{"id":"https://openalex.org/W2102308089","doi":"https://doi.org/10.1517/13543784.10.7.1291","title":"Therapeutic potential of endothelin receptor antagonists and nitric oxide donors in pulmonary hypertension","display_name":"Therapeutic potential of endothelin receptor antagonists and nitric oxide donors in pulmonary hypertension","publication_year":2001,"publication_date":"2001-07-01","ids":{"openalex":"https://openalex.org/W2102308089","doi":"https://doi.org/10.1517/13543784.10.7.1291","mag":"2102308089","pmid":"https://pubmed.ncbi.nlm.nih.gov/11772252"},"language":"en","primary_location":{"id":"doi:10.1517/13543784.10.7.1291","doi":"https://doi.org/10.1517/13543784.10.7.1291","is_oa":false,"landing_page_url":"https://doi.org/10.1517/13543784.10.7.1291","pdf_url":null,"source":{"id":"https://openalex.org/S131064935","display_name":"Expert Opinion on Investigational Drugs","issn_l":"1354-3784","issn":["1354-3784","1744-7658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Investigational Drugs","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5068799586","display_name":"Ronald G. Tilton","orcid":"https://orcid.org/0000-0001-5109-4164","observed_orcids":["https://orcid.org/0000-0001-5109-4164"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ronald G Tilton","raw_affiliation_strings":["Department of Pharmacology, Texas Biotechnology Corporation, Houston, Texas, TX 77030, USA. rtilton@tbc.com","Department of Pharmacology, Texas Biotechnology Corporation, Houston, Texas, TX 77030, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Texas Biotechnology Corporation, Houston, Texas, TX 77030, USA. rtilton@tbc.com","institution_ids":[]},{"raw_affiliation_string":"Department of Pharmacology, Texas Biotechnology Corporation, Houston, Texas, TX 77030, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109813561","display_name":"Tommy A. Brock","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tommy A Brock","raw_affiliation_strings":["Encysive Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Encysive Pharmaceuticals","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5060164161","display_name":"Richard A. F. Dixon","orcid":"https://orcid.org/0000-0002-8138-7256","observed_orcids":["https://orcid.org/0000-0002-8138-7256"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Richard AF Dixon","raw_affiliation_strings":["Encysive Pharmaceuticals"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Encysive Pharmaceuticals","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.8594,"has_fulltext":false,"cited_by_count":20,"citation_normalized_percentile":{"value":0.63657957,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":94},"biblio":{"volume":"10","issue":"7","first_page":"1291","last_page":"1308"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10728","display_name":"Pulmonary Hypertension Research and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12199","display_name":"Vascular Anomalies and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10155","display_name":"Nitric Oxide and Endothelin Effects","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pulmonary-hypertension","display_name":"pulmonary hypertension","score":0.9919999837875366},{"id":"https://openalex.org/keywords/endothelin-receptor-antagonists","display_name":"endothelin receptor antagonists","score":1.0},{"id":"https://openalex.org/keywords/nitric-oxide-donors","display_name":"nitric oxide donors","score":0.9940000176429749},{"id":"https://openalex.org/keywords/vasodilators","display_name":"vasodilators","score":0.8009999990463257},{"id":"https://openalex.org/keywords/pulmonary-vascular-resistance","display_name":"pulmonary vascular resistance","score":0.7300000190734863},{"id":"https://openalex.org/keywords/right-heart-failure","display_name":"right heart failure","score":0.6570000052452087},{"id":"https://openalex.org/keywords/prostacyclin-analogues","display_name":"prostacyclin analogues","score":0.7059999704360962},{"id":"https://openalex.org/keywords/calcium-channel-blockers","display_name":"calcium channel blockers","score":0.8889999985694885},{"id":"https://openalex.org/keywords/inhaled-nitric-oxide","display_name":"inhaled nitric oxide","score":0.8759999871253967},{"id":"https://openalex.org/keywords/drug-development","display_name":"drug development","score":0.5460000038146973},{"id":"https://openalex.org/keywords/systemic-sclerosis","display_name":"systemic sclerosis","score":0.8830000162124634},{"id":"https://openalex.org/keywords/chronic-obstructive-pulmonary-disease","display_name":"chronic obstructive pulmonary disease","score":0.6449999809265137},{"id":"https://openalex.org/keywords/mitral-stenosis","display_name":"mitral stenosis","score":0.8220000267028809}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8775172233581543},{"id":"https://openalex.org/C2780930700","wikidata":"https://www.wikidata.org/wiki/Q1128595","display_name":"Pulmonary hypertension","level":2,"score":0.8513699173927307},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.6466376185417175},{"id":"https://openalex.org/C58245268","wikidata":"https://www.wikidata.org/wiki/Q456026","display_name":"Vascular resistance","level":3,"score":0.6300647258758545},{"id":"https://openalex.org/C2778198053","wikidata":"https://www.wikidata.org/wiki/Q181754","display_name":"Heart failure","level":2,"score":0.5658810138702393},{"id":"https://openalex.org/C519581460","wikidata":"https://www.wikidata.org/wiki/Q207843","display_name":"Nitric oxide","level":2,"score":0.5606656670570374},{"id":"https://openalex.org/C2781109936","wikidata":"https://www.wikidata.org/wiki/Q419769","display_name":"Bosentan","level":4,"score":0.5605693459510803},{"id":"https://openalex.org/C120770815","wikidata":"https://www.wikidata.org/wiki/Q14859627","display_name":"Vasodilation","level":2,"score":0.5250739455223083},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5247842669487},{"id":"https://openalex.org/C57190642","wikidata":"https://www.wikidata.org/wiki/Q7144839","display_name":"Pathophysiology of hypertension","level":3,"score":0.5131076574325562},{"id":"https://openalex.org/C2781128415","wikidata":"https://www.wikidata.org/wiki/Q412050","display_name":"Prostacyclin","level":2,"score":0.4555172026157379},{"id":"https://openalex.org/C144980905","wikidata":"https://www.wikidata.org/wiki/Q24721308","display_name":"Endothelin receptor","level":3,"score":0.3476560711860657},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.31404995918273926},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2721841335296631},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.06684422492980957}],"mesh":[{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000959","descriptor_name":"Antihypertensive Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":false},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D006976","descriptor_name":"Hypertension, Pulmonary","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009569","descriptor_name":"Nitric Oxide","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016896","descriptor_name":"Treatment Outcome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019332","descriptor_name":"Endothelin-1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020030","descriptor_name":"Nitric Oxide Donors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D020030","descriptor_name":"Nitric Oxide Donors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D065128","descriptor_name":"Endothelin Receptor Antagonists","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1517/13543784.10.7.1291","doi":"https://doi.org/10.1517/13543784.10.7.1291","is_oa":false,"landing_page_url":"https://doi.org/10.1517/13543784.10.7.1291","pdf_url":null,"source":{"id":"https://openalex.org/S131064935","display_name":"Expert Opinion on Investigational Drugs","issn_l":"1354-3784","issn":["1354-3784","1744-7658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320547","host_organization_name":"Taylor & Francis","host_organization_lineage":["https://openalex.org/P4310320547","https://openalex.org/P4310320449"],"host_organization_lineage_names":["Taylor & Francis","Informa"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert Opinion on Investigational Drugs","raw_type":"journal-article"},{"id":"pmid:11772252","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/11772252","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Expert opinion on investigational drugs","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"},{"id":"https://openalex.org/F4320320859","display_name":"Ulster University","ror":"https://ror.org/01yp9g959"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":159,"referenced_works":["https://openalex.org/W131407775","https://openalex.org/W187224587","https://openalex.org/W1434707050","https://openalex.org/W1504236746","https://openalex.org/W1547749433","https://openalex.org/W1548437752","https://openalex.org/W1571941655","https://openalex.org/W1606441445","https://openalex.org/W1607853670","https://openalex.org/W1675282228","https://openalex.org/W1773228510","https://openalex.org/W1796385735","https://openalex.org/W1800849354","https://openalex.org/W1834041853","https://openalex.org/W1880313810","https://openalex.org/W1899558579","https://openalex.org/W1907994445","https://openalex.org/W1927678108","https://openalex.org/W1929009802","https://openalex.org/W1951867641","https://openalex.org/W1963635094","https://openalex.org/W1965002463","https://openalex.org/W1965835598","https://openalex.org/W1968021701","https://openalex.org/W1968308873","https://openalex.org/W1969264369","https://openalex.org/W1969934580","https://openalex.org/W1970320105","https://openalex.org/W1970609251","https://openalex.org/W1972469636","https://openalex.org/W1972748491","https://openalex.org/W1977343715","https://openalex.org/W1979896022","https://openalex.org/W1980762198","https://openalex.org/W1983771708","https://openalex.org/W1985507549","https://openalex.org/W1986668856","https://openalex.org/W1987023646","https://openalex.org/W1988581086","https://openalex.org/W1989347499","https://openalex.org/W1990345361","https://openalex.org/W1992113771","https://openalex.org/W1992290763","https://openalex.org/W1992583442","https://openalex.org/W1992912134","https://openalex.org/W1997034758","https://openalex.org/W2005876444","https://openalex.org/W2006876044","https://openalex.org/W2007737411","https://openalex.org/W2007747817","https://openalex.org/W2008580181","https://openalex.org/W2008684260","https://openalex.org/W2009114315","https://openalex.org/W2009235383","https://openalex.org/W2010171666","https://openalex.org/W2010590731","https://openalex.org/W2010746529","https://openalex.org/W2011347602","https://openalex.org/W2016370003","https://openalex.org/W2017054020","https://openalex.org/W2019805402","https://openalex.org/W2019814232","https://openalex.org/W2020738602","https://openalex.org/W2021237750","https://openalex.org/W2022051858","https://openalex.org/W2024683060","https://openalex.org/W2025252445","https://openalex.org/W2029432831","https://openalex.org/W2029491963","https://openalex.org/W2031197996","https://openalex.org/W2032115597","https://openalex.org/W2036100871","https://openalex.org/W2037502378","https://openalex.org/W2038113052","https://openalex.org/W2038978204","https://openalex.org/W2039962752","https://openalex.org/W2040054610","https://openalex.org/W2040218128","https://openalex.org/W2041618727","https://openalex.org/W2042519036","https://openalex.org/W2044555799","https://openalex.org/W2045997348","https://openalex.org/W2048981702","https://openalex.org/W2052372952","https://openalex.org/W2053890291","https://openalex.org/W2054404735","https://openalex.org/W2059369537","https://openalex.org/W2061837563","https://openalex.org/W2062964400","https://openalex.org/W2063348761","https://openalex.org/W2064514516","https://openalex.org/W2065190526","https://openalex.org/W2065590887","https://openalex.org/W2068285130","https://openalex.org/W2070157303","https://openalex.org/W2071175492","https://openalex.org/W2072849495","https://openalex.org/W2075068003","https://openalex.org/W2076072002","https://openalex.org/W2079063592","https://openalex.org/W2085683908","https://openalex.org/W2086726580","https://openalex.org/W2087649101","https://openalex.org/W2088964290","https://openalex.org/W2089751994","https://openalex.org/W2091193879","https://openalex.org/W2091595242","https://openalex.org/W2092310248","https://openalex.org/W2092591926","https://openalex.org/W2094151199","https://openalex.org/W2095737987","https://openalex.org/W2101994376","https://openalex.org/W2103815234","https://openalex.org/W2109009802","https://openalex.org/W2119091075","https://openalex.org/W2122216584","https://openalex.org/W2122850556","https://openalex.org/W2122941568","https://openalex.org/W2123546645","https://openalex.org/W2124389594","https://openalex.org/W2125823894","https://openalex.org/W2126534770","https://openalex.org/W2131897774","https://openalex.org/W2134831738","https://openalex.org/W2138565072","https://openalex.org/W2142707503","https://openalex.org/W2148663698","https://openalex.org/W2149636968","https://openalex.org/W2151492425","https://openalex.org/W2151869895","https://openalex.org/W2156431631","https://openalex.org/W2158398145","https://openalex.org/W2162804111","https://openalex.org/W2165326434","https://openalex.org/W2166431337","https://openalex.org/W2169115202","https://openalex.org/W2171934314","https://openalex.org/W2184679592","https://openalex.org/W2254587825","https://openalex.org/W2259379690","https://openalex.org/W2313098007","https://openalex.org/W2313158847","https://openalex.org/W2313326603","https://openalex.org/W2313468178","https://openalex.org/W2321522617","https://openalex.org/W2321562677","https://openalex.org/W2331798828","https://openalex.org/W2336538695","https://openalex.org/W2402393070","https://openalex.org/W2412242234","https://openalex.org/W2591539149","https://openalex.org/W2606370469","https://openalex.org/W2769112780","https://openalex.org/W2889442946","https://openalex.org/W2952808556","https://openalex.org/W2988610037","https://openalex.org/W3096506887","https://openalex.org/W3122113627","https://openalex.org/W3176347204"],"related_works":["https://openalex.org/W2073097097","https://openalex.org/W2805248143","https://openalex.org/W2312554730","https://openalex.org/W1995521712","https://openalex.org/W2084908835","https://openalex.org/W3215049146","https://openalex.org/W2794997186","https://openalex.org/W2183419270","https://openalex.org/W2370781106","https://openalex.org/W2009127091"],"abstract_inverted_index":{"Pulmonary":[0,57],"hypertension":[1,58,145],"can":[2,17],"occur":[3],"idiopathically":[4],"as":[5,19,55,66,68,93,95],"a":[6,20,24],"primary":[7],"disorder":[8],"of":[9,23,27,75,81,104,128,165,191,202],"the":[10,72,79,82,101,105,153,166,187,200],"pulmonary":[11,28,84,144,154,180,203],"circulation":[12],"or":[13],"more":[14],"commonly,":[15],"it":[16],"exist":[18],"haemodynamic":[21],"manifestation":[22],"wide":[25],"variety":[26],"and":[29,50,116,120,132,159,195],"cardiovascular":[30],"diseases,":[31],"including":[32],"acute":[33],"lung":[34,38],"injury,":[35],"chronic":[36,45],"obstructive":[37],"disease,":[39,42],"congenital":[40],"heart":[41,48,161],"mitral":[43],"stenosis,":[44],"left-sided":[46],"congestive":[47],"failure":[49],"connective":[51],"tissue":[52],"diseases":[53],"such":[54],"scleroderma.":[56],"is":[59,137],"associated":[60],"with":[61,71,135,142],"changes":[62,149],"in":[63,140,146],"vascular":[64,69,85],"tone":[65],"well":[67,94],"structure,":[70],"relative":[73],"contribution":[74],"each":[76],"dependent":[77],"upon":[78],"aetiology":[80],"increased":[83],"resistance.":[86],"Most":[87],"currently":[88],"available":[89],"treatments":[90],"utilise":[91],"anticoagulants":[92],"vasodilator":[96],"drugs":[97],"that":[98],"only":[99],"attenuate":[100],"vasoconstrictive":[102],"component":[103],"disease.":[106],"The":[107],"latter":[108],"category":[109],"includes":[110],"oral":[111],"calcium":[112],"channel":[113],"blockers,":[114],"iv.":[115],"aerosolised":[117],"prostacyclin":[118],"analogues":[119],"inhaled":[121],"nitric":[122,196],"oxide":[123,197],"but":[124],"all":[125],"three":[126],"classes":[127],"vasodilators":[129,136],"have":[130],"disadvantages":[131],"limitations.":[133],"Treatment":[134],"often":[138],"ineffective":[139],"patients":[141],"longstanding":[143],"which":[147],"structural":[148],"contribute":[150],"significantly":[151],"to":[152,178],"hypertension,":[155],"blood":[156],"flow":[157],"obstruction":[158],"right":[160],"failure.":[162],"In":[163],"view":[164],"immense":[167],"clinical":[168],"need,":[169],"new":[170],"therapies":[171],"are":[172],"being":[173],"developed":[174],"by":[175],"pharmaceutical":[176],"companies":[177],"treat":[179],"hypertension.":[181,204],"This":[182],"update":[183],"will":[184],"focus":[185],"on":[186],"current":[188],"development":[189],"status":[190],"endothelin":[192],"receptor":[193],"antagonists":[194],"donors":[198],"for":[199],"treatment":[201]},"counts_by_year":[{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":1},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
