{"id":"https://openalex.org/W2102439908","doi":"https://doi.org/10.1093/bioinformatics/btu059","title":"Induction of T-cell memory by a dendritic cell vaccine: a computational model","display_name":"Induction of T-cell memory by a dendritic cell vaccine: a computational model","publication_year":2014,"publication_date":"2014-03-06","ids":{"openalex":"https://openalex.org/W2102439908","doi":"https://doi.org/10.1093/bioinformatics/btu059","mag":"2102439908","pmid":"https://pubmed.ncbi.nlm.nih.gov/24603984"},"language":"en","primary_location":{"id":"doi:10.1093/bioinformatics/btu059","doi":"https://doi.org/10.1093/bioinformatics/btu059","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu059","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","ccf-a","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://re.public.polimi.it/bitstream/11311/787321/1/PAPPF01-14.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5044340074","display_name":"Francesco Pappalardo","orcid":"https://orcid.org/0000-0003-1668-3320","observed_orcids":["https://orcid.org/0000-0003-1668-3320"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Pappalardo","raw_affiliation_strings":["1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy","institution_ids":["https://openalex.org/I154387261","https://openalex.org/I39063666","https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003874484","display_name":"Marzio Alfio Pennisi","orcid":"https://orcid.org/0000-0003-0231-7653","observed_orcids":["https://orcid.org/0000-0003-0231-7653"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Marzio Pennisi","raw_affiliation_strings":["1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy","institution_ids":["https://openalex.org/I154387261","https://openalex.org/I39063666","https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068703055","display_name":"Alessia Ricupito","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessia Ricupito","raw_affiliation_strings":["1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy","institution_ids":["https://openalex.org/I154387261","https://openalex.org/I39063666","https://openalex.org/I93860229"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036488441","display_name":"Francesco Topputo","orcid":"https://orcid.org/0000-0002-5369-6887","observed_orcids":["https://orcid.org/0000-0002-5369-6887"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Francesco Topputo","raw_affiliation_strings":["1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy","institution_ids":["https://openalex.org/I154387261","https://openalex.org/I39063666","https://openalex.org/I93860229"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5020944852","display_name":"Matteo Bellone","orcid":"https://orcid.org/0000-0002-2586-2569","observed_orcids":["https://orcid.org/0000-0002-2586-2569"]},"institutions":[{"id":"https://openalex.org/I154387261","display_name":"Vita-Salute San Raffaele University","ror":"https://ror.org/01gmqr298","country_code":"IT","type":"education","lineage":["https://openalex.org/I154387261"]},{"id":"https://openalex.org/I39063666","display_name":"University of Catania","ror":"https://ror.org/03a64bh57","country_code":"IT","type":"education","lineage":["https://openalex.org/I39063666"]},{"id":"https://openalex.org/I93860229","display_name":"Politecnico di Milano","ror":"https://ror.org/01nffqt88","country_code":"IT","type":"education","lineage":["https://openalex.org/I93860229"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Matteo Bellone","raw_affiliation_strings":["1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"1 Department of Drug Science and 2Department of Mathematics and Computer Science, University of Catania, 95125 Catania, 3San Raffaele Scientific Institute and Universit\u00e0 Vita Salute San Raffaele, 20132 Milan, 4Politecnico di Milano, 20133 Milano and 5San Raffaele Scientific Institute, 20132 Milan, Italy","institution_ids":["https://openalex.org/I154387261","https://openalex.org/I39063666","https://openalex.org/I93860229"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3989,"currency":"USD","value_usd":3989},"apc_paid":null,"fwci":2.8915,"has_fulltext":true,"cited_by_count":41,"citation_normalized_percentile":{"value":0.91318782,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":90,"max":99},"biblio":{"volume":"30","issue":"13","first_page":"1884","last_page":"1891"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.9907000064849854,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.007400000002235174,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13410","display_name":"Immune responses and vaccinations","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/dendritic-cell-vaccine","display_name":"dendritic cell vaccine","score":0.8759999871253967},{"id":"https://openalex.org/keywords/t-cell-memory","display_name":"T cell memory","score":0.8159999847412109},{"id":"https://openalex.org/keywords/memory-t-cells","display_name":"memory T cells","score":0.7910000085830688},{"id":"https://openalex.org/keywords/cytotoxic-t-lymphocytes","display_name":"cytotoxic T lymphocytes","score":0.902999997138977},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.7519999742507935},{"id":"https://openalex.org/keywords/prime-boost-vaccination","display_name":"prime-boost vaccination","score":0.7049999833106995},{"id":"https://openalex.org/keywords/ordinary-differential-equation-model","display_name":"ordinary differential equation model","score":0.7879999876022339},{"id":"https://openalex.org/keywords/tumor-antigens","display_name":"tumor antigens","score":0.44200000166893005},{"id":"https://openalex.org/keywords/mathematical-modeling-of-immune-response","display_name":"mathematical modeling of immune response","score":0.5600000023841858},{"id":"https://openalex.org/keywords/wild-type-mice","display_name":"wild-type mice","score":0.5740000009536743}],"concepts":[{"id":"https://openalex.org/C154317977","wikidata":"https://www.wikidata.org/wiki/Q376266","display_name":"Cytotoxic T cell","level":3,"score":0.6339743137359619},{"id":"https://openalex.org/C2779343474","wikidata":"https://www.wikidata.org/wiki/Q3109175","display_name":"Context (archaeology)","level":2,"score":0.631117045879364},{"id":"https://openalex.org/C2775905019","wikidata":"https://www.wikidata.org/wiki/Q192572","display_name":"In silico","level":3,"score":0.5685802698135376},{"id":"https://openalex.org/C46686674","wikidata":"https://www.wikidata.org/wiki/Q466303","display_name":"Boosting (machine learning)","level":2,"score":0.529998242855072},{"id":"https://openalex.org/C22070199","wikidata":"https://www.wikidata.org/wiki/Q192995","display_name":"Vaccination","level":2,"score":0.5149096250534058},{"id":"https://openalex.org/C147483822","wikidata":"https://www.wikidata.org/wiki/Q103537","display_name":"Antigen","level":2,"score":0.4826505780220032},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.46815991401672363},{"id":"https://openalex.org/C2778170410","wikidata":"https://www.wikidata.org/wiki/Q506253","display_name":"Dendritic cell","level":3,"score":0.46185553073883057},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.45592784881591797},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4304938316345215},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.385574609041214},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.3625979721546173},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2900862693786621},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.21352961659431458},{"id":"https://openalex.org/C119857082","wikidata":"https://www.wikidata.org/wiki/Q2539","display_name":"Machine learning","level":1,"score":0.13915035128593445},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.07726296782493591},{"id":"https://openalex.org/C151730666","wikidata":"https://www.wikidata.org/wiki/Q7205","display_name":"Paleontology","level":1,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000941","descriptor_name":"Antigens","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D003713","descriptor_name":"Dendritic Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D007156","descriptor_name":"Immunologic Memory","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014612","descriptor_name":"Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019496","descriptor_name":"Cancer Vaccines","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1093/bioinformatics/btu059","doi":"https://doi.org/10.1093/bioinformatics/btu059","is_oa":false,"landing_page_url":"https://doi.org/10.1093/bioinformatics/btu059","pdf_url":null,"source":{"id":"https://openalex.org/S52395412","display_name":"Bioinformatics","issn_l":"1367-4803","issn":["1367-4803","1367-4811"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["abdc-a","anvur-class-a","anvur-scientific","ccf-a","cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics","raw_type":"journal-article"},{"id":"pmid:24603984","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24603984","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bioinformatics (Oxford, England)","raw_type":"Journal Article"},{"id":"pmh:oai:re.public.polimi.it:11311/787321","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11311/787321","pdf_url":"https://re.public.polimi.it/bitstream/11311/787321/1/PAPPF01-14.pdf","source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"pmh:oai:re.public.polimi.it:11311/787321","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/11311/787321","pdf_url":"https://re.public.polimi.it/bitstream/11311/787321/1/PAPPF01-14.pdf","source":{"id":"https://openalex.org/S4306400312","display_name":"Virtual Community of Pathological Anatomy (University of Castilla La Mancha)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I79189158","host_organization_name":"University of Castilla-La Mancha","host_organization_lineage":["https://openalex.org/I79189158"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.8048999905586243}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1008820181","display_name":null,"funder_award_id":"PRIN 2009","funder_id":"https://openalex.org/F4320323054","funder_display_name":"Associazione Italiana per la Ricerca sul Cancro"}],"funders":[{"id":"https://openalex.org/F4320323054","display_name":"Associazione Italiana per la Ricerca sul Cancro","ror":"https://ror.org/02g2x7380"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2102439908.pdf","grobid_xml":"https://content.openalex.org/works/W2102439908.grobid-xml"},"referenced_works_count":51,"referenced_works":["https://openalex.org/W124478246","https://openalex.org/W1507160172","https://openalex.org/W1515234451","https://openalex.org/W1583482357","https://openalex.org/W1661544713","https://openalex.org/W1971201122","https://openalex.org/W1973291618","https://openalex.org/W1975655284","https://openalex.org/W1977489896","https://openalex.org/W1988136067","https://openalex.org/W1988620205","https://openalex.org/W1995062641","https://openalex.org/W1998319032","https://openalex.org/W2002069581","https://openalex.org/W2007186471","https://openalex.org/W2013167047","https://openalex.org/W2028633108","https://openalex.org/W2034810751","https://openalex.org/W2038669746","https://openalex.org/W2041691264","https://openalex.org/W2043514557","https://openalex.org/W2049491375","https://openalex.org/W2054822772","https://openalex.org/W2058158581","https://openalex.org/W2079604837","https://openalex.org/W2083052382","https://openalex.org/W2096866753","https://openalex.org/W2102264469","https://openalex.org/W2102742832","https://openalex.org/W2103959341","https://openalex.org/W2105218945","https://openalex.org/W2109963121","https://openalex.org/W2110518406","https://openalex.org/W2111733722","https://openalex.org/W2119896120","https://openalex.org/W2128112344","https://openalex.org/W2129046400","https://openalex.org/W2130815390","https://openalex.org/W2135360970","https://openalex.org/W2135899333","https://openalex.org/W2142715392","https://openalex.org/W2143853304","https://openalex.org/W2145494207","https://openalex.org/W2147763277","https://openalex.org/W2152803686","https://openalex.org/W2162742070","https://openalex.org/W2170904230","https://openalex.org/W3011730451","https://openalex.org/W4255758041","https://openalex.org/W4285719527","https://openalex.org/W6630369749"],"related_works":["https://openalex.org/W3100486985","https://openalex.org/W2060530677","https://openalex.org/W2947662066","https://openalex.org/W4210722327","https://openalex.org/W2043512609","https://openalex.org/W2035588631","https://openalex.org/W2113304724","https://openalex.org/W93859680","https://openalex.org/W2088178465","https://openalex.org/W2361509172"],"abstract_inverted_index":{"MOTIVATION:":[0],"Although":[1],"results":[2,139],"from":[3],"phase":[4],"III":[5],"clinical":[6],"trials":[7],"substantially":[8,176],"support":[9],"the":[10,54,103,109,123,128,132,150,156,192],"use":[11],"of":[12,56,61,105,111,134,140,160,181],"prophylactic":[13],"and":[14,28,38,63,67,97,101,130,143,158,175],"therapeutic":[15],"vaccines":[16],"against":[17,43],"cancer,":[18],"what":[19],"has":[20],"yet":[21],"to":[22,34,74,154,170],"be":[23,168],"defined":[24],"is":[25,48,152,188],"how":[26,29],"many":[27],"frequent":[30],"boosts":[31],"are":[32,64],"needed":[33],"sustain":[35],"a":[36,57,71,116],"long-lasting":[37],"protecting":[39],"memory":[40,98,107,135,162],"T-cell":[41],"response":[42],"tumor":[44],"antigens.":[45],"Common":[46],"experience":[47],"that":[49,86,149],"such":[50],"preclinical":[51],"tests":[52],"require":[53],"sacrifice":[55],"relatively":[58],"large":[59],"number":[60],"animals,":[62],"particularly":[65],"time-":[66],"money-consuming.":[68],"RESULTS:":[69],"As":[70],"first":[72],"step":[73],"overcome":[75],"these":[76],"hurdles,":[77],"we":[78,147],"have":[79,121],"developed":[80],"an":[81],"ordinary":[82],"differential":[83],"equation":[84],"model":[85,151,166,187],"includes":[87],"all":[88],"relevant":[89],"entities":[90],"(such":[91],"as":[92],"activated":[93],"cytotoxic":[94],"T":[95,99,136,163],"lymphocytes":[96],"cells),":[100],"investigated":[102],"induction":[104],"immunological":[106],"in":[108,127,131,144,177,191],"context":[110],"wild-type":[112],"mice":[113],"injected":[114],"with":[115],"dendritic":[117],"cell-based":[118],"vaccine.":[119],"We":[120],"simulated":[122],"biological":[124,179],"behavior":[125],"both":[126],"presence":[129],"absence":[133],"cells.":[137,164],"Comparing":[138],"ex":[141],"vivo":[142],"silico":[145],"experiments,":[146],"show":[148],"able":[153],"envisage":[155],"expansion":[157],"persistence":[159],"antigen-specific":[161],"The":[165,186],"might":[167],"applicable":[169],"more":[171],"complex":[172],"vaccination":[173],"schedules":[174],"any":[178],"condition":[180],"prime-boosting.":[182],"AVAILABILITY":[183],"AND":[184],"IMPLEMENTATION:":[185],"fully":[189],"described":[190],"article.":[193]},"counts_by_year":[{"year":2025,"cited_by_count":1},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":5},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":4},{"year":2015,"cited_by_count":5},{"year":2014,"cited_by_count":5}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}