{"id":"https://openalex.org/W2102146294","doi":"https://doi.org/10.1002/jnr.21273","title":"Matrix metalloproteinases in brain development and remodeling: Synaptic functions and targets","display_name":"Matrix metalloproteinases in brain development and remodeling: Synaptic functions and targets","publication_year":2007,"publication_date":"2007-03-23","ids":{"openalex":"https://openalex.org/W2102146294","doi":"https://doi.org/10.1002/jnr.21273","mag":"2102146294","pmid":"https://pubmed.ncbi.nlm.nih.gov/17387691"},"language":"en","primary_location":{"id":"doi:10.1002/jnr.21273","doi":"https://doi.org/10.1002/jnr.21273","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jnr.21273","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5059159627","display_name":"Iryna M. Ethell","orcid":"https://orcid.org/0000-0002-1324-6611","observed_orcids":["https://orcid.org/0000-0002-1324-6611"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Iryna M. Ethell","raw_affiliation_strings":["Division of Biomedical Sciences, University of California Riverside, Riverside, California 92521-0121, USA. iryna.ethell@ucr.edu","Division of Biomedical Sciences, University of California Riverside, Riverside, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Sciences, University of California Riverside, Riverside, California 92521-0121, USA. iryna.ethell@ucr.edu","institution_ids":["https://openalex.org/I103635307"]},{"raw_affiliation_string":"Division of Biomedical Sciences, University of California Riverside, Riverside, California","institution_ids":["https://openalex.org/I103635307"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5079722104","display_name":"Douglas W. Ethell","orcid":"https://orcid.org/0000-0002-9237-0265","observed_orcids":["https://orcid.org/0000-0002-9237-0265"]},"institutions":[{"id":"https://openalex.org/I103635307","display_name":"University of California, Riverside","ror":"https://ror.org/03nawhv43","country_code":"US","type":"education","lineage":["https://openalex.org/I103635307"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Douglas W. Ethell","raw_affiliation_strings":["Division of Biomedical Sciences, University of California Riverside, Riverside, California"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Biomedical Sciences, University of California Riverside, Riverside, California","institution_ids":["https://openalex.org/I103635307"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5059159627"],"corresponding_institution_ids":["https://openalex.org/I103635307"],"apc_list":{"value":4840,"currency":"USD","value_usd":4840},"apc_paid":null,"fwci":1.9928,"has_fulltext":false,"cited_by_count":374,"citation_normalized_percentile":{"value":0.87601958,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":99,"max":100},"biblio":{"volume":"85","issue":"13","first_page":"2813","last_page":"2823"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.7060999870300293,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10620","display_name":"Protease and Inhibitor Mechanisms","score":0.7060999870300293,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.2433999925851822,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.00800000037997961,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":1.0},{"id":"https://openalex.org/keywords/synaptogenesis","display_name":"synaptogenesis","score":0.9049999713897705},{"id":"https://openalex.org/keywords/synaptic-plasticity","display_name":"synaptic plasticity","score":0.9950000047683716},{"id":"https://openalex.org/keywords/long-term-potentiation","display_name":"long-term potentiation","score":0.9980000257492065},{"id":"https://openalex.org/keywords/perineuronal-nets","display_name":"perineuronal nets","score":0.9760000109672546},{"id":"https://openalex.org/keywords/brevican","display_name":"brevican","score":0.9549999833106995},{"id":"https://openalex.org/keywords/tenascin-r","display_name":"tenascin-R","score":0.996999979019165},{"id":"https://openalex.org/keywords/laminin","display_name":"laminin","score":0.9850000143051147},{"id":"https://openalex.org/keywords/trkb-receptor","display_name":"TrkB receptor","score":0.9179999828338623},{"id":"https://openalex.org/keywords/ephrins","display_name":"ephrins","score":0.9470000267028809},{"id":"https://openalex.org/keywords/eph-receptors","display_name":"Eph receptors","score":0.9829999804496765},{"id":"https://openalex.org/keywords/cadherins","display_name":"cadherins","score":0.9990000128746033},{"id":"https://openalex.org/keywords/tnf-alpha","display_name":"TNF-\u03b1","score":0.8569999933242798},{"id":"https://openalex.org/keywords/neurodegenerative-diseases","display_name":"neurodegenerative diseases","score":0.781000018119812},{"id":"https://openalex.org/keywords/brain-development","display_name":"brain development","score":0.6970000267028809},{"id":"https://openalex.org/keywords/hippocampus","display_name":"hippocampus","score":0.5}],"concepts":[{"id":"https://openalex.org/C65232495","wikidata":"https://www.wikidata.org/wiki/Q1813773","display_name":"Synaptogenesis","level":2,"score":0.6368089318275452},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.6235454082489014},{"id":"https://openalex.org/C98229152","wikidata":"https://www.wikidata.org/wiki/Q1551556","display_name":"Synaptic plasticity","level":3,"score":0.5752802491188049},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5558246970176697},{"id":"https://openalex.org/C25274449","wikidata":"https://www.wikidata.org/wiki/Q1805481","display_name":"Long-term potentiation","level":3,"score":0.5392265915870667},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.521821916103363},{"id":"https://openalex.org/C97124661","wikidata":"https://www.wikidata.org/wiki/Q14897782","display_name":"Tropomyosin receptor kinase B","level":4,"score":0.5114494562149048},{"id":"https://openalex.org/C129987498","wikidata":"https://www.wikidata.org/wiki/Q7168586","display_name":"Perineuronal net","level":3,"score":0.46903857588768005},{"id":"https://openalex.org/C160539049","wikidata":"https://www.wikidata.org/wiki/Q3064187","display_name":"Neurotrophic factors","level":3,"score":0.4029660224914551},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.276516318321228},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2533205449581146},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.08483031392097473}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000201","qualifier_name":"enzymology","is_major_topic":true},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":true},{"descriptor_ui":"D008959","descriptor_name":"Models, Neurological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009473","descriptor_name":"Neuronal Plasticity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D013569","descriptor_name":"Synapses","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1002/jnr.21273","doi":"https://doi.org/10.1002/jnr.21273","is_oa":false,"landing_page_url":"https://doi.org/10.1002/jnr.21273","pdf_url":null,"source":{"id":"https://openalex.org/S76417895","display_name":"Journal of Neuroscience Research","issn_l":"0360-4012","issn":["0360-4012","1097-4547"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Neuroscience Research","raw_type":"journal-article"},{"id":"pmid:17387691","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17387691","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of neuroscience research","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.6240000128746033}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":94,"referenced_works":["https://openalex.org/W1482195692","https://openalex.org/W1491678226","https://openalex.org/W1542136448","https://openalex.org/W1548862642","https://openalex.org/W1554147846","https://openalex.org/W1600951028","https://openalex.org/W1619234695","https://openalex.org/W1649452503","https://openalex.org/W1669342624","https://openalex.org/W1706443485","https://openalex.org/W1872514198","https://openalex.org/W1911664005","https://openalex.org/W1919303367","https://openalex.org/W1928161708","https://openalex.org/W1963482376","https://openalex.org/W1965858834","https://openalex.org/W1966389850","https://openalex.org/W1968072037","https://openalex.org/W1973629131","https://openalex.org/W1974815300","https://openalex.org/W1975861627","https://openalex.org/W1976484413","https://openalex.org/W1978771622","https://openalex.org/W1978837916","https://openalex.org/W1979841422","https://openalex.org/W1984332535","https://openalex.org/W1987825791","https://openalex.org/W1988804288","https://openalex.org/W1993360635","https://openalex.org/W1999845366","https://openalex.org/W2000831618","https://openalex.org/W2004101410","https://openalex.org/W2008864017","https://openalex.org/W2009484631","https://openalex.org/W2012105257","https://openalex.org/W2015163495","https://openalex.org/W2017193677","https://openalex.org/W2029527760","https://openalex.org/W2030776545","https://openalex.org/W2033449185","https://openalex.org/W2036792388","https://openalex.org/W2039724703","https://openalex.org/W2041216210","https://openalex.org/W2046329404","https://openalex.org/W2047121898","https://openalex.org/W2048361100","https://openalex.org/W2049031559","https://openalex.org/W2049879969","https://openalex.org/W2054464763","https://openalex.org/W2056539843","https://openalex.org/W2056745170","https://openalex.org/W2061497228","https://openalex.org/W2062122607","https://openalex.org/W2063081369","https://openalex.org/W2063885093","https://openalex.org/W2065778432","https://openalex.org/W2066693652","https://openalex.org/W2081656219","https://openalex.org/W2082812095","https://openalex.org/W2087090756","https://openalex.org/W2091012424","https://openalex.org/W2091334133","https://openalex.org/W2091564781","https://openalex.org/W2093338466","https://openalex.org/W2093552981","https://openalex.org/W2098622411","https://openalex.org/W2102599317","https://openalex.org/W2105028929","https://openalex.org/W2105604932","https://openalex.org/W2109129502","https://openalex.org/W2111476808","https://openalex.org/W2115976216","https://openalex.org/W2117308838","https://openalex.org/W2128049766","https://openalex.org/W2131548712","https://openalex.org/W2135585199","https://openalex.org/W2136560728","https://openalex.org/W2138406651","https://openalex.org/W2138530343","https://openalex.org/W2139137961","https://openalex.org/W2139565721","https://openalex.org/W2146302811","https://openalex.org/W2147528917","https://openalex.org/W2158241217","https://openalex.org/W2159022089","https://openalex.org/W2161262083","https://openalex.org/W2165335202","https://openalex.org/W2165809424","https://openalex.org/W2167122805","https://openalex.org/W2167768159","https://openalex.org/W2170802361","https://openalex.org/W2171288469","https://openalex.org/W2186135786","https://openalex.org/W2414678570"],"related_works":["https://openalex.org/W2080822716","https://openalex.org/W4402735704","https://openalex.org/W2995588844","https://openalex.org/W1981571957","https://openalex.org/W1706443485","https://openalex.org/W2117308838","https://openalex.org/W2033449185","https://openalex.org/W1965208860","https://openalex.org/W2954884521","https://openalex.org/W2097769598"],"abstract_inverted_index":{"Matrix":[0],"metalloproteinases":[1],"(MMPs)":[2],"play":[3,47],"critical":[4],"roles":[5,49],"in":[6,50,82,117,135,145,184,206,210,225],"egg":[7],"fertilization,":[8],"embryonic":[9],"development,":[10],"wound":[11],"repair,":[12],"cancer,":[13],"and":[14,16,29,54,73,85,100,119,121,157,178,187,238,243],"inflammatory":[15],"neurologic":[17,211],"diseases.":[18],"This":[19],"subfamily":[20],"of":[21,66,75,97,103,161,219,235],"metzincin":[22],"peptidases":[23],"can":[24,69,148,190],"cleave":[25],"extracellular":[26],"matrix":[27],"(ECM)":[28],"pericellular":[30],"proteins":[31,45,68],"that":[32,46,94,146,202],"have":[33],"profound":[34],"effects":[35],"on":[36],"cell":[37],"behavior.":[38],"Among":[39],"known":[40],"MMP":[41,128,171,223],"substrates":[42,172],"are":[43,89,95,181],"several":[44,155],"important":[48],"synaptogenesis,":[51],"synaptic":[52,169,236],"plasticity,":[53],"long-term":[55],"potentiation":[56],"(LTP).":[57],"In":[58],"this":[59],"Mini-Review":[60],"we":[61,214],"discuss":[62,215],"how":[63,216],"MMP-directed":[64],"cleavage":[65,109],"these":[67],"impact":[70],"the":[71,78,83,162,168,217,241],"formation":[72,237],"function":[74,239],"synapses":[76],"within":[77,240],"brain.":[79,245],"Pyramidal":[80],"neurons":[81],"hippocampus,":[84],"other":[86],"large":[87],"neurons,":[88],"surrounded":[90],"by":[91,110,154],"perineuronal":[92],"nets":[93],"composed":[96],"brevican,":[98],"tenascin-R,":[99],"laminin,":[101],"each":[102],"which":[104,142,180],"is":[105,132,143,203],"subject":[106],"to":[107,221],"proteolytic":[108],"MMPs.":[111],"Tenascin-R":[112],"knockout":[113,140],"mice":[114],"show":[115],"deficits":[116],"learning":[118],"memory":[120],"LTP,":[122],"as":[123],"do":[124],"at":[125],"least":[126],"two":[127],"knockouts.":[129],"Impaired":[130],"LTP":[131],"also":[133,173,182,191],"seen":[134],"brain-derived":[136],"neurotrophic":[137],"factor":[138],"(BDNF)":[139],"mice,":[141],"interesting":[144],"pro-BDNF":[147],"be":[149],"processed":[150],"into":[151,197],"mature":[152,244],"BDNF":[153,164],"MMPs":[156,189],"thereby":[158],"regulate":[159],"activation":[160],"high-affinity":[163],"receptor":[165],"TrkB.":[166],"At":[167],"level,":[170],"include":[174],"ephrins,":[175],"Eph":[176],"receptors,":[177],"cadherins,":[179],"involved":[183],"synapse":[185],"development":[186,218],"plasticity.":[188],"process":[192],"membrane-bound":[193],"tumor":[194],"necrosis":[195],"factor-alpha":[196],"a":[198],"potent":[199],"soluble":[200],"cytokine":[201],"increasingly":[204],"implicated":[205],"neuron-glial":[207],"signaling,":[208],"particularly":[209],"disease.":[212],"Finally,":[213],"therapeutics":[220],"attenuate":[222],"activity":[224],"neurodegenerative":[226],"disorders":[227],"may":[228],"become":[229],"powerful":[230],"tools":[231],"for":[232],"future":[233],"studies":[234],"developing":[242]},"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":8},{"year":2024,"cited_by_count":17},{"year":2023,"cited_by_count":10},{"year":2022,"cited_by_count":19},{"year":2021,"cited_by_count":21},{"year":2020,"cited_by_count":18},{"year":2019,"cited_by_count":11},{"year":2018,"cited_by_count":24},{"year":2017,"cited_by_count":12},{"year":2016,"cited_by_count":30},{"year":2015,"cited_by_count":31},{"year":2014,"cited_by_count":29},{"year":2013,"cited_by_count":24},{"year":2012,"cited_by_count":24}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
