{"id":"https://openalex.org/W2102455002","doi":"https://doi.org/10.1111/j.1471-4159.1985.tb10558.x","title":"N\u2010Methyl\u20104\u2010Phenyl\u20101,2,3,6\u2010Tetrahydropyridine Increases Acetylcholine and Decreases Dopamine in Mouse Striatum: Both Responses Are Blocked by Anticholinergic Drugs","display_name":"N\u2010Methyl\u20104\u2010Phenyl\u20101,2,3,6\u2010Tetrahydropyridine Increases Acetylcholine and Decreases Dopamine in Mouse Striatum: Both Responses Are Blocked by Anticholinergic Drugs","publication_year":1985,"publication_date":"1985-12-01","ids":{"openalex":"https://openalex.org/W2102455002","doi":"https://doi.org/10.1111/j.1471-4159.1985.tb10558.x","mag":"2102455002","pmid":"https://pubmed.ncbi.nlm.nih.gov/3877147"},"language":"en","primary_location":{"id":"doi:10.1111/j.1471-4159.1985.tb10558.x","doi":"https://doi.org/10.1111/j.1471-4159.1985.tb10558.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1985.tb10558.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5112710104","display_name":"Maria Hadjiconstantinou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802104953","display_name":"St. Elizabeths Hospital","ror":"https://ror.org/022w03s59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802104953","https://openalex.org/I4210099492"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"M. Hadjiconstantinou","raw_affiliation_strings":["Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C., U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C., U.S.A","institution_ids":["https://openalex.org/I2802104953","https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063703256","display_name":"David Cavalla","orcid":"https://orcid.org/0000-0002-8652-9110","observed_orcids":["https://orcid.org/0000-0002-8652-9110"]},"institutions":[{"id":"https://openalex.org/I2802104953","display_name":"St. Elizabeths Hospital","ror":"https://ror.org/022w03s59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802104953","https://openalex.org/I4210099492"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D. Cavalla","raw_affiliation_strings":["Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C., U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C., U.S.A","institution_ids":["https://openalex.org/I2802104953","https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5051129331","display_name":"E. Anthoupoulou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802104953","display_name":"St. Elizabeths Hospital","ror":"https://ror.org/022w03s59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802104953","https://openalex.org/I4210099492"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"E. Anthoupoulou","raw_affiliation_strings":["Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C., U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C., U.S.A","institution_ids":["https://openalex.org/I2802104953","https://openalex.org/I4210158500"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110180507","display_name":"Hugh E. Laird","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802104953","display_name":"St. Elizabeths Hospital","ror":"https://ror.org/022w03s59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802104953","https://openalex.org/I4210099492"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"H. E. Laird","raw_affiliation_strings":["Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C., U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C., U.S.A","institution_ids":["https://openalex.org/I2802104953","https://openalex.org/I4210158500"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5111447017","display_name":"Norton H. Neff","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2802104953","display_name":"St. Elizabeths Hospital","ror":"https://ror.org/022w03s59","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802104953","https://openalex.org/I4210099492"]},{"id":"https://openalex.org/I4210158500","display_name":"National Institute of Mental Health","ror":"https://ror.org/04xeg9z08","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210158500"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"N. H. Neff","raw_affiliation_strings":["Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C., U.S.A"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Preclinical Pharmacology, National Institute of Mental Health, Saint Elizabeths Hospital, Washington, D.C., U.S.A","institution_ids":["https://openalex.org/I2802104953","https://openalex.org/I4210158500"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5111447017"],"corresponding_institution_ids":["https://openalex.org/I2802104953","https://openalex.org/I4210158500"],"apc_list":{"value":5330,"currency":"USD","value_usd":5330},"apc_paid":null,"fwci":1.4178,"has_fulltext":false,"cited_by_count":14,"citation_normalized_percentile":{"value":0.83076589,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"45","issue":"6","first_page":"1957","last_page":"1959"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10056","display_name":"Neurotransmitter Receptor Influence on Behavior","score":0.0015999999595806003,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mptp-neurotoxicity","display_name":"MPTP-induced neurotoxicity","score":0.9330000281333923},{"id":"https://openalex.org/keywords/parkinsonism","display_name":"parkinsonism","score":0.6579999923706055},{"id":"https://openalex.org/keywords/dopamine-depletion","display_name":"dopamine depletion","score":0.8109999895095825},{"id":"https://openalex.org/keywords/acetylcholine","display_name":"acetylcholine","score":0.9599999785423279},{"id":"https://openalex.org/keywords/neostriatum","display_name":"neostriatum","score":0.9259999990463257},{"id":"https://openalex.org/keywords/atropine","display_name":"atropine","score":0.9110000133514404},{"id":"https://openalex.org/keywords/trihexyphenidyl","display_name":"trihexyphenidyl","score":0.9990000128746033},{"id":"https://openalex.org/keywords/anticholinergic-drugs","display_name":"anticholinergic agents","score":0.9409999847412109}],"concepts":[{"id":"https://openalex.org/C2778674702","wikidata":"https://www.wikidata.org/wiki/Q239816","display_name":"MPTP","level":4,"score":0.9215388894081116},{"id":"https://openalex.org/C513476851","wikidata":"https://www.wikidata.org/wiki/Q170304","display_name":"Dopamine","level":2,"score":0.7705363035202026},{"id":"https://openalex.org/C2780358027","wikidata":"https://www.wikidata.org/wiki/Q407752","display_name":"Neurotoxin","level":2,"score":0.6869527697563171},{"id":"https://openalex.org/C2776525014","wikidata":"https://www.wikidata.org/wiki/Q1531991","display_name":"Parkinsonism","level":3,"score":0.6681079864501953},{"id":"https://openalex.org/C2775910092","wikidata":"https://www.wikidata.org/wiki/Q180623","display_name":"Acetylcholine","level":2,"score":0.6666027307510376},{"id":"https://openalex.org/C2779406339","wikidata":"https://www.wikidata.org/wiki/Q2991856","display_name":"Trihexyphenidyl","level":2,"score":0.5745195150375366},{"id":"https://openalex.org/C2775859210","wikidata":"https://www.wikidata.org/wiki/Q26272","display_name":"Atropine","level":2,"score":0.49466201663017273},{"id":"https://openalex.org/C2780062018","wikidata":"https://www.wikidata.org/wiki/Q1319792","display_name":"Striatum","level":3,"score":0.4916020333766937},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48281630873680115},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4732808768749237},{"id":"https://openalex.org/C2778689640","wikidata":"https://www.wikidata.org/wiki/Q113259","display_name":"Anticholinergic","level":2,"score":0.447269082069397},{"id":"https://openalex.org/C2910393698","wikidata":"https://www.wikidata.org/wiki/Q415026","display_name":"Benztropine","level":3,"score":0.44399380683898926},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.42381057143211365},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.401146799325943},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3679395914077759},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3104483485221863},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2642717957496643},{"id":"https://openalex.org/C137183658","wikidata":"https://www.wikidata.org/wiki/Q461076","display_name":"Dopaminergic","level":3,"score":0.24369394779205322},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001285","descriptor_name":"Atropine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D003342","descriptor_name":"Corpus Striatum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D004298","descriptor_name":"Dopamine","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010276","descriptor_name":"Parasympatholytics","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D011725","descriptor_name":"Pyridines","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D014282","descriptor_name":"Trihexyphenidyl","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015632","descriptor_name":"1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1111/j.1471-4159.1985.tb10558.x","doi":"https://doi.org/10.1111/j.1471-4159.1985.tb10558.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1471-4159.1985.tb10558.x","pdf_url":null,"source":{"id":"https://openalex.org/S135837084","display_name":"Journal of Neurochemistry","issn_l":"0022-3042","issn":["0022-3042","1471-4159"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neurochemistry","raw_type":"journal-article"},{"id":"pmid:3877147","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/3877147","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neurochemistry","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":14,"referenced_works":["https://openalex.org/W1969800514","https://openalex.org/W1973811050","https://openalex.org/W2005102504","https://openalex.org/W2006230427","https://openalex.org/W2018998508","https://openalex.org/W2023211111","https://openalex.org/W2041734419","https://openalex.org/W2047629945","https://openalex.org/W2062704464","https://openalex.org/W2064501458","https://openalex.org/W2070849668","https://openalex.org/W2115044619","https://openalex.org/W2152929301","https://openalex.org/W2169622817"],"related_works":["https://openalex.org/W2053798182","https://openalex.org/W1981232750","https://openalex.org/W1966244573","https://openalex.org/W2027303088","https://openalex.org/W2052899919","https://openalex.org/W2015698319","https://openalex.org/W2491315885","https://openalex.org/W2049604574","https://openalex.org/W1984061110","https://openalex.org/W2069051213"],"abstract_inverted_index":{"The":[0],"neurotoxin":[1],"N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine":[2],"(MPTP)":[3],"produces":[4],"neuropathology":[5],"and":[6,14,40],"clinical":[7],"symptoms":[8],"that":[9,33],"resemble":[10],"Parkinsonism":[11],"in":[12,45],"primates":[13],"humans.":[15],"In":[16],"mice":[17],"it":[18],"induces":[19,35],"a":[20,36,41],"long-lasting":[21],"depletion":[22],"of":[23,38,43],"neostriatal":[24],"3,4-dihydroxyphenylethylamine":[25],"(dopamine)":[26],"content.":[27],"Using":[28],"the":[29,46],"mouse,":[30],"we":[31],"found":[32],"MPTP":[34,51],"fall":[37],"dopamine":[39],"rise":[42],"acetylcholine":[44],"neostriatum.":[47],"Both":[48],"responses":[49],"to":[50],"can":[52],"be":[53],"blocked":[54],"by":[55],"prior":[56],"treatment":[57],"with":[58],"atropine":[59],"or":[60],"trihexyphenidyl.":[61]},"counts_by_year":[],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
