{"id":"https://openalex.org/W2102097271","doi":"https://doi.org/10.1099/vir.0.011783-0","title":"Toll-like receptor 7-induced immune response to cutaneous West Nile virus infection","display_name":"Toll-like receptor 7-induced immune response to cutaneous West Nile virus infection","publication_year":2009,"publication_date":"2009-10-09","ids":{"openalex":"https://openalex.org/W2102097271","doi":"https://doi.org/10.1099/vir.0.011783-0","mag":"2102097271","pmid":"https://pubmed.ncbi.nlm.nih.gov/19641044","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/2771433"},"language":"en","primary_location":{"id":"doi:10.1099/vir.0.011783-0","doi":"https://doi.org/10.1099/vir.0.011783-0","is_oa":false,"landing_page_url":"https://doi.org/10.1099/vir.0.011783-0","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2771433","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5051427169","display_name":"Thomas Welte","orcid":"https://orcid.org/0000-0002-1749-9886","observed_orcids":["https://orcid.org/0000-0002-1749-9886"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas Welte","raw_affiliation_strings":["Departments of Microbiology and Immunology, and Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Microbiology and Immunology, and Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042394223","display_name":"Krystle L. Reagan","orcid":"https://orcid.org/0000-0003-3426-6352","observed_orcids":["https://orcid.org/0000-0003-3426-6352"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Krystle Reagan","raw_affiliation_strings":["Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hao Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hao Fang","raw_affiliation_strings":["Departments of Microbiology and Immunology, and Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Microbiology and Immunology, and Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067248355","display_name":"Carlos Macha\u00edn-Williams","orcid":"https://orcid.org/0000-0002-7747-8868","observed_orcids":["https://orcid.org/0000-0002-7747-8868"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carlos Machain-Williams","raw_affiliation_strings":["Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5070573479","display_name":"Xin Zheng","orcid":"https://orcid.org/0000-0001-6564-7807","observed_orcids":["https://orcid.org/0000-0001-6564-7807"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Xin Zheng","raw_affiliation_strings":["Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038046953","display_name":"Nicole L. Mendell","orcid":"https://orcid.org/0009-0007-2551-7769","observed_orcids":["https://orcid.org/0009-0007-2551-7769"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Nicole Mendell","raw_affiliation_strings":["Departments of Microbiology and Immunology, and Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Microbiology and Immunology, and Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048026541","display_name":"Gwong\u2010Jen J. Chang","orcid":"https://orcid.org/0000-0001-9959-6585","observed_orcids":["https://orcid.org/0000-0001-9959-6585"]},"institutions":[{"id":"https://openalex.org/I1289490764","display_name":"Centers for Disease Control and Prevention","ror":"https://ror.org/042twtr12","country_code":"US","type":"government","lineage":["https://openalex.org/I1289490764","https://openalex.org/I1299022934"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gwong-Jen J. Chang","raw_affiliation_strings":["Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Road, CDC-Foothills Campus, Fort Collins, CO 80521, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Vector-Borne Infectious Diseases, Centers for Disease Control and Prevention, 3150 Rampart Road, CDC-Foothills Campus, Fort Collins, CO 80521, USA","institution_ids":["https://openalex.org/I1289490764"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101473021","display_name":"Ping Wu","orcid":"https://orcid.org/0000-0002-7020-6237","observed_orcids":["https://orcid.org/0000-0002-7020-6237"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ping Wu","raw_affiliation_strings":["Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555-0620, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Cell Biology, University of Texas Medical Branch, Galveston, TX 77555-0620, USA","institution_ids":["https://openalex.org/I55302922"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022926563","display_name":"Carol D. Blair","orcid":"https://orcid.org/0000-0002-2803-0354","observed_orcids":["https://orcid.org/0000-0002-2803-0354"]},"institutions":[{"id":"https://openalex.org/I92446798","display_name":"Colorado State University","ror":"https://ror.org/03k1gpj17","country_code":"US","type":"education","lineage":["https://openalex.org/I92446798"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carol D. Blair","raw_affiliation_strings":["Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523, USA","institution_ids":["https://openalex.org/I92446798"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100428388","display_name":"Tian Wang","orcid":"https://orcid.org/0000-0002-1511-0793","observed_orcids":["https://orcid.org/0000-0002-1511-0793"]},"institutions":[{"id":"https://openalex.org/I55302922","display_name":"The University of Texas Medical Branch at Galveston","ror":"https://ror.org/016tfm930","country_code":"US","type":"education","lineage":["https://openalex.org/I55302922"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tian Wang","raw_affiliation_strings":["Departments of Microbiology and Immunology, and Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Microbiology and Immunology, and Pathology, University of Texas Medical Branch, Galveston, TX 77555-0609, USA","institution_ids":["https://openalex.org/I55302922"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.9849,"has_fulltext":false,"cited_by_count":95,"citation_normalized_percentile":{"value":0.91381033,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"90","issue":"11","first_page":"2660","last_page":"2668"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8320000171661377,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.8320000171661377,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10166","display_name":"Mosquito-borne diseases and control","score":0.11900000274181366,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.010900000110268593,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr7","display_name":"TLR7","score":0.9800000190734863},{"id":"https://openalex.org/keywords/west-nile-virus","display_name":"West Nile virus","score":0.9959999918937683},{"id":"https://openalex.org/keywords/skin-infections","display_name":"skin infections","score":0.9440000057220459},{"id":"https://openalex.org/keywords/langerhans-cells","display_name":"Langerhans cells","score":0.8629999756813049},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cytokine-response","display_name":"cytokine response","score":0.6980000138282776},{"id":"https://openalex.org/keywords/interferon-alpha","display_name":"interferon-alpha","score":0.9190000295639038},{"id":"https://openalex.org/keywords/il-12","display_name":"IL-12","score":0.8389999866485596},{"id":"https://openalex.org/keywords/interleukin-6","display_name":"interleukin-6","score":0.7260000109672546},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.949999988079071},{"id":"https://openalex.org/keywords/langerhans-cell-migration","display_name":"Langerhans cell migration","score":0.8539999723434448},{"id":"https://openalex.org/keywords/skin-draining-lymph-nodes","display_name":"skin-draining lymph nodes","score":0.6990000009536743},{"id":"https://openalex.org/keywords/mosquito-feeding-behavior","display_name":"mosquito feeding behavior","score":0.36899998784065247}],"concepts":[{"id":"https://openalex.org/C2779836521","wikidata":"https://www.wikidata.org/wiki/Q14914081","display_name":"TLR7","level":5,"score":0.8663161993026733},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7981383800506592},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.661928653717041},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6214138865470886},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5486156344413757},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.5311431288719177},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.4942913055419922},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.45273134112358093},{"id":"https://openalex.org/C2779734145","wikidata":"https://www.wikidata.org/wiki/Q3053951","display_name":"Viral encephalitis","level":4,"score":0.44450896978378296},{"id":"https://openalex.org/C2780568436","wikidata":"https://www.wikidata.org/wiki/Q1165479","display_name":"Flavivirus","level":3,"score":0.43800896406173706},{"id":"https://openalex.org/C2776458125","wikidata":"https://www.wikidata.org/wiki/Q1827343","display_name":"Epidermis (zoology)","level":2,"score":0.41816943883895874},{"id":"https://openalex.org/C83455156","wikidata":"https://www.wikidata.org/wiki/Q199615","display_name":"Encephalitis","level":3,"score":0.28910839557647705},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.28205615282058716},{"id":"https://openalex.org/C105702510","wikidata":"https://www.wikidata.org/wiki/Q514","display_name":"Anatomy","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007801","descriptor_name":"Langerhans Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D012367","descriptor_name":"RNA, Viral","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D014901","descriptor_name":"West Nile Fever","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014902","descriptor_name":"West Nile virus","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D015603","descriptor_name":"Keratinocytes","qualifier_ui":"Q000821","qualifier_name":"virology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018920","descriptor_name":"Coculture Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019562","descriptor_name":"Viral Load","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051199","descriptor_name":"Toll-Like Receptor 7","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051199","descriptor_name":"Toll-Like Receptor 7","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1099/vir.0.011783-0","doi":"https://doi.org/10.1099/vir.0.011783-0","is_oa":false,"landing_page_url":"https://doi.org/10.1099/vir.0.011783-0","pdf_url":null,"source":{"id":"https://openalex.org/S103035011","display_name":"Journal of General Virology","issn_l":"0022-1317","issn":["0022-1317","1465-2099"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320497","host_organization_name":"Microbiology Society","host_organization_lineage":["https://openalex.org/P4310320497"],"host_organization_lineage_names":["Microbiology Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of General Virology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:2771433","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2771433","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gen Virol","raw_type":"Text"},{"id":"pmid:19641044","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/19641044","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of general virology","raw_type":"Journal Article"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:2771433","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/2771433","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Gen Virol","raw_type":"Text"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1415970015","display_name":"MyD88-mediated innate immunity against West Nile virus","funder_award_id":"R03AI067409","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4041012329","display_name":null,"funder_award_id":"T01/CCT 822307","funder_id":"https://openalex.org/F4320332505","funder_display_name":"U.S. Public Health Service"},{"id":"https://openalex.org/G5268618238","display_name":"U.S. Based Collaboration in Emerging Viral Diseases","funder_award_id":"n01ai25489-12-0-1","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G6616382793","display_name":null,"funder_award_id":"N01 AI025489","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G8634763553","display_name":"Gammadelta T cell Regulation of Adaptive Immunity in West Nile Virus Infection","funder_award_id":"R01AI072060","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320308380","display_name":"Yale University","ror":"https://ror.org/03v76x132"},{"id":"https://openalex.org/F4320311600","display_name":"Regeneron Pharmaceuticals","ror":"https://ror.org/02f51rf24"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332505","display_name":"U.S. Public Health Service","ror":"https://ror.org/05xf94514"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":53,"referenced_works":["https://openalex.org/W1493210615","https://openalex.org/W1499978168","https://openalex.org/W1501518736","https://openalex.org/W1502104604","https://openalex.org/W1511903547","https://openalex.org/W1534658432","https://openalex.org/W1669165205","https://openalex.org/W1764179577","https://openalex.org/W1904661552","https://openalex.org/W1958745508","https://openalex.org/W1959254653","https://openalex.org/W1966396614","https://openalex.org/W1967605755","https://openalex.org/W1967821522","https://openalex.org/W1968875620","https://openalex.org/W1970136118","https://openalex.org/W1972326511","https://openalex.org/W1978702543","https://openalex.org/W1979714321","https://openalex.org/W1994391392","https://openalex.org/W1995866508","https://openalex.org/W2005262608","https://openalex.org/W2014018213","https://openalex.org/W2016926086","https://openalex.org/W2017680126","https://openalex.org/W2027458478","https://openalex.org/W2030611349","https://openalex.org/W2038341037","https://openalex.org/W2040777809","https://openalex.org/W2043384253","https://openalex.org/W2045428863","https://openalex.org/W2056423038","https://openalex.org/W2058756509","https://openalex.org/W2071107608","https://openalex.org/W2073831244","https://openalex.org/W2076361525","https://openalex.org/W2078811876","https://openalex.org/W2085512015","https://openalex.org/W2090862099","https://openalex.org/W2095048886","https://openalex.org/W2110161909","https://openalex.org/W2115119197","https://openalex.org/W2124473438","https://openalex.org/W2140944306","https://openalex.org/W2142913420","https://openalex.org/W2152102509","https://openalex.org/W2153342952","https://openalex.org/W2161208630","https://openalex.org/W2170694569","https://openalex.org/W2176474689","https://openalex.org/W2184454519","https://openalex.org/W2313417098","https://openalex.org/W4239341883"],"related_works":["https://openalex.org/W2058756509","https://openalex.org/W2899162298","https://openalex.org/W2043384253","https://openalex.org/W2259044051","https://openalex.org/W2809231867","https://openalex.org/W7044049705","https://openalex.org/W2021655479","https://openalex.org/W2603086480","https://openalex.org/W2025345062","https://openalex.org/W2053763801"],"abstract_inverted_index":{"The":[0],"Toll-like":[1],"receptor":[2],"(TLR)":[3],"7":[4],"response":[5,31,231],"represents":[6],"a":[7,12,86],"vital":[8],"host-defence":[9],"mechanism":[10],"in":[11,43,69,91,107,188,207,212,217,247],"murine":[13],"model":[14],"of":[15,27,66,75,79,89,94,100,141,149,153,159,177,180,191],"systemic":[16,248],"West":[17],"Nile":[18],"virus":[19],"(WNV)":[20],"infection.":[21,35,83,223,249],"Here,":[22],"we":[23],"investigated":[24],"the":[25,28,70,92,108,126,174,189,208,229,239],"role":[26],"TLR7-induced":[29],"immune":[30],"following":[32,81,220,232],"cutaneous":[33,233],"WNV":[34,46,67,121,139,222],"We":[36],"found":[37],"that":[38,138,148,228],"there":[39],"was":[40,85,105,144],"no":[41],"difference":[42,104],"susceptibility":[44],"to":[45,120,128],"encephalitis":[47],"between":[48],"wild-type":[49,95,150,154,181,185,213],"and":[50,73,110,123,162,166,194],"TLR7(-/-)":[51,142,198,218],"mice":[52,80,96,182],"upon":[53,132],"intradermal":[54,82,133,221],"injection":[55],"or":[56,200],"infected":[57],"mosquito":[58],"feeding.":[59],"Viral":[60],"load":[61],"analysis":[62],"revealed":[63],"similar":[64],"levels":[65,158],"RNA":[68],"peripheral":[71],"tissues":[72],"brains":[74,111],"these":[76],"two":[77],"groups":[78],"There":[84],"higher":[87,146,157],"level":[88],"cytokines":[90],"blood":[93,109],"at":[97,112],"early":[98],"stages":[99],"infection;":[101],"however,":[102],"this":[103],"diminished":[106],"later":[113],"stages.":[114],"Langerhans":[115],"cells":[116],"(LCs)":[117],"are":[118],"permissive":[119],"infection":[122,140,234],"migrate":[124],"from":[125,173,238],"skin":[127],"draining":[129],"lymph":[130],"nodes":[131],"challenge.":[134],"Our":[135],"data":[136],"showed":[137],"keratinocytes":[143,155,186,199],"significantly":[145],"than":[147,196],"keratinocytes.":[151],"Infection":[152],"induced":[156],"alpha":[160],"interferon":[161],"interleukin-1beta":[163],"(IL-1beta),":[164],"IL-6":[165,193],"IL-12,":[167],"which":[168,241],"might":[169,242],"promote":[170],"LC":[171,236],"migration":[172,237],"skin.":[175],"Co-culture":[176],"na\u00efve":[178],"LCs":[179,203,206],"with":[183,197],"WNV-infected":[184],"resulted":[187],"production":[190],"more":[192],"IL-12":[195],"by":[201],"cultured":[202],"alone.":[204],"Moreover,":[205],"epidermis":[209],"were":[210],"reduced":[211],"mice,":[214,219],"but":[215],"not":[216],"Overall,":[224],"our":[225],"results":[226],"suggest":[227],"TLR7":[230],"promotes":[235],"skin,":[240],"compromise":[243],"its":[244],"protective":[245],"effect":[246]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":5},{"year":2024,"cited_by_count":3},{"year":2023,"cited_by_count":3},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":5},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":8},{"year":2017,"cited_by_count":8},{"year":2016,"cited_by_count":8},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":11},{"year":2013,"cited_by_count":10},{"year":2012,"cited_by_count":5}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}