{"id":"https://openalex.org/W2102670868","doi":null,"title":"Cathelicidin LL-37, granzymes, TGF-beta1 and cytokines levels in induced sputum from farmers with and without COPD.","display_name":"Cathelicidin LL-37, granzymes, TGF-beta1 and cytokines levels in induced sputum from farmers with and without COPD.","publication_year":2009,"publication_date":"2009-01-01","ids":{"openalex":"https://openalex.org/W2102670868","mag":"2102670868","pmid":"https://pubmed.ncbi.nlm.nih.gov/20047264"},"language":"en","primary_location":{"id":"pmid:20047264","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20047264","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of agricultural and environmental medicine : AAEM","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5042359219","display_name":"Marcin Golec","orcid":"https://orcid.org/0000-0001-9115-6358","observed_orcids":["https://orcid.org/0000-0001-9115-6358"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marcin Golec","raw_affiliation_strings":["Unit of Fibroproliferative Diseases, Institute of Agricultural Medicine, Jaczewskiego 2, 20-950 Lublin, Poland. msgolec@yahoo.com","Unit of Fibroproliferative Diseases, Institute of Agricultural Medicine, Jaczewskiego 2, 20-950 Lublin, Poland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Unit of Fibroproliferative Diseases, Institute of Agricultural Medicine, Jaczewskiego 2, 20-950 Lublin, Poland. msgolec@yahoo.com","institution_ids":[]},{"raw_affiliation_string":"Unit of Fibroproliferative Diseases, Institute of Agricultural Medicine, Jaczewskiego 2, 20-950 Lublin, Poland","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013698198","display_name":"Christian Reichel","orcid":"https://orcid.org/0000-0003-4256-8465","observed_orcids":["https://orcid.org/0000-0003-4256-8465"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Christian Reichel","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057300072","display_name":"Barbara Ma\u0107kiewicz","orcid":"https://orcid.org/0000-0002-0466-8724","observed_orcids":["https://orcid.org/0000-0002-0466-8724"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Barbara Mackiewicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109250029","display_name":"Czes\u0142awa Sk\u00f3rska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Czeslawa Skorska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008794080","display_name":"Katarzyna Curzytek","orcid":"https://orcid.org/0000-0002-6354-1563","observed_orcids":["https://orcid.org/0000-0002-6354-1563"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katarzyna Curzytek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056447505","display_name":"Marta Kinga Lemieszek","orcid":"https://orcid.org/0000-0001-9367-0684","observed_orcids":["https://orcid.org/0000-0001-9367-0684"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Marta Lemieszek","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010404535","display_name":"Jacek K. Dutkiewicz","orcid":"https://orcid.org/0000-0003-1965-8702","observed_orcids":["https://orcid.org/0000-0003-1965-8702"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jacek Dutkiewicz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036218652","display_name":"Anna G\u00f3ra","orcid":"https://orcid.org/0000-0002-6294-6147","observed_orcids":["https://orcid.org/0000-0002-6294-6147"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Anna Gora","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045421554","display_name":"Rolf Ziesche","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rolf Ziesche","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043151055","display_name":"Jolanta Boltuc","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jolanta Boltuc","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002637512","display_name":"Katarzyna Sodolska","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Katarzyna Sodolska","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100336115","display_name":"Janusz Milanowski","orcid":"https://orcid.org/0000-0002-8616-596X","observed_orcids":["https://orcid.org/0000-0002-8616-596X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janusz Milanowski","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5036238665","display_name":"Rados\u0142aw \u015apiewak","orcid":"https://orcid.org/0000-0001-5968-0555","observed_orcids":["https://orcid.org/0000-0001-5968-0555"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Radoslaw Spiewak","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":1.5316,"has_fulltext":false,"cited_by_count":29,"citation_normalized_percentile":{"value":0.83404897,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"16","issue":"2","first_page":"289","last_page":"97"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10143","display_name":"Chronic Obstructive Pulmonary Disease (COPD) Research","score":0.9648000001907349,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11103","display_name":"Antimicrobial Peptides and Activities","score":0.016699999570846558,"subfield":{"id":"https://openalex.org/subfields/2404","display_name":"Microbiology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10051","display_name":"Asthma and respiratory diseases","score":0.002899999963119626,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ll-37","display_name":"LL-37","score":0.7850000262260437},{"id":"https://openalex.org/keywords/cathelicidin","display_name":"cathelicidin","score":0.9879999756813049},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.9229999780654907},{"id":"https://openalex.org/keywords/induced-sputum","display_name":"induced sputum","score":0.9110000133514404},{"id":"https://openalex.org/keywords/tgf-beta1","display_name":"TGF-\u03b21","score":0.9890000224113464},{"id":"https://openalex.org/keywords/interleukin-8","display_name":"interleukin-8","score":0.8199999928474426},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.953000009059906},{"id":"https://openalex.org/keywords/organic-dust-exposure","display_name":"organic dust exposure","score":0.9419999718666077},{"id":"https://openalex.org/keywords/farmers","display_name":"farmers","score":0.9440000057220459},{"id":"https://openalex.org/keywords/occupational-exposure","display_name":"occupational exposure","score":0.45899999141693115},{"id":"https://openalex.org/keywords/lipopolysaccharide","display_name":"lipopolysaccharide","score":0.7699999809265137},{"id":"https://openalex.org/keywords/airway-inflammation","display_name":"airway inflammation","score":0.49300000071525574}],"concepts":[{"id":"https://openalex.org/C2776301714","wikidata":"https://www.wikidata.org/wiki/Q259346","display_name":"Sputum","level":3,"score":0.8073945045471191},{"id":"https://openalex.org/C2776780178","wikidata":"https://www.wikidata.org/wiki/Q199804","display_name":"COPD","level":2,"score":0.7406808137893677},{"id":"https://openalex.org/C2777379352","wikidata":"https://www.wikidata.org/wiki/Q24739493","display_name":"Cathelicidin","level":4,"score":0.60532546043396},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.506341814994812},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4349588453769684},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.3665981590747833},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.26644080877304077},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.23631206154823303},{"id":"https://openalex.org/C540938839","wikidata":"https://www.wikidata.org/wiki/Q1201508","display_name":"Antimicrobial peptides","level":3,"score":0.2228538691997528},{"id":"https://openalex.org/C4937899","wikidata":"https://www.wikidata.org/wiki/Q68541106","display_name":"Antimicrobial","level":2,"score":0.17516037821769714},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.15113312005996704},{"id":"https://openalex.org/C2781069245","wikidata":"https://www.wikidata.org/wiki/Q12204","display_name":"Tuberculosis","level":2,"score":0.08145570755004883}],"mesh":[{"descriptor_ui":"D000382","descriptor_name":"Agricultural Workers' Diseases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D003430","descriptor_name":"Cross-Sectional Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004391","descriptor_name":"Dust","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004731","descriptor_name":"Endotoxins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013183","descriptor_name":"Sputum","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D023181","descriptor_name":"Antimicrobial Cationic Peptides","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D029424","descriptor_name":"Pulmonary Disease, Chronic Obstructive","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D053773","descriptor_name":"Transforming Growth Factor beta1","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D053804","descriptor_name":"Granzymes","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D054804","descriptor_name":"Cathelicidins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":1,"locations":[{"id":"pmid:20047264","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20047264","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of agricultural and environmental medicine : AAEM","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9907000064849854,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":57,"referenced_works":["https://openalex.org/W4339111","https://openalex.org/W203985185","https://openalex.org/W1502615329","https://openalex.org/W1661091834","https://openalex.org/W1756202744","https://openalex.org/W1976950325","https://openalex.org/W1978359304","https://openalex.org/W1980798450","https://openalex.org/W1990674750","https://openalex.org/W1993982427","https://openalex.org/W1994178441","https://openalex.org/W1997774756","https://openalex.org/W1997942004","https://openalex.org/W1998268569","https://openalex.org/W1999522654","https://openalex.org/W2013160328","https://openalex.org/W2014123675","https://openalex.org/W2015611806","https://openalex.org/W2027276808","https://openalex.org/W2036882537","https://openalex.org/W2039402345","https://openalex.org/W2040127827","https://openalex.org/W2042514042","https://openalex.org/W2045616259","https://openalex.org/W2047580124","https://openalex.org/W2050057798","https://openalex.org/W2063116767","https://openalex.org/W2068048185","https://openalex.org/W2081925999","https://openalex.org/W2085486913","https://openalex.org/W2094275247","https://openalex.org/W2095179563","https://openalex.org/W2104982541","https://openalex.org/W2105246337","https://openalex.org/W2105822176","https://openalex.org/W2109190813","https://openalex.org/W2114322648","https://openalex.org/W2115862501","https://openalex.org/W2116569033","https://openalex.org/W2124001941","https://openalex.org/W2127951128","https://openalex.org/W2127952905","https://openalex.org/W2142461098","https://openalex.org/W2145280006","https://openalex.org/W2147737222","https://openalex.org/W2147854629","https://openalex.org/W2150285844","https://openalex.org/W2156035167","https://openalex.org/W2157174496","https://openalex.org/W2165790227","https://openalex.org/W2182167178","https://openalex.org/W2197553214","https://openalex.org/W2329491863","https://openalex.org/W2398051313","https://openalex.org/W2411342695","https://openalex.org/W2416056314","https://openalex.org/W3215332570"],"related_works":["https://openalex.org/W1987029769","https://openalex.org/W2410661177","https://openalex.org/W4229377315","https://openalex.org/W4293778022","https://openalex.org/W2563274746","https://openalex.org/W3031300454","https://openalex.org/W2973840664","https://openalex.org/W2389440437","https://openalex.org/W1843519474","https://openalex.org/W2563988105"],"abstract_inverted_index":{"The":[0,33,119,180,195,205,225],"cathelicidin":[1],"LL-37":[2,42,74,123,166,183,212],"is":[3,57],"an":[4,232],"antimicrobial":[5],"and":[6,14,54,100,109,116,132,139,143,158,203,213,216],"lipopolysaccharide":[7,53],"neutralizing":[8],"peptide,":[9],"possessing":[10],"pro-inflammatory,":[11],"tissue":[12],"repair":[13],"remodeling":[15],"activities.":[16],"Recent":[17],"reports":[18],"indicate":[19],"that":[20,211],"the":[21,38,44,47,60,71,76,89,122,221],"progression":[22],"of":[23,31,41,59,73,78,92,106,121,136,165,182,207,223],"COPD":[24,62,93,175],"might":[25],"be":[26],"connected":[27],"with":[28,174],"increased":[29],"levels":[30,164],"LL-37.":[32],"numerous":[34],"experimental":[35],"data":[36],"show":[37],"potential":[39],"role":[40,72,230],"in":[43,75,85,88,124,145,169,184,231],"response":[45,234],"to":[46,49,68,95,177,192,220,235],"exposure":[48],"organic":[50,236],"dust":[51,237],"(containing":[52],"microorganisms)":[55],"which":[56],"one":[58],"major":[61],"causative":[63],"factors.":[64],"This":[65],"work":[66],"strives":[67],"further":[69],"prove":[70],"development":[77,222],"COPD.":[79,224],"A":[80,138,202,215],"cross-sectional":[81],"study":[82,209],"was":[83,127,154,188,197],"conducted":[84,114,155],"30":[86],"farmers":[87,99,173,187],"early":[90],"stages":[91],"according":[94],"GOLD,":[96],"36":[97],"healthy":[98,102,178],"16":[101],"urban":[103,193],"dwellers.":[104,194],"Collection":[105],"induced-sputum":[107],"samples":[108,126,171],"lung":[110],"function":[111],"testing":[112],"were":[113,147,167],"before":[115],"after":[117],"work.":[118],"quantification":[120],"sputum":[125,146,170,185],"performed":[128],"by":[129,149,156],"mass":[130],"spectrometry":[131],"radioisotope":[133],"techniques.":[134],"Levels":[135],"granzymes":[137,201,214],"B,":[140],"IL-8,":[141],"IFN-gamma":[142],"TGF-beta1":[144],"measured":[148],"ELISA":[150],"technique.":[151],"Statistical":[152],"analysis":[153],"Kruskal-Wallis":[157],"Mann-Whitney":[159],"U":[160],"tests.":[161],"Significantly":[162],"higher":[163,190],"observed":[168],"from":[172,186],"compared":[176,191],"individuals.":[179],"concentration":[181],"significantly":[189],"same":[196],"true":[198],"for":[199],"both":[200],"B.":[204],"results":[206,226],"this":[208],"suggest":[210,227],"B":[217],"may":[218],"add":[219],"also":[228],"their":[229],"organism's":[233],"exposure.":[238]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
