{"id":"https://openalex.org/W2102561457","doi":"https://doi.org/10.1177/0748233710389853","title":"Hepatotoxic activity of toluene inhalation and protective role of melatonin","display_name":"Hepatotoxic activity of toluene inhalation and protective role of melatonin","publication_year":2011,"publication_date":"2011-02-22","ids":{"openalex":"https://openalex.org/W2102561457","doi":"https://doi.org/10.1177/0748233710389853","mag":"2102561457","pmid":"https://pubmed.ncbi.nlm.nih.gov/21343225"},"language":"en","primary_location":{"id":"doi:10.1177/0748233710389853","doi":"https://doi.org/10.1177/0748233710389853","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0748233710389853","pdf_url":null,"source":{"id":"https://openalex.org/S6336342","display_name":"Toxicology and Industrial Health","issn_l":"0748-2337","issn":["0748-2337","1477-0393"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Industrial Health","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://hdl.handle.net/11508/51883","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113924763","display_name":"Ufuk Ta\u015f","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I238144855","display_name":"Tokat Gaziosmanpa\u015fa \u00dcniversitesi","ror":"https://ror.org/01rpe9k96","country_code":"TR","type":"education","lineage":["https://openalex.org/I238144855"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ufuk Tas","raw_affiliation_strings":["Department of Anatomy, Faculty of Medicine, Gaziosmanpa\u015fa University, Tokat, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Medicine, Gaziosmanpa\u015fa University, Tokat, Turkey","institution_ids":["https://openalex.org/I238144855"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064156279","display_name":"Murat \u00d6get\u00fcrk","orcid":"https://orcid.org/0000-0002-5744-4812","observed_orcids":["https://orcid.org/0000-0002-5744-4812"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":true,"raw_author_name":"Murat Ogeturk","raw_affiliation_strings":["Department of Anatomy, Faculty of Medicine, Firat University, Elazig, Turkey,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Medicine, Firat University, Elazig, Turkey,","institution_ids":["https://openalex.org/I143396566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034905083","display_name":"Sedat Meydan","orcid":"https://orcid.org/0000-0002-1393-3235","observed_orcids":["https://orcid.org/0000-0002-1393-3235"]},"institutions":[{"id":"https://openalex.org/I46000314","display_name":"Mustafa Kemal University","ror":"https://ror.org/056hcgc41","country_code":"TR","type":"education","lineage":["https://openalex.org/I46000314"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Sedat Meydan","raw_affiliation_strings":["Department of Anatomy, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Medicine, Mustafa Kemal University, Hatay, Turkey","institution_ids":["https://openalex.org/I46000314"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105529509","display_name":"\u0130lter Ku\u015f","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I115600380","display_name":"Bal\u0131kesir University","ror":"https://ror.org/02tv7db43","country_code":"TR","type":"education","lineage":["https://openalex.org/I115600380"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Ilter Kus","raw_affiliation_strings":["Department of Anatomy, Faculty of Medicine, Bal\u0131kesir University, Hatay, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Medicine, Bal\u0131kesir University, Hatay, Turkey","institution_ids":["https://openalex.org/I115600380"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080306709","display_name":"Tuncay Kulo\u011flu","orcid":"https://orcid.org/0000-0001-9874-3838","observed_orcids":["https://orcid.org/0000-0001-9874-3838"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Tuncay Kuloglu","raw_affiliation_strings":["Department of Histology and Embryology, Faculty of Medicine F\u0131rat University, Elazig, Turkey","Department of Histology and Embryology, Faculty of Medicine, Firat University, Elazig, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine F\u0131rat University, Elazig, Turkey","institution_ids":["https://openalex.org/I143396566"]},{"raw_affiliation_string":"Department of Histology and Embryology, Faculty of Medicine, Firat University, Elazig, Turkey","institution_ids":["https://openalex.org/I143396566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039672518","display_name":"Nevin \u0130lhan","orcid":"https://orcid.org/0000-0002-0208-8929","observed_orcids":["https://orcid.org/0000-0002-0208-8929","https://orcid.org/0000-0001-9997-0418"]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Necip Ilhan","raw_affiliation_strings":["Department of Biochemistry, F\u0131rat University, Faculty of Medicine, Elazig, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry, F\u0131rat University, Faculty of Medicine, Elazig, Turkey","institution_ids":["https://openalex.org/I143396566"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089909101","display_name":"Evren K\u00f6se","orcid":"https://orcid.org/0000-0002-0246-2589","observed_orcids":["https://orcid.org/0000-0002-0246-2589"]},"institutions":[{"id":"https://openalex.org/I20126385","display_name":"Inonu University","ror":"https://ror.org/04asck240","country_code":"TR","type":"education","lineage":["https://openalex.org/I20126385"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Evren Kose","raw_affiliation_strings":["Department of Anatomy, Faculty of Medicine, Inonu University, Malatya, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Medicine, Inonu University, Malatya, Turkey","institution_ids":["https://openalex.org/I20126385"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047740699","display_name":"Mustafa Sars\u0131lmaz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I143396566","display_name":"F\u0131rat University","ror":"https://ror.org/05teb7b63","country_code":"TR","type":"education","lineage":["https://openalex.org/I143396566"]}],"countries":["TR"],"is_corresponding":false,"raw_author_name":"Mustafa Sarsilmaz","raw_affiliation_strings":["Department of Anatomy, Faculty of Medicine, Firat University, Elazig, Turkey"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anatomy, Faculty of Medicine, Firat University, Elazig, Turkey","institution_ids":["https://openalex.org/I143396566"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5064156279"],"corresponding_institution_ids":["https://openalex.org/I143396566"],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":2.6082,"has_fulltext":false,"cited_by_count":52,"citation_normalized_percentile":{"value":0.87790168,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":98},"biblio":{"volume":"27","issue":"5","first_page":"465","last_page":"473"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11465","display_name":"Drug-Induced Hepatotoxicity and Protection","score":0.9926999807357788,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.005200000014156103,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T14072","display_name":"Immunotoxicology and immune responses","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/toluene-inhalation","display_name":"toluene inhalation","score":0.9810000061988831},{"id":"https://openalex.org/keywords/hepatotoxicity","display_name":"hepatotoxicity","score":0.9359999895095825},{"id":"https://openalex.org/keywords/melatonin","display_name":"melatonin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/hepatoprotective-effect","display_name":"hepatoprotection","score":0.9760000109672546},{"id":"https://openalex.org/keywords/oxidative-stress","display_name":"oxidative stress","score":0.8769999742507935},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":0.9150000214576721},{"id":"https://openalex.org/keywords/malondialdehyde","display_name":"malondialdehyde","score":0.9660000205039978},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.734000027179718},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9100000262260437},{"id":"https://openalex.org/keywords/liver-enzymes","display_name":"liver enzymes","score":0.5659999847412109},{"id":"https://openalex.org/keywords/hepatocyte-degeneration","display_name":"hepatocyte degeneration","score":0.7979999780654907},{"id":"https://openalex.org/keywords/antioxidant-enzymes","display_name":"antioxidant enzymes","score":0.753000020980835}],"concepts":[{"id":"https://openalex.org/C2778182776","wikidata":"https://www.wikidata.org/wiki/Q180912","display_name":"Melatonin","level":2,"score":0.7723549604415894},{"id":"https://openalex.org/C2776954882","wikidata":"https://www.wikidata.org/wiki/Q840343","display_name":"Inhalation","level":2,"score":0.7092288136482239},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.619653582572937},{"id":"https://openalex.org/C2775838275","wikidata":"https://www.wikidata.org/wiki/Q410776","display_name":"Superoxide dismutase","level":3,"score":0.6163460612297058},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.6125982403755188},{"id":"https://openalex.org/C2776125364","wikidata":"https://www.wikidata.org/wiki/Q169219","display_name":"Albumin","level":2,"score":0.5934404134750366},{"id":"https://openalex.org/C2778401633","wikidata":"https://www.wikidata.org/wiki/Q418661","display_name":"Malondialdehyde","level":3,"score":0.5766578912734985},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5675745606422424},{"id":"https://openalex.org/C160160445","wikidata":"https://www.wikidata.org/wiki/Q24769688","display_name":"Alkaline phosphatase","level":3,"score":0.5235233306884766},{"id":"https://openalex.org/C2778760513","wikidata":"https://www.wikidata.org/wiki/Q24773045","display_name":"Glutathione peroxidase","level":4,"score":0.4972744286060333},{"id":"https://openalex.org/C2779777708","wikidata":"https://www.wikidata.org/wiki/Q6033622","display_name":"Inhalation exposure","level":3,"score":0.4848948121070862},{"id":"https://openalex.org/C2777513400","wikidata":"https://www.wikidata.org/wiki/Q104219","display_name":"Bilirubin","level":2,"score":0.46233129501342773},{"id":"https://openalex.org/C2778979269","wikidata":"https://www.wikidata.org/wiki/Q106951292","display_name":"Catalase","level":3,"score":0.41203078627586365},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.3222976624965668},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.2513911724090576},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.22369906306266785},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20290538668632507},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.11967894434928894},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.0927267074584961}],"mesh":[{"descriptor_ui":"D000410","descriptor_name":"Alanine Transaminase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000469","descriptor_name":"Alkaline Phosphatase","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000975","descriptor_name":"Antioxidants","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D001219","descriptor_name":"Aspartate Aminotransferases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D001663","descriptor_name":"Bilirubin","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D002374","descriptor_name":"Catalase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D005979","descriptor_name":"Glutathione Peroxidase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":"Q000379","qualifier_name":"methods","is_major_topic":false},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D008099","descriptor_name":"Liver","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008315","descriptor_name":"Malondialdehyde","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D008550","descriptor_name":"Melatonin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D012709","descriptor_name":"Serum Albumin","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D013482","descriptor_name":"Superoxide Dismutase","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D014050","descriptor_name":"Toluene","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":true},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019570","descriptor_name":"Inhalation Exposure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D051028","descriptor_name":"bcl-2-Associated X Protein","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":5,"locations":[{"id":"doi:10.1177/0748233710389853","doi":"https://doi.org/10.1177/0748233710389853","is_oa":false,"landing_page_url":"https://doi.org/10.1177/0748233710389853","pdf_url":null,"source":{"id":"https://openalex.org/S6336342","display_name":"Toxicology and Industrial Health","issn_l":"0748-2337","issn":["0748-2337","1477-0393"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","jufo-1","medline","norway-1","poland-40","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and Industrial Health","raw_type":"journal-article"},{"id":"pmid:21343225","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21343225","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Toxicology and industrial health","raw_type":"Journal Article"},{"id":"pmid:29885178","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/29885178","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"JPMA. The Journal of the Pakistan Medical Association","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.971.6383","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.971.6383","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"http://tih.sagepub.com/content/27/5/465.full.pdf","raw_type":"text"},{"id":"pmh:oai:openaccess.firat.edu.tr:11508/51883","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11508/51883","pdf_url":null,"source":{"id":"https://openalex.org/S4377196733","display_name":"DSpace - FIRAT (F\u0131rat University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143396566","host_organization_name":"F\u0131rat University","host_organization_lineage":["https://openalex.org/I143396566"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":{"id":"pmh:oai:openaccess.firat.edu.tr:11508/51883","doi":null,"is_oa":true,"landing_page_url":"https://hdl.handle.net/11508/51883","pdf_url":null,"source":{"id":"https://openalex.org/S4377196733","display_name":"DSpace - FIRAT (F\u0131rat University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I143396566","host_organization_name":"F\u0131rat University","host_organization_lineage":["https://openalex.org/I143396566"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9922999739646912,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":47,"referenced_works":["https://openalex.org/W749998245","https://openalex.org/W969915667","https://openalex.org/W1510891824","https://openalex.org/W1515460837","https://openalex.org/W1574518973","https://openalex.org/W1971643799","https://openalex.org/W1972656444","https://openalex.org/W1990057346","https://openalex.org/W1991738855","https://openalex.org/W2007342212","https://openalex.org/W2013274656","https://openalex.org/W2020573233","https://openalex.org/W2024047421","https://openalex.org/W2026413424","https://openalex.org/W2029459733","https://openalex.org/W2029596769","https://openalex.org/W2031022505","https://openalex.org/W2037180842","https://openalex.org/W2037424198","https://openalex.org/W2038503626","https://openalex.org/W2059176213","https://openalex.org/W2059177685","https://openalex.org/W2061608793","https://openalex.org/W2072739036","https://openalex.org/W2073149784","https://openalex.org/W2075136248","https://openalex.org/W2077155194","https://openalex.org/W2079475076","https://openalex.org/W2080720690","https://openalex.org/W2089733904","https://openalex.org/W2093332302","https://openalex.org/W2101518804","https://openalex.org/W2104897256","https://openalex.org/W2112901679","https://openalex.org/W2114292865","https://openalex.org/W2127630656","https://openalex.org/W2132234674","https://openalex.org/W2154291735","https://openalex.org/W2158817614","https://openalex.org/W2159305277","https://openalex.org/W2162035286","https://openalex.org/W2166200602","https://openalex.org/W2402071310","https://openalex.org/W2464662412","https://openalex.org/W4205407119","https://openalex.org/W4302566517","https://openalex.org/W4376544320"],"related_works":["https://openalex.org/W2129873578","https://openalex.org/W1483064108","https://openalex.org/W2950970160","https://openalex.org/W2432950362","https://openalex.org/W2026123029","https://openalex.org/W1977947486","https://openalex.org/W2728163725","https://openalex.org/W2141462609","https://openalex.org/W1533689962","https://openalex.org/W3044999174"],"abstract_inverted_index":{"This":[0],"study":[1],"was":[2,243],"designed":[3],"to":[4,57],"investigate":[5],"the":[6,13,66,83,86,96,128,133,250,259,267],"harmful":[7],"effects":[8,20,277],"of":[9,15,21,85,143,149,224,261,266],"toluene":[10,58,80,212,279],"inhalation":[11,166,213],"in":[12,43,52,68,201,258],"liver":[14,89,146,260],"rats":[16,34,51,67],"and":[17,90,111,125,158,172,175,188,192,204,207,234,254],"possible":[18],"protective":[19],"melatonin":[22,74,218,274],"on":[23],"these":[24],"detrimental":[25],"effects.":[26],"For":[27],"this":[28],"purpose,":[29],"21":[30],"adult":[31],"male":[32],"Wistar-albino":[33],"were":[35,46,55,71,93,114,119,135,162,214,238],"randomly":[36],"divided":[37],"into":[38],"three":[39],"equal":[40],"groups.":[41],"Animals":[42],"group":[44,53,69],"I":[45],"used":[47],"as":[48],"control.":[49],"The":[50,145,199],"II":[54],"exposed":[56],"(3000":[59],"ppm/1":[60],"hour/day)":[61],"for":[62,141],"4":[63],"weeks,":[64],"while":[65],"III":[70],"treated":[72],"with":[73,121,197],"(10":[75],"mg/kg/day,":[76],"intraperitoneally":[77],"[ip])":[78],"plus":[79],"inhalation.":[81],"At":[82],"end":[84],"experimental":[87],"period,":[88],"blood":[91],"samples":[92],"taken":[94],"from":[95,226],"decapitated":[97],"animals.":[98],"Serum":[99],"aspartate":[100],"aminotransferase":[101,104],"(AST),":[102],"alanine":[103],"(ALT),":[105],"alkaline":[106],"phosphatase":[107],"(ALP),":[108],"total":[109,185],"bilirubin":[110,186],"albumin":[112],"levels":[113,161,187,209],"determined.":[115],"Liver":[116],"tissue":[117,147,173,189,202],"sections":[118,134],"stained":[120,137],"routine":[122],"histological":[123],"methods":[124],"examined":[126],"under":[127],"light":[129,221],"microscope.":[130],"In":[131,220,264],"addition,":[132],"immunohistochemically":[136],"using":[138],"avidin-biotin-peroxidase":[139],"method":[140],"determination":[142],"apoptosis.":[144],"activities":[148],"superoxide":[150],"dismutase":[151],"(SOD),":[152],"glutathione":[153],"peroxidase":[154],"(GSH-Px),":[155],"catalase":[156],"(CAT)":[157],"malondialdehyde":[159],"(MDA)":[160],"also":[163,244],"measured.":[164],"Toluene":[165],"significantly":[167,215],"increased":[168,245],"serum":[169,177,183,205],"ALT,":[170],"AST":[171,208],"MDA,":[174],"decreased":[176,249],"albumin,":[178],"but":[179],"did":[180],"not":[181],"affect":[182],"ALP,":[184],"SOD,":[190],"GSH-Px":[191],"CAT":[193],"activity":[194],"when":[195],"compared":[196],"controls.":[198],"increases":[200],"MDA":[203],"ALT":[206],"induced":[210],"by":[211,217],"inhibited":[216],"treatment.":[219],"microscopic":[222],"observations":[223],"tissues":[225],"toluene-inhaled":[227,262],"rats,":[228],"massive":[229],"hepatocyte":[230],"degeneration,":[231,252],"ballooning":[232],"degeneration":[233],"mild":[235],"pericentral":[236],"fibrosis":[237,253],"observed.":[239],"Bax":[240,255],"immune":[241,256],"reactivity":[242,257],"significantly.":[246],"Melatonin":[247],"treatment":[248],"balloon":[251],"rats.":[263],"view":[265],"present":[268],"findings,":[269],"it":[270],"is":[271],"suggested":[272],"that":[273],"has":[275],"hepatoprotective":[276],"against":[278],"toxicity":[280],"via":[281],"primarily":[282],"antioxidative":[283],"properties.":[284]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":4},{"year":2020,"cited_by_count":4},{"year":2019,"cited_by_count":4},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":3},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":6}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}