{"id":"https://openalex.org/W2102458026","doi":null,"title":"Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade.","display_name":"Combination immunotherapy of primary prostate cancer in a transgenic mouse model using CTLA-4 blockade.","publication_year":2000,"publication_date":"2000-05-01","ids":{"openalex":"https://openalex.org/W2102458026","mag":"2102458026","pmid":"https://pubmed.ncbi.nlm.nih.gov/10811122"},"language":"en","primary_location":{"id":"pmid:10811122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10811122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114012484","display_name":"Arthur A. Hurwitz","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I20388574","display_name":"SUNY Upstate Medical University","ror":"https://ror.org/040kfrw16","country_code":"US","type":"education","lineage":["https://openalex.org/I20388574"]},{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A A Hurwitz","raw_affiliation_strings":["Cancer Research Laboratory, University of California, Berkeley 94720, USA. hurwitza@mail.upstate.edu","SUNY Upstate Medical University","University of California at Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cancer Research Laboratory, University of California, Berkeley 94720, USA. hurwitza@mail.upstate.edu","institution_ids":["https://openalex.org/I95457486"]},{"raw_affiliation_string":"SUNY Upstate Medical University","institution_ids":["https://openalex.org/I20388574"]},{"raw_affiliation_string":"University of California at Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001441690","display_name":"Barbara A. Foster","orcid":"https://orcid.org/0000-0003-0459-7011","observed_orcids":["https://orcid.org/0000-0003-0459-7011"]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B A Foster","raw_affiliation_strings":["Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112904768","display_name":"Eugene D. Kwon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I1925986","display_name":"Loyola University Chicago","ror":"https://ror.org/04b6x2g63","country_code":"US","type":"education","lineage":["https://openalex.org/I1925986"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E D Kwon","raw_affiliation_strings":["Loyola University Chicago","National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Loyola University Chicago","institution_ids":["https://openalex.org/I1925986"]},{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102313725","display_name":"Tan N. Truong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Truong","raw_affiliation_strings":["University of California at Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043344645","display_name":"Eugene M. Choi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I95457486","display_name":"University of California, Berkeley","ror":"https://ror.org/01an7q238","country_code":"US","type":"education","lineage":["https://openalex.org/I95457486"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E M Choi","raw_affiliation_strings":["University of California at Berkeley"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California at Berkeley","institution_ids":["https://openalex.org/I95457486"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112157310","display_name":"Norman M. Greenberg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I181547552","display_name":"Baylor College of Medicine","ror":"https://ror.org/02pttbw34","country_code":"US","type":"education","lineage":["https://openalex.org/I181547552","https://openalex.org/I2801539370"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"N M Greenberg","raw_affiliation_strings":["Baylor College of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Baylor College of Medicine","institution_ids":["https://openalex.org/I181547552"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025916093","display_name":"Maurice B. Burg","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M B Burg","raw_affiliation_strings":["National Institutes of Health"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"National Institutes of Health","institution_ids":["https://openalex.org/I1299303238"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5047117233","display_name":"James Patrick Allison","orcid":"https://orcid.org/0000-0001-8980-5697","observed_orcids":["https://orcid.org/0000-0001-8980-5697"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"J P Allison","raw_affiliation_strings":["Immunology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Immunology","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":5.1861,"has_fulltext":false,"cited_by_count":427,"citation_normalized_percentile":{"value":0.96213175,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":97,"max":100},"biblio":{"volume":"60","issue":"9","first_page":"2444","last_page":"8"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.5464000105857849,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.5464000105857849,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.36160001158714294,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10543","display_name":"Prostate Cancer Treatment and Research","score":0.07209999859333038,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostate-cancer","display_name":"prostate cancer","score":0.8769999742507935},{"id":"https://openalex.org/keywords/ctla-4-blockade","display_name":"CTLA-4 blockade","score":0.9850000143051147},{"id":"https://openalex.org/keywords/anti-ctla-4-antibody","display_name":"anti-CTLA-4 antibody","score":0.8289999961853027},{"id":"https://openalex.org/keywords/tumor-cell-vaccine","display_name":"tumor cell vaccine","score":0.6660000085830688},{"id":"https://openalex.org/keywords/tramp-mice","display_name":"TRAMP mice","score":0.7379999756813049},{"id":"https://openalex.org/keywords/combination-immunotherapy","display_name":"combination immunotherapy","score":0.6840000152587891},{"id":"https://openalex.org/keywords/gm-csf","display_name":"GM-CSF","score":0.9190000295639038},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.6019999980926514},{"id":"https://openalex.org/keywords/prostatitis","display_name":"prostatitis","score":0.8149999976158142},{"id":"https://openalex.org/keywords/tumor-antigens","display_name":"tumor antigens","score":0.4699999988079071},{"id":"https://openalex.org/keywords/t-cell-inhibitory-receptors","display_name":"T cell inhibitory receptors","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C2780192828","wikidata":"https://www.wikidata.org/wiki/Q181257","display_name":"Prostate cancer","level":3,"score":0.6710328459739685},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.6283565759658813},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6207448840141296},{"id":"https://openalex.org/C2776235491","wikidata":"https://www.wikidata.org/wiki/Q9625","display_name":"Prostate","level":3,"score":0.5925095677375793},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5386042594909668},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5338152050971985},{"id":"https://openalex.org/C2780940892","wikidata":"https://www.wikidata.org/wiki/Q1965933","display_name":"Tramp","level":4,"score":0.5174477696418762},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4876207411289215},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4746304750442505},{"id":"https://openalex.org/C21705690","wikidata":"https://www.wikidata.org/wiki/Q2907609","display_name":"CTLA-4","level":4,"score":0.43546563386917114},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4302184283733368},{"id":"https://openalex.org/C2780524745","wikidata":"https://www.wikidata.org/wiki/Q372752","display_name":"Prostatitis","level":4,"score":0.4165671467781067},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.35994091629981995},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3075428009033203}],"mesh":[{"descriptor_ui":"D000069594","descriptor_name":"Abatacept","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000912","descriptor_name":"Antibodies, Neoplasm","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000943","descriptor_name":"Antigens, Differentiation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007116","descriptor_name":"Immunization, Passive","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007150","descriptor_name":"Immunohistochemistry","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008822","descriptor_name":"Mice, Transgenic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011471","descriptor_name":"Prostatic Neoplasms","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":true},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D060908","descriptor_name":"CTLA-4 Antigen","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10811122","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10811122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer research","raw_type":"Journal Article"},{"id":"mag:2102458026","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10811122","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":33,"referenced_works":["https://openalex.org/W31716916","https://openalex.org/W1528386340","https://openalex.org/W1588713113","https://openalex.org/W1594509286","https://openalex.org/W1606500885","https://openalex.org/W1967577151","https://openalex.org/W1967877886","https://openalex.org/W1974565005","https://openalex.org/W1974620735","https://openalex.org/W1978373343","https://openalex.org/W1978416272","https://openalex.org/W1988450289","https://openalex.org/W1988959205","https://openalex.org/W2002323372","https://openalex.org/W2010057554","https://openalex.org/W2042392285","https://openalex.org/W2043732783","https://openalex.org/W2060910588","https://openalex.org/W2063495860","https://openalex.org/W2071483270","https://openalex.org/W2087013294","https://openalex.org/W2092312916","https://openalex.org/W2094366129","https://openalex.org/W2099458553","https://openalex.org/W2107629538","https://openalex.org/W2116293732","https://openalex.org/W2125200489","https://openalex.org/W2140066663","https://openalex.org/W2149244682","https://openalex.org/W2162856391","https://openalex.org/W2167614869","https://openalex.org/W2169388007","https://openalex.org/W2411241104"],"related_works":["https://openalex.org/W7098200815","https://openalex.org/W2126496267","https://openalex.org/W1541394341","https://openalex.org/W2071144245","https://openalex.org/W7098097187","https://openalex.org/W2281477325","https://openalex.org/W7098006382","https://openalex.org/W2142633341","https://openalex.org/W2080681649","https://openalex.org/W1976113809"],"abstract_inverted_index":{"We":[0],"have":[1],"previously":[2],"shown":[3],"that":[4,29,48,88,132,149],"antibodies":[5],"to":[6],"CTLA-4,":[7],"an":[8,30,53],"inhibitory":[9],"receptor":[10],"on":[11],"T":[12],"cells,":[13],"can":[14,42,153],"be":[15,43],"effective":[16,31],"at":[17,62,137],"inducing":[18],"regression":[19],"of":[20,59,65,99,116,129,162,167],"transplantable":[21],"murine":[22],"tumors.":[23],"In":[24],"this":[25,120,150,163],"study,":[26],"we":[27],"demonstrate":[28,148],"immune":[32,134],"response":[33,135,158],"against":[34,142],"primary":[35],"prostate":[36,144,168],"tumors":[37],"in":[38,68,72,102,123,139],"transgenic":[39],"(TRAMP)":[40],"mice":[41,61,90,118],"elicited":[44],"using":[45],"a":[46,69,92,110,155],"strategy":[47],"combines":[49],"CTLA-4":[50],"blockade":[51],"and":[52,109,159],"irradiated":[54],"tumor":[55,73,94],"cell":[56],"vaccine.":[57,114],"Treatment":[58],"TRAMP":[60],"14":[63],"weeks":[64],"age":[66],"resulted":[67,122],"significant":[70,97],"reduction":[71],"incidence":[74],"(15%":[75],"versus":[76],"control,":[77],"75%),":[78],"as":[79],"assessed":[80],"2":[81],"months":[82],"after":[83],"treatment.":[84],"Histopathological":[85],"analysis":[86],"revealed":[87],"treated":[89,106],"had":[91],"lower":[93],"grade":[95],"with":[96,107,119],"accumulation":[98],"inflammatory":[100],"cells":[101],"interductal":[103],"spaces":[104],"when":[105],"anti-CTLA-4":[108],"granulocyte-macrophage":[111],"colony-stimulating":[112],"factor-expressing":[113],"Vaccination":[115],"nontransgenic":[117],"regimen":[121],"marked":[124],"prostatitis":[125],"accompanied":[126],"by":[127],"destruction":[128],"epithelium,":[130],"indicating":[131],"the":[133],"was,":[136],"least":[138],"part,":[140],"directed":[141],"normal":[143],"antigens.":[145],"These":[146],"findings":[147],"combinatorial":[151],"treatment":[152,166],"elicit":[154],"potent":[156],"antiprostate":[157],"suggest":[160],"potential":[161],"approach":[164],"for":[165],"cancer.":[169]},"counts_by_year":[{"year":2025,"cited_by_count":4},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":11},{"year":2022,"cited_by_count":7},{"year":2021,"cited_by_count":10},{"year":2020,"cited_by_count":14},{"year":2019,"cited_by_count":7},{"year":2018,"cited_by_count":10},{"year":2017,"cited_by_count":13},{"year":2016,"cited_by_count":9},{"year":2015,"cited_by_count":20},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":28},{"year":2012,"cited_by_count":15}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
