{"id":"https://openalex.org/W2102811797","doi":"https://doi.org/10.1128/aem.71.8.4185-4190.2005","title":"Inhibition of Clostridium perfringens by a Novel Strain of Bacillus subtilis Isolated from the Gastrointestinal Tracts of Healthy Chickens","display_name":"Inhibition of Clostridium perfringens by a Novel Strain of Bacillus subtilis Isolated from the Gastrointestinal Tracts of Healthy Chickens","publication_year":2005,"publication_date":"2005-08-01","ids":{"openalex":"https://openalex.org/W2102811797","doi":"https://doi.org/10.1128/aem.71.8.4185-4190.2005","mag":"2102811797","pmid":"https://pubmed.ncbi.nlm.nih.gov/16085801","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/1183296"},"language":"en","primary_location":{"id":"doi:10.1128/aem.71.8.4185-4190.2005","doi":"https://doi.org/10.1128/aem.71.8.4185-4190.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aem.71.8.4185-4190.2005","pdf_url":null,"source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},"parent_works":[],"lineage":["https://openalex.org/W2102811797"],"child_works_count":0,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://europepmc.org/pmc/articles/PMC1183296","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068564722","display_name":"Alex Yeow-Lim Teo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103443","display_name":"Kemin (Belgium)","ror":"https://ror.org/01jh73d13","country_code":"BE","type":"company","lineage":["https://openalex.org/I4210103443"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Alex Yeow-Lim Teo","raw_affiliation_strings":["Kemin Industries (Asia) Pte Ltd., 12 Senoko Drive, Singapore 758200, Republic of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kemin Industries (Asia) Pte Ltd., 12 Senoko Drive, Singapore 758200, Republic of Singapore","institution_ids":["https://openalex.org/I4210103443"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5102113770","display_name":"Hai-Meng Tan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210103443","display_name":"Kemin (Belgium)","ror":"https://ror.org/01jh73d13","country_code":"BE","type":"company","lineage":["https://openalex.org/I4210103443"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Hai-Meng Tan","raw_affiliation_strings":["Kemin Industries (Asia) Pte Ltd., 12 Senoko Drive, Singapore 758200, Republic of Singapore"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Kemin Industries (Asia) Pte Ltd., 12 Senoko Drive, Singapore 758200, Republic of Singapore","institution_ids":["https://openalex.org/I4210103443"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I4210103443"],"apc_list":null,"apc_paid":null,"fwci":1.4926,"has_fulltext":false,"cited_by_count":165,"citation_normalized_percentile":{"value":0.8032028,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"71","issue":"8","first_page":"4185","last_page":"4190"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11288","display_name":"Clostridium difficile and Clostridium perfringens research","score":0.8773999810218811,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10141","display_name":"Probiotics and Fermented Foods","score":0.07500000298023224,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10152","display_name":"Animal Nutrition and Physiology","score":0.01730000041425228,"subfield":{"id":"https://openalex.org/subfields/1103","display_name":"Animal Science and Zoology"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/clostridium-perfringens","display_name":"Clostridium perfringens","score":0.9869999885559082},{"id":"https://openalex.org/keywords/bacillus-subtilis","display_name":"Bacillus subtilis","score":0.972000002861023},{"id":"https://openalex.org/keywords/necrotic-enteritis","display_name":"necrotic enteritis","score":0.9539999961853027},{"id":"https://openalex.org/keywords/poultry","display_name":"poultry","score":0.8220000267028809},{"id":"https://openalex.org/keywords/chickens","display_name":"chickens","score":0.5299999713897705},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.5839999914169312},{"id":"https://openalex.org/keywords/antimicrobial-activity","display_name":"antimicrobial activity","score":0.7670000195503235},{"id":"https://openalex.org/keywords/protein-stability","display_name":"protein stability","score":0.45899999141693115},{"id":"https://openalex.org/keywords/molecular-weight","display_name":"molecular weight","score":0.6159999966621399},{"id":"https://openalex.org/keywords/probiotic-bacteria","display_name":"probiotic bacteria","score":0.35199999809265137},{"id":"https://openalex.org/keywords/clostridioides-difficile","display_name":"Clostridium difficile","score":0.8569999933242798},{"id":"https://openalex.org/keywords/campylobacter","display_name":"Campylobacter","score":0.8740000128746033}],"concepts":[{"id":"https://openalex.org/C2779116991","wikidata":"https://www.wikidata.org/wiki/Q309465","display_name":"Clostridium perfringens","level":3,"score":0.964533805847168},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.8157670497894287},{"id":"https://openalex.org/C2777272437","wikidata":"https://www.wikidata.org/wiki/Q131238","display_name":"Bacillus subtilis","level":3,"score":0.7043047547340393},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6040659546852112},{"id":"https://openalex.org/C2781092032","wikidata":"https://www.wikidata.org/wiki/Q327663","display_name":"Clostridium","level":3,"score":0.5172658562660217},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.47699978947639465},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.45932409167289734},{"id":"https://openalex.org/C2776957140","wikidata":"https://www.wikidata.org/wiki/Q265488","display_name":"Campylobacter jejuni","level":3,"score":0.43028295040130615},{"id":"https://openalex.org/C2777276588","wikidata":"https://www.wikidata.org/wiki/Q1041276","display_name":"Streptococcus thermophilus","level":4,"score":0.4223182797431946},{"id":"https://openalex.org/C2776607351","wikidata":"https://www.wikidata.org/wiki/Q592153","display_name":"Clostridiaceae","level":3,"score":0.42011579871177673},{"id":"https://openalex.org/C2777367657","wikidata":"https://www.wikidata.org/wiki/Q184651","display_name":"Toxin","level":2,"score":0.2260424792766571},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.22302421927452087},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000898","descriptor_name":"Antibiosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000145","qualifier_name":"classification","is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D001412","descriptor_name":"Bacillus subtilis","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001430","descriptor_name":"Bacteriocins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D001430","descriptor_name":"Bacteriocins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001430","descriptor_name":"Bacteriocins","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002645","descriptor_name":"Chickens","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D003016","descriptor_name":"Clostridium perfringens","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D003016","descriptor_name":"Clostridium perfringens","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D003470","descriptor_name":"Culture Media","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006863","descriptor_name":"Hydrogen-Ion Concentration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D013696","descriptor_name":"Temperature","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D041981","descriptor_name":"Gastrointestinal Tract","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true}],"locations_count":4,"locations":[{"id":"doi:10.1128/aem.71.8.4185-4190.2005","doi":"https://doi.org/10.1128/aem.71.8.4185-4190.2005","is_oa":false,"landing_page_url":"https://doi.org/10.1128/aem.71.8.4185-4190.2005","pdf_url":null,"source":{"id":"https://openalex.org/S158228368","display_name":"Applied and Environmental Microbiology","issn_l":"0099-2240","issn":["0099-2240","1070-6291","1098-5336"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and Environmental Microbiology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:95453","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1183296","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:16085801","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16085801","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Applied and environmental microbiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:1183296","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC1183296/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Appl Environ Microbiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:95453","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/pmc/articles/PMC1183296","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},"sustainable_development_goals":[{"score":0.6875,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"},{"score":0.46810001134872437,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":41,"referenced_works":["https://openalex.org/W129418876","https://openalex.org/W369485878","https://openalex.org/W403644148","https://openalex.org/W998870816","https://openalex.org/W1654194654","https://openalex.org/W1883135925","https://openalex.org/W1917238311","https://openalex.org/W1926130930","https://openalex.org/W1981462868","https://openalex.org/W1982393487","https://openalex.org/W1989338833","https://openalex.org/W1990405289","https://openalex.org/W1996211329","https://openalex.org/W2009221323","https://openalex.org/W2020963925","https://openalex.org/W2022450939","https://openalex.org/W2041729036","https://openalex.org/W2052852720","https://openalex.org/W2062312508","https://openalex.org/W2063781389","https://openalex.org/W2066139706","https://openalex.org/W2068138024","https://openalex.org/W2080830937","https://openalex.org/W2089705909","https://openalex.org/W2096056856","https://openalex.org/W2096079655","https://openalex.org/W2119905737","https://openalex.org/W2125473674","https://openalex.org/W2143691738","https://openalex.org/W2145991374","https://openalex.org/W2148124716","https://openalex.org/W2159401663","https://openalex.org/W2238620661","https://openalex.org/W2321981887","https://openalex.org/W2323324529","https://openalex.org/W2347433445","https://openalex.org/W2469668594","https://openalex.org/W4230664740","https://openalex.org/W4240149779","https://openalex.org/W4244732422","https://openalex.org/W4292994528"],"related_works":["https://openalex.org/W3013390237","https://openalex.org/W7212349777","https://openalex.org/W2244726192","https://openalex.org/W7164172853","https://openalex.org/W7131127553","https://openalex.org/W1981959055","https://openalex.org/W165579423","https://openalex.org/W2300579724","https://openalex.org/W2156962447","https://openalex.org/W3106983387"],"abstract_inverted_index":{"The":[0,63,120],"objectives":[1],"of":[2,10,16,29,35,41,82,92,112,129,150,168,180],"this":[3,61],"study":[4],"were":[5,133],"to":[6,20,46,73,156,163],"isolate":[7],"beneficial":[8],"strains":[9,179],"microorganisms":[11],"from":[12,161],"the":[13,36,54,80,89,93,113,118,130,141,146,151,159,169,172],"gastrointestinal":[14],"tracts":[15],"healthy":[17],"chickens":[18],"and":[19,85,124,137,195],"screen":[21],"them":[22],"against":[23],"Clostridium":[24,189],"perfringens,":[25],"a":[26,39],"causative":[27],"agent":[28],"necrotic":[30,185],"enteritis":[31,186],"in":[32,60,79,117,158,184,187],"poultry.":[33],"One":[34],"bacteria":[37],"isolated,":[38],"strain":[40],"Bacillus":[42],"subtilis,":[43],"was":[44,71,96,154,175],"found":[45,72],"possess":[47],"an":[48],"anticlostridial":[49,64,94,131,152,173],"factor":[50,65,95,132,153,174],"that":[51],"could":[52],"inhibit":[53],"C.":[55,181],"perfringens":[56,182],"ATCC":[57],"13124":[58],"used":[59,116],"study.":[62,119],"produced":[66],"by":[67,99,108],"B.":[68],"subtilis":[69],"PB6":[70],"be":[74,157],"fully":[75],"or":[76,103,107],"partially":[77],"inactivated":[78],"presence":[81],"pronase,":[83],"trypsin,":[84],"pepsin.":[86],"In":[87,166],"contrast,":[88],"antimicrobial":[90,170],"activity":[91],"not":[97],"affected":[98],"treatment":[100,109],"at":[101],"100":[102],"121":[104],"degrees":[105,135],"C":[106,136],"with":[110],"any":[111],"organic":[114],"solvents":[115],"optimum":[121,125],"growth":[122],"temperature":[123],"pH":[126],"for":[127],"production":[128],"37":[134],"6.20,":[138],"respectively.":[139],"Using":[140],"mass":[142,149],"spectroscopy-mass":[143],"spectroscopy":[144],"technique,":[145],"apparent":[147],"molecular":[148],"estimated":[155],"range":[160],"960":[162],"983":[164],"Da.":[165],"terms":[167],"spectrum,":[171],"inhibitory":[176],"toward":[177],"various":[178],"implicated":[183],"poultry,":[188],"difficile,":[190],"Streptococcus":[191],"pneumoniae,":[192],"Campylobacter":[193,196],"jejuni,":[194],"coli.":[197]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":18},{"year":2021,"cited_by_count":12},{"year":2020,"cited_by_count":15},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":6},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":6},{"year":2015,"cited_by_count":11},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":6},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-14T11:04:58.165337","created_date":"2016-06-24T00:00:00"}