786034244","https://openalex.org/W1826549280","https://openalex.org/W1835972708","https://openalex.org/W1883330721","https://openalex.org/W1886156337","https://openalex.org/W1908801241","https://openalex.org/W1917492683","https://openalex.org/W1927710737","https://openalex.org/W1937940610","https://openalex.org/W1943239370","https://openalex.org/W1951350042","https://openalex.org/W1964596167","https://openalex.org/W1964997589","https://openalex.org/W1965740863","https://openalex.org/W1965933207","https://openalex.org/W1966291152","https://openalex.org/W1966422462","https://openalex.org/W1967096501","https://openalex.org/W1967882105","https://openalex.org/W1969086323","https://openalex.org/W1969834697","https://openalex.org/W1970210368","https://openalex.org/W1970828359","https://openalex.org/W1971044068","https://openalex.org/W1971384581","https://openalex.org/W1971880089","https://openalex.org/W1972584860","https://openalex.org/W1972892361","https://openalex.org/W1973737821","https://openalex.org/W1974159415","https://openalex.org/W1974332070","https://openalex.org/W1975833234","https://openalex.org/W1977390310","https://openalex.org/W1979640753","https://openalex.org/W1980544949","https://openalex.org/W1981536893","https://openalex.org/W1982812308","https://openalex.org/W1985281394","https://openalex.org/W1985682361","https://openalex.org/W1985826042","https://openalex.org/W1986145438","https://openalex.org/W1986469118","https://openalex.org/W1987176983","https://openalex.org/W1987453246","https://openalex.org/W1988692408","https://openalex.org/W1988875615","https://openalex.org/W1988933692","https://openalex.org/W1989584274","https://openalex.org/W1989797513","https://openalex.org/W1989963027","https://openalex.org/W1990605253","https://openalex.org/W1993355508","https://openalex.org/W1993624518","https://openalex.org/W1994596418","https://openalex.org/W1994898751","https://openalex.org/W1998944182","https://openalex.org/W2001108771","https://openalex.org/W2001622184","https://openalex.org/W2001631200","https://openalex.org/W2002165667","https://openalex.org/W2002274453","https://openalex.org/W2002519246","https://openalex.org/W2002582091","https://openalex.org/W2002886501","https://openalex.org/W2003520177","https://openalex.org/W2006623403","https://openalex.org/W2006906242","https://openalex.org/W2006950202","https://openalex.org/W2009629707","https://openalex.org/W2009647055","https://openalex.org/W2009672985","https://openalex.org/W2009862260","https://openalex.org/W2010160865","https://openalex.org/W2010658278","https://openalex.org/W2011114620","https://openalex.org/W2011658360","https://openalex.org/W2011759881","https://openalex.org/W2011919971","https://openalex.org/W2012660030","https://openalex.org/W2013676086","https://openalex.org/W2013788023","https://openalex.org/W2014602995","https://openalex.org/W2015032348","https://openalex.org/W2015496410","https://openalex.org/W2016449014","https://openalex.org/W2018224744","https://openalex.org/W2018562153","https://openalex.org/W2018683165","https://openalex.org/W2019283447","https://openalex.org/W2023189561","https://openalex.org/W2024941123","https://openalex.org/W2026632078","https://openalex.org/W2026897875","https://openalex.org/W2028135584","https://openalex.org/W2028970423","https://openalex.org/W2030522563","https://openalex.org/W2030837323","https://openalex.org/W2033245926","https://openalex.org/W2035205542","https://openalex.org/W2035443401","https://openalex.org/W2036386470","https://openalex.org/W2036719828","https://openalex.org/W2037769333","https://openalex.org/W2038338126","https://openalex.org/W2038559883","https://openalex.org/W2040249570","https://openalex.org/W2040435335","https://openalex.org/W2040516865","https://openalex.org/W2041558541","https://openalex.org/W2041940909","https://openalex.org/W2042032972","https://openalex.org/W2042193781","https://openalex.org/W2042222615","https://openalex.org/W2043129312","https://openalex.org/W2043310171","https://openalex.org/W2045498839","https://openalex.org/W2046633785","https://openalex.org/W2047569790","https://openalex.org/W2048410503","https://openalex.org/W2048603602","https://openalex.org/W2048604637","https://openalex.org/W2050351042","https://openalex.org/W2050590316","https://openalex.org/W2050921552","https://openalex.org/W2052609811","https://openalex.org/W2052868121","https://openalex.org/W2052976216","https://openalex.org/W2053113457","https://openalex.org/W2054361923","https://openalex.org/W2054400601","https://openalex.org/W2055110202","https://openalex.org/W2055269543","https://openalex.org/W2055679705","https://openalex.org/W2056162678","https://openalex.org/W2056376534","https://openalex.org/W2057609586","https://openalex.org/W2058460506","https://openalex.org/W2058461583","https://openalex.org/W2059098323","https://openalex.org/W2059992589","https://openalex.org/W2061533734","https://openalex.org/W2061769351","https://openalex.org/W2062128212","https://openalex.org/W2062929782","https://openalex.org/W2064127449","https://openalex.org/W2065968827","https://openalex.org/W2066193591","https://openalex.org/W2067427748","https://openalex.org/W2067912936","https://openalex.org/W2067996486","https://openalex.org/W2069507241","https://openalex.org/W2069519855","https://openalex.org/W2069652778","https://openalex.org/W2071655943","https://openalex.org/W2071849288","https://openalex.org/W2071991375","https://openalex.org/W2073534348","https://openalex.org/W2074701970","https://openalex.org/W2074776278","https://openalex.org/W2075199712","https://openalex.org/W2075279905","https://openalex.org/W2075792406","https://openalex.org/W2076343619","https://openalex.org/W2077177273","https://openalex.org/W2077559627","https://openalex.org/W2078201925","https://openalex.org/W2078766485","https://openalex.org/W2079898904","https://openalex.org/W2080415915","https://openalex.org/W2080988481","https://openalex.org/W2081806906","https://openalex.org/W2084324934","https://openalex.org/W2085412371","https://openalex.org/W2086768516","https://openalex.org/W2087250138","https://openalex.org/W2087346309","https://openalex.org/W2088716692","https://openalex.org/W2089687291","https://openalex.org/W2091670449","https://openalex.org/W2093582718","https://openalex.org/W2094389211","https://openalex.org/W2094907909","https://openalex.org/W2097899015","https://openalex.org/W2098547254","https://openalex.org/W2098799479","https://openalex.org/W2098900647","https://openalex.org/W2099025040","https://openalex.org/W2100458582","https://openalex.org/W2100750822","https://openalex.org/W2101347416","https://openalex.org/W2102070943","https://openalex.org/W2102799896","https://openalex.org/W2106486907","https://openalex.org/W2107301060","https://openalex.org/W2107348072","https://openalex.org/W2107396952","https://openalex.org/W2107503723","https://openalex.org/W2107960447","https://openalex.org/W2109155501","https://openalex.org/W2109441210","https://openalex.org/W2110048188","https://openalex.org/W2110675735","https://openalex.org/W2110921202","https://openalex.org/W2111643738","https://openalex.org/W2112091653","https://openalex.org/W2112847494","https://openalex.org/W2113242413","https://openalex.org/W2117347882","https://openalex.org/W2118246527","https://openalex.org/W2118540273","https://openalex.org/W2119698183","https://openalex.org/W2119706727","https://openalex.org/W2120108270","https://openalex.org/W2120510959","https://openalex.org/W2121049679","https://openalex.org/W2121550910","https://openalex.org/W2125155374","https://openalex.org/W2126712376","https://openalex.org/W2129695120","https://openalex.org/W2129816768","https://openalex.org/W2130274346","https://openalex.org/W2130699680","https://openalex.org/W2131424836","https://openalex.org/W2131862834","https://openalex.org/W2133739193","https://openalex.org/W2135116577","https://openalex.org/W2135271579","https://openalex.org/W2135573420","https://openalex.org/W2136104104","https://openalex.org/W2136348413","https://openalex.org/W2136646494","https://openalex.org/W2138531353","https://openalex.org/W2139300012","https://openalex.org/W2139466117","https://openalex.org/W2140205166","https://openalex.org/W2140480932","https://openalex.org/W2140723257","https://openalex.org/W2141211778","https://openalex.org/W2143572181","https://openalex.org/W2145641640","https://openalex.org/W2145975100","https://openalex.org/W2146335969","https://openalex.org/W2146511487","https://openalex.org/W2147507695","https://openalex.org/W2148867518","https://openalex.org/W2149879897","https://openalex.org/W2150674116","https://openalex.org/W2153222060","https://openalex.org/W2153799561","https://openalex.org/W2153955991","https://openalex.org/W2154568166","https://openalex.org/W2155515147","https://openalex.org/W2155607308","https://openalex.org/W2156668426","https://openalex.org/W2156754275","https://openalex.org/W2157956550","https://openalex.org/W2159505514","https://openalex.org/W2159999899","https://openalex.org/W2160542010","https://openalex.org/W2160663135","https://openalex.org/W2160724997","https://openalex.org/W2162263062","https://openalex.org/W2162562074","https://openalex.org/W2162575108","https://openalex.org/W2162981856","https://openalex.org/W2165027208","https://openalex.org/W2167039827","https://openalex.org/W2167277251","https://openalex.org/W2167941377","https://openalex.org/W2168534792","https://openalex.org/W2169054659","https://openalex.org/W2169174986","https://openalex.org/W2169799220","https://openalex.org/W2170203838","https://openalex.org/W2170311610","https://openalex.org/W2170349147","https://openalex.org/W2172230191","https://openalex.org/W2174923068","https://openalex.org/W2182596905","https://openalex.org/W2300586499","https://openalex.org/W2322523258","https://openalex.org/W2340572385","https://openalex.org/W2397865238","https://openalex.org/W2413606879","https://openalex.org/W2414061918","https://openalex.org/W2418107326","https://openalex.org/W2418400115","https://openalex.org/W2418611766","https://openalex.org/W2418788314","https://openalex.org/W2588425011","https://openalex.org/W2898712814","https://openalex.org/W2916426481","https://openalex.org/W3021510377"],"related_works":["https://openalex.org/W3106793841","https://openalex.org/W6991555091","https://openalex.org/W3105763487","https://openalex.org/W2563175401","https://openalex.org/W2794023995","https://openalex.org/W2274928816","https://openalex.org/W2018683165","https://openalex.org/W107235116","https://openalex.org/W2091093723","https://openalex.org/W2945805943"],"abstract_inverted_index":{"Avances":[0],"en":[1,6,26,47,206,211,216,236,247],"ingenieria":[2,190],"de":[3,12,16,21,23,33,38,43,63,68,75,87,91,96,112,116,125,147,155,169,176,181,191,198,219,230,244,250,261,291],"tejidos":[4,35,89,192],"y":[5,41,67,81,100,108,114,119,129,142,196,233,264],"terapias":[7,194],"celulares":[8,195,208,239],"requeriran":[9],"el":[10,31,61,136,162,217,228,248,259],"desarrollo":[11],"un":[13,203,225,284],"nuevo":[14],"abanico":[15],"tecnologias.":[17],"Estas":[18],"incluiran":[19],"sistemas":[20,37,42],"cultivo":[22],"lineas":[24],"primarias":[25],"tres":[27],"dimensiones":[28],"(3D)":[29],"con":[30,60,135,157],"fin":[32],"construir":[34],"artificiales,":[36],"transduccion":[39],"eficientes":[40],"regulacion":[44,95],"genetica":[45],"compatibles":[46],"humanos":[48],"para":[49,98,131,151,172,193,209,227,258,288],"ajustar":[50],"intervenciones":[51],"moleculares.":[52],"Todo":[53],"ello":[54],"permitira":[55],"reprogramar":[56],"las":[57,83,174],"celulas":[58,158],"animales":[59],"objetivo":[62,74,163],"obtener":[64],"fenotipos":[65],"deseados":[66],"optimizar":[69,152],"la":[70,94,102,122,140,145,167,177,189,212,273,289],"productividad":[71,146],"celular.":[72],"El":[73],"esta":[76],"tesis":[77],"es":[78,164],"(i)":[79],"estudiar":[80],"manipular":[82],"propiedades":[84],"(electro)":[85],"fisiologicas":[86],"los":[88,110,126,148,153,221,252,279],"artificiales":[90,150,223,254,281],"miocardio":[92],"mediante":[93,121],"BMP-2":[97,128],"controlar":[99],"regenerar":[101],"funcionalidad":[103],"cardiaca,":[104],"(ii)":[105],"estudiar,":[106],"inducir":[107],"caracterizar":[109],"procesos":[111,154,238],"diferenciacion":[113],"transdiferenciacion":[115],"microtejidos":[117,149,170,222,253,280],"adiposos":[118],"oseos":[120],"sobre":[123],"expresion":[124],"genes":[127,232,263],"FosB":[130],"tratar":[132],"enfermedades":[133],"relacionadas":[134],"tejido":[137],"oseo":[138],"como":[139],"osteoporosis,":[141],"(iii)":[143],"evaluar":[144],"produccion":[156,168,290],"animales.":[159],"Por":[160],"ultimo,":[161],"tambien":[165,201],"automatizar":[166],"artificials":[171],"satisfacer":[173],"necesidades":[175],"industria.":[178],"Microtejidos":[179],"libres":[180],"scaffold":[182],"no":[183],"solo":[184],"presentan":[185,224],"una":[186,256,271],"alternativa":[187],"a":[188],"regeneracion":[197],"tejidos,":[199],"sino":[200],"tienen":[202],"gran":[204],"potencial":[205],"estudios":[207],"aplicaciones":[210],"industria":[213],"bio-farmaceutica.":[214],"Mientras":[215],"area":[218,249],"investigacion,":[220],"modelo":[226],"estudio":[229],"nuevos":[231],"proteinas":[234,265,292],"implicadas":[235],"diferentes":[237],"(diferenciacion,":[240],"proliferacion,":[241],"apoptosis,":[242],"sintesis":[243],"proteinas,":[245],"etc.),":[246],"desarrollo,":[251],"representan":[255],"herramienta":[257],"analisis":[260],"dichos":[262],"por":[266],"su":[267],"accion":[268],"terapeutica.":[269],"Finalmente,":[270],"vez":[272],"proteina":[274],"terapeutica":[275],"ha":[276],"sido":[277],"identificada,":[278],"podrian":[282],"proveer":[283],"ambiente":[285],"mas":[286],"beneficioso":[287],"terapeuticas.":[293]},"counts_by_year":[],"updated_date":"2026-09-26T08:19:03.415552","created_date":"2016-06-24T00:00:00"}
