{"id":"https://openalex.org/W2102136386","doi":null,"title":"Mechanisms underlying impaired humoral immunity in primary and chronic HIV-1 infection","display_name":"Mechanisms underlying impaired humoral immunity in primary and chronic HIV-1 infection","publication_year":2006,"publication_date":"2006-04-14","ids":{"openalex":"https://openalex.org/W2102136386","mag":"2102136386"},"language":"en","primary_location":{"id":"pmh:oai:figshare.com:article/26925553","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Mechanisms_underlying_impaired_humoral_immunity_in_primary_and_chronic_HIV-1_infection/26925553","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},"volume":null,"type":"dissertation","indexed_in":[],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"http://hdl.handle.net/10616/40000","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5014015676","display_name":"Kehmia Titanji","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Kehmia Titanji","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5014015676"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10112","display_name":"HIV Research and Treatment","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2406","display_name":"Virology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11655","display_name":"HIV-related health complications and treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2711","display_name":"Emergency Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hiv-1","display_name":"HIV-1","score":0.7020000219345093},{"id":"https://openalex.org/keywords/humoral-immunity","display_name":"humoral immunity","score":0.7229999899864197},{"id":"https://openalex.org/keywords/b-cell-dysfunction","display_name":"B cell dysfunction","score":0.9829999804496765},{"id":"https://openalex.org/keywords/primary-hiv-1-infection","display_name":"primary HIV-1 infection","score":0.925000011920929},{"id":"https://openalex.org/keywords/chronic-hiv-1-infection","display_name":"chronic HIV-1 infection","score":0.9359999895095825},{"id":"https://openalex.org/keywords/immune-activation","display_name":"immune activation","score":0.9390000104904175},{"id":"https://openalex.org/keywords/naive-b-cells","display_name":"naive B cells","score":0.7200000286102295},{"id":"https://openalex.org/keywords/memory-b-cells","display_name":"memory B cells","score":0.8479999899864197},{"id":"https://openalex.org/keywords/fas-fasl-apoptosis","display_name":"Fas/FasL apoptosis","score":0.7850000262260437},{"id":"https://openalex.org/keywords/hypergammaglobulinemia","display_name":"hypergammaglobulinemia","score":0.925000011920929},{"id":"https://openalex.org/keywords/vaccine-response","display_name":"vaccine response","score":0.5730000138282776},{"id":"https://openalex.org/keywords/hiv-2","display_name":"HIV-2","score":0.7429999709129333},{"id":"https://openalex.org/keywords/cd27","display_name":"CD27","score":0.5839999914169312},{"id":"https://openalex.org/keywords/beta2-microglobulin","display_name":"beta2-microglobulin","score":0.7870000004768372},{"id":"https://openalex.org/keywords/igg","display_name":"IgG","score":0.5600000023841858},{"id":"https://openalex.org/keywords/pneumococcal-polysaccharide","display_name":"pneumococcal polysaccharide","score":0.800000011920929}],"concepts":[{"id":"https://openalex.org/C2776548049","wikidata":"https://www.wikidata.org/wiki/Q1142875","display_name":"Humoral immunity","level":3,"score":0.6160993576049805},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6084915995597839},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.5726611614227295},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.5488916635513306},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4484902024269104},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.4005826413631439},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3392549157142639},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.32330480217933655}],"mesh":[],"locations_count":3,"locations":[{"id":"pmh:oai:figshare.com:article/26925553","doi":null,"is_oa":false,"landing_page_url":"https://figshare.com/articles/thesis/Mechanisms_underlying_impaired_humoral_immunity_in_primary_and_chronic_HIV-1_infection/26925553","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Thesis"},{"id":"pmh:oai:openarchive.ki.se:10616/40000","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/40000","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},{"id":"mag:2102136386","doi":null,"is_oa":false,"landing_page_url":"https://openarchive.ki.se/xmlui/bitstream/10616/40000/1/thesis.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":{"id":"pmh:oai:openarchive.ki.se:10616/40000","doi":null,"is_oa":true,"landing_page_url":"http://hdl.handle.net/10616/40000","pdf_url":null,"source":{"id":"https://openalex.org/S4306400147","display_name":"Open Archive (Karolinska Institutet)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I28166907","host_organization_name":"Karolinska Institutet","host_organization_lineage":["https://openalex.org/I28166907"],"host_organization_lineage_names":[],"type":"repository"},"license":"other-oa","license_id":"https://openalex.org/licenses/other-oa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"info:eu-repo/semantics/doctoralThesis"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":221,"referenced_works":["https://openalex.org/W3508737","https://openalex.org/W26089772","https://openalex.org/W82184047","https://openalex.org/W114176068","https://openalex.org/W229319184","https://openalex.org/W1485066483","https://openalex.org/W1486133890","https://openalex.org/W1493673711","https://openalex.org/W1500168279","https://openalex.org/W1500217023","https://openalex.org/W1504970236","https://openalex.org/W1508333056","https://openalex.org/W1515033630","https://openalex.org/W1523933945","https://openalex.org/W1528520360","https://openalex.org/W1539984014","https://openalex.org/W1550154089","https://openalex.org/W1563485932","https://openalex.org/W1574561647","https://openalex.org/W1586015366","https://openalex.org/W1593599243","https://openalex.org/W1594804329","https://openalex.org/W1606321542","https://openalex.org/W1611185316","https://openalex.org/W1625166229","https://openalex.org/W1636503434","https://openalex.org/W1655510925","https://openalex.org/W1673227951","https://openalex.org/W1808985647","https://openalex.org/W1841983536","https://openalex.org/W1911233976","https://openalex.org/W1930372002","https://openalex.org/W1935116877","https://openalex.org/W1968211025","https://openalex.org/W1969952390","https://openalex.org/W1970132486","https://openalex.org/W1970768125","https://openalex.org/W1971860154","https://openalex.org/W1973398091","https://openalex.org/W1974102127","https://openalex.org/W1974138678","https://openalex.org/W1974450295","https://openalex.org/W1976860874","https://openalex.org/W1977282539","https://openalex.org/W1978141065","https://openalex.org/W1978593760","https://openalex.org/W1979918788","https://openalex.org/W1981098164","https://openalex.org/W1982612158","https://openalex.org/W1983885062","https://openalex.org/W1984409141","https://openalex.org/W1985591364","https://openalex.org/W1986006520","https://openalex.org/W1986152436","https://openalex.org/W1987039284","https://openalex.org/W1988363221","https://openalex.org/W1988973539","https://openalex.org/W1990291720","https://openalex.org/W1990768351","https://openalex.org/W1992991204","https://openalex.org/W1995355944","https://openalex.org/W1996464851","https://openalex.org/W1997489674","https://openalex.org/W1997677784","https://openalex.org/W1998342817","https://openalex.org/W1999396723","https://openalex.org/W2003227439","https://openalex.org/W2003830418","https://openalex.org/W2006370225","https://openalex.org/W2007766444","https://openalex.org/W2008754040","https://openalex.org/W2009752005","https://openalex.org/W2011630381","https://openalex.org/W2012139740","https://openalex.org/W2012149683","https://openalex.org/W2014571704","https://openalex.org/W2017051726","https://openalex.org/W2018340804","https://openalex.org/W2019722722","https://openalex.org/W2021445133","https://openalex.org/W2021906926","https://openalex.org/W2022098233","https://openalex.org/W2022931362","https://openalex.org/W2023833143","https://openalex.org/W2024109749","https://openalex.org/W2025373690","https://openalex.org/W2026444780","https://openalex.org/W2030676469","https://openalex.org/W2030844138","https://openalex.org/W2033139060","https://openalex.org/W2033757712","https://openalex.org/W2034160159","https://openalex.org/W2034293576","https://openalex.org/W2036398690","https://openalex.org/W2036785641","https://openalex.org/W2037343680","https://openalex.org/W2039862437","https://openalex.org/W2041538272","https://openalex.org/W2041851366","https://openalex.org/W2042476299","https://openalex.org/W2045045232","https://openalex.org/W2047269867","https://openalex.org/W2050489828","https://openalex.org/W2051108441","https://openalex.org/W2053297567","https://openalex.org/W2055887598","https://openalex.org/W2056227477","https://openalex.org/W2057591590","https://openalex.org/W2058357901","https://openalex.org/W2058922480","https://openalex.org/W2059337777","https://openalex.org/W2059544448","https://openalex.org/W2064557078","https://openalex.org/W2065684180","https://openalex.org/W2065772392","https://openalex.org/W2066030558","https://openalex.org/W2067034588","https://openalex.org/W2067044581","https://openalex.org/W2067237014","https://openalex.org/W2069282346","https://openalex.org/W2070558900","https://openalex.org/W2070997543","https://openalex.org/W2073231427","https://openalex.org/W2073738573","https://openalex.org/W2075135942","https://openalex.org/W2075847325","https://openalex.org/W2076742437","https://openalex.org/W2077713919","https://openalex.org/W2077903075","https://openalex.org/W2078069915","https://openalex.org/W2079504777","https://openalex.org/W2079999509","https://openalex.org/W2082860553","https://openalex.org/W2083090125","https://openalex.org/W2084229810","https://openalex.org/W2085919513","https://openalex.org/W2086297790","https://openalex.org/W2086703018","https://openalex.org/W2090356138","https://openalex.org/W2090646713","https://openalex.org/W2092168645","https://openalex.org/W2093381281","https://openalex.org/W2093514748","https://openalex.org/W2094829985","https://openalex.org/W2099019634","https://openalex.org/W2100928031","https://openalex.org/W2101098507","https://openalex.org/W2106296417","https://openalex.org/W2106421596","https://openalex.org/W2106741340","https://openalex.org/W2107212181","https://openalex.org/W2107889299","https://openalex.org/W2109349187","https://openalex.org/W2114366448","https://openalex.org/W2115101818","https://openalex.org/W2116458521","https://openalex.org/W2117156406","https://openalex.org/W2118362622","https://openalex.org/W2123525329","https://openalex.org/W2124135314","https://openalex.org/W2124136539","https://openalex.org/W2124969212","https://openalex.org/W2126141460","https://openalex.org/W2126651853","https://openalex.org/W2127436087","https://openalex.org/W2129578219","https://openalex.org/W2130719514","https://openalex.org/W2131099542","https://openalex.org/W2132185205","https://openalex.org/W2132547595","https://openalex.org/W2133649749","https://openalex.org/W2134817712","https://openalex.org/W2135668656","https://openalex.org/W2135816279","https://openalex.org/W2136045513","https://openalex.org/W2136137425","https://openalex.org/W2136347300","https://openalex.org/W2138634802","https://openalex.org/W2141514558","https://openalex.org/W2143788821","https://openalex.org/W2144882745","https://openalex.org/W2145145884","https://openalex.org/W2146471131","https://openalex.org/W2147071499","https://openalex.org/W2147188734","https://openalex.org/W2148123079","https://openalex.org/W2150484278","https://openalex.org/W2151338681","https://openalex.org/W2151864174","https://openalex.org/W2155607098","https://openalex.org/W2156961356","https://openalex.org/W2157713905","https://openalex.org/W2159578627","https://openalex.org/W2160594014","https://openalex.org/W2163182609","https://openalex.org/W2163206714","https://openalex.org/W2164206375","https://openalex.org/W2166022914","https://openalex.org/W2167906381","https://openalex.org/W2168208975","https://openalex.org/W2168379509","https://openalex.org/W2168777278","https://openalex.org/W2168885953","https://openalex.org/W2170620478","https://openalex.org/W2171098307","https://openalex.org/W2171141994","https://openalex.org/W2282756759","https://openalex.org/W2290831667","https://openalex.org/W2319153630","https://openalex.org/W2320498484","https://openalex.org/W2321852728","https://openalex.org/W2327503296","https://openalex.org/W2329856427","https://openalex.org/W2330826215","https://openalex.org/W2338264038","https://openalex.org/W2339006876","https://openalex.org/W2339219218","https://openalex.org/W2342220526","https://openalex.org/W2410908409","https://openalex.org/W2412951508","https://openalex.org/W2615187673"],"related_works":["https://openalex.org/W114176068","https://openalex.org/W3021671064","https://openalex.org/W2330826215","https://openalex.org/W2006831840","https://openalex.org/W1993039369","https://openalex.org/W1996101538","https://openalex.org/W1572923378","https://openalex.org/W1576301798","https://openalex.org/W2300160747","https://openalex.org/W7100154948"],"abstract_inverted_index":{"B":[0,42,47,88,105,124,153,165,181,205,223,241,277,315,345,398,487,518],"cells":[1,89,92,106,166,182,242,278,316,519],"of":[2,27,41,46,56,79,83,93,103,144,179,204,219,238,246,261,276,298,358,397,403,417,442,516,522,552],"HIV-1-infected":[3],"patients":[4,185],"have":[5,73,194],"both":[6],"phenotypic":[7],"and":[8,61,71,81,90,107,151,158,167,190,214,231,303,309,329,348,393,414,444,555],"functional":[9],"dysfunctions":[10,49,126,155,207,347,400],"which":[11,352],"may":[12,36,65,72,108,139,170,232,257,268],"be":[13,37,110,171,258,378],"important":[14,74,344,407,486],"in":[15,69,156,173,211,228,253,273,279,319,334,337,353,401,408,449,561],"HIV-1":[16,51,113,131,229,291,320,338,450,480,527,565],"pathogenesis.":[17],"Immune":[18,148,322],"activation":[19,57,149,560],"during":[20,50,112,129,136,289,526],"HIV":[21,160,174,280,340,375,404],"infection":[22,52,80,132,138,146,213,230,255,292,341,364,405,481],"is":[23,97,243,250,285,332,381,406],"an":[24,259,367],"essential":[25,98],"part":[26],"the":[28,33,38,77,84,94,100,104,180,217,220,274,356,359,363,371,395,483],"body":[29],"s":[30],"defense":[31],"against":[32],"virus,":[34],"but":[35,249],"root":[39],"cause":[40],"cell":[43,48,125,154,346,399],"dysfunctions.":[44,489],"Evidence":[45],"include":[53],"altered":[54,111,172],"expression":[55],"markers,":[58],"spontaneous":[59],"apoptosis,":[60],"polyclonal":[62],"activation.":[63],"These":[64],"occur":[66],"very":[67],"early":[68,210,288],"infection,":[70,175,248],"effects":[75],"on":[76],"outcome":[78],"treatment":[82],"patient.":[85],"Interaction":[86],"between":[87,164],"other":[91,168],"immune":[95,263,387,559],"system":[96],"to":[99,120,177,188,234,301,343,361,370,383,564],"proper":[101],"functioning":[102],"also":[109,286],"infection.":[114,339,451,528,566],"With":[115],"this":[116],"thesis":[117],"I":[118],"wanted":[119],"investigate":[121],"if:":[122],"(1)":[123],"are":[127,208,225,317],"initiated":[128,209],"primary":[130,137,157,212,254,290],"(2)":[133],"Patients":[134],"treated":[135],"stand":[140],"a":[141,244,270],"better":[142],"chance":[143],"controlling":[145],"(3)":[147],"induces":[150],"enhances":[152],"chronic":[159,247],"infection;":[161,281,321],"(4)":[162],"Interactions":[163],"lymphocytes":[169,224],"leading":[176],"malfunction":[178],"(5)":[183],"HIV-infected":[184],"respond":[186],"poorly":[187],"vaccination":[189],"infections":[191],"because":[192],"they":[193],"impaired":[195,287,349,445],"serological":[196,524],"memory.":[197],"The":[198,265],"results":[199],"obtained":[200],"indicate":[201,557],"that:":[202],"Majority":[203],"lymphocyte":[206,488],"persist":[215],"throughout":[216],"course":[218],"disease;":[221],"Naive":[222],"abnormally":[226],"activated":[227],"contribute":[233],"excessive":[235],"hypergammaglobulinemia;":[236],"Loss":[237,515],"memory":[239,314,517,525],"(CD27+)":[240],"feature":[245],"not":[251],"observed":[252],"thus":[256],"effect":[260],"persistent":[262],"activation;":[264],"Fas-FasL":[266],"pathway":[267],"play":[269],"key":[271],"role":[272,396],"deletion":[275],"Antigen-specific":[282],"humoral":[283,350,386,447],"immunity":[284,351,448],"as":[293,307,388,390],"shown":[294],"by":[295,325],"reduced":[296],"levels":[297,551],"specific":[299],"antibodies":[300],"HIV,":[302],"non-HIV":[304],"antigens":[305],"such":[306],"measles":[308],"pneumococcus":[310],"polysaccharide":[311],"antigens;":[312],"Measles-specific":[313],"deleted":[318],"activation,":[323],"assessed":[324],"plasma":[326],"sCD27,":[327],"IgG":[328,556],"beta-2":[330],"microglobulin,":[331],"lower":[333,558],"HIV-2":[335,562],"than":[336],"leads":[342],"turn":[354],"impair":[355],"ability":[357],"patient":[360],"control":[362],"and/or":[365],"mount":[366],"effective":[368,412],"response":[369],"virus.":[372],"An":[373],"ideal":[374],"vaccine":[376],"would":[377],"one":[379],"that":[380],"able":[382],"elicit":[384],"strong":[385],"well":[389],"cell-mediated":[391],"responses":[392],"understanding":[394],"immunopathogenesis":[402],"refining":[409],"strategies":[410],"for":[411,485],"therapies":[413],"vaccines.":[415],"List":[416],"scientific":[418],"papers":[419],"I.":[420],"De":[421,475,497],"Milito":[422,476],"A,":[423,425,437,499,501,511,543],"Nilsson":[424,510],"Titanji":[426,457,495,531],"K,":[427,458,496,532],"Thorstensson":[428,502],"R,":[429,462,503],"Reizenstein":[430],"E,":[431],"Narita":[432],"M,":[433],"Grutzmeier":[434,471,504],"S,":[435,472,505,534],"Sonnerborg":[436],"Chiodi":[438,459,512,544],"F":[439,513],"(2004).":[440],"Mechanisms":[441],"hypergammaglobulinemia":[443],"antigen-specific":[446],"Blood.":[452],"103(6):":[453],"2180-6.":[454],"https://doi.org/10.1182/blood-2003-07-2375":[455],"II.":[456],"F,":[460,545],"Bellocco":[461],"Schepis":[463],"D,":[464],"Osorio":[465],"L,":[466,474,509],"Tassandin":[467],"C,":[468],"Tambussi":[469],"G,":[470],"Lopalco":[473,508],"A":[477,548],"(2005).":[478],"Primary":[479],"sets":[482],"stage":[484],"AIDS.":[490],"19(17):":[491],"1947-55.":[492],"https://doi.org/10.1097/01.aids.0000191231.54170.89":[493],"III.":[494],"milito":[498],"Cagigi":[500],"Hejdeman":[506],"B,":[507],"(2006).":[514,549],"impairs":[520],"maintenance":[521],"long-term":[523],"[Submitted]":[529],"IV.":[530],"Andersson":[533],"Sousa":[535],"AE,":[536],"da":[537],"Silva":[538],"Z,":[539],"Norrgren":[540],"H,":[541],"Atlas":[542],"de":[546],"Milto":[547],"Plasma":[550],"soluble":[553],"CD27":[554],"compared":[563],"[Manuscript]":[567]},"counts_by_year":[],"updated_date":"2026-09-11T09:22:31.653822","created_date":"2016-06-24T00:00:00"}