{"id":"https://openalex.org/W2102525221","doi":"https://doi.org/10.1002/stem.1908","title":"Age-Specific Functional Epigenetic Changes in p21 and p16 in Injury-Activated Satellite Cells","display_name":"Age-Specific Functional Epigenetic Changes in p21 and p16 in Injury-Activated Satellite Cells","publication_year":2014,"publication_date":"2014-11-28","ids":{"openalex":"https://openalex.org/W2102525221","doi":"https://doi.org/10.1002/stem.1908","mag":"2102525221","pmid":"https://pubmed.ncbi.nlm.nih.gov/25447026","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4333004"},"language":"en","primary_location":{"id":"doi:10.1002/stem.1908","doi":"https://doi.org/10.1002/stem.1908","is_oa":true,"landing_page_url":"https://doi.org/10.1002/stem.1908","pdf_url":"https://academic.oup.com/stmcls/article-pdf/33/3/951/42015256/stmcls_33_3_951.pdf","source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/stmcls/article-pdf/33/3/951/42015256/stmcls_33_3_951.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080809194","display_name":"Ju Li","orcid":"https://orcid.org/0000-0003-0037-4144","observed_orcids":["https://orcid.org/0000-0003-0037-4144"]},"institutions":[{"id":"https://openalex.org/I103922791","display_name":"QB3","ror":"https://ror.org/04n1n3n22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I103922791","https://openalex.org/I180670191","https://openalex.org/I185103710","https://openalex.org/I95457486"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Ju Li","raw_affiliation_strings":["California Institute for Quantitative Biosciences (QB3), Berkeley, California, USA","Department of Bioengineering University of California-Berkeley, Berkeley, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California Institute for Quantitative Biosciences (QB3), Berkeley, California, USA","institution_ids":["https://openalex.org/I103922791"]},{"raw_affiliation_string":"Department of Bioengineering University of California-Berkeley, Berkeley, California, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040878697","display_name":"Suhyoun Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Suhyoun Han","raw_affiliation_strings":["Department of Bioengineering University of California-Berkeley, Berkeley, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering University of California-Berkeley, Berkeley, California, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052621427","display_name":"Wendy Cousin","orcid":"https://orcid.org/0009-0007-6216-6902","observed_orcids":["https://orcid.org/0009-0007-6216-6902"]},"institutions":[{"id":"https://openalex.org/I103922791","display_name":"QB3","ror":"https://ror.org/04n1n3n22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I103922791","https://openalex.org/I180670191","https://openalex.org/I185103710","https://openalex.org/I95457486"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Wendy Cousin","raw_affiliation_strings":["California Institute for Quantitative Biosciences (QB3), Berkeley, California, USA","Department of Bioengineering University of California-Berkeley, Berkeley, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California Institute for Quantitative Biosciences (QB3), Berkeley, California, USA","institution_ids":["https://openalex.org/I103922791"]},{"raw_affiliation_string":"Department of Bioengineering University of California-Berkeley, Berkeley, California, USA","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016353918","display_name":"Irina M. Conboy","orcid":"https://orcid.org/0000-0002-4276-0644","observed_orcids":["https://orcid.org/0000-0002-4276-0644"]},"institutions":[{"id":"https://openalex.org/I103922791","display_name":"QB3","ror":"https://ror.org/04n1n3n22","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I103922791","https://openalex.org/I180670191","https://openalex.org/I185103710","https://openalex.org/I95457486"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Irina M. Conboy","raw_affiliation_strings":["California Institute for Quantitative Biosciences (QB3), Berkeley, California, USA","Department of Bioengineering University of California-Berkeley, Berkeley, California, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"California Institute for Quantitative Biosciences (QB3), Berkeley, California, USA","institution_ids":["https://openalex.org/I103922791"]},{"raw_affiliation_string":"Department of Bioengineering University of California-Berkeley, Berkeley, California, USA","institution_ids":["https://openalex.org/I95457486"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5016353918","https://openalex.org/A5080809194"],"corresponding_institution_ids":["https://openalex.org/I103922791","https://openalex.org/I95457486"],"apc_list":{"value":4477,"currency":"USD","value_usd":4477},"apc_paid":null,"fwci":1.5422,"has_fulltext":true,"cited_by_count":56,"citation_normalized_percentile":{"value":0.82474738,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"33","issue":"3","first_page":"951","last_page":"961"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10269","display_name":"Epigenetics and DNA Methylation","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10222","display_name":"Genomics and Chromatin Dynamics","score":0.0008999999845400453,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/muscle-stem-cells","display_name":"muscle stem cells","score":0.6380000114440918},{"id":"https://openalex.org/keywords/satellite-cells","display_name":"satellite cells","score":0.9950000047683716},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.7730000019073486},{"id":"https://openalex.org/keywords/epigenetic-silencing","display_name":"epigenetic silencing","score":0.9240000247955322},{"id":"https://openalex.org/keywords/p21","display_name":"p21","score":0.9909999966621399},{"id":"https://openalex.org/keywords/p16","display_name":"p16","score":1.0},{"id":"https://openalex.org/keywords/cyclin-dependent-kinase-inhibitors","display_name":"cyclin-dependent kinase inhibitors","score":0.9309999942779541},{"id":"https://openalex.org/keywords/fgf2","display_name":"FGF2","score":0.859000027179718},{"id":"https://openalex.org/keywords/erk1-2-phosphorylation","display_name":"ERK1/2 phosphorylation","score":0.9430000185966492},{"id":"https://openalex.org/keywords/muscle-regeneration","display_name":"muscle regeneration","score":0.7139999866485596},{"id":"https://openalex.org/keywords/cdkn2b","display_name":"CDKN2B","score":0.8669999837875366},{"id":"https://openalex.org/keywords/p27","display_name":"p27","score":0.9860000014305115},{"id":"https://openalex.org/keywords/tissue-injury-response","display_name":"tissue injury response","score":0.6240000128746033}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8921999335289001},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.7026677131652832},{"id":"https://openalex.org/C41091548","wikidata":"https://www.wikidata.org/wiki/Q26939","display_name":"Epigenetics","level":3,"score":0.6100283861160278},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.575738251209259},{"id":"https://openalex.org/C124320809","wikidata":"https://www.wikidata.org/wiki/Q46292","display_name":"Cyclin-dependent kinase","level":4,"score":0.4439700245857239},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.436939001083374},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.3315662145614624},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.24358689785003662},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.19123724102973938},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.08301708102226257}],"mesh":[{"descriptor_ui":"D000367","descriptor_name":"Age Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000293","qualifier_name":"injuries","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D019941","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p16","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032496","descriptor_name":"Satellite Cells, Skeletal Muscle","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032496","descriptor_name":"Satellite Cells, Skeletal Muscle","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D044127","descriptor_name":"Epigenesis, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048091","descriptor_name":"Guided Tissue Regeneration","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050759","descriptor_name":"Cyclin-Dependent Kinase Inhibitor p21","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/stem.1908","doi":"https://doi.org/10.1002/stem.1908","is_oa":true,"landing_page_url":"https://doi.org/10.1002/stem.1908","pdf_url":"https://academic.oup.com/stmcls/article-pdf/33/3/951/42015256/stmcls_33_3_951.pdf","source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},{"id":"pmid:25447026","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25447026","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem cells (Dayton, Ohio)","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4333004","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4333004","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Stem Cells","raw_type":"Text"},{"id":"pmh:oai:escholarship.org:ark:/13030/qt6bm0535p","doi":null,"is_oa":false,"landing_page_url":"https://escholarship.org/uc/item/6bm0535p","pdf_url":null,"source":{"id":"https://openalex.org/S4306400115","display_name":"eScholarship (California Digital Library)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2801248553","host_organization_name":"California Digital Library","host_organization_lineage":["https://openalex.org/I2801248553"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Stem Cells, vol 33, iss 3","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/stem.1908","doi":"https://doi.org/10.1002/stem.1908","is_oa":true,"landing_page_url":"https://doi.org/10.1002/stem.1908","pdf_url":"https://academic.oup.com/stmcls/article-pdf/33/3/951/42015256/stmcls_33_3_951.pdf","source":{"id":"https://openalex.org/S65139510","display_name":"Stem Cells","issn_l":"1066-5099","issn":["1066-5099","1549-4918"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Stem Cells","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8371999859809875}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5910689489","display_name":"Effects of the systemic environment on muscle aging","funder_award_id":"R01AG027252","funder_id":"https://openalex.org/F4320337337","funder_display_name":"National Institute on Aging"}],"funders":[{"id":"https://openalex.org/F4320306159","display_name":"W. M. Keck Foundation","ror":"https://ror.org/000dswa46"},{"id":"https://openalex.org/F4320309885","display_name":"California Institute of Regenerative Medicine","ror":"https://ror.org/033m8b439"},{"id":"https://openalex.org/F4320322702","display_name":"Tasly Holding Group","ror":"https://ror.org/034kb7s93"},{"id":"https://openalex.org/F4320337337","display_name":"National Institute on Aging","ror":"https://ror.org/049v75w11"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2102525221.pdf","grobid_xml":"https://content.openalex.org/works/W2102525221.grobid-xml"},"referenced_works_count":63,"referenced_works":["https://openalex.org/W67653824","https://openalex.org/W127170646","https://openalex.org/W1574633507","https://openalex.org/W1968931043","https://openalex.org/W1969385456","https://openalex.org/W1973704051","https://openalex.org/W1974508591","https://openalex.org/W1974761743","https://openalex.org/W1976764293","https://openalex.org/W1978269248","https://openalex.org/W1992934869","https://openalex.org/W1993797415","https://openalex.org/W1997686190","https://openalex.org/W2001775703","https://openalex.org/W2002698073","https://openalex.org/W2003223749","https://openalex.org/W2003750107","https://openalex.org/W2015050458","https://openalex.org/W2016153631","https://openalex.org/W2022487205","https://openalex.org/W2024209230","https://openalex.org/W2029868343","https://openalex.org/W2031126348","https://openalex.org/W2031253060","https://openalex.org/W2032983525","https://openalex.org/W2035596000","https://openalex.org/W2041036994","https://openalex.org/W2044057392","https://openalex.org/W2049085719","https://openalex.org/W2065564965","https://openalex.org/W2066843562","https://openalex.org/W2070061120","https://openalex.org/W2071023973","https://openalex.org/W2072088194","https://openalex.org/W2072325197","https://openalex.org/W2072399660","https://openalex.org/W2073786632","https://openalex.org/W2081067390","https://openalex.org/W2084289371","https://openalex.org/W2087821016","https://openalex.org/W2092015664","https://openalex.org/W2093184953","https://openalex.org/W2093355627","https://openalex.org/W2093958228","https://openalex.org/W2094625175","https://openalex.org/W2096083625","https://openalex.org/W2096707410","https://openalex.org/W2098810297","https://openalex.org/W2104384655","https://openalex.org/W2121619780","https://openalex.org/W2124948004","https://openalex.org/W2127150495","https://openalex.org/W2129976097","https://openalex.org/W2131277634","https://openalex.org/W2137297192","https://openalex.org/W2141376240","https://openalex.org/W2141460919","https://openalex.org/W2146035452","https://openalex.org/W2169617007","https://openalex.org/W2404013489","https://openalex.org/W2410680505","https://openalex.org/W2418172960","https://openalex.org/W6716867743"],"related_works":["https://openalex.org/W2081067390","https://openalex.org/W2045410669","https://openalex.org/W2735603440","https://openalex.org/W2047289569","https://openalex.org/W1498299841","https://openalex.org/W2073466774","https://openalex.org/W2511930191","https://openalex.org/W1502108393","https://openalex.org/W2008405100","https://openalex.org/W2559087576"],"abstract_inverted_index":{"The":[0],"regenerative":[1,166],"capacity":[2],"of":[3,36,124,168,176],"muscle":[4,11,51,128],"dramatically":[5],"decreases":[6],"with":[7,83,120,159],"age":[8],"because":[9],"old":[10,93,98,137,169],"stem":[12,52,129],"cells":[13,61,75,130,158],"fail":[14],"to":[15,19,56,65,109],"proliferate":[16],"in":[17,49,59,73,81,91,96,156],"response":[18],"tissue":[20,66,177,184],"damage.":[21],"Here,":[22],"we":[23],"uncover":[24],"key":[25],"age-specific":[26],"differences":[27],"underlying":[28],"this":[29],"proliferative":[30],"decline:":[31],"namely,":[32],"the":[33,92,97,121,125,164],"genetic":[34],"loci":[35],"cyclin/cyclin-dependent":[37],"kinase":[38],"(CDK)":[39],"inhibitors":[40],"(CDKIs)":[41],"p21":[42,84,103,111],"and":[43,62,85,88,105,114,151,162],"p16":[44,86],"are":[45],"more":[46],"epigenetically":[47,104],"silenced":[48],"young":[50,127],"cells,":[53,100],"as":[54,134,136],"compared":[55],"old,":[57],"both":[58],"quiescent":[60],"those":[63],"responding":[64],"injury.":[67],"Interestingly,":[68],"phosphorylated":[69],"ERK":[70],"(pERK)":[71],"induced":[72],"these":[74],"by":[76],"ectopic":[77,139],"FGF2":[78],"is":[79],"found":[80],"association":[82],"promoters,":[87],"moreover,":[89],"only":[90],"cells.":[94],"Importantly,":[95],"satellite":[99,157],"FGF2/pERK":[101],"silences":[102],"transcriptionally,":[106],"which":[107],"leads":[108],"reduced":[110],"protein":[112],"levels":[113],"enhanced":[115],"cell":[116],"proliferation.":[117,144],"In":[118,145],"agreement":[119],"epigenetic":[122],"silencing":[123],"loci,":[126],"do":[131],"not":[132],"depend":[133],"much":[135],"on":[138],"FGF/pERK":[140],"for":[141,181],"their":[142],"myogenic":[143],"addition,":[146],"other":[147],"CDKIs,":[148],"such":[149],"asp15(INK4B)":[150],"p27(KIP1)":[152],",":[153],"become":[154],"elevated":[155],"age,":[160],"confirming":[161],"explaining":[163],"profound":[165],"defect":[167],"muscle.":[170],"This":[171],"work":[172],"enhances":[173],"our":[174],"understanding":[175],"aging,":[178],"promoting":[179],"strategies":[180],"combating":[182],"age-imposed":[183],"degeneration.":[185]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":4},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":9},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":6},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":5}],"updated_date":"2026-11-06T12:05:46.655746","created_date":"2016-06-24T00:00:00"}
