{"id":"https://openalex.org/W2102218960","doi":null,"title":"Cost-effectiveness of bevacizumab and ranibizumab for newly diagnosed neovascular macular degeneration (an American Ophthalmological Society thesis).","display_name":"Cost-effectiveness of bevacizumab and ranibizumab for newly diagnosed neovascular macular degeneration (an American Ophthalmological Society thesis).","publication_year":2013,"publication_date":"2013-09-01","ids":{"openalex":"https://openalex.org/W2102218960","mag":"2102218960","pmid":"https://pubmed.ncbi.nlm.nih.gov/24167325","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3797829"},"language":"en","primary_location":{"id":"pmh:oai:europepmc.org:2796444","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3797829","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"volume":null,"type":"article","indexed_in":["pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3797829","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5085528800","display_name":"Joshua D. Stein","orcid":"https://orcid.org/0000-0003-2937-6987","observed_orcids":["https://orcid.org/0000-0003-2937-6987"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joshua D Stein","raw_affiliation_strings":["Department of Ophthalmology and Visual Sciences (Dr Stein, Dr Newman-Casey, Dr Lee) and the Department of Health Management and Policy (Ms Mrinalini, Dr Hutton), University of Michigan, Ann Arbor"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology and Visual Sciences (Dr Stein, Dr Newman-Casey, Dr Lee) and the Department of Health Management and Policy (Ms Mrinalini, Dr Hutton), University of Michigan, Ann Arbor","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042341272","display_name":"Paula Anne Newman-Casey","orcid":"https://orcid.org/0000-0002-0847-1929","observed_orcids":["https://orcid.org/0000-0002-0847-1929"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paula Anne Newman-Casey","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036378405","display_name":"Mrinalini Tavag","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Tavag Mrinalini","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070015133","display_name":"Paul P. Lee","orcid":"https://orcid.org/0000-0002-3338-136X","observed_orcids":["https://orcid.org/0000-0002-3338-136X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Paul P Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5035376582","display_name":"David W. Hutton","orcid":"https://orcid.org/0000-0001-9677-1632","observed_orcids":["https://orcid.org/0000-0001-9677-1632"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David W Hutton","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.0548,"has_fulltext":false,"cited_by_count":15,"citation_normalized_percentile":{"value":0.85882753,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":97},"biblio":{"volume":"111","issue":null,"first_page":"56","last_page":"69"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9282000064849854,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10804","display_name":"Health Systems, Economic Evaluations, Quality of Life","score":0.0640999972820282,"subfield":{"id":"https://openalex.org/subfields/2002","display_name":"Economics and Econometrics"},"field":{"id":"https://openalex.org/fields/20","display_name":"Economics, Econometrics and Finance"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neovascular-age-related-macular-degeneration","display_name":"neovascular age-related macular degeneration","score":0.9390000104904175},{"id":"https://openalex.org/keywords/bevacizumab","display_name":"bevacizumab","score":0.9909999966621399},{"id":"https://openalex.org/keywords/ranibizumab","display_name":"ranibizumab","score":1.0},{"id":"https://openalex.org/keywords/cost-effectiveness","display_name":"cost-effectiveness","score":0.9459999799728394},{"id":"https://openalex.org/keywords/anti-vegf-therapy","display_name":"anti-VEGF therapy","score":0.8799999952316284},{"id":"https://openalex.org/keywords/quality-adjusted-life-years","display_name":"quality-adjusted life years","score":0.925000011920929},{"id":"https://openalex.org/keywords/age-related-macular-degeneration","display_name":"age-related macular degeneration","score":0.7649999856948853},{"id":"https://openalex.org/keywords/serious-adverse-events","display_name":"serious adverse events","score":0.6359999775886536},{"id":"https://openalex.org/keywords/vision-loss","display_name":"vision loss","score":0.46299999952316284}],"concepts":[{"id":"https://openalex.org/C2776403814","wikidata":"https://www.wikidata.org/wiki/Q27429789","display_name":"Macular degeneration","level":2,"score":0.9311483502388},{"id":"https://openalex.org/C2781100027","wikidata":"https://www.wikidata.org/wiki/Q414270","display_name":"Ranibizumab","level":4,"score":0.8684930801391602},{"id":"https://openalex.org/C2777802072","wikidata":"https://www.wikidata.org/wiki/Q413299","display_name":"Bevacizumab","level":3,"score":0.8036285638809204},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7708919048309326},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5906055569648743},{"id":"https://openalex.org/C119767625","wikidata":"https://www.wikidata.org/wiki/Q618211","display_name":"Optometry","level":1,"score":0.3847326636314392},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3473900854587555},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2192016839981079},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.1348722279071808},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000068258","descriptor_name":"Bevacizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000069579","descriptor_name":"Ranibizumab","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000369","descriptor_name":"Aged, 80 and over","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003362","descriptor_name":"Cost-Benefit Analysis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008268","descriptor_name":"Macular Degeneration","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D008390","descriptor_name":"Markov Chains","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008962","descriptor_name":"Models, Theoretical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014792","descriptor_name":"Visual Acuity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015331","descriptor_name":"Cohort Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019057","descriptor_name":"Quality-Adjusted Life Years","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D020256","descriptor_name":"Choroidal Neovascularization","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D020533","descriptor_name":"Angiogenesis Inhibitors","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000191","qualifier_name":"economics","is_major_topic":false},{"descriptor_ui":"D061067","descriptor_name":"Antibodies, Monoclonal, Humanized","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":4,"locations":[{"id":"pmh:oai:europepmc.org:2796444","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3797829","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:3797829","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3797829","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Trans Am Ophthalmol Soc","raw_type":"Text"},{"id":"pmid:24167325","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24167325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Transactions of the American Ophthalmological Society","raw_type":"Journal Article"},{"id":"mag:2102218960","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24167325","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":{"id":"pmh:oai:europepmc.org:2796444","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3797829","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4870012041","display_name":"The Association Between Cataract Surgery and Progression of Diabetic Retinopathy","funder_award_id":"K23EY019511","funder_id":"https://openalex.org/F4320337350","funder_display_name":"National Eye Institute"},{"id":"https://openalex.org/G9000863382","display_name":"Michigan Center for Diabetes Translational Research","funder_award_id":"P30DK092926","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337350","display_name":"National Eye Institute","ror":"https://ror.org/03wkg3b53"},{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":49,"referenced_works":["https://openalex.org/W180812339","https://openalex.org/W560609042","https://openalex.org/W1481978003","https://openalex.org/W1487528435","https://openalex.org/W1500728559","https://openalex.org/W1550578859","https://openalex.org/W1595046345","https://openalex.org/W1981972240","https://openalex.org/W1991583017","https://openalex.org/W1995781156","https://openalex.org/W1998100865","https://openalex.org/W2002020452","https://openalex.org/W2006370082","https://openalex.org/W2009734383","https://openalex.org/W2011000634","https://openalex.org/W2012852444","https://openalex.org/W2013520033","https://openalex.org/W2014466117","https://openalex.org/W2017080821","https://openalex.org/W2026593223","https://openalex.org/W2027875367","https://openalex.org/W2029688619","https://openalex.org/W2044558504","https://openalex.org/W2045201722","https://openalex.org/W2062041341","https://openalex.org/W2064533456","https://openalex.org/W2066334011","https://openalex.org/W2070716505","https://openalex.org/W2072636991","https://openalex.org/W2073005444","https://openalex.org/W2074620139","https://openalex.org/W2077681522","https://openalex.org/W2077891356","https://openalex.org/W2085442615","https://openalex.org/W2085712747","https://openalex.org/W2095783086","https://openalex.org/W2101421486","https://openalex.org/W2103699088","https://openalex.org/W2107057433","https://openalex.org/W2108921960","https://openalex.org/W2111157054","https://openalex.org/W2114209995","https://openalex.org/W2119756876","https://openalex.org/W2124415048","https://openalex.org/W2146673937","https://openalex.org/W2152081338","https://openalex.org/W2463967878","https://openalex.org/W3133607852","https://openalex.org/W4253904110"],"related_works":["https://openalex.org/W1972305015","https://openalex.org/W1976000255","https://openalex.org/W4110361","https://openalex.org/W1931298798","https://openalex.org/W2142475605","https://openalex.org/W2126693257","https://openalex.org/W2044558504","https://openalex.org/W2119756876","https://openalex.org/W2212725224","https://openalex.org/W3007231415"],"abstract_inverted_index":{"PURPOSE:":[0],"To":[1],"determine":[2],"the":[3,38,68,77,82,90,145,167,232,253],"most":[4],"cost-effective":[5],"treatment":[6,254],"for":[7,170,234,252],"patients":[8,48,209],"with":[9,31,49,87,161],"newly":[10,50],"diagnosed":[11,51],"neovascular":[12,52,256],"macular":[13,53,257],"degeneration:":[14],"monthly":[15,21,56,60,95,112,131],"or":[16,20,22,62],"as-needed":[17,23,58,63,88,171,216],"bevacizumab":[18,96,113,162,192,245],"injections,":[19],"ranibizumab":[24,105,127,172,211,217,251],"injections.":[25],"METHODS:":[26],"Using":[27],"a":[28,32,43,137],"Markov":[29],"model":[30],"20-year":[33],"time":[34],"horizon,":[35],"we":[36],"compared":[37],"incremental":[39,91,116,176,221],"cost-effectiveness":[40,92,117,177,222],"of":[41,46,70,94,119,141,148,179,224,238,255],"treating":[42],"hypothetical":[44],"cohort":[45],"80-year-old":[47],"degeneration":[54],"using":[55],"bevacizumab,":[57,59,89],"ranibizumab,":[61],"ranibizumab.":[64],"Data":[65],"came":[66],"from":[67,200],"Comparison":[69],"Age-Related":[71],"Macular":[72],"Degeneration":[73],"Treatment":[74],"Trial":[75],"(CATT),":[76],"Medicare":[78],"Fee":[79],"Schedules,":[80],"and":[81,242],"medical":[83],"literature.":[84],"RESULTS:":[85],"Compared":[86],"ratio":[93,118,178,223],"is":[97],"$242,357":[98],"per":[99,124,143,181,226],"quality-adjusted":[100],"life":[101],"year":[102],"(QALY).":[103],"Monthly":[104],"gains":[106],"an":[107,115,175,220],"additional":[108],"0.02":[109],"QALYs":[110],"vs":[111],"at":[114,156],"more":[120],"than":[121,163,250],"$10":[122],"million":[123],"QALY.":[125,182,227],"As-needed":[126],"was":[128],"dominated":[129],"by":[130,196],"bevacizumab.":[132],"In":[133,183],"sensitivity":[134,185],"analyses":[135],"assuming":[136],"willingness":[138],"to":[139,154,173,202],"pay":[140],"$100,000":[142],"QALY,":[144],"annual":[146],"risk":[147],"serious":[149,239],"vascular":[150],"events":[151,241],"would":[152,218],"have":[153,174,219],"be":[155],"least":[157],"2.5":[158],"times":[159],"higher":[160],"that":[164],"observed":[165],"in":[166,236],"CATT":[168],"trial":[169],"<$100,000":[180],"another":[184],"analysis,":[186],"even":[187],"if":[188],"every":[189],"patient":[190],"receiving":[191,210],"experienced":[193],"declining":[194],"vision":[195,214],"one":[197],"category":[198],"(eg,":[199],"20/25-20/40":[201],"20/50-20/80)":[203],"after":[204,230],"2":[205],"years":[206],"but":[207],"all":[208],"retained":[212],"their":[213],"level,":[215],"$97,340":[225],"CONCLUSION:":[228],"Even":[229],"considering":[231],"potential":[233],"differences":[235],"risks":[237],"adverse":[240],"therapeutic":[243],"effectiveness,":[244],"confers":[246],"considerably":[247],"greater":[248],"value":[249],"degeneration.":[258]},"counts_by_year":[{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":1},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
