{"id":"https://openalex.org/W2102632736","doi":"https://doi.org/10.1093/cvr/cvs261","title":"SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway","display_name":"SOCS1 gene transfer accelerates the transition to heart failure through the inhibition of the gp130/JAK/STAT pathway","publication_year":2012,"publication_date":"2012-08-08","ids":{"openalex":"https://openalex.org/W2102632736","doi":"https://doi.org/10.1093/cvr/cvs261","mag":"2102632736","pmid":"https://pubmed.ncbi.nlm.nih.gov/22875468","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3732068"},"language":"en","primary_location":{"id":"doi:10.1093/cvr/cvs261","doi":"https://doi.org/10.1093/cvr/cvs261","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cvr/cvs261","pdf_url":"https://academic.oup.com/cardiovascres/article-pdf/96/3/381/17200265/cvs261.pdf","source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/cardiovascres/article-pdf/96/3/381/17200265/cvs261.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5107499810","display_name":"Antonio Cittadini","orcid":"https://orcid.org/0000-0002-9905-9277","observed_orcids":["https://orcid.org/0000-0002-9905-9277"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Antonio Cittadini","raw_affiliation_strings":["Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy. antonio.cittadini@unina.it","Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy. antonio.cittadini@unina.it","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"raw_affiliation_string":"Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091065300","display_name":"Maria Gaia Monti","orcid":"https://orcid.org/0000-0002-3795-5762","observed_orcids":["https://orcid.org/0000-0002-3795-5762"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Gaia Monti","raw_affiliation_strings":["Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015226386","display_name":"Guido Iaccarino","orcid":"https://orcid.org/0000-0002-8997-835X","observed_orcids":["https://orcid.org/0000-0002-8997-835X"]},"institutions":[{"id":"https://openalex.org/I131729948","display_name":"University of Salerno","ror":"https://ror.org/0192m2k53","country_code":"IT","type":"education","lineage":["https://openalex.org/I131729948"]},{"id":"https://openalex.org/I4210094922","display_name":"MultiMedica","ror":"https://ror.org/01h8ey223","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210094922","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Guido Iaccarino","raw_affiliation_strings":["Department of Medicine and Surgery, University of Salerno, Salerno, Italy","IRCCS Multimedica, Milano, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine and Surgery, University of Salerno, Salerno, Italy","institution_ids":["https://openalex.org/I131729948"]},{"raw_affiliation_string":"IRCCS Multimedica, Milano, Italy","institution_ids":["https://openalex.org/I4210094922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073682057","display_name":"Maria Carmina Castiello","orcid":"https://orcid.org/0000-0003-2581-9648","observed_orcids":["https://orcid.org/0000-0003-2581-9648"]},"institutions":[{"id":"https://openalex.org/I4210142418","display_name":"The San Raffaele Telethon Institute for Gene Therapy","ror":"https://ror.org/036jn4298","country_code":"IT","type":"facility","lineage":["https://openalex.org/I4210133214","https://openalex.org/I4210142418","https://openalex.org/I4210153126","https://openalex.org/I4210154366"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Carmina Castiello","raw_affiliation_strings":["San Raffaele Telethon Institute for Gene Therapy, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"San Raffaele Telethon Institute for Gene Therapy, Milan, Italy","institution_ids":["https://openalex.org/I4210142418"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020924323","display_name":"Alfonso Baldi","orcid":"https://orcid.org/0000-0002-8693-3842","observed_orcids":["https://orcid.org/0000-0002-8693-3842"]},"institutions":[{"id":"https://openalex.org/I197809005","display_name":"University of Campania \"Luigi Vanvitelli\"","ror":"https://ror.org/02kqnpp86","country_code":"IT","type":"education","lineage":["https://openalex.org/I197809005"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alfonso Baldi","raw_affiliation_strings":["Section of Pathology, Department of Biochemistry, Second University of Naples, Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Section of Pathology, Department of Biochemistry, Second University of Naples, Naples, Italy","institution_ids":["https://openalex.org/I197809005"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044118984","display_name":"Eduardo Bossone","orcid":"https://orcid.org/0000-0003-2769-9950","observed_orcids":["https://orcid.org/0000-0003-2769-9950"]},"institutions":[{"id":"https://openalex.org/I4210099239","display_name":"IRCCS Policlinico San Donato","ror":"https://ror.org/01220jp31","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210099239","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Eduardo Bossone","raw_affiliation_strings":["Department of Cardiac Surgery, IRCSS Policlinico San Donato Milanese, Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiac Surgery, IRCSS Policlinico San Donato Milanese, Milan, Italy","institution_ids":["https://openalex.org/I4210099239"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103517509","display_name":"Salvatore Longobardi","orcid":"https://orcid.org/0000-0003-4573-8087","observed_orcids":["https://orcid.org/0000-0003-4573-8087"]},"institutions":[{"id":"https://openalex.org/I862255436","display_name":"Merck Serono S.p.A. (Italy)","ror":"https://ror.org/01z6wpz16","country_code":"IT","type":"company","lineage":["https://openalex.org/I164928964","https://openalex.org/I862255436"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Salvatore Longobardi","raw_affiliation_strings":["Merck Serono Group, Roma, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck Serono Group, Roma, Italy","institution_ids":["https://openalex.org/I862255436"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005702788","display_name":"Alberto Maria Marra","orcid":"https://orcid.org/0000-0002-9679-3003","observed_orcids":["https://orcid.org/0000-0002-9679-3003"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto Maria Marra","raw_affiliation_strings":["Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063195975","display_name":"Valentina Petrillo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Valentina Petrillo","raw_affiliation_strings":["Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066683191","display_name":"Lavinia Saldamarco","orcid":"https://orcid.org/0009-0002-8360-2965","observed_orcids":["https://orcid.org/0009-0002-8360-2965"]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Lavinia Saldamarco","raw_affiliation_strings":["Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109218920","display_name":"Matthew J. During","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthew John During","raw_affiliation_strings":["Department of Molecular Virology, Immunology, Medical Genetics, Neuroscience and Neurological Surgery, Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular Virology, Immunology, Medical Genetics, Neuroscience and Neurological Surgery, Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016385364","display_name":"Luigi Sacc\u00e0","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210117450","display_name":"Federico II University Hospital","ror":"https://ror.org/02jr6tp70","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]},{"id":"https://openalex.org/I71267560","display_name":"University of Naples Federico II","ror":"https://ror.org/05290cv24","country_code":"IT","type":"education","lineage":["https://openalex.org/I71267560"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Luigi Sacc\u00e0","raw_affiliation_strings":["Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine and Cardiovascular and Immunological Sciences, University Federico II, Via Sergio Pansini 5, 80131 Naples, Italy","institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010700645","display_name":"Gianluigi Condorelli","orcid":"https://orcid.org/0000-0003-0481-6843","observed_orcids":["https://orcid.org/0000-0003-0481-6843"]},"institutions":[{"id":"https://openalex.org/I4210155236","display_name":"National Research Council","ror":"https://ror.org/04zaypm56","country_code":"IT","type":"nonprofit","lineage":["https://openalex.org/I4210155236"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Gianluigi Condorelli","raw_affiliation_strings":["Institute of Genetics and Biomedical Research, National Research Council, Humanitas Clinical and Research Center, via Manzoni 56, Rozzano (MI), Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Genetics and Biomedical Research, National Research Council, Humanitas Clinical and Research Center, via Manzoni 56, Rozzano (MI), Italy","institution_ids":["https://openalex.org/I4210155236"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":10,"corresponding_author_ids":["https://openalex.org/A5107499810"],"corresponding_institution_ids":["https://openalex.org/I4210117450","https://openalex.org/I71267560"],"apc_list":{"value":4715,"currency":"EUR","value_usd":5329},"apc_paid":null,"fwci":1.6892,"has_fulltext":true,"cited_by_count":52,"citation_normalized_percentile":{"value":0.82769726,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"96","issue":"3","first_page":"381","last_page":"390"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.5404999852180481,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.5404999852180481,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11962","display_name":"Cardiac Fibrosis and Remodeling","score":0.4480000138282776,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12620","display_name":"Signaling Pathways in Disease","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/socs1","display_name":"SOCS1","score":1.0},{"id":"https://openalex.org/keywords/suppressor-of-cytokine-signaling","display_name":"suppressor of cytokine signaling","score":0.8629999756813049},{"id":"https://openalex.org/keywords/heart-failure-progression","display_name":"heart failure progression","score":0.8740000128746033},{"id":"https://openalex.org/keywords/cardiac-hypertrophy","display_name":"cardiac hypertrophy","score":0.8629999756813049},{"id":"https://openalex.org/keywords/pressure-overload","display_name":"pressure overload","score":0.8889999985694885},{"id":"https://openalex.org/keywords/aav-gene-delivery","display_name":"AAV gene delivery","score":0.8140000104904175},{"id":"https://openalex.org/keywords/myocardial-remodelling","display_name":"myocardial remodelling","score":0.8399999737739563},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6060000061988831},{"id":"https://openalex.org/keywords/mechanical-stretching","display_name":"mechanical stretch","score":0.8619999885559082},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.9580000042915344},{"id":"https://openalex.org/keywords/socs3","display_name":"SOCS3","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C14077384","wikidata":"https://www.wikidata.org/wiki/Q18033186","display_name":"Suppressor of cytokine signaling 1","level":4,"score":0.8411144018173218},{"id":"https://openalex.org/C2778271984","wikidata":"https://www.wikidata.org/wiki/Q17126794","display_name":"Pressure overload","level":4,"score":0.6837882995605469},{"id":"https://openalex.org/C126037660","wikidata":"https://www.wikidata.org/wiki/Q21116066","display_name":"Glycoprotein 130","level":4,"score":0.6380259990692139},{"id":"https://openalex.org/C157333092","wikidata":"https://www.wikidata.org/wiki/Q902835","display_name":"JAK-STAT signaling pathway","level":4,"score":0.5804412364959717},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5447616577148438},{"id":"https://openalex.org/C126042315","wikidata":"https://www.wikidata.org/wiki/Q18033763","display_name":"SOCS3","level":4,"score":0.4796195924282074},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4709281325340271},{"id":"https://openalex.org/C167414201","wikidata":"https://www.wikidata.org/wiki/Q1955391","display_name":"Muscle hypertrophy","level":2,"score":0.46236518025398254},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.45123088359832764},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4503161907196045},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4334310293197632},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4176998734474182},{"id":"https://openalex.org/C112392421","wikidata":"https://www.wikidata.org/wiki/Q903451","display_name":"Janus kinase","level":3,"score":0.4168476462364197},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.3463372588157654},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3417714834213257},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.317292183637619},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.24871286749839783},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.13598880171775818},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.06484702229499817},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.0},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C3018791406","wikidata":"https://www.wikidata.org/wiki/Q945225","display_name":"Cardiac hypertrophy","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000071222","descriptor_name":"Suppressor of Cytokine Signaling 1 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000071223","descriptor_name":"Suppressor of Cytokine Signaling 3 Protein","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000229","descriptor_name":"Dependovirus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005822","descriptor_name":"Genetic Vectors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D006333","descriptor_name":"Heart Failure","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D006439","descriptor_name":"Hemodynamics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D009206","descriptor_name":"Myocardium","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012333","descriptor_name":"RNA, Messenger","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014463","descriptor_name":"Ultrasonography","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016277","descriptor_name":"Ventricular Function, Left","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000000981","qualifier_name":"diagnostic imaging","is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017379","descriptor_name":"Hypertrophy, Left Ventricular","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D018014","descriptor_name":"Gene Transfer Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D042702","descriptor_name":"Angiopoietin-2","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050822","descriptor_name":"Cytokine Receptor gp130","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053613","descriptor_name":"Janus Kinase 1","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D053613","descriptor_name":"Janus Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":6,"locations":[{"id":"doi:10.1093/cvr/cvs261","doi":"https://doi.org/10.1093/cvr/cvs261","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cvr/cvs261","pdf_url":"https://academic.oup.com/cardiovascres/article-pdf/96/3/381/17200265/cvs261.pdf","source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2828903","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3732068","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3732068","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3732068","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovasc Res","raw_type":"Text"},{"id":"pmid:22875468","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/22875468","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular research","raw_type":"Journal Article"},{"id":"pmh:oai:iris.unicampania.it:11591/189508","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11591/189508","pdf_url":null,"source":{"id":"https://openalex.org/S7407055255","display_name":"Archivio Istituzionale della Ricerca - Universit\u00e0 degli Studi della Campania \"Luigi Vanvitelli\"","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.uniroma1.it:11573/964964","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11573/964964","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.1093/cvr/cvs261","doi":"https://doi.org/10.1093/cvr/cvs261","is_oa":true,"landing_page_url":"https://doi.org/10.1093/cvr/cvs261","pdf_url":"https://academic.oup.com/cardiovascres/article-pdf/96/3/381/17200265/cvs261.pdf","source":{"id":"https://openalex.org/S91067379","display_name":"Cardiovascular Research","issn_l":"0008-6363","issn":["0008-6363","1755-3245"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4202169808","display_name":"Somatic cell gene transfer/neurological & clinical applications","funder_award_id":"R01NS044576","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2102632736.pdf","grobid_xml":"https://content.openalex.org/works/W2102632736.grobid-xml"},"referenced_works_count":27,"referenced_works":["https://openalex.org/W189074344","https://openalex.org/W1647629157","https://openalex.org/W1668039320","https://openalex.org/W1995578798","https://openalex.org/W2000870731","https://openalex.org/W2013167680","https://openalex.org/W2016313989","https://openalex.org/W2031752381","https://openalex.org/W2047262272","https://openalex.org/W2053917755","https://openalex.org/W2068918386","https://openalex.org/W2072568452","https://openalex.org/W2086680192","https://openalex.org/W2095551553","https://openalex.org/W2103751536","https://openalex.org/W2106146046","https://openalex.org/W2117596573","https://openalex.org/W2122859027","https://openalex.org/W2139533724","https://openalex.org/W2152000177","https://openalex.org/W2158169578","https://openalex.org/W2169405818","https://openalex.org/W2314283404","https://openalex.org/W4229668346","https://openalex.org/W4285719527","https://openalex.org/W6675531792","https://openalex.org/W6699118601"],"related_works":["https://openalex.org/W2061775424","https://openalex.org/W2040736415","https://openalex.org/W2129501134","https://openalex.org/W2117596573","https://openalex.org/W2074187803","https://openalex.org/W3121987048","https://openalex.org/W1981694995","https://openalex.org/W7095652704","https://openalex.org/W2048199915","https://openalex.org/W2217745517"],"abstract_inverted_index":{"AIMS:":[0],"The":[1],"suppressors":[2],"of":[3,10,27,48,65,244,256],"cytokine":[4,11],"signalling":[5,15,33,230],"(SOCS)":[6],"are":[7],"identified":[8],"inhibitors":[9],"and":[12,25,119,134,158,180,184,199],"growth":[13],"factor":[14],"that":[16,209],"act":[17],"via":[18],"the":[19,46,51,63,148,200,254],"Janus":[20],"kinase":[21],"(JAK)":[22],"signal":[23],"transducers":[24],"activators":[26],"transcription":[28],"(STAT)":[29],"pathways.":[30],"Aberrant":[31],"JAK/STAT":[32],"promotes":[34],"progression":[35],"from":[36,53,236],"hypertrophy":[37,54,237],"to":[38,55,238],"heart":[39,56,257],"failure.":[40,57],"Little":[41],"information":[42],"is":[43,231],"available":[44],"concerning":[45],"role":[47],"SOCS":[49],"in":[50,70,80,165,217,240],"transition":[52,235],"To":[58],"this":[59],"aim,":[60],"we":[61],"investigated":[62],"effects":[64],"SOCS1":[66,126,151,213,228,247],"overexpression":[67],"obtained":[68],"by":[69,220],"vivo":[71,206],"adeno-associated":[72],"gene":[73],"transfer":[74],"using":[75],"an":[76,241,250],"aortopulmonary":[77],"cross-clamping":[78],"technique":[79],"a":[81],"chronic":[82],"pressure-overload":[83],"cardiac":[84],"rat":[85],"model.":[86],"METHODS":[87],"AND":[88],"RESULTS:":[89],"Rats":[90],"were":[91,137],"randomized":[92],"into":[93],"four":[94],"groups:":[95],"sham-operated":[96],"(n":[97,103],"=":[98,104,117,131],"18),":[99,105],"aortic":[100],"banding":[101],"(AB)":[102],"AB":[106,120,166,191],"+":[107,114,121,128,167,192],"viral":[108,122],"vector":[109,123],"encoding":[110,124],"for":[111,125,253],"haemoagglutinin":[112],"(AB":[113,127],"HA,":[115],"n":[116,130],"16),":[118],"SOCS1,":[129,168],"18).":[132],"Echocardiographic":[133],"haemodynamic":[135],"measurements":[136],"performed":[138],"15":[139,157],"weeks":[140],"after":[141],"banding.":[142],"While":[143],"SOCS3":[144],"was":[145,162,196,203,216],"upregulated":[146,212],"during":[147],"hypertrophic":[149],"phase,":[150],"transcript":[152],"levels":[153],"increased":[154,197],"significantly":[155],"between":[156],"20":[159],"weeks.":[160],"Remodelling":[161],"markedly":[163],"worse":[164],"showed":[169,208],"larger":[170],"left":[171],"ventricular":[172],"internal":[173],"dimensions":[174],"(+16%),":[175],"higher":[176],"end-diastolic":[177],"pressures":[178],"(+57%)":[179],"wall":[181],"stress":[182],"(+45%),":[183],"reduced":[185],"fractional":[186],"shortening":[187],"(-32%)":[188],"compared":[189],"with":[190,233],"HA;":[193],"apoptotic":[194],"rate":[195],"three-fold":[198],"gp130":[201],"pathway":[202],"inhibited.":[204],"Ex":[205],"experiments":[207],"mechanical":[210],"stretch":[211],"expression,":[214],"which":[215],"turn":[218],"attenuated":[219],"tumour":[221],"necrosis":[222],"factor-\u03b1":[223],"(TNF-\u03b1)":[224],"inhibition.":[225],"CONCLUSION:":[226],"Enhanced":[227],"myocardial":[229],"associated":[232],"accelerated":[234],"failure":[239,258],"established":[242],"model":[243],"pressure":[245],"overload.":[246],"may":[248],"represent":[249],"attractive":[251],"target":[252],"prevention":[255],"progression.":[259]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":3},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":7},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":4}],"updated_date":"2026-11-01T11:40:01.658920","created_date":"2016-06-24T00:00:00"}
