{"id":"https://openalex.org/W2102545802","doi":"https://doi.org/10.1155/2013/519724","title":"PPAR \u03b3 Agonists in Adaptive Immunity: What Do Immune Disorders and Their Models Have to Tell Us?","display_name":"PPAR \u03b3 Agonists in Adaptive Immunity: What Do Immune Disorders and Their Models Have to Tell Us?","publication_year":2013,"publication_date":"2013-01-01","ids":{"openalex":"https://openalex.org/W2102545802","doi":"https://doi.org/10.1155/2013/519724","mag":"2102545802","pmid":"https://pubmed.ncbi.nlm.nih.gov/23983678","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3747405"},"language":"en","primary_location":{"id":"doi:10.1155/2013/519724","doi":"https://doi.org/10.1155/2013/519724","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/519724","pdf_url":"https://downloads.hindawi.com/journals/ppar/2013/519724.pdf","source":{"id":"https://openalex.org/S71649485","display_name":"PPAR Research","issn_l":"1687-4757","issn":["1687-4757","1687-4765"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PPAR Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://downloads.hindawi.com/journals/ppar/2013/519724.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112318916","display_name":"Laurindo Ferreira da Rocha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I25112270","display_name":"Universidade Federal de Pernambuco","ror":"https://ror.org/047908t24","country_code":"BR","type":"education","lineage":["https://openalex.org/I25112270"]},{"id":"https://openalex.org/I4210138879","display_name":"Hospital das Cl\u00ednicas da Universidade Federal de Pernambuco","ror":"https://ror.org/03rehvw54","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210138879"]}],"countries":["BR"],"is_corresponding":true,"raw_author_name":"Laurindo Ferreira da Rocha Junior","raw_affiliation_strings":["Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Novas Abordagens Terap\u00eauticas (LINAT), N\u00facleo de Pesquisa em Inova\u00e7\u00e3o Terap\u00eautica (NUPIT SG), Universidade Federal de Pernambuco (UFPE), Recife 50670-901, PE, Brazil","Servi\u00e7o de Reumatologia do Hospital das Cl\u00ednicas da Universidade Federal de Pernambuco (HC-UFPE), Recife 50670-901, PE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Novas Abordagens Terap\u00eauticas (LINAT), N\u00facleo de Pesquisa em Inova\u00e7\u00e3o Terap\u00eautica (NUPIT SG), Universidade Federal de Pernambuco (UFPE), Recife 50670-901, PE, Brazil","institution_ids":["https://openalex.org/I25112270"]},{"raw_affiliation_string":"Servi\u00e7o de Reumatologia do Hospital das Cl\u00ednicas da Universidade Federal de Pernambuco (HC-UFPE), Recife 50670-901, PE, Brazil","institution_ids":["https://openalex.org/I4210138879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051370589","display_name":"Andr\u00e9a Tavares Dantas","orcid":"https://orcid.org/0000-0003-2345-3363","observed_orcids":["https://orcid.org/0000-0003-2345-3363"]},"institutions":[{"id":"https://openalex.org/I25112270","display_name":"Universidade Federal de Pernambuco","ror":"https://ror.org/047908t24","country_code":"BR","type":"education","lineage":["https://openalex.org/I25112270"]},{"id":"https://openalex.org/I4210138879","display_name":"Hospital das Cl\u00ednicas da Universidade Federal de Pernambuco","ror":"https://ror.org/03rehvw54","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210138879"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Andr\u00e9a Tavares Dantas","raw_affiliation_strings":["Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Novas Abordagens Terap\u00eauticas (LINAT), N\u00facleo de Pesquisa em Inova\u00e7\u00e3o Terap\u00eautica (NUPIT SG), Universidade Federal de Pernambuco (UFPE), Recife 50670-901, PE, Brazil","Servi\u00e7o de Reumatologia do Hospital das Cl\u00ednicas da Universidade Federal de Pernambuco (HC-UFPE), Recife 50670-901, PE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Novas Abordagens Terap\u00eauticas (LINAT), N\u00facleo de Pesquisa em Inova\u00e7\u00e3o Terap\u00eautica (NUPIT SG), Universidade Federal de Pernambuco (UFPE), Recife 50670-901, PE, Brazil","institution_ids":["https://openalex.org/I25112270"]},{"raw_affiliation_string":"Servi\u00e7o de Reumatologia do Hospital das Cl\u00ednicas da Universidade Federal de Pernambuco (HC-UFPE), Recife 50670-901, PE, Brazil","institution_ids":["https://openalex.org/I4210138879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049108731","display_name":"\u00c2ngela Luzia Branco Pinto Duarte","orcid":"https://orcid.org/0000-0001-6434-9939","observed_orcids":["https://orcid.org/0000-0001-6434-9939"]},"institutions":[{"id":"https://openalex.org/I4210138879","display_name":"Hospital das Cl\u00ednicas da Universidade Federal de Pernambuco","ror":"https://ror.org/03rehvw54","country_code":"BR","type":"healthcare","lineage":["https://openalex.org/I4210138879"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"\u00c2ngela Luzia Branco Pinto Duarte","raw_affiliation_strings":["Servi\u00e7o de Reumatologia do Hospital das Cl\u00ednicas da Universidade Federal de Pernambuco (HC-UFPE), Recife 50670-901, PE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Servi\u00e7o de Reumatologia do Hospital das Cl\u00ednicas da Universidade Federal de Pernambuco (HC-UFPE), Recife 50670-901, PE, Brazil","institution_ids":["https://openalex.org/I4210138879"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003939036","display_name":"Moacyr Jesus Barreto de Melo R\u00eago","orcid":"https://orcid.org/0000-0002-1883-6012","observed_orcids":["https://orcid.org/0000-0002-1883-6012"]},"institutions":[{"id":"https://openalex.org/I25112270","display_name":"Universidade Federal de Pernambuco","ror":"https://ror.org/047908t24","country_code":"BR","type":"education","lineage":["https://openalex.org/I25112270"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Moacyr Jesus Barreto de Melo Rego","raw_affiliation_strings":["Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Novas Abordagens Terap\u00eauticas (LINAT), N\u00facleo de Pesquisa em Inova\u00e7\u00e3o Terap\u00eautica (NUPIT SG), Universidade Federal de Pernambuco (UFPE), Recife 50670-901, PE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Novas Abordagens Terap\u00eauticas (LINAT), N\u00facleo de Pesquisa em Inova\u00e7\u00e3o Terap\u00eautica (NUPIT SG), Universidade Federal de Pernambuco (UFPE), Recife 50670-901, PE, Brazil","institution_ids":["https://openalex.org/I25112270"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074825762","display_name":"Ivan da Rocha Pitta","orcid":"https://orcid.org/0000-0002-2899-4049","observed_orcids":["https://orcid.org/0000-0002-2899-4049"]},"institutions":[{"id":"https://openalex.org/I25112270","display_name":"Universidade Federal de Pernambuco","ror":"https://ror.org/047908t24","country_code":"BR","type":"education","lineage":["https://openalex.org/I25112270"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Ivan da Rocha Pitta","raw_affiliation_strings":["Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Novas Abordagens Terap\u00eauticas (LINAT), N\u00facleo de Pesquisa em Inova\u00e7\u00e3o Terap\u00eautica (NUPIT SG), Universidade Federal de Pernambuco (UFPE), Recife 50670-901, PE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Novas Abordagens Terap\u00eauticas (LINAT), N\u00facleo de Pesquisa em Inova\u00e7\u00e3o Terap\u00eautica (NUPIT SG), Universidade Federal de Pernambuco (UFPE), Recife 50670-901, PE, Brazil","institution_ids":["https://openalex.org/I25112270"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079556443","display_name":"Ma\u00edra Galdino da Rocha Pitta","orcid":"https://orcid.org/0000-0001-5881-0338","observed_orcids":["https://orcid.org/0000-0001-5881-0338"]},"institutions":[{"id":"https://openalex.org/I25112270","display_name":"Universidade Federal de Pernambuco","ror":"https://ror.org/047908t24","country_code":"BR","type":"education","lineage":["https://openalex.org/I25112270"]}],"countries":["BR"],"is_corresponding":false,"raw_author_name":"Maira Galdino da Rocha Pitta","raw_affiliation_strings":["Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Novas Abordagens Terap\u00eauticas (LINAT), N\u00facleo de Pesquisa em Inova\u00e7\u00e3o Terap\u00eautica (NUPIT SG), Universidade Federal de Pernambuco (UFPE), Recife 50670-901, PE, Brazil"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laborat\u00f3rio de Imunomodula\u00e7\u00e3o e Novas Abordagens Terap\u00eauticas (LINAT), N\u00facleo de Pesquisa em Inova\u00e7\u00e3o Terap\u00eautica (NUPIT SG), Universidade Federal de Pernambuco (UFPE), Recife 50670-901, PE, Brazil","institution_ids":["https://openalex.org/I25112270"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5112318916"],"corresponding_institution_ids":["https://openalex.org/I25112270","https://openalex.org/I4210138879"],"apc_list":{"value":1630,"currency":"USD","value_usd":1630},"apc_paid":{"value":1630,"currency":"USD","value_usd":1630},"fwci":1.4115,"has_fulltext":true,"cited_by_count":38,"citation_normalized_percentile":{"value":0.79829579,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"2013","issue":null,"first_page":"1","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11072","display_name":"Peroxisome Proliferator-Activated Receptors","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10469","display_name":"Psoriasis: Treatment and Pathogenesis","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ppargamma-agonists","display_name":"PPAR\u03b3 agonists","score":0.8889999985694885},{"id":"https://openalex.org/keywords/adaptive-immunity","display_name":"adaptive immunity","score":0.9800000190734863},{"id":"https://openalex.org/keywords/t-cells","display_name":"T cells","score":0.5849999785423279},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.9750000238418579},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.7400000095367432},{"id":"https://openalex.org/keywords/inflammatory-diseases","display_name":"inflammatory diseases","score":0.8930000066757202},{"id":"https://openalex.org/keywords/th1-cells","display_name":"Th1 cells","score":0.675000011920929},{"id":"https://openalex.org/keywords/th2-cells","display_name":"Th2 cells","score":0.9929999709129333},{"id":"https://openalex.org/keywords/th17-cells","display_name":"Th17 cells","score":1.0},{"id":"https://openalex.org/keywords/regulatory-t-cells","display_name":"regulatory T cells","score":0.9819999933242798},{"id":"https://openalex.org/keywords/cytokines","display_name":"cytokines","score":0.7269999980926514},{"id":"https://openalex.org/keywords/chemokines","display_name":"chemokines","score":0.9599999785423279},{"id":"https://openalex.org/keywords/nuclear-receptors","display_name":"nuclear receptors","score":0.6819999814033508},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.5809999704360962},{"id":"https://openalex.org/keywords/t-cell-differentiation","display_name":"T cell differentiation","score":0.5680000185966492},{"id":"https://openalex.org/keywords/lipid-metabolism","display_name":"lipid metabolism","score":0.5529999732971191}],"concepts":[{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.7864540815353394},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5819774270057678},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.5784193277359009},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.5601965188980103},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.5206693410873413},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4991753101348877},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.49685147404670715},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4932231307029724},{"id":"https://openalex.org/C13373296","wikidata":"https://www.wikidata.org/wiki/Q421866","display_name":"Chemokine","level":3,"score":0.49213021993637085},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.47881680727005005},{"id":"https://openalex.org/C187345961","wikidata":"https://www.wikidata.org/wiki/Q419629","display_name":"Peroxisome proliferator-activated receptor","level":3,"score":0.45487838983535767},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.41960057616233826},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3439111113548279},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.12624526023864746},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0}],"mesh":[],"locations_count":6,"locations":[{"id":"doi:10.1155/2013/519724","doi":"https://doi.org/10.1155/2013/519724","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/519724","pdf_url":"https://downloads.hindawi.com/journals/ppar/2013/519724.pdf","source":{"id":"https://openalex.org/S71649485","display_name":"PPAR Research","issn_l":"1687-4757","issn":["1687-4757","1687-4765"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PPAR Research","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:2743783","doi":null,"is_oa":true,"landing_page_url":"http://europepmc.org/articles/PMC3747405","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"","raw_type":"Text"},{"id":"pmid:23983678","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23983678","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PPAR research","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3747405","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC3747405/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PPAR Res","raw_type":"Text"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.772.2862","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.772.2862","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/55/1c/PPAR2013-519724.PMC3747405.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:10a373e5d0264ebea29f633b944bbeb9","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/10a373e5d0264ebea29f633b944bbeb9","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"PPAR Research, Vol 2013 (2013)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1155/2013/519724","doi":"https://doi.org/10.1155/2013/519724","is_oa":true,"landing_page_url":"https://doi.org/10.1155/2013/519724","pdf_url":"https://downloads.hindawi.com/journals/ppar/2013/519724.pdf","source":{"id":"https://openalex.org/S71649485","display_name":"PPAR Research","issn_l":"1687-4757","issn":["1687-4757","1687-4765"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319869","host_organization_name":"Hindawi Publishing Corporation","host_organization_lineage":["https://openalex.org/P4310319869","https://openalex.org/P4310320595"],"host_organization_lineage_names":["Hindawi Publishing Corporation","Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"PPAR Research","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9476000070571899}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322025","display_name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","ror":"https://ror.org/03swz6y49"},{"id":"https://openalex.org/F4320322904","display_name":"Financiadora de Estudos e Projetos","ror":"https://ror.org/030w99567"},{"id":"https://openalex.org/F4320323678","display_name":"Funda\u00e7\u00e3o de Amparo \u00e0 Ci\u00eancia e Tecnologia do Estado de Pernambuco","ror":"https://ror.org/02te5rf52"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2102545802.pdf","grobid_xml":"https://content.openalex.org/works/W2102545802.grobid-xml"},"referenced_works_count":95,"referenced_works":["https://openalex.org/W9904803","https://openalex.org/W197632038","https://openalex.org/W1505047300","https://openalex.org/W1510730676","https://openalex.org/W1511195742","https://openalex.org/W1539079080","https://openalex.org/W1565566945","https://openalex.org/W1581720110","https://openalex.org/W1598861242","https://openalex.org/W1640854798","https://openalex.org/W1656162023","https://openalex.org/W1824998980","https://openalex.org/W1911435139","https://openalex.org/W1916337192","https://openalex.org/W1965734808","https://openalex.org/W1972503050","https://openalex.org/W1973022339","https://openalex.org/W1973557663","https://openalex.org/W1974618081","https://openalex.org/W1980218034","https://openalex.org/W1981300226","https://openalex.org/W1994088951","https://openalex.org/W1994668373","https://openalex.org/W1996237110","https://openalex.org/W2000520103","https://openalex.org/W2001018199","https://openalex.org/W2002726823","https://openalex.org/W2005139170","https://openalex.org/W2005278031","https://openalex.org/W2007128613","https://openalex.org/W2007794906","https://openalex.org/W2009925138","https://openalex.org/W2010957046","https://openalex.org/W2014425464","https://openalex.org/W2016535386","https://openalex.org/W2017191185","https://openalex.org/W2018424623","https://openalex.org/W2023019116","https://openalex.org/W2024859964","https://openalex.org/W2027193949","https://openalex.org/W2029383851","https://openalex.org/W2029853233","https://openalex.org/W2033981053","https://openalex.org/W2035212410","https://openalex.org/W2040565048","https://openalex.org/W2041544510","https://openalex.org/W2043310790","https://openalex.org/W2045190048","https://openalex.org/W2049372707","https://openalex.org/W2060702086","https://openalex.org/W2063340779","https://openalex.org/W2065307318","https://openalex.org/W2066680466","https://openalex.org/W2075067819","https://openalex.org/W2075503219","https://openalex.org/W2076889715","https://openalex.org/W2080067668","https://openalex.org/W2080550663","https://openalex.org/W2081611139","https://openalex.org/W2086460209","https://openalex.org/W2086595653","https://openalex.org/W2090627427","https://openalex.org/W2091230088","https://openalex.org/W2092001274","https://openalex.org/W2093797523","https://openalex.org/W2094683737","https://openalex.org/W2095157628","https://openalex.org/W2097194409","https://openalex.org/W2098009836","https://openalex.org/W2100763709","https://openalex.org/W2101328058","https://openalex.org/W2102830399","https://openalex.org/W2105854609","https://openalex.org/W2107008240","https://openalex.org/W2107235439","https://openalex.org/W2115124472","https://openalex.org/W2116828514","https://openalex.org/W2118994799","https://openalex.org/W2126538938","https://openalex.org/W2126801791","https://openalex.org/W2129704292","https://openalex.org/W2132070369","https://openalex.org/W2132975915","https://openalex.org/W2134453100","https://openalex.org/W2134624067","https://openalex.org/W2144465917","https://openalex.org/W2144473903","https://openalex.org/W2146687192","https://openalex.org/W2147822751","https://openalex.org/W2150652688","https://openalex.org/W2151960040","https://openalex.org/W2155432151","https://openalex.org/W2158969881","https://openalex.org/W2159568824","https://openalex.org/W4313050937"],"related_works":["https://openalex.org/W3032580390","https://openalex.org/W4313349824","https://openalex.org/W2001018199","https://openalex.org/W2029383851","https://openalex.org/W7097802229","https://openalex.org/W2167908723","https://openalex.org/W1969259773","https://openalex.org/W2031612442","https://openalex.org/W3038374791","https://openalex.org/W2070835301"],"abstract_inverted_index":{"Adaptive":[0],"immunity":[1],"has":[2,132],"evolved":[3],"as":[4,33,90,92],"a":[5,30],"very":[6],"powerful":[7],"and":[8,23,27,42,70,82,94,103,117,128,157],"highly":[9],"specialized":[10],"tool":[11],"of":[12,20,36,49,60,77,153,160,163,169],"host":[13],"defense.":[14],"Its":[15],"classical":[16],"protagonists":[17],"are":[18,45,75,83],"lymphocytes":[19],"the":[21,37,50,58,78,151,158,161,167],"T-":[22],"B-cell":[24],"lineage.":[25],"Cytokines":[26],"chemokines":[28],"play":[29],"key":[31],"role":[32],"effector":[34,123],"mechanisms":[35],"adaptive":[38,51,95,154,173],"immunity.":[39,96,174],"Some":[40],"autoimmune":[41,61],"inflammatory":[43],"diseases":[44,62],"caused":[46],"by":[47,101,145],"disturbance":[48],"immune":[52,155],"system.":[53],"Recent":[54],"advances":[55],"in":[56,87,150,172],"understanding":[57],"pathogenesis":[59],"have":[63,108],"led":[64],"to":[65],"research":[66],"on":[67],"new":[68],"molecular":[69],"therapeutic":[71],"targets.":[72],"PPAR":[73,97,111,130,147],"\u03b3":[74,98,131,148],"members":[76],"nuclear":[79],"receptor":[80],"superfamily":[81],"transcription":[84],"factors":[85],"involved":[86,171],"lipid":[88],"metabolism":[89],"well":[91],"innate":[93],"is":[99],"activated":[100],"synthetic":[102],"endogenous":[104],"ligands.":[105],"Previous":[106],"studies":[107],"shown":[109],"that":[110],"agonists":[112,149],"regulate":[113],"T-cell":[114],"survival,":[115],"activation":[116,162],"T":[118],"helper":[119],"cell":[120],"differentiation":[121],"into":[122],"subsets:":[124],"Th1,":[125],"Th2,":[126],"Th17,":[127],"Tregs.":[129],"also":[133],"been":[134],"associated":[135],"with":[136,166],"B":[137],"cells.":[138],"The":[139],"present":[140],"review":[141],"addresses":[142],"these":[143,164],"issues":[144],"placing":[146],"context":[152],"responses":[156],"relation":[159],"receptors":[165],"expression":[168],"cytokines":[170]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":7}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}