{"id":"https://openalex.org/W2102299697","doi":"https://doi.org/10.1111/j.1747-0285.2006.00373.x","title":"Mechanism of Action and Structural Requirements of Constrained Peptide Inhibitors of RGS Proteins","display_name":"Mechanism of Action and Structural Requirements of Constrained Peptide Inhibitors of RGS Proteins","publication_year":2006,"publication_date":"2006-04-01","ids":{"openalex":"https://openalex.org/W2102299697","doi":"https://doi.org/10.1111/j.1747-0285.2006.00373.x","mag":"2102299697","pmid":"https://pubmed.ncbi.nlm.nih.gov/16629824"},"language":"en","primary_location":{"id":"doi:10.1111/j.1747-0285.2006.00373.x","doi":"https://doi.org/10.1111/j.1747-0285.2006.00373.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1747-0285.2006.00373.x","pdf_url":null,"source":{"id":"https://openalex.org/S123587420","display_name":"Chemical Biology & Drug Design","issn_l":"1747-0277","issn":["1747-0277","1747-0285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Biology & Drug Design","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5023056099","display_name":"Rebecca A. Roof","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rebecca A. Roof","raw_affiliation_strings":["Department of Pharmacology, 1150 W. Medical Center Dr, University of Michigan, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, 1150 W. Medical Center Dr, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027609235","display_name":"Yafei Jin","orcid":"https://orcid.org/0000-0002-2501-7787","observed_orcids":["https://orcid.org/0000-0002-2501-7787"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yafei Jin","raw_affiliation_strings":["Department of Medicinal Chemistry, 428 Church Street, University of Michigan, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, 428 Church Street, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5040478281","display_name":"David L. Roman","orcid":"https://orcid.org/0000-0002-8250-0337","observed_orcids":["https://orcid.org/0000-0002-8250-0337"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"David L. Roman","raw_affiliation_strings":["Department of Pharmacology, 1150 W. Medical Center Dr, University of Michigan, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, 1150 W. Medical Center Dr, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006646972","display_name":"Roger K. Sunahara","orcid":"https://orcid.org/0000-0003-1702-8619","observed_orcids":["https://orcid.org/0000-0003-1702-8619"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Roger K. Sunahara","raw_affiliation_strings":["Department of Pharmacology, 1150 W. Medical Center Dr, University of Michigan, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, 1150 W. Medical Center Dr, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058118162","display_name":"Masaru Ishii","orcid":"https://orcid.org/0000-0002-4215-007X","observed_orcids":["https://orcid.org/0000-0002-4215-007X"]},"institutions":[{"id":"https://openalex.org/I98285908","display_name":"The University of Osaka","ror":"https://ror.org/035t8zc32","country_code":"JP","type":"education","lineage":["https://openalex.org/I98285908"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaru Ishii","raw_affiliation_strings":["Department of Pharmacology II, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan","Department of Pharmacology II, Graduate School of Medicine, Osaka University, 2\u20102, Yamada\u2010oka, Suita Osaka 565\u20100871 Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology II, Graduate School of Medicine, Osaka University, 2-2 Yamada-oka, Suita, Osaka 565-0871, Japan","institution_ids":["https://openalex.org/I98285908"]},{"raw_affiliation_string":"Department of Pharmacology II, Graduate School of Medicine, Osaka University, 2\u20102, Yamada\u2010oka, Suita Osaka 565\u20100871 Japan","institution_ids":["https://openalex.org/I98285908"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079002496","display_name":"Henry I. Mosberg","orcid":"https://orcid.org/0000-0002-4107-8870","observed_orcids":["https://orcid.org/0000-0002-4107-8870"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Henry I. Mosberg","raw_affiliation_strings":["Department of Medicinal Chemistry, 428 Church Street, University of Michigan, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicinal Chemistry, 428 Church Street, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016819654","display_name":"Richard R. Neubig","orcid":"https://orcid.org/0000-0003-0501-0008","observed_orcids":["https://orcid.org/0000-0003-0501-0008"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard R. Neubig","raw_affiliation_strings":["Department of Pharmacology, 1150 W. Medical Center Dr, University of Michigan, Ann Arbor, MI 48109, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, 1150 W. Medical Center Dr, University of Michigan, Ann Arbor, MI 48109, USA","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5079002496"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":3920,"currency":"USD","value_usd":3920},"apc_paid":null,"fwci":1.4854,"has_fulltext":false,"cited_by_count":33,"citation_normalized_percentile":{"value":0.79758006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"67","issue":"4","first_page":"266","last_page":"274"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10911","display_name":"Chemical Synthesis and Analysis","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rgs-proteins","display_name":"RGS proteins","score":0.8930000066757202},{"id":"https://openalex.org/keywords/rgs4","display_name":"RGS4","score":0.765999972820282},{"id":"https://openalex.org/keywords/rgs8","display_name":"RGS8","score":0.9670000076293945},{"id":"https://openalex.org/keywords/rgs7","display_name":"RGS7","score":0.8870000243186951},{"id":"https://openalex.org/keywords/g-protein-signaling","display_name":"G protein signaling","score":0.7139999866485596},{"id":"https://openalex.org/keywords/structure-activity-relationship","display_name":"structure-activity relationship","score":0.7699999809265137},{"id":"https://openalex.org/keywords/muscarinic-receptors","display_name":"muscarinic receptors","score":0.9139999747276306},{"id":"https://openalex.org/keywords/potassium-currents","display_name":"potassium currents","score":0.8809999823570251},{"id":"https://openalex.org/keywords/atrial-myocytes","display_name":"atrial myocytes","score":0.9959999918937683},{"id":"https://openalex.org/keywords/g-protein-coupled-receptor-signaling","display_name":"G protein-coupled receptor signaling","score":0.6570000052452087}],"concepts":[{"id":"https://openalex.org/C2779281246","wikidata":"https://www.wikidata.org/wiki/Q172847","display_name":"Peptide","level":2,"score":0.6280732750892639},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.522172212600708},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.5207095742225647},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.48458874225616455},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4474569857120514},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.4455288350582123},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.43457284569740295},{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.422674298286438},{"id":"https://openalex.org/C4963665","wikidata":"https://www.wikidata.org/wiki/Q18031115","display_name":"RGS2","level":5,"score":0.4225137233734131},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.34742361307144165},{"id":"https://openalex.org/C163181125","wikidata":"https://www.wikidata.org/wiki/Q408592","display_name":"GTPase-activating protein","level":4,"score":0.14596864581108093},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.09368616342544556}],"mesh":[{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000109","descriptor_name":"Acetylcholine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005998","descriptor_name":"Glycine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007700","descriptor_name":"Kinetics","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D010456","descriptor_name":"Peptides, Cyclic","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D011921","descriptor_name":"Rats, Inbred WKY","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011921","descriptor_name":"Rats, Inbred WKY","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011921","descriptor_name":"Rats, Inbred WKY","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D012694","descriptor_name":"Serine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013329","descriptor_name":"Structure-Activity Relationship","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018408","descriptor_name":"Patch-Clamp Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020558","descriptor_name":"GTP Phosphohydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020690","descriptor_name":"GTPase-Activating Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020710","descriptor_name":"RGS Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020710","descriptor_name":"RGS Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020710","descriptor_name":"RGS Proteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D020710","descriptor_name":"RGS Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020710","descriptor_name":"RGS Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020710","descriptor_name":"RGS Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D032383","descriptor_name":"Myocytes, Cardiac","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D044385","descriptor_name":"GTP-Binding Protein alpha Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044385","descriptor_name":"GTP-Binding Protein alpha Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044385","descriptor_name":"GTP-Binding Protein alpha Subunits","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D044385","descriptor_name":"GTP-Binding Protein alpha Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044385","descriptor_name":"GTP-Binding Protein alpha Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D044385","descriptor_name":"GTP-Binding Protein alpha Subunits","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051676","descriptor_name":"G Protein-Coupled Inwardly-Rectifying Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051676","descriptor_name":"G Protein-Coupled Inwardly-Rectifying Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051676","descriptor_name":"G Protein-Coupled Inwardly-Rectifying Potassium Channels","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/j.1747-0285.2006.00373.x","doi":"https://doi.org/10.1111/j.1747-0285.2006.00373.x","is_oa":false,"landing_page_url":"https://doi.org/10.1111/j.1747-0285.2006.00373.x","pdf_url":null,"source":{"id":"https://openalex.org/S123587420","display_name":"Chemical Biology & Drug Design","issn_l":"1747-0277","issn":["1747-0277","1747-0285"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical Biology & Drug Design","raw_type":"journal-article"},{"id":"pmid:16629824","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/16629824","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Chemical biology & drug design","raw_type":"Journal Article"},{"id":"pmh:oai:deepblue.lib.umich.edu:2027.42/66199","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2027.42/66199","pdf_url":null,"source":{"id":"https://openalex.org/S4306400393","display_name":"Deep Blue (University of Michigan)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I27837315","host_organization_name":"University of Michigan","host_organization_lineage":["https://openalex.org/I27837315"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.504800021648407,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G132595636","display_name":null,"funder_award_id":"GM 39561","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3065991305","display_name":"Physiological functions of G-alpha-i/o and control by regulators of G protein sig","funder_award_id":"R01GM039561","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3807689603","display_name":"Development of Mixed Function Opioid Peptides and Peptidomimetics","funder_award_id":"R01DA003910","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"},{"id":"https://openalex.org/G65427546","display_name":"Michigan Chemistry Biology Interface Training Program","funder_award_id":"T32GM008597","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G889217623","display_name":null,"funder_award_id":"DA03910","funder_id":"https://openalex.org/F4320337347","funder_display_name":"National Institute on Drug Abuse"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337347","display_name":"National Institute on Drug Abuse","ror":"https://ror.org/00fq5cm18"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W1586297894","https://openalex.org/W1934253322","https://openalex.org/W1968536472","https://openalex.org/W1972599573","https://openalex.org/W1985778833","https://openalex.org/W1988176512","https://openalex.org/W1989920655","https://openalex.org/W1993813624","https://openalex.org/W1997773937","https://openalex.org/W2005782689","https://openalex.org/W2009380370","https://openalex.org/W2010162415","https://openalex.org/W2014108369","https://openalex.org/W2014381207","https://openalex.org/W2018483093","https://openalex.org/W2025932643","https://openalex.org/W2027896877","https://openalex.org/W2048249386","https://openalex.org/W2048351462","https://openalex.org/W2050905518","https://openalex.org/W2060736945","https://openalex.org/W2071242185","https://openalex.org/W2082549941","https://openalex.org/W2082741589","https://openalex.org/W2090636422","https://openalex.org/W2092975281","https://openalex.org/W2131499687","https://openalex.org/W2133321625","https://openalex.org/W2135598278","https://openalex.org/W2140180474","https://openalex.org/W2146384245","https://openalex.org/W2791114118"],"related_works":["https://openalex.org/W2066521942","https://openalex.org/W1508028212","https://openalex.org/W642667308","https://openalex.org/W51949348","https://openalex.org/W2083787943","https://openalex.org/W2140180474","https://openalex.org/W2171312188","https://openalex.org/W3173698763","https://openalex.org/W182682403","https://openalex.org/W2059524658"],"abstract_inverted_index":{"Regulators":[0],"of":[1,26,41,46,55,64,90,106,124,146,148,166],"G-protein":[2],"signaling":[3,14],"(RGS)":[4],"accelerate":[5],"guanine":[6],"triphosphate":[7],"hydrolysis":[8],"by":[9,15,79],"Galpha-subunits":[10],"and":[11,23,81,92,100,158],"profoundly":[12],"inhibit":[13],"G":[16],"protein-coupled":[17],"receptors.":[18],"The":[19],"distinct":[20],"expression":[21],"patterns":[22],"pathophysiologic":[24],"regulation":[25],"RGS":[27,118,150,167],"proteins":[28],"suggest":[29],"that":[30,75,93,113],"inhibitors":[31],"may":[32],"have":[33],"therapeutic":[34],"potential.":[35],"We":[36],"previously":[37],"reported":[38],"the":[39,53,56,70,86,125,143,164],"design":[40,165],"a":[42,160],"constrained":[43],"peptide":[44,94,128,149],"inhibitor":[45,168],"RGS4":[47,78,99],"(1:":[48],"Ac-Val-Lys-[Cys-Thr-Gly-Ile-Cys]-Glu-NH2,":[49],"S-S)":[50],"based":[51],"on":[52],"structure":[54],"Galphai":[57,91],"switch":[58,87],"1":[59,76,88,95,110],"region":[60,89],"but":[61],"its":[62],"mechanism":[63,145],"action":[65,147,154],"was":[66],"not":[67],"established.":[68],"In":[69],"present":[71],"study,":[72],"we":[73,121],"show":[74],"inhibits":[77],"mimicking":[80],"competing":[82],"for":[83,98,117,163],"binding":[84],"with":[85],"shows":[96],"selectivity":[97],"RGS8":[101],"versus":[102],"RGS7.":[103],"Structure-activity":[104],"relationships":[105],"analogs":[107],"related":[108],"to":[109,131],"are":[111],"described":[112],"illustrate":[114],"key":[115],"features":[116],"inhibition.":[119],"Finally,":[120],"demonstrate":[122,152],"activity":[123],"methylene":[126],"dithioether-bridged":[127],"inhibitor,":[129],"2,":[130],"modulate":[132],"muscarinic":[133],"receptor-regulated":[134],"potassium":[135],"currents":[136],"in":[137,155],"atrial":[138],"myocytes.":[139],"These":[140],"data":[141],"support":[142],"proposed":[144],"inhibitors,":[151],"their":[153],"native":[156],"cells,":[157],"provide":[159],"starting":[161],"point":[162],"drugs.":[169]},"counts_by_year":[{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-29T09:56:32.521200","created_date":"2016-06-24T00:00:00"}