{"id":"https://openalex.org/W2102188264","doi":null,"title":"Characterization of signaling cascades triggered by human interleukin-6 versus Kaposi's sarcoma-associated herpes virus-encoded viral interleukin 6.","display_name":"Characterization of signaling cascades triggered by human interleukin-6 versus Kaposi's sarcoma-associated herpes virus-encoded viral interleukin 6.","publication_year":2000,"publication_date":"2000-03-01","ids":{"openalex":"https://openalex.org/W2102188264","mag":"2102188264","pmid":"https://pubmed.ncbi.nlm.nih.gov/10741750"},"language":"en","primary_location":{"id":"pmid:10741750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10741750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091207345","display_name":"Teru Hideshima","orcid":"https://orcid.org/0000-0003-2939-6224","observed_orcids":["https://orcid.org/0000-0003-2939-6224"]},"institutions":[{"id":"https://openalex.org/I4210117453","display_name":"Dana-Farber Cancer Institute","ror":"https://ror.org/02jzgtq86","country_code":"US","type":"facility","lineage":["https://openalex.org/I4210117453"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"T Hideshima","raw_affiliation_strings":["Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Adult Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I4210117453"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5006765393","display_name":"Dharminder Chauhan","orcid":"https://orcid.org/0000-0002-5548-6138","observed_orcids":["https://orcid.org/0000-0002-5548-6138"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"D Chauhan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110381085","display_name":"Gerrard Teoh","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"G Teoh","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052048627","display_name":"Noopur S Raje","orcid":"https://orcid.org/0000-0003-3066-1275","observed_orcids":["https://orcid.org/0000-0003-3066-1275"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"N Raje","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081299017","display_name":"Steven Peter Treon","orcid":"https://orcid.org/0000-0001-6393-6154","observed_orcids":["https://orcid.org/0000-0001-6393-6154"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"S P Treon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113803180","display_name":"Yu-Hui Tai","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y T Tai","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081617768","display_name":"Yoshihito Shima","orcid":"https://orcid.org/0000-0002-2523-2938","observed_orcids":["https://orcid.org/0000-0002-2523-2938"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Y Shima","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5032464400","display_name":"Kenneth Carl Anderson","orcid":"https://orcid.org/0000-0002-6418-0886","observed_orcids":["https://orcid.org/0000-0002-6418-0886"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"K C Anderson","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.3749,"has_fulltext":false,"cited_by_count":71,"citation_normalized_percentile":{"value":0.88462006,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"6","issue":"3","first_page":"1180","last_page":"9"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9330999851226807,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10685","display_name":"Viral-associated cancers and disorders","score":0.05779999867081642,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11591","display_name":"NF-\u03baB Signaling Pathways","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/kaposi-s-sarcoma-associated-herpesvirus","display_name":"Kaposi's sarcoma-associated herpesvirus","score":0.9539999961853027},{"id":"https://openalex.org/keywords/viral-interleukin-6","display_name":"viral interleukin-6","score":0.9580000042915344},{"id":"https://openalex.org/keywords/signaling-pathways","display_name":"signaling pathways","score":0.7799999713897705},{"id":"https://openalex.org/keywords/gp130","display_name":"gp130","score":0.8309999704360962},{"id":"https://openalex.org/keywords/jak1","display_name":"JAK1","score":0.8859999775886536},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.9269999861717224},{"id":"https://openalex.org/keywords/mek1","display_name":"MEK1","score":0.796999990940094},{"id":"https://openalex.org/keywords/mitogen-activated-protein-kinase","display_name":"mitogen-activated protein kinase","score":0.6549999713897705},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.847000002861023},{"id":"https://openalex.org/keywords/dna-synthesis","display_name":"DNA synthesis","score":0.8389999866485596},{"id":"https://openalex.org/keywords/anti-apoptotic-effects","display_name":"anti-apoptotic effects","score":0.7429999709129333},{"id":"https://openalex.org/keywords/dexamethasone-induced-apoptosis","display_name":"dexamethasone-induced apoptosis","score":0.8939999938011169},{"id":"https://openalex.org/keywords/kaposi-sarcoma","display_name":"Kaposi's sarcoma","score":0.8619999885559082}],"concepts":[{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.524577796459198},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5135045647621155},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4886651337146759},{"id":"https://openalex.org/C112392421","wikidata":"https://www.wikidata.org/wiki/Q903451","display_name":"Janus kinase","level":3,"score":0.4752340614795685},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.468882292509079},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4622952342033386},{"id":"https://openalex.org/C126037660","wikidata":"https://www.wikidata.org/wiki/Q21116066","display_name":"Glycoprotein 130","level":4,"score":0.45362865924835205},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.4464244842529297},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.43568602204322815},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.4126877784729004},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.33770889043807983},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.22353029251098633},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.0},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000906","descriptor_name":"Antibodies","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D002455","descriptor_name":"Cell Division","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003907","descriptor_name":"Dexamethasone","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004268","descriptor_name":"DNA-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004789","descriptor_name":"Enzyme Activation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D004791","descriptor_name":"Enzyme Inhibitors","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D005419","descriptor_name":"Flavonoids","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006825","descriptor_name":"Hybridomas","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009500","descriptor_name":"Neutralization Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D011505","descriptor_name":"Protein-Tyrosine Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D011994","descriptor_name":"Recombinant Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D014407","descriptor_name":"Tumor Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014764","descriptor_name":"Viral Proteins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":true},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015534","descriptor_name":"Trans-Activators","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015703","descriptor_name":"Antigens, CD","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015850","descriptor_name":"Interleukin-6","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D017346","descriptor_name":"Protein Serine-Threonine Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D019288","descriptor_name":"Herpesvirus 8, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019947","descriptor_name":"Receptors, Interleukin-6","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019950","descriptor_name":"Mitogen-Activated Protein Kinase 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020929","descriptor_name":"Mitogen-Activated Protein Kinase Kinases","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":false},{"descriptor_ui":"D048369","descriptor_name":"MAP Kinase Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050794","descriptor_name":"STAT1 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050795","descriptor_name":"STAT2 Transcription Factor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050822","descriptor_name":"Cytokine Receptor gp130","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053613","descriptor_name":"Janus Kinase 1","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053614","descriptor_name":"Janus Kinase 2","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"pmid:10741750","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10741750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Clinical cancer research : an official journal of the American Association for Cancer Research","raw_type":"Journal Article"},{"id":"mag:2102188264","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10741750","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"PubMed","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3549977710","display_name":"Host-tumor cell interaction in myeloma: therapeutic applications","funder_award_id":"P01CA078378","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"},{"id":"https://openalex.org/G5276536440","display_name":"Molecular Sequelae of Myeloma-Bone Marrow Interactions: Therapeutic Applications","funder_award_id":"R01CA050947","funder_id":"https://openalex.org/F4320337351","funder_display_name":"National Cancer Institute"}],"funders":[{"id":"https://openalex.org/F4320337351","display_name":"National Cancer Institute","ror":"https://ror.org/040gcmg81"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W139500099","https://openalex.org/W150478668","https://openalex.org/W1494751477","https://openalex.org/W1500857648","https://openalex.org/W1564694728","https://openalex.org/W1568956696","https://openalex.org/W1572954385","https://openalex.org/W1608821961","https://openalex.org/W1743711678","https://openalex.org/W1777722644","https://openalex.org/W1777794242","https://openalex.org/W1822742523","https://openalex.org/W1955814101","https://openalex.org/W1964842789","https://openalex.org/W1971908211","https://openalex.org/W1985208420","https://openalex.org/W1999028040","https://openalex.org/W2003757684","https://openalex.org/W2005592215","https://openalex.org/W2007000374","https://openalex.org/W2007119824","https://openalex.org/W2007540708","https://openalex.org/W2020211894","https://openalex.org/W2021841541","https://openalex.org/W2030624761","https://openalex.org/W2034974668","https://openalex.org/W2035936653","https://openalex.org/W2045560618","https://openalex.org/W2062005942","https://openalex.org/W2065537276","https://openalex.org/W2067804511","https://openalex.org/W2089097621","https://openalex.org/W2090786978","https://openalex.org/W2094111001","https://openalex.org/W2096216895","https://openalex.org/W2110863828","https://openalex.org/W2115798976","https://openalex.org/W2118310862","https://openalex.org/W2119120508","https://openalex.org/W2122248986","https://openalex.org/W2132134210","https://openalex.org/W2132797069","https://openalex.org/W2140611891","https://openalex.org/W2154819235","https://openalex.org/W2158946057","https://openalex.org/W2159163386","https://openalex.org/W2160508776","https://openalex.org/W2165119257","https://openalex.org/W2166187451","https://openalex.org/W2276983539","https://openalex.org/W2280492586","https://openalex.org/W2288106601","https://openalex.org/W2336241188","https://openalex.org/W2410723119","https://openalex.org/W2474873081"],"related_works":["https://openalex.org/W2090702421","https://openalex.org/W2129685169","https://openalex.org/W1973666901","https://openalex.org/W2140611891","https://openalex.org/W2126755470","https://openalex.org/W2088830809","https://openalex.org/W7097450938","https://openalex.org/W2050672551","https://openalex.org/W2949493606","https://openalex.org/W2166187451"],"abstract_inverted_index":{"Kaposi's":[0,8,246],"sarcoma-associated":[1],"herpes":[2],"virus":[3],"(KSHV)":[4],"is":[5],"associated":[6],"with":[7,41],"sarcoma,":[9],"multicentric":[10],"Castleman's":[11],"disease,":[12],"and":[13,65,77,83,140,149,153,160,173,200,208,211,229,248],"body":[14],"cavity-based":[15],"lymphomas,":[16],"settings":[17],"in":[18,73,91,94,98,116,157,168,242,245],"which":[19,48],"human":[20,217],"interleukin-6":[21],"(hIL-6)":[22],"acts":[23],"as":[24],"a":[25,39,99],"growth":[26,52,228],"factor.":[27],"The":[28],"KSHV":[29],"open":[30],"reading":[31],"frame":[32],"K2":[33],"encodes":[34],"for":[35],"viral":[36],"IL-6":[37,125],"(vIL-6),":[38],"protein":[40,155],"25%":[42],"amino":[43],"acid":[44],"identity":[45],"to":[46,118,131,136,170,194],"hIL-6,":[47,111],"can":[49],"promote":[50],"the":[51,58,74,121,191,223,227],"of":[53,151,164,181,205,215,222,232],"hIL-6-dependent":[54,75],"cell":[55,79,96,166],"lines.":[56,80],"In":[57],"present":[59],"study,":[60],"we":[61],"characterized":[62],"biological":[63],"sequelae":[64],"signaling":[66,224],"cascades":[67,225],"triggered":[68,109],"by":[69,110,177],"hIL-6":[70,82,139,172,199,235],"versus":[71,234],"vIL-6":[72,84,141,174,201,233],"MH60":[76,159,207],"B9":[78,161,209],"Both":[81,138],"induced":[85],"significant":[86],"increases":[87],"(P":[88],"<":[89],"0.01)":[90],"DNA":[92,107],"synthesis":[93,108],"these":[95,165],"lines":[97,167],"dose-dependent":[100],"fashion.":[101],"Neutralizing":[102],"anti-hIL-6":[103],"antibody":[104],"(Ab)":[105],"inhibited":[106],"without":[112],"similarly":[113],"affecting":[114],"proliferation":[115],"response":[117,130,169,193],"vIL-6.":[119],"On":[120],"other":[122,249],"hand,":[123],"antimouse":[124],"receptor":[126],"(mIL-6R)":[127],"Ab":[128],"blocked":[129,176,212],"vIL-6,":[132],"but":[133],"not":[134],"that":[135,187],"hIL-6.":[137],"activated":[142],"gp130,":[143],"Janus":[144],"kinase":[145,156],"1,":[146],"signal":[147],"transducers":[148],"activators":[150],"transcription-3,":[152],"mitogen-activated":[154],"both":[158,171,195,198],"cells.":[162,219],"Proliferation":[163],"was":[175],"PD98059,":[178],"an":[179],"inhibitor":[180],"MEK1":[182,188],"activation.":[183],"These":[184],"data":[185],"suggest":[186],"activation":[189],"mediates":[190],"proliferative":[192],"cytokines.":[196],"Finally,":[197],"also":[202],"maintained":[203],"viability":[204],"serum-starved":[206],"cells":[210],"dexamethasone-induced":[213],"apoptosis":[214],"MM.1S":[216],"myeloma":[218],"Further":[220],"characterization":[221],"mediating":[226],"antiapoptotic":[230],"effects":[231],"may":[236],"help":[237],"identify":[238],"their":[239],"unique":[240],"roles":[241],"disease":[243],"pathogenesis":[244],"sarcoma":[247],"KSHV-associated":[250],"neoplasms.":[251]},"counts_by_year":[{"year":2024,"cited_by_count":1},{"year":2022,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2016-06-24T00:00:00"}
