{"id":"https://openalex.org/W2102746962","doi":null,"title":"EFFICACY OF MEMANTINE ON COGNITIVE FUNCTIONS OF PATIENTS WITH MODERATE VASCULAR DEMENTIA","display_name":"EFFICACY OF MEMANTINE ON COGNITIVE FUNCTIONS OF PATIENTS WITH MODERATE VASCULAR DEMENTIA","publication_year":2015,"publication_date":"2015-01-01","ids":{"openalex":"https://openalex.org/W2102746962","mag":"2102746962"},"language":"en","primary_location":{"id":"pmh:oai:ecommons.aku.edu:pjns-1015","doi":null,"is_oa":true,"landing_page_url":"https://ecommons.aku.edu/pjns/vol10/iss1/4","pdf_url":"https://ecommons.aku.edu/pjns/vol10/iss1/4","source":{"id":"https://openalex.org/S4377196301","display_name":"eCommons - AKU (Aga Khan University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118185606","host_organization_name":"Aga Khan University","host_organization_lineage":["https://openalex.org/I118185606"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pakistan Journal of Neurological Sciences (PJNS)","raw_type":"article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://ecommons.aku.edu/pjns/vol10/iss1/4","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5006613745","display_name":"Saima Nazish","orcid":"https://orcid.org/0000-0003-4301-8836","observed_orcids":["https://orcid.org/0000-0003-4301-8836"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Saima Nazish","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0003-4301-8836","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053781049","display_name":"Bashir Ahmed Soomro","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Bashir Ahmed Soomro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5073427504","display_name":"Shafaq Alvi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Shafaq Alvi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.2253,"has_fulltext":true,"cited_by_count":1,"citation_normalized_percentile":{"value":0.56390146,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"10","issue":"1","first_page":"6","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":0.9603999853134155,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T14144","display_name":"Neurological Disease Mechanisms and Treatments","score":0.0340999998152256,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13796","display_name":"Neuroprotection in Cerebral Ischemia","score":0.00279999990016222,"subfield":{"id":"https://openalex.org/subfields/2808","display_name":"Neurology"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/memantine","display_name":"memantine","score":0.9990000128746033},{"id":"https://openalex.org/keywords/vascular-dementia","display_name":"vascular dementia","score":0.996999979019165},{"id":"https://openalex.org/keywords/cognitive-function","display_name":"cognitive function","score":0.7990000247955322},{"id":"https://openalex.org/keywords/nmda-receptor-antagonist","display_name":"NMDA receptor antagonists","score":0.8370000123977661},{"id":"https://openalex.org/keywords/drug-efficacy","display_name":"drug efficacy","score":0.5559999942779541},{"id":"https://openalex.org/keywords/moderate-dementia","display_name":"moderate dementia","score":0.5410000085830688},{"id":"https://openalex.org/keywords/mini-mental-state-examination","display_name":"Mini-Mental State Examination","score":0.7940000295639038},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.6439999938011169}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9051485061645508},{"id":"https://openalex.org/C2779484449","wikidata":"https://www.wikidata.org/wiki/Q412189","display_name":"Memantine","level":4,"score":0.8185245394706726},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.8001687526702881},{"id":"https://openalex.org/C2777952318","wikidata":"https://www.wikidata.org/wiki/Q583908","display_name":"Vascular dementia","level":4,"score":0.7756235599517822},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.5108067989349365},{"id":"https://openalex.org/C68122502","wikidata":"https://www.wikidata.org/wiki/Q764527","display_name":"Informed consent","level":3,"score":0.4371837377548218},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.43106207251548767},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.41459745168685913},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3939932882785797},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.3524000346660614},{"id":"https://openalex.org/C1862650","wikidata":"https://www.wikidata.org/wiki/Q186005","display_name":"Physical therapy","level":1,"score":0.33476123213768005},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.2843543291091919},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.19116395711898804},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.088804692029953}],"mesh":[],"locations_count":2,"locations":[{"id":"pmh:oai:ecommons.aku.edu:pjns-1015","doi":null,"is_oa":true,"landing_page_url":"https://ecommons.aku.edu/pjns/vol10/iss1/4","pdf_url":"https://ecommons.aku.edu/pjns/vol10/iss1/4","source":{"id":"https://openalex.org/S4377196301","display_name":"eCommons - AKU (Aga Khan University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118185606","host_organization_name":"Aga Khan University","host_organization_lineage":["https://openalex.org/I118185606"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pakistan Journal of Neurological Sciences (PJNS)","raw_type":"article"},{"id":"mag:2102746962","doi":null,"is_oa":false,"landing_page_url":"https://ecommons.aku.edu/cgi/viewcontent.cgi?article=1015&context=pjns","pdf_url":null,"source":{"id":"https://openalex.org/S2764453659","display_name":"Pakistan Journal of Neurological Sciences","issn_l":"1990-6269","issn":["1990-6269","1990-813X"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Pakistan Journal of Neurological Sciences","raw_type":null}],"best_oa_location":{"id":"pmh:oai:ecommons.aku.edu:pjns-1015","doi":null,"is_oa":true,"landing_page_url":"https://ecommons.aku.edu/pjns/vol10/iss1/4","pdf_url":"https://ecommons.aku.edu/pjns/vol10/iss1/4","source":{"id":"https://openalex.org/S4377196301","display_name":"eCommons - AKU (Aga Khan University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I118185606","host_organization_name":"Aga Khan University","host_organization_lineage":["https://openalex.org/I118185606"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Pakistan Journal of Neurological Sciences (PJNS)","raw_type":"article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2102746962.pdf","grobid_xml":"https://content.openalex.org/works/W2102746962.grobid-xml"},"referenced_works_count":37,"referenced_works":["https://openalex.org/W51438213","https://openalex.org/W73617113","https://openalex.org/W1498106911","https://openalex.org/W1591164913","https://openalex.org/W1847168837","https://openalex.org/W1895538680","https://openalex.org/W1933077421","https://openalex.org/W1962254068","https://openalex.org/W1964889409","https://openalex.org/W1982423241","https://openalex.org/W1991078666","https://openalex.org/W1992903980","https://openalex.org/W2004454873","https://openalex.org/W2008348302","https://openalex.org/W2009090334","https://openalex.org/W2010490217","https://openalex.org/W2014000620","https://openalex.org/W2015697540","https://openalex.org/W2015701223","https://openalex.org/W2019739565","https://openalex.org/W2031276587","https://openalex.org/W2037053046","https://openalex.org/W2038360535","https://openalex.org/W2049890856","https://openalex.org/W2067457311","https://openalex.org/W2071252381","https://openalex.org/W2076016121","https://openalex.org/W2086912587","https://openalex.org/W2107191158","https://openalex.org/W2115455636","https://openalex.org/W2124204149","https://openalex.org/W2130167936","https://openalex.org/W2144708078","https://openalex.org/W2145059764","https://openalex.org/W2147290536","https://openalex.org/W2166039854","https://openalex.org/W2184615429"],"related_works":["https://openalex.org/W2067457311","https://openalex.org/W1990057142","https://openalex.org/W2015701223","https://openalex.org/W2397416127","https://openalex.org/W4255736316","https://openalex.org/W3036176789","https://openalex.org/W2336546248","https://openalex.org/W2913370239","https://openalex.org/W312925543","https://openalex.org/W2392865605"],"abstract_inverted_index":{"Introduction:":[0],"Vascular":[1],"dementia":[2,209],"is":[3,10,41,185,200],"a":[4,22,169],"common":[5],"condition":[6],"for":[7,25],"which":[8],"there":[9],"no":[11],"effective":[12,19],"approved":[13],"pharmacological":[14],"treatment":[15,20],"available.":[16],"Absence":[17],"of":[18,38,45,69,71,131,151,191,205],"creates":[21],"difficult":[23],"situation":[24],"those":[26],"suffering":[27],"from":[28],"the":[29,43,93,108],"disease,":[30],"their":[31],"caregivers,":[32],"and":[33,57,75,116],"healthcare":[34],"providers.":[35],"The":[36,101],"objective":[37],"this":[39,192],"study":[40,62],"todetermine":[42],"Efficacy":[44],"Memantine":[46,166],"on":[47],"cognitive":[48],"functions":[49],"in":[50,161,172,178,194],"patients":[51,88,179,206],"with":[52,180,207],"Moderate":[53],"vascular":[54,182,195,208],"dementia.":[55,183,196],"Material":[56],"methods:":[58],"This":[59],"Case":[60],"series":[61],"was":[63,105,133,142,154,159],"carried":[64],"out":[65],"inthe":[66],"Neurology":[67],"Section":[68],"department":[70],"Medicine":[72],"Ziauddin":[73],"University":[74],"Hospitals":[76],"North":[77],"Nazimabad":[78],"campus,":[79],"Karachifrom":[80],"12th":[81],"March":[82,86],"2010":[83],"to":[84,107,187,202],"11th":[85],"2011.90":[87],"were":[89,112],"included,":[90],"who":[91,210],"fulfilled":[92],"inclusion":[94],"criteria":[95],"after":[96,148],"taking":[97],"an":[98],"informed":[99],"consent.":[100],"SPSS":[102],"version":[103],"11":[104],"applied":[106],"data.":[109],"Results:":[110],"There":[111],"55":[113],"(59.1%)":[114],"males":[115],"38":[117],"(40.9%)":[118],"females.":[119],"Mean":[120],"\u00b1":[121,126,135,144,156],"standard":[122],"deviation":[123],"age":[124],"69.7":[125],"6.6":[127],"years,":[128],"mean":[129],"duration":[130],"symptoms":[132],"1.76":[134],"1.1":[136],"years.":[137],"Baseline":[138],"minimental":[139],"examination":[140],"score":[141,147],"15.14":[143],"3.1.":[145],"Minimental":[146],"24":[149],"weeks":[150],"drug":[152,193],"therapy":[153],"17.14":[155],"4.1.":[157],"Efficiency":[158],"found":[160],"62":[162],"(66.7%)":[163],"patients.":[164],"Conclusion:":[165],"produced":[167],"only":[168],"small":[170],"benefit":[171],"cognition":[173],"(of":[174],"uncertain":[175],"clinical":[176],"significance)":[177],"moderate":[181],"Data":[184],"insufficient":[186],"support":[188],"widespread":[189],"use":[190],"Individual":[197],"patient":[198],"analysis":[199],"needed":[201],"identify":[203],"subgroups":[204],"might":[211],"benefit.":[212]},"counts_by_year":[{"year":2018,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}