{"id":"https://openalex.org/W2102045372","doi":"https://doi.org/10.1038/emboj.2011.348","title":"NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons","display_name":"NYAP: a phosphoprotein family that links PI3K to WAVE1 signalling in neurons","publication_year":2011,"publication_date":"2011-09-23","ids":{"openalex":"https://openalex.org/W2102045372","doi":"https://doi.org/10.1038/emboj.2011.348","mag":"2102045372","pmid":"https://pubmed.ncbi.nlm.nih.gov/21946561","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3243607"},"language":"en","primary_location":{"id":"doi:10.1038/emboj.2011.348","doi":"https://doi.org/10.1038/emboj.2011.348","is_oa":true,"landing_page_url":"https://doi.org/10.1038/emboj.2011.348","pdf_url":"https://link.springer.com/content/pdf/10.1038/emboj.2011.348.pdf","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://link.springer.com/content/pdf/10.1038/emboj.2011.348.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5103745716","display_name":"Kazumasa Yokoyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazumasa Yokoyama","raw_affiliation_strings":["Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000786225","display_name":"Tohru Tezuka","orcid":"https://orcid.org/0000-0003-4762-8578","observed_orcids":["https://orcid.org/0000-0003-4762-8578"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Tohru Tezuka","raw_affiliation_strings":["Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090936024","display_name":"Masaharu Kotani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I30181195","display_name":"Ohu University","ror":"https://ror.org/01fe6f215","country_code":"JP","type":"education","lineage":["https://openalex.org/I30181195"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Masaharu Kotani","raw_affiliation_strings":["Department of Molecular and Cellular Biology, School of Pharmaceutical Sciences, Ohu University, Fukushima, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular and Cellular Biology, School of Pharmaceutical Sciences, Ohu University, Fukushima, Japan","institution_ids":["https://openalex.org/I30181195"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062513710","display_name":"Takanobu Nakazawa","orcid":"https://orcid.org/0000-0003-4863-1277","observed_orcids":["https://orcid.org/0000-0003-4863-1277"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takanobu Nakazawa","raw_affiliation_strings":["Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086807527","display_name":"Naosuke Hoshina","orcid":"https://orcid.org/0000-0003-2575-1356","observed_orcids":["https://orcid.org/0000-0003-2575-1356"]},"institutions":[{"id":"https://openalex.org/I142637625","display_name":"Okinawa Institute of Science and Technology Graduate University","ror":"https://ror.org/02qg15b79","country_code":"JP","type":"education","lineage":["https://openalex.org/I142637625"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Naosuke Hoshina","raw_affiliation_strings":["Cell Signal Unit, Okinawa Institute of Science and Technology, Okinawa, Japan","Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Signal Unit, Okinawa Institute of Science and Technology, Okinawa, Japan","institution_ids":["https://openalex.org/I142637625"]},{"raw_affiliation_string":"Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027278347","display_name":"Yasushi Shimoda","orcid":"https://orcid.org/0000-0001-9230-6784","observed_orcids":["https://orcid.org/0000-0001-9230-6784"]},"institutions":[{"id":"https://openalex.org/I85922643","display_name":"Nagaoka University of Technology","ror":"https://ror.org/00ys1hz88","country_code":"JP","type":"education","lineage":["https://openalex.org/I85922643"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yasushi Shimoda","raw_affiliation_strings":["Department of Bioengineering, Nagaoka University of Technology, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Nagaoka University of Technology, Niigata, Japan","institution_ids":["https://openalex.org/I85922643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059569764","display_name":"Shigeru Kakuta","orcid":"https://orcid.org/0000-0002-5900-1425","observed_orcids":["https://orcid.org/0000-0002-5900-1425"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Shigeru Kakuta","raw_affiliation_strings":["Laboratory of Molecular Pathogenesis, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pathogenesis, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044756754","display_name":"Katsuko Sudo","orcid":"https://orcid.org/0000-0002-5286-7648","observed_orcids":["https://orcid.org/0000-0002-5286-7648"]},"institutions":[{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Katsuko Sudo","raw_affiliation_strings":["Laboratory of Molecular Pathogenesis, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Pathogenesis, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061818588","display_name":"Kazutada Watanabe","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I85922643","display_name":"Nagaoka University of Technology","ror":"https://ror.org/00ys1hz88","country_code":"JP","type":"education","lineage":["https://openalex.org/I85922643"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Kazutada Watanabe","raw_affiliation_strings":["Department of Bioengineering, Nagaoka University of Technology, Niigata, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioengineering, Nagaoka University of Technology, Niigata, Japan","institution_ids":["https://openalex.org/I85922643"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074919264","display_name":"Yoichiro Iwakura","orcid":"https://orcid.org/0000-0002-9934-5775","observed_orcids":["https://orcid.org/0000-0002-9934-5775"]},"institutions":[{"id":"https://openalex.org/I4210086780","display_name":"Japan Science and Technology Agency","ror":"https://ror.org/00097mb19","country_code":"JP","type":"government","lineage":["https://openalex.org/I1319490839","https://openalex.org/I4210086780"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Yoichiro Iwakura","raw_affiliation_strings":["CREST, Japan Science and Technology Agency, Saitama, Japan","Laboratory of Molecular Pathogenesis, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"CREST, Japan Science and Technology Agency, Saitama, Japan","institution_ids":["https://openalex.org/I4210086780"]},{"raw_affiliation_string":"Laboratory of Molecular Pathogenesis, Center for Experimental Medicine and Systems Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5024136589","display_name":"Tadashi S. Yamamoto","orcid":"https://orcid.org/0000-0002-5938-9378","observed_orcids":["https://orcid.org/0000-0002-5938-9378"]},"institutions":[{"id":"https://openalex.org/I142637625","display_name":"Okinawa Institute of Science and Technology Graduate University","ror":"https://ror.org/02qg15b79","country_code":"JP","type":"education","lineage":["https://openalex.org/I142637625"]},{"id":"https://openalex.org/I4405286826","display_name":"Institute of Medical Science, The University of Tokyo","ror":"https://ror.org/0376e0j29","country_code":"JP","type":"facility","lineage":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"id":"https://openalex.org/I74801974","display_name":"The University of Tokyo","ror":"https://ror.org/057zh3y96","country_code":"JP","type":"education","lineage":["https://openalex.org/I74801974"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Tadashi Yamamoto","raw_affiliation_strings":["Cell Signal Unit, Okinawa Institute of Science and Technology, Okinawa, Japan","Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, 4\u20106\u20101 Shirokanedai, Minato\u2010ku, Tokyo, 108\u20108639, Japan","Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cell Signal Unit, Okinawa Institute of Science and Technology, Okinawa, Japan","institution_ids":["https://openalex.org/I142637625"]},{"raw_affiliation_string":"Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, 4\u20106\u20101 Shirokanedai, Minato\u2010ku, Tokyo, 108\u20108639, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]},{"raw_affiliation_string":"Division of Oncology, Department of Cancer Biology, Institute of Medical Science, University of Tokyo, Tokyo, Japan","institution_ids":["https://openalex.org/I4405286826","https://openalex.org/I74801974"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5024136589"],"corresponding_institution_ids":["https://openalex.org/I142637625","https://openalex.org/I4405286826","https://openalex.org/I74801974"],"apc_list":{"value":7990,"currency":"USD","value_usd":7990},"apc_paid":null,"fwci":0.642,"has_fulltext":true,"cited_by_count":77,"citation_normalized_percentile":{"value":0.64670252,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":99},"biblio":{"volume":"30","issue":"23","first_page":"4739","last_page":"4754"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8184000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.8184000253677368,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10952","display_name":"PI3K/AKT/mTOR signaling in cancer","score":0.08240000158548355,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12061","display_name":"Axon Guidance and Neuronal Signaling","score":0.03420000150799751,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/phosphatidylinositol-3-kinase","display_name":"phosphatidylinositol 3-kinase","score":0.8389999866485596},{"id":"https://openalex.org/keywords/neuronal-morphogenesis","display_name":"neuronal morphogenesis","score":0.6759999990463257},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.9240000247955322},{"id":"https://openalex.org/keywords/actin-cytoskeleton-reorganization","display_name":"actin cytoskeleton remodeling","score":0.9070000052452087},{"id":"https://openalex.org/keywords/fyn-tyrosine-kinase","display_name":"Fyn tyrosine kinase","score":0.8600000143051147},{"id":"https://openalex.org/keywords/tyrosine-phosphorylation","display_name":"tyrosine phosphorylation","score":0.8960000276565552},{"id":"https://openalex.org/keywords/pi3k-p85","display_name":"PI3K p85","score":0.9459999799728394},{"id":"https://openalex.org/keywords/akt","display_name":"Akt","score":0.8889999985694885},{"id":"https://openalex.org/keywords/rac1","display_name":"Rac1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/phosphatidylinositol-3-4-5-trisphosphate","display_name":"phosphatidylinositol 3,4,5-trisphosphate","score":0.8550000190734863},{"id":"https://openalex.org/keywords/brain-size","display_name":"brain size","score":0.7409999966621399},{"id":"https://openalex.org/keywords/developing-neurons","display_name":"developing neurons","score":0.4059999883174896}],"concepts":[{"id":"https://openalex.org/C161191863","wikidata":"https://www.wikidata.org/wiki/Q199655","display_name":"Library science","level":1,"score":0.5058736205101013},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.46994855999946594},{"id":"https://openalex.org/C3020610715","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medical science","level":2,"score":0.43312519788742065},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20831289887428284},{"id":"https://openalex.org/C509550671","wikidata":"https://www.wikidata.org/wiki/Q126945","display_name":"Medical education","level":1,"score":0.15975534915924072},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.09529417753219604}],"mesh":[{"descriptor_ui":"D000199","descriptor_name":"Actins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D001921","descriptor_name":"Brain","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D003599","descriptor_name":"Cytoskeleton","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D006367","descriptor_name":"HeLa Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010766","descriptor_name":"Phosphorylation","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D017386","descriptor_name":"Sequence Homology, Amino Acid","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D019579","descriptor_name":"Neocortex","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D019579","descriptor_name":"Neocortex","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D019579","descriptor_name":"Neocortex","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051076","descriptor_name":"Proto-Oncogene Proteins c-fyn","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051300","descriptor_name":"Wiskott-Aldrich Syndrome Protein Family","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1038/emboj.2011.348","doi":"https://doi.org/10.1038/emboj.2011.348","is_oa":true,"landing_page_url":"https://doi.org/10.1038/emboj.2011.348","pdf_url":"https://link.springer.com/content/pdf/10.1038/emboj.2011.348.pdf","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3243607","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3243607","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"EMBO J","raw_type":"Text"},{"id":"pmid:21946561","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21946561","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1038/emboj.2011.348","doi":"https://doi.org/10.1038/emboj.2011.348","is_oa":true,"landing_page_url":"https://doi.org/10.1038/emboj.2011.348","pdf_url":"https://link.springer.com/content/pdf/10.1038/emboj.2011.348.pdf","source":{"id":"https://openalex.org/S127916151","display_name":"The EMBO Journal","issn_l":"0261-4189","issn":["0261-4189","1460-2075"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The EMBO Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.428600013256073,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1532108711","display_name":"Studies on the phosphorylation-mediated regulation of neural morphogenesis and its involvement in hydrocephalus","funder_award_id":"21680033","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G2796775268","display_name":"Functional analysis of novel NYAP family proteins","funder_award_id":"22700391","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G3292315349","display_name":"Dissection of mRNA degradation pathways and anomalies associated with targeted disruption of CCR4-NOT deadenylase complex","funder_award_id":"21229006","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G6665554086","display_name":"Establishment of an IL-1-related gene-manipulated mice library, aiming at uncovering pathophysiology of disease from a view point of systems biology","funder_award_id":"20220009","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"},{"id":"https://openalex.org/G7442178938","display_name":"Analysis of IL-1/IL-17 system-dependent promoting mechanisms for development of colon cancer using model mice","funder_award_id":"22700448","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320320912","display_name":"Ministry of Education, Culture, Sports, Science and Technology","ror":"https://ror.org/048rj2z13"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2102045372.pdf","grobid_xml":"https://content.openalex.org/works/W2102045372.grobid-xml"},"referenced_works_count":81,"referenced_works":["https://openalex.org/W21338461","https://openalex.org/W1499352093","https://openalex.org/W1535419937","https://openalex.org/W1557470610","https://openalex.org/W1907575477","https://openalex.org/W1965185534","https://openalex.org/W1967248496","https://openalex.org/W1967251877","https://openalex.org/W1968611232","https://openalex.org/W1968783143","https://openalex.org/W1969435846","https://openalex.org/W1972933543","https://openalex.org/W1973155317","https://openalex.org/W1983188620","https://openalex.org/W1985876473","https://openalex.org/W1985876982","https://openalex.org/W1987388768","https://openalex.org/W1989899772","https://openalex.org/W1990197377","https://openalex.org/W1996708080","https://openalex.org/W2005061638","https://openalex.org/W2016742231","https://openalex.org/W2021329171","https://openalex.org/W2021856025","https://openalex.org/W2022889556","https://openalex.org/W2026376328","https://openalex.org/W2029066126","https://openalex.org/W2030102659","https://openalex.org/W2032321712","https://openalex.org/W2032419047","https://openalex.org/W2044161108","https://openalex.org/W2045959681","https://openalex.org/W2048108096","https://openalex.org/W2049315117","https://openalex.org/W2049705063","https://openalex.org/W2051861976","https://openalex.org/W2053507081","https://openalex.org/W2054179202","https://openalex.org/W2054760273","https://openalex.org/W2056959025","https://openalex.org/W2057308155","https://openalex.org/W2060240421","https://openalex.org/W2060538012","https://openalex.org/W2062535336","https://openalex.org/W2064258387","https://openalex.org/W2066953183","https://openalex.org/W2067166571","https://openalex.org/W2074258117","https://openalex.org/W2084434864","https://openalex.org/W2086107539","https://openalex.org/W2088477641","https://openalex.org/W2088678425","https://openalex.org/W2089075706","https://openalex.org/W2089472706","https://openalex.org/W2090501101","https://openalex.org/W2091564806","https://openalex.org/W2091751009","https://openalex.org/W2095571257","https://openalex.org/W2096791952","https://openalex.org/W2101741807","https://openalex.org/W2102837197","https://openalex.org/W2104619025","https://openalex.org/W2106507395","https://openalex.org/W2116721774","https://openalex.org/W2121034339","https://openalex.org/W2124009013","https://openalex.org/W2125227184","https://openalex.org/W2128134322","https://openalex.org/W2130139152","https://openalex.org/W2131426434","https://openalex.org/W2144601878","https://openalex.org/W2151492695","https://openalex.org/W2152186846","https://openalex.org/W2157140132","https://openalex.org/W2159755129","https://openalex.org/W2164682544","https://openalex.org/W2171629301","https://openalex.org/W2290802694","https://openalex.org/W2491492261","https://openalex.org/W2527840914","https://openalex.org/W4321429240"],"related_works":["https://openalex.org/W2124101414","https://openalex.org/W2980854824","https://openalex.org/W2116721774","https://openalex.org/W2682588673","https://openalex.org/W2575051636","https://openalex.org/W2086464445","https://openalex.org/W2131401895","https://openalex.org/W1971225568","https://openalex.org/W2026376328","https://openalex.org/W2058381459"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":6},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":3},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":6},{"year":2019,"cited_by_count":15},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":7},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":4}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}