{"id":"https://openalex.org/W2102583328","doi":"https://doi.org/10.4172/2157-7633.s10-007","title":"Embryonic Stem Cells: A Perfect Tool for Studying Mammalian Transcriptional Enhancers","display_name":"Embryonic Stem Cells: A Perfect Tool for Studying Mammalian Transcriptional Enhancers","publication_year":2012,"publication_date":"2012-01-01","ids":{"openalex":"https://openalex.org/W2102583328","doi":"https://doi.org/10.4172/2157-7633.s10-007","mag":"2102583328","pmid":"https://pubmed.ncbi.nlm.nih.gov/24303336","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3844140"},"language":"en","primary_location":{"id":"doi:10.4172/2157-7633.s10-007","doi":"https://doi.org/10.4172/2157-7633.s10-007","is_oa":true,"landing_page_url":"https://doi.org/10.4172/2157-7633.s10-007","pdf_url":"https://doi.org/10.4172/2157-7633.s10-007","source":{"id":"https://openalex.org/S2764349506","display_name":"Journal of Stem Cell Research & Therapy","issn_l":"2157-7633","issn":["2157-7633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Stem Cell Research &amp; Therapy","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://doi.org/10.4172/2157-7633.s10-007","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5031833096","display_name":"Sridhar Rao","orcid":"https://orcid.org/0000-0003-2688-9541","observed_orcids":["https://orcid.org/0000-0003-2688-9541"]},"institutions":[{"id":"https://openalex.org/I204308271","display_name":"Medical College of Wisconsin","ror":"https://ror.org/00qqv6244","country_code":"US","type":"education","lineage":["https://openalex.org/I204308271"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Sridhar Rao","raw_affiliation_strings":["Blood Research Institute, Blood Center of Wisconsin, USA ; Departments of Pediatrics, and Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, USA","Blood Research Institute, Blood Center of Wisconsin, USA","Departments of Pediatrics, and Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Blood Research Institute, Blood Center of Wisconsin, USA ; Departments of Pediatrics, and Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, USA","institution_ids":["https://openalex.org/I204308271"]},{"raw_affiliation_string":"Blood Research Institute, Blood Center of Wisconsin, USA","institution_ids":[]},{"raw_affiliation_string":"Departments of Pediatrics, and Cell Biology, Neurobiology, and Anatomy, Medical College of Wisconsin, USA","institution_ids":["https://openalex.org/I204308271"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5031833096"],"corresponding_institution_ids":["https://openalex.org/I204308271"],"apc_list":null,"apc_paid":null,"fwci":0.1049,"has_fulltext":true,"cited_by_count":5,"citation_normalized_percentile":{"value":0.39526234,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":96},"biblio":{"volume":"01","issue":"S10","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.9961000084877014,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10505","display_name":"Pluripotent Stem Cells Research","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/enhancers","display_name":"enhancers","score":0.8989999890327454},{"id":"https://openalex.org/keywords/embryonic-stem-cells","display_name":"embryonic stem cells","score":0.9919999837875366},{"id":"https://openalex.org/keywords/non-coding-rna","display_name":"non-coding RNA","score":0.9279999732971191},{"id":"https://openalex.org/keywords/insulation-materials","display_name":"insulators","score":0.8109999895095825},{"id":"https://openalex.org/keywords/gene-expression-regulation","display_name":"gene expression regulation","score":0.6840000152587891}],"concepts":[{"id":"https://openalex.org/C111936080","wikidata":"https://www.wikidata.org/wiki/Q913367","display_name":"Enhancer","level":4,"score":0.9218072891235352},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7247081995010376},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.7014015913009644},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.5678408741950989},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5554013252258301},{"id":"https://openalex.org/C27153228","wikidata":"https://www.wikidata.org/wiki/Q3787274","display_name":"Transcriptional regulation","level":4,"score":0.5211719870567322},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.5073201060295105},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46123552322387695},{"id":"https://openalex.org/C21784809","wikidata":"https://www.wikidata.org/wiki/Q17119097","display_name":"Enhancer RNAs","level":5,"score":0.457481324672699},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.44042178988456726},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.42723405361175537},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.40081533789634705},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3657858371734619},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.35525572299957275},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C111472728","wikidata":"https://www.wikidata.org/wiki/Q9471","display_name":"Epistemology","level":1,"score":0.0}],"mesh":[],"locations_count":5,"locations":[{"id":"doi:10.4172/2157-7633.s10-007","doi":"https://doi.org/10.4172/2157-7633.s10-007","is_oa":true,"landing_page_url":"https://doi.org/10.4172/2157-7633.s10-007","pdf_url":"https://doi.org/10.4172/2157-7633.s10-007","source":{"id":"https://openalex.org/S2764349506","display_name":"Journal of Stem Cell Research & Therapy","issn_l":"2157-7633","issn":["2157-7633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Stem Cell Research &amp; Therapy","raw_type":"journal-article"},{"id":"pmid:24303336","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24303336","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of stem cell research & therapy","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:2834011","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3844140","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"","raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3844140","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3844140/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Stem Cell Res Ther","raw_type":"Text"},{"id":"mag:2312785788","doi":null,"is_oa":false,"landing_page_url":"https://www.omicsonline.org/2157-7633/2157-7633-S10-007.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"doi:10.4172/2157-7633.s10-007","doi":"https://doi.org/10.4172/2157-7633.s10-007","is_oa":true,"landing_page_url":"https://doi.org/10.4172/2157-7633.s10-007","pdf_url":"https://doi.org/10.4172/2157-7633.s10-007","source":{"id":"https://openalex.org/S2764349506","display_name":"Journal of Stem Cell Research & Therapy","issn_l":"2157-7633","issn":["2157-7633"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":"https://openalex.org/P4310320466","host_organization_name":"OMICS Publishing Group","host_organization_lineage":["https://openalex.org/P4310320466"],"host_organization_lineage_names":["OMICS Publishing Group"],"type":"journal"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Stem Cell Research &amp; Therapy","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G8340833797","display_name":"Exploring the Transcriptional Network regulating ES cell Pluripotency","funder_award_id":"K08HL087951","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2102583328.pdf","grobid_xml":"https://content.openalex.org/works/W2102583328.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1545156714","https://openalex.org/W1595665778","https://openalex.org/W1728698863","https://openalex.org/W1945579058","https://openalex.org/W1965425724","https://openalex.org/W1965428318","https://openalex.org/W1968931043","https://openalex.org/W1969770714","https://openalex.org/W1975394594","https://openalex.org/W1978901723","https://openalex.org/W1980197759","https://openalex.org/W1981030303","https://openalex.org/W1981138517","https://openalex.org/W1981543052","https://openalex.org/W1988294855","https://openalex.org/W1991485331","https://openalex.org/W1992213480","https://openalex.org/W1996060670","https://openalex.org/W2002179012","https://openalex.org/W2008027677","https://openalex.org/W2008837855","https://openalex.org/W2013785611","https://openalex.org/W2014623973","https://openalex.org/W2014787267","https://openalex.org/W2017050785","https://openalex.org/W2017840637","https://openalex.org/W2030523067","https://openalex.org/W2032882684","https://openalex.org/W2034709147","https://openalex.org/W2036619779","https://openalex.org/W2038756976","https://openalex.org/W2039053594","https://openalex.org/W2047005748","https://openalex.org/W2048263136","https://openalex.org/W2055141743","https://openalex.org/W2067761440","https://openalex.org/W2073026107","https://openalex.org/W2073587729","https://openalex.org/W2077359452","https://openalex.org/W2078002929","https://openalex.org/W2078370799","https://openalex.org/W2078526277","https://openalex.org/W2080251115","https://openalex.org/W2083065209","https://openalex.org/W2083245183","https://openalex.org/W2101780023","https://openalex.org/W2102936471","https://openalex.org/W2107575419","https://openalex.org/W2111375636","https://openalex.org/W2114951390","https://openalex.org/W2123355890","https://openalex.org/W2123564569","https://openalex.org/W2125397535","https://openalex.org/W2125987139","https://openalex.org/W2138208673","https://openalex.org/W2138472595","https://openalex.org/W2138977668","https://openalex.org/W2142046859","https://openalex.org/W2145144631","https://openalex.org/W2149118429","https://openalex.org/W2152636479","https://openalex.org/W2154746182","https://openalex.org/W2156821248","https://openalex.org/W2161017385","https://openalex.org/W2168602111","https://openalex.org/W2171111703","https://openalex.org/W2171442811","https://openalex.org/W2175853567","https://openalex.org/W3206736034","https://openalex.org/W4229791749"],"related_works":["https://openalex.org/W2312785788","https://openalex.org/W2763155429","https://openalex.org/W2725576187","https://openalex.org/W7133061373","https://openalex.org/W2295037017","https://openalex.org/W2102936471","https://openalex.org/W2035294650","https://openalex.org/W2120998158","https://openalex.org/W2557493613","https://openalex.org/W1992210670"],"abstract_inverted_index":{"Transcriptional":[0],"enhancers":[1],"are":[2,33],"DNA":[3],"elements":[4,32],"capable":[5],"of":[6,17,53,61,83,87,92,104],"regulating":[7],"gene":[8],"expression":[9],"in-cis":[10],"over":[11],"great":[12],"distances.With":[13],"the":[14,51,59,80,90,123],"recent":[15],"availability":[16],"genomic":[18],"approaches":[19],"to":[20,30,49],"define":[21],"epigenetic":[22,81],"marks":[23],"and":[24,89,106],"RNA":[25],"levels,":[26],"these":[27],"previously":[28],"difficult":[29],"study":[31,60],"now":[34],"being":[35],"extensively":[36],"examined":[37],"for":[38,72,111],"their":[39,85],"critical":[40],"role":[41,91],"in":[42,58,115],"lineage-specific":[43],"transcriptional":[44,76],"regulation.This":[45,77],"review":[46,78,100],"sets":[47],"out":[48],"highlight":[50],"use":[52],"embryonic":[54],"stem":[55],"cells":[56],"(ESCs)":[57],"enhancers,":[62,84,105],"emphasizing":[63],"that":[64],"ESC":[65],"have":[66],"become":[67],"an":[68],"ideal":[69],"model":[70,109],"system":[71,110],"questions":[73,121],"regarding":[74],"mammalian":[75],"highlights":[79],"\"signature\"":[82],"mechanism":[86],"action,":[88],"non-coding":[93],"RNAs":[94],"(ncRNAs)":[95],"on":[96],"enhancer":[97,113],"function.We":[98],"briefly":[99],"insulators,":[101],"a":[102,107],"sub-type":[103],"novel":[108],"studying":[112],"function":[114],"vivo.We":[116],"conclude":[117],"with":[118],"some":[119],"ongoing":[120],"within":[122],"field.":[124]},"counts_by_year":[{"year":2022,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}
