{"id":"https://openalex.org/W2102699153","doi":"https://doi.org/10.1128/mcb.2.3.308","title":"Single-Copy and Amplified CAD Genes in Syrian Hamster Chromosomes Localized by a Highly Sensitive Method for In Situ Hybridization","display_name":"Single-Copy and Amplified CAD Genes in Syrian Hamster Chromosomes Localized by a Highly Sensitive Method for In Situ Hybridization","publication_year":1982,"publication_date":"1982-03-01","ids":{"openalex":"https://openalex.org/W2102699153","doi":"https://doi.org/10.1128/mcb.2.3.308","mag":"2102699153","pmid":"https://pubmed.ncbi.nlm.nih.gov/6180304","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/369790"},"language":"en","primary_location":{"id":"doi:10.1128/mcb.2.3.308","doi":"https://doi.org/10.1128/mcb.2.3.308","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.2.3.308","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/369790","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5038885111","display_name":"Geoffrey M. Wahl","orcid":"https://orcid.org/0000-0003-3658-2279","observed_orcids":["https://orcid.org/0000-0003-3658-2279"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G M Wahl","raw_affiliation_strings":["Salk Institute for Biological Studies"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salk Institute for Biological Studies","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003051226","display_name":"Louise Vitto","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"L Vitto","raw_affiliation_strings":["Salk Institute for Biological Studies"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salk Institute for Biological Studies","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053933323","display_name":"Richard A. Padgett","orcid":"https://orcid.org/0000-0002-2910-1134","observed_orcids":["https://orcid.org/0000-0002-2910-1134"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R A Padgett","raw_affiliation_strings":["Salk Institute for Biological Studies"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salk Institute for Biological Studies","institution_ids":["https://openalex.org/I1307098950"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080998429","display_name":"George Robert Stark","orcid":"https://orcid.org/0000-0002-8776-9597","observed_orcids":["https://orcid.org/0000-0002-8776-9597"]},"institutions":[{"id":"https://openalex.org/I1307098950","display_name":"Salk Institute for Biological Studies","ror":"https://ror.org/03xez1567","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1307098950"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"G R Stark","raw_affiliation_strings":["Salk Institute for Biological Studies"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Salk Institute for Biological Studies","institution_ids":["https://openalex.org/I1307098950"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1307098950"],"apc_list":null,"apc_paid":null,"fwci":10.1058,"has_fulltext":false,"cited_by_count":90,"citation_normalized_percentile":{"value":0.99028822,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"2","issue":"3","first_page":"308","last_page":"319"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.8101000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11213","display_name":"Genomic variations and chromosomal abnormalities","score":0.8101000189781189,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.06560000032186508,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10433","display_name":"Carcinogens and Genotoxicity Assessment","score":0.02329999953508377,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aspartate-transcarbamoylase","display_name":"aspartate transcarbamylase","score":0.8489999771118164},{"id":"https://openalex.org/keywords/cad-gene","display_name":"CAD gene","score":0.8299999833106995},{"id":"https://openalex.org/keywords/gene-amplification","display_name":"gene amplification","score":0.9710000157356262},{"id":"https://openalex.org/keywords/syrian-hamster","display_name":"golden hamster","score":0.8640000224113464},{"id":"https://openalex.org/keywords/double-minute-chromosomes","display_name":"double minute chromosomes","score":0.7289999723434448},{"id":"https://openalex.org/keywords/genetic-mapping","display_name":"gene mapping","score":0.5680000185966492},{"id":"https://openalex.org/keywords/chromosome-localization","display_name":"chromosomal localization","score":0.4699999988079071},{"id":"https://openalex.org/keywords/dextran-sulfate","display_name":"dextran sulfate","score":0.6330000162124634}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.9028657674789429},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.7503513097763062},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.6405113339424133},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5600839257240295},{"id":"https://openalex.org/C70278784","wikidata":"https://www.wikidata.org/wiki/Q574427","display_name":"Metaphase","level":4,"score":0.5376120805740356},{"id":"https://openalex.org/C81439078","wikidata":"https://www.wikidata.org/wiki/Q2304142","display_name":"In situ hybridization","level":4,"score":0.49445271492004395},{"id":"https://openalex.org/C122735190","wikidata":"https://www.wikidata.org/wiki/Q715789","display_name":"Gene mapping","level":4,"score":0.43842613697052},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.43733251094818115},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.4089284837245941},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.12467402219772339}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D001224","descriptor_name":"Aspartic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002869","descriptor_name":"Chromosome Aberrations","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002874","descriptor_name":"Chromosome Mapping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D003911","descriptor_name":"Dextrans","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004247","descriptor_name":"DNA","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D004274","descriptor_name":"DNA, Recombinant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004351","descriptor_name":"Drug Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005784","descriptor_name":"Gene Amplification","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006224","descriptor_name":"Cricetinae","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007621","descriptor_name":"Karyotyping","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007668","descriptor_name":"Kidney","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008647","descriptor_name":"Mesocricetus","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009097","descriptor_name":"Multienzyme Complexes","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D009693","descriptor_name":"Nucleic Acid Hybridization","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010746","descriptor_name":"Phosphonoacetic Acid","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":false},{"descriptor_ui":"D010746","descriptor_name":"Phosphonoacetic Acid","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016264","descriptor_name":"Dextran Sulfate","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1128/mcb.2.3.308","doi":"https://doi.org/10.1128/mcb.2.3.308","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.2.3.308","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"doi:10.1128/mcb.2.3.308-319.1982","doi":"https://doi.org/10.1128/mcb.2.3.308-319.1982","is_oa":false,"landing_page_url":"https://doi.org/10.1128/mcb.2.3.308-319.1982","pdf_url":null,"source":{"id":"https://openalex.org/S81455967","display_name":"Molecular and Cellular Biology","issn_l":"0270-7306","issn":["0270-7306","1067-8824","1098-5549"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and Cellular Biology","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:1295650","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/369790","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:369790","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/369790","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Cell Biol","raw_type":"Text"},{"id":"pmid:6180304","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/6180304","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular and cellular biology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:1295650","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/369790","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1480437404","https://openalex.org/W1487534034","https://openalex.org/W1507212424","https://openalex.org/W1507462705","https://openalex.org/W1923503891","https://openalex.org/W1945819707","https://openalex.org/W1976492411","https://openalex.org/W1978305379","https://openalex.org/W1980814484","https://openalex.org/W1984696016","https://openalex.org/W1985920234","https://openalex.org/W1987007964","https://openalex.org/W1994263437","https://openalex.org/W2000850714","https://openalex.org/W2017104783","https://openalex.org/W2028082957","https://openalex.org/W2029987769","https://openalex.org/W2031412627","https://openalex.org/W2033328319","https://openalex.org/W2038961110","https://openalex.org/W2039156696","https://openalex.org/W2042378550","https://openalex.org/W2045890708","https://openalex.org/W2065262914","https://openalex.org/W2066689347","https://openalex.org/W2073804448","https://openalex.org/W2082749146","https://openalex.org/W2086955288","https://openalex.org/W2104417677","https://openalex.org/W2111486924","https://openalex.org/W2117741144","https://openalex.org/W2143785459","https://openalex.org/W2213383144","https://openalex.org/W2226570905","https://openalex.org/W2255468422","https://openalex.org/W2587196717"],"related_works":["https://openalex.org/W2019625257","https://openalex.org/W152340868","https://openalex.org/W2075233656","https://openalex.org/W2911589279","https://openalex.org/W1806960687","https://openalex.org/W891066093","https://openalex.org/W2079191392","https://openalex.org/W2004116111","https://openalex.org/W1945819707","https://openalex.org/W2056362680"],"abstract_inverted_index":{"Syrian":[0],"hamster":[1],"cells":[2],"resistant":[3],"to":[4,41,100,113,205],"N-(phosphonacetyl)-L-aspartate":[5],"(PALA),":[6],"a":[7,24,35,135,153,166,213],"specific":[8,207],"inhibitor":[9],"of":[10,15,26,28,47,73,77,92,121,124,170,184,222,228],"the":[11,16,29,74,83,89,118,132,171,182,191,226,229],"aspartate":[12],"transcarbamylase":[13],"activity":[14],"multifunctional":[17],"protein":[18,22],"CAD,":[19],"overproduce":[20],"this":[21],"as":[23,194,196],"result":[25],"amplification":[27],"CAD":[30,43,84,102,210],"gene.":[31],"We":[32],"have":[33],"used":[34],"sensitive":[36],"in":[37,45,69,134,146,152,165,181,212],"situ":[38,177],"hybridization":[39],"technique":[40],"localize":[42],"genomes":[44],"spreads":[46,173],"metaphase":[48],"chromosomes":[49,162],"from":[50,56],"several":[51,125],"independent":[52],"PALA-resistant":[53],"lines":[54],"and":[55,111,225],"wild-type":[57,81],"PALA-sensitive":[58],"cells.":[59],"The":[60,142,175],"amplified":[61,143],"genes":[62,103,133,144,211],"were":[63,104,116,145,150,163,179,217],"always":[64],"found":[65,105],"within":[66,106],"chromosomes,":[67],"usually":[68],"an":[70,107],"expanded":[71,108],"region":[72,216],"short":[75,90],"arm":[76,91,123],"chromosome":[78,93,110,137,140],"B9.":[79,94],"In":[80,95],"cells,":[82],"gene":[85,231],"was":[86],"also":[87],"on":[88],"one":[96,122],"mutant":[97],"line,":[98],"90":[99],"100":[101],"B9":[109],"10":[112,209],"15":[114],"more":[115],"near":[117],"distal":[119],"end":[120],"different":[126],"chromosomes.":[127],"Another":[128],"line":[129],"contained":[130],"most":[131],"telomeric":[136],"or":[138],"large":[139],"fragment.":[141],"chromosomal":[147,215],"regions":[148],"that":[149],"stained":[151],"banded":[154],"pattern":[155],"by":[156,193],"trypsin-Giemsa.":[157],"A":[158],"few":[159],"double":[160],"minute":[161],"observed":[164],"very":[167],"small":[168],"fraction":[169],"total":[172],"examined.":[174],"it":[176],"hybridizations":[178],"performed":[180],"presence":[183],"10%":[185],"dextral":[186],"sulfate":[187],"500,":[188],"which":[189],"increases":[190],"signal":[192],"much":[195],"100-fold.":[197],"Using":[198],"recombinant":[199],"DNA":[200],"plasmids":[201],"nick-translated":[202],"with":[203],"[125I]dCTP":[204],"high":[206],"radioactivity,":[208],"single":[214],"revealed":[218],"after":[219,235],"1":[220,236],"week":[221],"autoradiographic":[223],"exposure,":[224],"position":[227],"unique":[230],"could":[232],"be":[233],"seen":[234],"month.":[237]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-11-03T10:50:19.383937","created_date":"2016-06-24T00:00:00"}
