{"id":"https://openalex.org/W2102467528","doi":"https://doi.org/10.1093/jac/dkq278","title":"Activity of a novel aminoglycoside, ACHN-490, against clinical isolates of Escherichia coli and Klebsiella pneumoniae from New York City","display_name":"Activity of a novel aminoglycoside, ACHN-490, against clinical isolates of Escherichia coli and Klebsiella pneumoniae from New York City","publication_year":2010,"publication_date":"2010-07-28","ids":{"openalex":"https://openalex.org/W2102467528","doi":"https://doi.org/10.1093/jac/dkq278","mag":"2102467528","pmid":"https://pubmed.ncbi.nlm.nih.gov/20667885"},"language":"en","primary_location":{"id":"doi:10.1093/jac/dkq278","doi":"https://doi.org/10.1093/jac/dkq278","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/dkq278","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5039985590","display_name":"David Landman","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Landman","raw_affiliation_strings":["State University of New York-Downstate Medical Center, Brooklyn, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of New York-Downstate Medical Center, Brooklyn, New York, NY, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":null,"display_name":"E. Babu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Babu","raw_affiliation_strings":["State University of New York-Downstate Medical Center, Brooklyn, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of New York-Downstate Medical Center, Brooklyn, New York, NY, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":null,"display_name":"N. Shah","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N. Shah","raw_affiliation_strings":["State University of New York-Downstate Medical Center, Brooklyn, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of New York-Downstate Medical Center, Brooklyn, New York, NY, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":null,"display_name":"P. Kelly","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"P. Kelly","raw_affiliation_strings":["State University of New York-Downstate Medical Center, Brooklyn, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of New York-Downstate Medical Center, Brooklyn, New York, NY, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003903091","display_name":"Mart\u00edn B\u00e4cker","orcid":"https://orcid.org/0000-0001-8061-5838","observed_orcids":["https://orcid.org/0000-0001-8061-5838"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Backer","raw_affiliation_strings":["State University of New York-Downstate Medical Center, Brooklyn, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of New York-Downstate Medical Center, Brooklyn, New York, NY, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058977225","display_name":"Simona Bratu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"S. Bratu","raw_affiliation_strings":["State University of New York-Downstate Medical Center, Brooklyn, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of New York-Downstate Medical Center, Brooklyn, New York, NY, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024228283","display_name":"John M. Quale","orcid":"https://orcid.org/0000-0001-6043-4298","observed_orcids":["https://orcid.org/0000-0001-6043-4298"]},"institutions":[{"id":"https://openalex.org/I1327163397","display_name":"State University of New York","ror":"https://ror.org/01q1z8k08","country_code":"US","type":"education","lineage":["https://openalex.org/I1327163397"]},{"id":"https://openalex.org/I181697535","display_name":"SUNY Downstate Health Sciences University","ror":"https://ror.org/0041qmd21","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I181697535"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"J. Quale","raw_affiliation_strings":["State University of New York-Downstate Medical Center, Brooklyn, New York, NY, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"State University of New York-Downstate Medical Center, Brooklyn, New York, NY, USA","institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5024228283"],"corresponding_institution_ids":["https://openalex.org/I1327163397","https://openalex.org/I181697535"],"apc_list":{"value":2869,"currency":"GBP","value_usd":3784},"apc_paid":null,"fwci":1.793,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.81466957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":94,"max":99},"biblio":{"volume":"65","issue":"10","first_page":"2123","last_page":"2127"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/1313","display_name":"Molecular Medicine"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11036","display_name":"Antibiotics Pharmacokinetics and Efficacy","score":0.0010999999940395355,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2402","display_name":"Applied Microbiology and Biotechnology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aminoglycosides","display_name":"aminoglycosides","score":0.8989999890327454},{"id":"https://openalex.org/keywords/escherichia-coli","display_name":"Escherichia coli","score":0.9660000205039978},{"id":"https://openalex.org/keywords/klebsiella-pneumoniae","display_name":"Klebsiella pneumoniae","score":1.0},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.9599999785423279},{"id":"https://openalex.org/keywords/enterobacteriaceae","display_name":"Enterobacteriaceae","score":0.8690000176429749},{"id":"https://openalex.org/keywords/aminoglycoside-resistance","display_name":"aminoglycoside resistance","score":0.7730000019073486},{"id":"https://openalex.org/keywords/aminoglycoside-modifying-enzymes","display_name":"aminoglycoside-modifying enzymes","score":0.9539999961853027},{"id":"https://openalex.org/keywords/kpc-carbapenemase","display_name":"KPC carbapenemase","score":0.902999997138977},{"id":"https://openalex.org/keywords/gentamicin","display_name":"gentamicin","score":0.7009999752044678},{"id":"https://openalex.org/keywords/tobramycin","display_name":"tobramycin","score":0.9900000095367432},{"id":"https://openalex.org/keywords/amikacin","display_name":"amikacin","score":0.9950000047683716},{"id":"https://openalex.org/keywords/bactericidal-activity","display_name":"bactericidal activity","score":0.8809999823570251},{"id":"https://openalex.org/keywords/antimicrobial-susceptibility","display_name":"antimicrobial susceptibility","score":0.6930000185966492},{"id":"https://openalex.org/keywords/new-york-city-hospitals","display_name":"New York City hospitals","score":0.9200000166893005}],"concepts":[{"id":"https://openalex.org/C2777058267","wikidata":"https://www.wikidata.org/wiki/Q132592","display_name":"Klebsiella pneumoniae","level":4,"score":0.8410180807113647},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.8101998567581177},{"id":"https://openalex.org/C2777427914","wikidata":"https://www.wikidata.org/wiki/Q408529","display_name":"Amikacin","level":3,"score":0.8020817041397095},{"id":"https://openalex.org/C2777787772","wikidata":"https://www.wikidata.org/wiki/Q45355603","display_name":"Aminoglycoside","level":3,"score":0.794448971748352},{"id":"https://openalex.org/C2775832221","wikidata":"https://www.wikidata.org/wiki/Q422482","display_name":"Gentamicin","level":3,"score":0.7239995002746582},{"id":"https://openalex.org/C2778974779","wikidata":"https://www.wikidata.org/wiki/Q1758380","display_name":"Tobramycin","level":4,"score":0.6857749819755554},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5844997763633728},{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.5566321015357971},{"id":"https://openalex.org/C133936738","wikidata":"https://www.wikidata.org/wiki/Q643839","display_name":"Multiple drug resistance","level":3,"score":0.5550200343132019},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.46211913228034973},{"id":"https://openalex.org/C200082930","wikidata":"https://www.wikidata.org/wiki/Q22327148","display_name":"Efflux","level":2,"score":0.45307278633117676},{"id":"https://openalex.org/C501593827","wikidata":"https://www.wikidata.org/wiki/Q12187","display_name":"Antibiotics","level":2,"score":0.41466689109802246},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.10031527280807495},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.04044920206069946}],"mesh":[{"descriptor_ui":"D000617","descriptor_name":"Aminoglycosides","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000900","descriptor_name":"Anti-Bacterial Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001618","descriptor_name":"beta-Lactamases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D004927","descriptor_name":"Escherichia coli Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D006761","descriptor_name":"Hospitals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007710","descriptor_name":"Klebsiella Infections","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D007711","descriptor_name":"Klebsiella pneumoniae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D008826","descriptor_name":"Microbial Sensitivity Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009519","descriptor_name":"New York City","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012359","descriptor_name":"tRNA Methyltransferases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012853","descriptor_name":"Sisomicin","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D012853","descriptor_name":"Sisomicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D016133","descriptor_name":"Polymerase Chain Reaction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/jac/dkq278","doi":"https://doi.org/10.1093/jac/dkq278","is_oa":false,"landing_page_url":"https://doi.org/10.1093/jac/dkq278","pdf_url":null,"source":{"id":"https://openalex.org/S124275759","display_name":"Journal of Antimicrobial Chemotherapy","issn_l":"0305-7453","issn":["0305-7453","1460-2091"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Antimicrobial Chemotherapy","raw_type":"journal-article"},{"id":"pmid:20667885","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20667885","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of antimicrobial chemotherapy","raw_type":"Journal Article"},{"id":"pmh:oai:open-archive.highwire.org:jac:dkq278v1","doi":null,"is_oa":false,"landing_page_url":"http://jac.oxfordjournals.org/cgi/content/short/dkq278v1","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"},{"id":"pmh:oai:open-archive.highwire.org:jac:dkq278v2","doi":null,"is_oa":false,"landing_page_url":"http://jac.oxfordjournals.org/cgi/content/short/dkq278v2","pdf_url":null,"source":{"id":"https://openalex.org/S4406923041","display_name":"HighWire Press Open Archive","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"TEXT"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":17,"referenced_works":["https://openalex.org/W1505626160","https://openalex.org/W1581962345","https://openalex.org/W1985779241","https://openalex.org/W1990965169","https://openalex.org/W2028504401","https://openalex.org/W2074663598","https://openalex.org/W2095675572","https://openalex.org/W2103171109","https://openalex.org/W2105503269","https://openalex.org/W2111924369","https://openalex.org/W2124509911","https://openalex.org/W2124712500","https://openalex.org/W2146643307","https://openalex.org/W2151554370","https://openalex.org/W2151980628","https://openalex.org/W2272090139","https://openalex.org/W4255310200"],"related_works":["https://openalex.org/W2095675572","https://openalex.org/W2110803731","https://openalex.org/W2157925105","https://openalex.org/W2160999491","https://openalex.org/W7097022604","https://openalex.org/W2100869224","https://openalex.org/W7098549349","https://openalex.org/W2362494161","https://openalex.org/W2097543140","https://openalex.org/W4400266290"],"abstract_inverted_index":{"OBJECTIVES:":[0],"Reports":[1],"of":[2,23,33,56,83,92,106,117,131,145,153,159,170,178,205,219],"Enterobacteriaceae":[3],"resistant":[4],"to":[5,78,111,140,234],"all":[6],"commonly":[7,179],"used":[8],"antimicrobial":[9],"agents,":[10],"including":[11,138,211],"\u03b2-lactams,":[12],"fluoroquinolones":[13],"and":[14,36,59,74,80,99,120,125,142,208,222],"aminoglycosides,":[15,113],"are":[16,50,227],"increasing":[17],"in":[18,41,68,72,151,187,229],"hospitals":[19,40,66],"worldwide.":[20],"The":[21,129,168,196],"activity":[22,184,201],"ACHN-490,":[24],"a":[25],"next-generation":[26],"aminoglycoside,":[27],"was":[28,133,147,164,185],"examined":[29],"against":[30,202],"clinical":[31],"isolates":[32,55,84,105,152,189,204,230],"Escherichia":[34],"coli":[35,58,108,207],"Klebsiella":[37],"pneumoniae":[38,61,163],"from":[39,64],"New":[42,69],"York":[43,70],"City,":[44],"an":[45],"area":[46],"where":[47],"multidrug-resistant":[48,212],"organisms":[49],"endemic.":[51],"METHODS:":[52],"Unique":[53],"patient":[54],"E.":[57,107,206],"K.":[60,154,162,209],"were":[62,85,109,122],"gathered":[63],"16":[65],"located":[67],"City":[71],"2009":[73],"underwent":[75],"susceptibility":[76,233],"testing":[77],"aminoglycosides":[79,141],"ACHN-490.":[81],"Subsets":[82],"characterized":[86],"by":[87],"PCR":[88],"for":[89,161],"the":[90,112,114,143,157,176,193,217],"presence":[91,144,177],"genes":[93],"encoding":[94],"aminoglycoside-modifying":[95,181],"enzymes,":[96],"ribosomal":[97],"methylases":[98],"KPC-type":[100],"carbapenemases.":[101],"RESULTS:":[102],"Although":[103],"most":[104,188,203],"susceptible":[110],"MIC(90)":[115,130,158],"values":[116],"gentamicin,":[118],"tobramycin":[119],"amikacin":[121],"32,":[123],"8":[124],"4":[126],"mg/L,":[127],"respectively.":[128],"ACHN-490":[132,160,171,199],"1":[134,166],"mg/L.":[135,167],"Multidrug":[136],"resistance,":[137],"resistance":[139],"bla(KPC),":[146],"much":[148],"more":[149],"common":[150],"pneumoniae.":[155],"However,":[156],"also":[165],"MICs":[169],"did":[172],"not":[173],"correlate":[174],"with":[175,231],"recovered":[180],"enzymes.":[182],"Bactericidal":[183],"evident":[186],"at":[190],"concentrations":[191],"4\u00d7":[192],"MIC.":[194],"CONCLUSIONS:":[195],"novel":[197],"aminoglycoside":[198],"retains":[200],"pneumoniae,":[210],"strains.":[213],"Additional":[214],"studies":[215],"examining":[216],"roles":[218],"efflux":[220],"systems":[221],"outer":[223],"membrane":[224],"permeability":[225],"alterations":[226],"recommended":[228],"reduced":[232],"this":[235],"agent.":[236]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":7},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":5},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":3},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}