{"id":"https://openalex.org/W2102380087","doi":"https://doi.org/10.1073/pnas.92.2.407","title":"Systemin activates synthesis of wound-inducible tomato leaf polyphenol oxidase via the octadecanoid defense signaling pathway.","display_name":"Systemin activates synthesis of wound-inducible tomato leaf polyphenol oxidase via the octadecanoid defense signaling pathway.","publication_year":1995,"publication_date":"1995-01-17","ids":{"openalex":"https://openalex.org/W2102380087","doi":"https://doi.org/10.1073/pnas.92.2.407","mag":"2102380087","pmid":"https://pubmed.ncbi.nlm.nih.gov/7831300","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/42749"},"language":"en","primary_location":{"id":"doi:10.1073/pnas.92.2.407","doi":"https://doi.org/10.1073/pnas.92.2.407","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.92.2.407","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC42749/","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085689588","display_name":"C. Peter Constabel","orcid":"https://orcid.org/0000-0002-7627-7597","observed_orcids":["https://orcid.org/0000-0002-7627-7597"]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C P Constabel","raw_affiliation_strings":["Institute of Biological Chemistry, Washington State University, Pullman 99164-6340"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Chemistry, Washington State University, Pullman 99164-6340","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108374159","display_name":"Daniel R. Bergey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D R Bergey","raw_affiliation_strings":["Institute of Biological Chemistry, Washington State University, Pullman 99164-6340"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Chemistry, Washington State University, Pullman 99164-6340","institution_ids":["https://openalex.org/I72951846"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5108398931","display_name":"Clarence A. Ryan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I72951846","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17","country_code":"US","type":"education","lineage":["https://openalex.org/I72951846"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C A Ryan","raw_affiliation_strings":["Institute of Biological Chemistry, Washington State University, Pullman 99164-6340"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Biological Chemistry, Washington State University, Pullman 99164-6340","institution_ids":["https://openalex.org/I72951846"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I72951846"],"apc_list":null,"apc_paid":null,"fwci":26.5019,"has_fulltext":false,"cited_by_count":348,"citation_normalized_percentile":{"value":0.9983198,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":95,"max":100},"biblio":{"volume":"92","issue":"2","first_page":"407","last_page":"411"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10135","display_name":"Insect-Plant Interactions and Control","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10135","display_name":"Insect-Plant Interactions and Control","score":0.9032999873161316,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10076","display_name":"Plant-Microbe Interactions and Immunity","score":0.06759999692440033,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10014","display_name":"Plant Stress Responses and Tolerance","score":0.013199999928474426,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/systemin","display_name":"systemin","score":0.9959999918937683},{"id":"https://openalex.org/keywords/polyphenol-oxidase","display_name":"polyphenol oxidase","score":0.9399999976158142},{"id":"https://openalex.org/keywords/tomato","display_name":"tomato","score":0.6389999985694885},{"id":"https://openalex.org/keywords/protease-inhibitors","display_name":"protease inhibitors","score":0.7289999723434448},{"id":"https://openalex.org/keywords/methyl-jasmonate","display_name":"methyl jasmonate","score":0.9350000023841858},{"id":"https://openalex.org/keywords/wound-signaling","display_name":"wound signaling","score":0.5509999990463257},{"id":"https://openalex.org/keywords/genetically-modified-plants","display_name":"transgenic plants","score":0.5410000085830688},{"id":"https://openalex.org/keywords/plant-defense-gene-expression","display_name":"plant defense gene expression","score":0.5590000152587891}],"concepts":[{"id":"https://openalex.org/C2777942875","wikidata":"https://www.wikidata.org/wiki/Q26840883","display_name":"Methyl jasmonate","level":3,"score":0.8362486958503723},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5694030523300171},{"id":"https://openalex.org/C2776338311","wikidata":"https://www.wikidata.org/wiki/Q904493","display_name":"Polyphenol oxidase","level":4,"score":0.5348773002624512},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.532876193523407},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5319086909294128},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.511513352394104},{"id":"https://openalex.org/C122172344","wikidata":"https://www.wikidata.org/wiki/Q1503477","display_name":"Genetically modified crops","level":4,"score":0.5042678117752075},{"id":"https://openalex.org/C70899900","wikidata":"https://www.wikidata.org/wiki/Q290439","display_name":"Polyphenol","level":3,"score":0.4834795594215393},{"id":"https://openalex.org/C2779719074","wikidata":"https://www.wikidata.org/wiki/Q2038057","display_name":"NADPH oxidase","level":3,"score":0.4220781922340393},{"id":"https://openalex.org/C183570298","wikidata":"https://www.wikidata.org/wiki/Q2004252","display_name":"Plant defense against herbivory","level":3,"score":0.4217032194137573},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.38813596963882446},{"id":"https://openalex.org/C59822182","wikidata":"https://www.wikidata.org/wiki/Q441","display_name":"Botany","level":1,"score":0.3494080901145935},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.30258968472480774},{"id":"https://openalex.org/C2778004101","wikidata":"https://www.wikidata.org/wiki/Q133948","display_name":"Antioxidant","level":2,"score":0.1293656826019287},{"id":"https://openalex.org/C162008176","wikidata":"https://www.wikidata.org/wiki/Q419305","display_name":"Peroxidase","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000085","descriptor_name":"Acetates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000595","descriptor_name":"Amino Acid Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003517","descriptor_name":"Cyclopentanes","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004156","descriptor_name":"Catechol Oxidase","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D004156","descriptor_name":"Catechol Oxidase","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D004790","descriptor_name":"Enzyme Induction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008969","descriptor_name":"Molecular Sequence Data","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010450","descriptor_name":"Endopeptidases","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010940","descriptor_name":"Plant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015180","descriptor_name":"Electrophoresis, Gel, Two-Dimensional","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017421","descriptor_name":"Sequence Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018506","descriptor_name":"Gene Expression Regulation, Plant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018515","descriptor_name":"Plant Leaves","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D018551","descriptor_name":"Solanum lycopersicum","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D018551","descriptor_name":"Solanum lycopersicum","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":false},{"descriptor_ui":"D018551","descriptor_name":"Solanum lycopersicum","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018551","descriptor_name":"Solanum lycopersicum","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D030821","descriptor_name":"Plants, Genetically Modified","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054883","descriptor_name":"Oxylipins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1073/pnas.92.2.407","doi":"https://doi.org/10.1073/pnas.92.2.407","is_oa":false,"landing_page_url":"https://doi.org/10.1073/pnas.92.2.407","pdf_url":null,"source":{"id":"https://openalex.org/S125754415","display_name":"Proceedings of the National Academy of Sciences","issn_l":"0027-8424","issn":["0027-8424","1091-6490"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320052","host_organization_name":"National Academy of Sciences","host_organization_lineage":["https://openalex.org/P4310320052"],"host_organization_lineage_names":["National Academy of Sciences"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences","raw_type":"journal-article"},{"id":"pmid:7831300","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7831300","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proceedings of the National Academy of Sciences of the United States of America","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:42749","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC42749/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:42749","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC42749/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Proc Natl Acad Sci U S A","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Zero hunger","score":0.5666999816894531,"id":"https://metadata.un.org/sdg/2"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G5966910708","display_name":"Signal Transduction Pathways for Inducible Plant            Defense Genes","funder_award_id":"9117795","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320309913","display_name":"Washington State University","ror":"https://ror.org/05dk0ce17"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":27,"referenced_works":["https://openalex.org/W271849597","https://openalex.org/W1514322339","https://openalex.org/W1606423922","https://openalex.org/W1968127259","https://openalex.org/W1969631672","https://openalex.org/W1973107494","https://openalex.org/W1980948432","https://openalex.org/W1994654612","https://openalex.org/W1998251412","https://openalex.org/W2018289835","https://openalex.org/W2028186704","https://openalex.org/W2043263321","https://openalex.org/W2045002759","https://openalex.org/W2053277124","https://openalex.org/W2061765768","https://openalex.org/W2064271701","https://openalex.org/W2074084429","https://openalex.org/W2087151511","https://openalex.org/W2092314167","https://openalex.org/W2100837269","https://openalex.org/W2119460480","https://openalex.org/W2122405943","https://openalex.org/W2128635872","https://openalex.org/W2131507553","https://openalex.org/W2132886964","https://openalex.org/W2151317882","https://openalex.org/W2162955775"],"related_works":["https://openalex.org/W1982034942","https://openalex.org/W2028046404","https://openalex.org/W2128464956","https://openalex.org/W2409010201","https://openalex.org/W2164911887","https://openalex.org/W2467593680","https://openalex.org/W2137069161","https://openalex.org/W2051816481","https://openalex.org/W2074084429","https://openalex.org/W1585368899"],"abstract_inverted_index":{"Tomato":[0],"plants":[1,48,79,97,118,134],"overexpressing":[2,135],"a":[3,11,163],"prosystemin":[4,137],"gene":[5],"that":[6,43,61,142,160],"encodes":[7],"the":[8,36,136,154],"precursor":[9],"of":[10,27,38,45,52,72,94],"mobile":[12],"wound":[13],"signal":[14,156],"called":[15],"systemin":[16,81,161],"have":[17],"been":[18],"shown":[19],"previously":[20,174],"to":[21,64,107,110,119,130],"constitutively":[22],"synthesize":[23],"extraordinarily":[24],"high":[25],"levels":[26,51,60,68,108,131],"two":[28],"defensive":[29,54,170],"proteinase":[30,145],"inhibitor":[31,146],"proteins":[32],"in":[33,35,70,88,101,126,133,167],"leaves":[34,44,71,93,106],"absence":[37],"wounding.":[39],"We":[40],"herein":[41],"report":[42],"these":[46],"transgenic":[47],"possess":[49],"enhanced":[50],"another":[53],"protein,":[55],"polyphenol":[56],"oxidase":[57],"(PPO)":[58],"at":[59],"are":[62,148],"up":[63],"70-fold":[65],"higher":[66],"than":[67,172],"found":[69,132],"wild-type":[73,77],"plants.":[74],"Supplying":[75],"young":[76,95,116],"tomato":[78,96,117],"with":[80],"through":[82],"cut":[83],"stems":[84],"induced":[85,98,112],"PPO":[86,99,127,143],"activity":[87,100,128],"leaves,":[89],"and":[90,104,144,159],"wounding":[91,152],"lower":[92],"both":[102],"wounded":[103],"unwounded":[105],"equal":[109],"those":[111],"by":[113,151],"systemin.":[114],"Exposing":[115],"methyl":[120],"jasmonate":[121],"vapor":[122],"caused":[123],"an":[124],"increase":[125],"equivalent":[129],"gene.":[138],"The":[139],"data":[140],"indicate":[141],"genes":[147,171],"coactivated":[149],"systemically":[150],"via":[153],"octadecanoid":[155],"transduction":[157],"pathway":[158],"has":[162],"much":[164],"broader":[165],"role":[166],"signaling":[168],"plant":[169],"was":[173],"known.":[175]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":12},{"year":2021,"cited_by_count":5},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":8},{"year":2018,"cited_by_count":12},{"year":2017,"cited_by_count":14},{"year":2016,"cited_by_count":15},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":19},{"year":2013,"cited_by_count":15},{"year":2012,"cited_by_count":8}],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2016-06-24T00:00:00"}