{"id":"https://openalex.org/W2102287009","doi":null,"title":"SEARCHING FOR RADIOSENSITIZERS: DEVELOPMENT OF A NOVEL ASSAY AND HIGH-THROUGHPUT SCREENING","display_name":"SEARCHING FOR RADIOSENSITIZERS: DEVELOPMENT OF A NOVEL ASSAY AND HIGH-THROUGHPUT SCREENING","publication_year":2008,"publication_date":"2008-01-01","ids":{"openalex":"https://openalex.org/W2102287009","mag":"2102287009"},"language":"en","primary_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/17184","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/17184","pdf_url":"https://utoronto.scholaris.ca/bitstreams/cb6feacd-2955-4f73-8a6a-40763e83a67f/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://utoronto.scholaris.ca/bitstreams/cb6feacd-2955-4f73-8a6a-40763e83a67f/download","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"David R. Katz","orcid":"https://orcid.org/0000-0001-7695-8774","observed_orcids":["https://orcid.org/0000-0001-7695-8774"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"David R. Katz","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0001-7695-8774","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.7289999723434448,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11176","display_name":"Radiation Therapy and Dosimetry","score":0.7289999723434448,"subfield":{"id":"https://openalex.org/subfields/3108","display_name":"Radiation"},"field":{"id":"https://openalex.org/fields/31","display_name":"Physics and Astronomy"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11359","display_name":"Effects of Radiation Exposure","score":0.179299995303154,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.013399999588727951,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/radiosensitizers","display_name":"radiosensitizers","score":0.9860000014305115},{"id":"https://openalex.org/keywords/clonogenic-assay","display_name":"clonogenic assay","score":0.9769999980926514},{"id":"https://openalex.org/keywords/high-throughput-screening","display_name":"high-throughput screening","score":0.9599999785423279},{"id":"https://openalex.org/keywords/ionizing-radiation","display_name":"ionizing radiation","score":0.8640000224113464},{"id":"https://openalex.org/keywords/cisplatin","display_name":"cisplatin","score":0.9419999718666077},{"id":"https://openalex.org/keywords/combination-therapy","display_name":"combination therapy","score":0.9179999828338623},{"id":"https://openalex.org/keywords/cytotoxicity-assay","display_name":"cytotoxicity assay","score":0.7730000019073486},{"id":"https://openalex.org/keywords/fadu-cells","display_name":"FaDu cells","score":0.8550000190734863},{"id":"https://openalex.org/keywords/a549-cells","display_name":"A549 cells","score":1.0}],"concepts":[{"id":"https://openalex.org/C157764524","wikidata":"https://www.wikidata.org/wiki/Q1383412","display_name":"Throughput","level":3,"score":0.5933303833007812},{"id":"https://openalex.org/C51323132","wikidata":"https://www.wikidata.org/wiki/Q626251","display_name":"High-throughput screening","level":2,"score":0.5899777412414551},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.4562162458896637},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.4056384265422821},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2764055132865906},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.24626383185386658},{"id":"https://openalex.org/C111919701","wikidata":"https://www.wikidata.org/wiki/Q9135","display_name":"Operating system","level":1,"score":0.09893304109573364},{"id":"https://openalex.org/C555944384","wikidata":"https://www.wikidata.org/wiki/Q249","display_name":"Wireless","level":2,"score":0.0}],"mesh":[],"locations_count":4,"locations":[{"id":"pmh:oai:utoronto.scholaris.ca:1807/17184","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/17184","pdf_url":"https://utoronto.scholaris.ca/bitstreams/cb6feacd-2955-4f73-8a6a-40763e83a67f/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.535.8319","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.535.8319","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"https://tspace.library.utoronto.ca/bitstream/1807/17184/1/Katz_David_200811_MSc_thesis.pdf","raw_type":"text"},{"id":"pmh:oai:collectionscanada.gc.ca:OTU.1807/17184","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/1807/17184","pdf_url":null,"source":{"id":"https://openalex.org/S4306402307","display_name":"Library and Archives Canada (Government of Canada)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2802286613","host_organization_name":"Government of Canada","host_organization_lineage":["https://openalex.org/I2802286613"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Thesis"},{"id":"mag:2102287009","doi":null,"is_oa":false,"landing_page_url":"https://tspace.library.utoronto.ca/bitstream/1807/17184/1/Katz_David_200811_MSc_thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:utoronto.scholaris.ca:1807/17184","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/1807/17184","pdf_url":"https://utoronto.scholaris.ca/bitstreams/cb6feacd-2955-4f73-8a6a-40763e83a67f/download","source":{"id":"https://openalex.org/S4306400261","display_name":"TSpace (University of Toronto)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I185261750","host_organization_name":"University of Toronto","host_organization_lineage":["https://openalex.org/I185261750"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"sustainable_development_goals":[{"score":0.8560000061988831,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320334506","display_name":"Canadian Institutes of Health Research","ror":"https://ror.org/01gavpb45"},{"id":"https://openalex.org/F4320334593","display_name":"Natural Sciences and Engineering Research Council of Canada","ror":"https://ror.org/01h531d29"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2102287009.pdf","grobid_xml":"https://content.openalex.org/works/W2102287009.grobid-xml"},"referenced_works_count":190,"referenced_works":["https://openalex.org/W19199159","https://openalex.org/W90292846","https://openalex.org/W102725257","https://openalex.org/W192422576","https://openalex.org/W1259399738","https://openalex.org/W1480741751","https://openalex.org/W1490790087","https://openalex.org/W1493427854","https://openalex.org/W1520995753","https://openalex.org/W1540649941","https://openalex.org/W1552177814","https://openalex.org/W1579641819","https://openalex.org/W1587031599","https://openalex.org/W1603973043","https://openalex.org/W1660787335","https://openalex.org/W1670810514","https://openalex.org/W1804130247","https://openalex.org/W1843659135","https://openalex.org/W1861478519","https://openalex.org/W1872107160","https://openalex.org/W1916114318","https://openalex.org/W1919629952","https://openalex.org/W1955547739","https://openalex.org/W1966254852","https://openalex.org/W1968469516","https://openalex.org/W1968601707","https://openalex.org/W1968768545","https://openalex.org/W1971917580","https://openalex.org/W1973030224","https://openalex.org/W1975342712","https://openalex.org/W1975608733","https://openalex.org/W1977532213","https://openalex.org/W1980034972","https://openalex.org/W1980083933","https://openalex.org/W1983218764","https://openalex.org/W1985064413","https://openalex.org/W1985883143","https://openalex.org/W1988280121","https://openalex.org/W1988377311","https://openalex.org/W1991091663","https://openalex.org/W1991952977","https://openalex.org/W1993327656","https://openalex.org/W1993491727","https://openalex.org/W1995750237","https://openalex.org/W1997495591","https://openalex.org/W1997813612","https://openalex.org/W1999554125","https://openalex.org/W2000476840","https://openalex.org/W2000752368","https://openalex.org/W2001503472","https://openalex.org/W2002189627","https://openalex.org/W2003691881","https://openalex.org/W2006202974","https://openalex.org/W2007415320","https://openalex.org/W2009073211","https://openalex.org/W2013226893","https://openalex.org/W2015925058","https://openalex.org/W2016320725","https://openalex.org/W2016866011","https://openalex.org/W2017619447","https://openalex.org/W2018488144","https://openalex.org/W2022811243","https://openalex.org/W2026207397","https://openalex.org/W2027844138","https://openalex.org/W2029923264","https://openalex.org/W2029980980","https://openalex.org/W2030575063","https://openalex.org/W2033989981","https://openalex.org/W2034969741","https://openalex.org/W2036789410","https://openalex.org/W2037113635","https://openalex.org/W2037490361","https://openalex.org/W2038266181","https://openalex.org/W2038556082","https://openalex.org/W2038908941","https://openalex.org/W2039143648","https://openalex.org/W2039231974","https://openalex.org/W2040838669","https://openalex.org/W2041898066","https://openalex.org/W2043990544","https://openalex.org/W2046691565","https://openalex.org/W2048454485","https://openalex.org/W2049108649","https://openalex.org/W2052521064","https://openalex.org/W2052853635","https://openalex.org/W2053528106","https://openalex.org/W2059775855","https://openalex.org/W2061274398","https://openalex.org/W2062284662","https://openalex.org/W2064377499","https://openalex.org/W2064419187","https://openalex.org/W2064766554","https://openalex.org/W2065588235","https://openalex.org/W2066060839","https://openalex.org/W2066800131","https://openalex.org/W2070070758","https://openalex.org/W2071673734","https://openalex.org/W2072142313","https://openalex.org/W2076065497","https://openalex.org/W2077570209","https://openalex.org/W2077945404","https://openalex.org/W2078532650","https://openalex.org/W2079208402","https://openalex.org/W2079571554","https://openalex.org/W2085593233","https://openalex.org/W2085609942","https://openalex.org/W2091446215","https://openalex.org/W2091894720","https://openalex.org/W2092606584","https://openalex.org/W2092831742","https://openalex.org/W2093224212","https://openalex.org/W2093313266","https://openalex.org/W2096287682","https://openalex.org/W2096530939","https://openalex.org/W2099268944","https://openalex.org/W2100518470","https://openalex.org/W2101331356","https://openalex.org/W2101988823","https://openalex.org/W2102757030","https://openalex.org/W2105175865","https://openalex.org/W2109126550","https://openalex.org/W2109456034","https://openalex.org/W2109492293","https://openalex.org/W2111802021","https://openalex.org/W2113465576","https://openalex.org/W2113541736","https://openalex.org/W2117075401","https://openalex.org/W2117374129","https://openalex.org/W2117502397","https://openalex.org/W2118085282","https://openalex.org/W2119334677","https://openalex.org/W2120068217","https://openalex.org/W2121175754","https://openalex.org/W2121604817","https://openalex.org/W2121781767","https://openalex.org/W2126532376","https://openalex.org/W2126614953","https://openalex.org/W2126796352","https://openalex.org/W2130108221","https://openalex.org/W2130420198","https://openalex.org/W2130771548","https://openalex.org/W2131837045","https://openalex.org/W2133427241","https://openalex.org/W2135732933","https://openalex.org/W2142093446","https://openalex.org/W2143578354","https://openalex.org/W2144252460","https://openalex.org/W2144263975","https://openalex.org/W2144318283","https://openalex.org/W2144599319","https://openalex.org/W2145703501","https://openalex.org/W2145953677","https://openalex.org/W2146148650","https://openalex.org/W2146561699","https://openalex.org/W2146762842","https://openalex.org/W2147966099","https://openalex.org/W2148135357","https://openalex.org/W2148505042","https://openalex.org/W2149294014","https://openalex.org/W2150983705","https://openalex.org/W2152440925","https://openalex.org/W2153666475","https://openalex.org/W2153708110","https://openalex.org/W2154248376","https://openalex.org/W2155377609","https://openalex.org/W2155384808","https://openalex.org/W2156604743","https://openalex.org/W2156773723","https://openalex.org/W2157795344","https://openalex.org/W2158366782","https://openalex.org/W2160433948","https://openalex.org/W2160576631","https://openalex.org/W2160793656","https://openalex.org/W2160981368","https://openalex.org/W2161965319","https://openalex.org/W2162412306","https://openalex.org/W2162424885","https://openalex.org/W2167779978","https://openalex.org/W2170121627","https://openalex.org/W2170781946","https://openalex.org/W2171775098","https://openalex.org/W2203778714","https://openalex.org/W2211952688","https://openalex.org/W2285157229","https://openalex.org/W2314753133","https://openalex.org/W2317448174","https://openalex.org/W2324392028","https://openalex.org/W2331395194","https://openalex.org/W2409512192","https://openalex.org/W2616852889"],"related_works":["https://openalex.org/W2126614547","https://openalex.org/W2144563936","https://openalex.org/W2973040697","https://openalex.org/W2083192883","https://openalex.org/W4387191108","https://openalex.org/W2009269528","https://openalex.org/W2102458977","https://openalex.org/W1973259025","https://openalex.org/W4225248008","https://openalex.org/W3153245022"],"abstract_inverted_index":{"The":[0,32,61],"colony":[1,29],"formation":[2],"assay":[3,118],"(CFA)":[4],"is":[5],"the":[6,18,42,79,109,120,124,217,243,257],"gold":[7],"standard":[8],"for":[9,70,78,139,168,246],"measuring":[10],"cytotoxic":[11],"effects":[12],"on":[13,41,234],"cells.":[14],"To":[15],"increase":[16],"efficiency,":[17],"CFA":[19,34,63,111,122],"was":[20,35,55,64],"converted":[21],"to":[22,51,66,119,134,158,162,200,205,215,242,249,255],"a":[23,67,73,131,179,202],"96-well":[24,33,62,110],"format":[25],"using":[26,37,57],"an":[27,116],"automated":[28],"counting":[30],"algorithm.":[31],"validated":[36],"ionizing":[38],"radiation":[39],"(IR)":[40],"FaDu":[43],"and":[44,59,85,93,104,153,172,191,226,236],"A549":[45],"cancer":[46],"cell":[47],"lines.":[48],"Its":[49],"ability":[50],"evaluate":[52],"combination":[53],"therapies":[54],"investigated":[56],"cisplatin":[58],"IR.":[60],"transferred":[65],"robotic":[68],"platform":[69],"evaluation":[71,125],"as":[72,115,178],"high-throughput":[74],"screen":[75],"(HTS)":[76],"readout":[77,133],"discovery":[80],"of":[81,126,219],"novel":[82],"anti-cancer":[83,91,102,141],"compounds,":[84,103,142],"radiosensitizers.":[86,149],"Screening":[87],"yielded":[88],"eight":[89],"putative":[90,95],"hits,":[92],"five":[94],"radiosensitizing":[96,106],"hits.":[97],"Secondary":[98],"screening":[99],"confirmed":[100],"6/8":[101],"0/5":[105],"compounds.":[107],"Thus,":[108],"can":[112],"be":[113,135,201],"adopted":[114],"alternative":[117],"6-well":[121],"in":[123,128,137,147,192],"cytotoxicity":[127],"vitro,":[129],"providing":[130],"possible":[132],"utilized":[136],"HTS":[138],"discovering":[140,148],"but":[143],"with":[144,240],"limited":[145],"applicability":[146],"ii":[150],"Acknowledgements":[151],"First":[152],"foremost,":[154],"I":[155,212,251],"would":[156,213,252],"like":[157,214,254],"extend":[159],"great":[160],"thanks":[161],"my":[163,175,189,194,208,220,247],"supervisor,":[164],"Dr.":[165,223,227],"Fei-Fei":[166],"Liu,":[167],"her":[169],"incredible":[170],"guidance":[171],"support":[173],"during":[174],"two":[176],"years":[177],"Master":[180],"Student.":[181],"Her":[182],"mentorship":[183],"has":[184],"guided":[185],"me":[186,206,233],"through":[187],"both":[188],"research":[190,248],"establishing":[193],"career":[195],"path.":[196],"She":[197],"will":[198],"continue":[199],"role":[203],"model":[204],"throughout":[207],"career.":[209],"As":[210],"well,":[211],"thank":[216,256],"members":[218,258],"supervisory":[221],"committee,":[222],"Aaron":[224],"Schimmer":[225],"Suzanne":[228],"Trudel.":[229],"They":[230],"have":[231],"kept":[232],"track":[235],"provided":[237],"integral":[238],"advice":[239],"respect":[241],"best":[244],"path":[245],"follow.":[250],"also":[253]},"counts_by_year":[],"updated_date":"2026-09-29T14:09:16.559479","created_date":"2016-06-24T00:00:00"}