{"id":"https://openalex.org/W2102041964","doi":"https://doi.org/10.1021/jm2001426","title":"Tyrosine-Based 1-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) Prodrugs: Synthesis, Stability, Antiviral Activity, and in Vivo Transport Studies","display_name":"Tyrosine-Based 1-(S)-[3-Hydroxy-2-(phosphonomethoxy)propyl]cytosine and -adenine ((S)-HPMPC and (S)-HPMPA) Prodrugs: Synthesis, Stability, Antiviral Activity, and in Vivo Transport Studies","publication_year":2011,"publication_date":"2011-08-03","ids":{"openalex":"https://openalex.org/W2102041964","doi":"https://doi.org/10.1021/jm2001426","mag":"2102041964","pmid":"https://pubmed.ncbi.nlm.nih.gov/21812420","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/3166236"},"language":"en","primary_location":{"id":"doi:10.1021/jm2001426","doi":"https://doi.org/10.1021/jm2001426","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm2001426","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3166236","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065716039","display_name":"Valeria M. Zakharova","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Valeria M. Zakharova","raw_affiliation_strings":["Department of Chemistry, University of Southern California, Los Angeles, California 90089-0744, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Southern California, Los Angeles, California 90089-0744, United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003417223","display_name":"Michaela Serpi","orcid":"https://orcid.org/0000-0002-6162-7910","observed_orcids":["https://orcid.org/0000-0002-6162-7910"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michaela Serpi","raw_affiliation_strings":["Department of Chemistry, University of Southern California, Los Angeles, California 90089-0744, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Southern California, Los Angeles, California 90089-0744, United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038871868","display_name":"Ivan S. Krylov","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ivan S. Krylov","raw_affiliation_strings":["Department of Chemistry, University of Southern California, Los Angeles, California 90089-0744, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Southern California, Los Angeles, California 90089-0744, United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063169488","display_name":"Larryn W. Peterson","orcid":"https://orcid.org/0000-0003-4448-9154","observed_orcids":["https://orcid.org/0000-0003-4448-9154"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Larryn W. Peterson","raw_affiliation_strings":["Department of Chemistry, University of Southern California, Los Angeles, California 90089-0744, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Southern California, Los Angeles, California 90089-0744, United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076281231","display_name":"Julie M. Breitenbach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julie M. Breitenbach","raw_affiliation_strings":["School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109-1078, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109-1078, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5058536742","display_name":"Katherine Z. Borysko","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Z. Borysko","raw_affiliation_strings":["School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109-1078, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109-1078, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110073621","display_name":"John C. Drach","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John C. Drach","raw_affiliation_strings":["School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109-1078, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"School of Dentistry, University of Michigan, Ann Arbor, Michigan 48109-1078, United States","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033856453","display_name":"Mindy Collins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127861","display_name":"Therapeutics Systems Research Laboratories (United States)","ror":"https://ror.org/03hbd7c15","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mindy Collins","raw_affiliation_strings":["TSRL, Inc., Ann Arbor, Michigan 48108, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TSRL, Inc., Ann Arbor, Michigan 48108, United States","institution_ids":["https://openalex.org/I4210127861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112712077","display_name":"John M. Hilfinger","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210127861","display_name":"Therapeutics Systems Research Laboratories (United States)","ror":"https://ror.org/03hbd7c15","country_code":"US","type":"company","lineage":["https://openalex.org/I4210127861"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John M. Hilfinger","raw_affiliation_strings":["TSRL, Inc., Ann Arbor, Michigan 48108, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"TSRL, Inc., Ann Arbor, Michigan 48108, United States","institution_ids":["https://openalex.org/I4210127861"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041489306","display_name":"B. A. Kashemirov","orcid":"https://orcid.org/0000-0001-7175-9960","observed_orcids":["https://orcid.org/0000-0001-7175-9960"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Boris A. Kashemirov","raw_affiliation_strings":["Department of Chemistry, University of Southern California, Los Angeles, California 90089-0744, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Southern California, Los Angeles, California 90089-0744, United States","institution_ids":["https://openalex.org/I1174212"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5011933351","display_name":"Charles E. McKenna","orcid":"https://orcid.org/0000-0002-3540-6663","observed_orcids":["https://orcid.org/0000-0002-3540-6663"]},"institutions":[{"id":"https://openalex.org/I1174212","display_name":"University of Southern California","ror":"https://ror.org/03taz7m60","country_code":"US","type":"education","lineage":["https://openalex.org/I1174212"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Charles E. McKenna","raw_affiliation_strings":["Department of Chemistry, University of Southern California, Los Angeles, California 90089-0744, United States"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Chemistry, University of Southern California, Los Angeles, California 90089-0744, United States","institution_ids":["https://openalex.org/I1174212"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5011933351"],"corresponding_institution_ids":["https://openalex.org/I1174212"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":3.1201,"has_fulltext":false,"cited_by_count":40,"citation_normalized_percentile":{"value":0.90952307,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"54","issue":"16","first_page":"5680","last_page":"5693"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.4426000118255615,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10625","display_name":"Herpesvirus Infections and Treatments","score":0.4426000118255615,"subfield":{"id":"https://openalex.org/subfields/2713","display_name":"Epidemiology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11748","display_name":"Organophosphorus compounds synthesis","score":0.37279999256134033,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10526","display_name":"HIV/AIDS drug development and treatment","score":0.041999999433755875,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prodrugs","display_name":"prodrugs","score":0.6899999976158142},{"id":"https://openalex.org/keywords/antiviral-activity","display_name":"antiviral activity","score":0.6980000138282776},{"id":"https://openalex.org/keywords/vaccinia-virus","display_name":"vaccinia virus","score":0.8399999737739563},{"id":"https://openalex.org/keywords/cowpox-virus","display_name":"cowpox virus","score":0.9409999847412109},{"id":"https://openalex.org/keywords/human-cytomegalovirus","display_name":"human cytomegalovirus","score":0.9419999718666077},{"id":"https://openalex.org/keywords/herpes-simplex-virus-type-1","display_name":"herpes simplex virus type 1","score":0.9120000004768372},{"id":"https://openalex.org/keywords/plasma-metabolism","display_name":"plasma metabolism","score":0.5339999794960022},{"id":"https://openalex.org/keywords/oral-bioavailability","display_name":"oral bioavailability","score":0.9369999766349792},{"id":"https://openalex.org/keywords/diastereomers","display_name":"diastereomers","score":0.5350000262260437},{"id":"https://openalex.org/keywords/cytotoxicity","display_name":"cytotoxicity","score":0.5389999747276306}],"concepts":[{"id":"https://openalex.org/C108215921","wikidata":"https://www.wikidata.org/wiki/Q603741","display_name":"Prodrug","level":2,"score":0.9105908870697021},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.8491091728210449},{"id":"https://openalex.org/C2776824251","wikidata":"https://www.wikidata.org/wiki/Q423445","display_name":"Cidofovir","level":3,"score":0.8449691534042358},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.5777082443237305},{"id":"https://openalex.org/C2776023528","wikidata":"https://www.wikidata.org/wiki/Q178425","display_name":"Cytosine","level":3,"score":0.5694280862808228},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5337511301040649},{"id":"https://openalex.org/C2781196997","wikidata":"https://www.wikidata.org/wiki/Q655331","display_name":"Herpes simplex virus","level":3,"score":0.5154710412025452},{"id":"https://openalex.org/C181389837","wikidata":"https://www.wikidata.org/wiki/Q461809","display_name":"Bioavailability","level":2,"score":0.4647473692893982},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.44358959794044495},{"id":"https://openalex.org/C2779138802","wikidata":"https://www.wikidata.org/wiki/Q418602","display_name":"Dipeptide","level":3,"score":0.41264596581459045},{"id":"https://openalex.org/C515207424","wikidata":"https://www.wikidata.org/wiki/Q8066","display_name":"Amino acid","level":2,"score":0.28343918919563293},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.23791363835334778},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.21600022912025452},{"id":"https://openalex.org/C2522874641","wikidata":"https://www.wikidata.org/wiki/Q808","display_name":"Virus","level":2,"score":0.19186386466026306},{"id":"https://openalex.org/C159047783","wikidata":"https://www.wikidata.org/wiki/Q7215","display_name":"Virology","level":1,"score":0.1509031355381012},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.0},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.0}],"mesh":[{"descriptor_ui":"D000077404","descriptor_name":"Cidofovir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000225","descriptor_name":"Adenine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D000998","descriptor_name":"Antiviral Agents","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002470","descriptor_name":"Cell Survival","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003587","descriptor_name":"Cytomegalovirus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000031","qualifier_name":"analogs & derivatives","is_major_topic":true},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D003596","descriptor_name":"Cytosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008956","descriptor_name":"Models, Chemical","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D011355","descriptor_name":"Prodrugs","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014443","descriptor_name":"Tyrosine","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D014616","descriptor_name":"Vaccinia virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015394","descriptor_name":"Molecular Structure","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015608","descriptor_name":"Cowpox virus","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018259","descriptor_name":"Herpesvirus 1, Human","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019540","descriptor_name":"Area Under Curve","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020128","descriptor_name":"Inhibitory Concentration 50","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D063065","descriptor_name":"Organophosphonates","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1021/jm2001426","doi":"https://doi.org/10.1021/jm2001426","is_oa":false,"landing_page_url":"https://doi.org/10.1021/jm2001426","pdf_url":null,"source":{"id":"https://openalex.org/S162030435","display_name":"Journal of Medicinal Chemistry","issn_l":"0022-2623","issn":["0022-2623","1520-4804"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Medicinal Chemistry","raw_type":"journal-article"},{"id":"pmid:21812420","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/21812420","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of medicinal chemistry","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:3166236","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3166236","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Med Chem","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:3166236","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/3166236","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"J Med Chem","raw_type":"Text"},"sustainable_development_goals":[{"score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"score":0.6700000166893005,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G413231951","display_name":"Oral Antiviral Prodrugs for Biodefense Initiative","funder_award_id":"U01AI061457","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G4610483761","display_name":"Improving Absorption and Targeting of Antiviral Drugs","funder_award_id":"R43AI056864","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G565843111","display_name":null,"funder_award_id":"AI061457","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G6890810315","display_name":"Improving Absorption and Targeting of Antiviral Drugs","funder_award_id":"R44AI056864","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"},{"id":"https://openalex.org/G7722949512","display_name":null,"funder_award_id":"AI056864","funder_id":"https://openalex.org/F4320337355","funder_display_name":"National Institute of Allergy and Infectious Diseases"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337355","display_name":"National Institute of Allergy and Infectious Diseases","ror":"https://ror.org/043z4tv69"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":39,"referenced_works":["https://openalex.org/W28907751","https://openalex.org/W86427758","https://openalex.org/W146859325","https://openalex.org/W1505283491","https://openalex.org/W1967081038","https://openalex.org/W1968522516","https://openalex.org/W1972241043","https://openalex.org/W1972770998","https://openalex.org/W1974599773","https://openalex.org/W1986985179","https://openalex.org/W1989116461","https://openalex.org/W1994077410","https://openalex.org/W1996283238","https://openalex.org/W2004483101","https://openalex.org/W2010843246","https://openalex.org/W2020283057","https://openalex.org/W2030938318","https://openalex.org/W2031578673","https://openalex.org/W2037183326","https://openalex.org/W2038737569","https://openalex.org/W2040625597","https://openalex.org/W2054649126","https://openalex.org/W2059286898","https://openalex.org/W2062597360","https://openalex.org/W2062835586","https://openalex.org/W2082622136","https://openalex.org/W2086623092","https://openalex.org/W2091805975","https://openalex.org/W2096451853","https://openalex.org/W2122884948","https://openalex.org/W2139537513","https://openalex.org/W2145502034","https://openalex.org/W2158548456","https://openalex.org/W2158721163","https://openalex.org/W2316912275","https://openalex.org/W2950051868","https://openalex.org/W2952421180","https://openalex.org/W4233104009","https://openalex.org/W4256661946"],"related_works":["https://openalex.org/W2518961597","https://openalex.org/W2092834169","https://openalex.org/W6908244873","https://openalex.org/W2071954771","https://openalex.org/W2054649126","https://openalex.org/W124544113","https://openalex.org/W1996283238","https://openalex.org/W2170279581","https://openalex.org/W1987214487","https://openalex.org/W1591250500"],"abstract_inverted_index":{"Eight":[0],"novel":[1],"single":[2],"amino":[3],"acid":[4],"(6-11)":[5],"and":[6,18,27,45,108,129],"dipeptide":[7],"(12,":[8],"13)":[9],"tyrosine":[10,103],"P-O":[11],"esters":[12],"of":[13,84,97,106],"cyclic":[14,20],"cidofovir":[15],"((S)-cHPMPC,":[16],"4)":[17],"its":[19],"adenine":[21],"analogue":[22],"((S)-cHPMPA,":[23],"3)":[24],"were":[25,51,110],"synthesized":[26],"evaluated":[28],"as":[29],"prodrugs.":[30],"In":[31],"vitro":[32],"IC(50)":[33,63],"values":[34],"for":[35,55],"the":[36,56,111],"prodrugs":[37,79],"(<0.1-50":[38],"\u03bcM)":[39],"vs":[40,135,144],"vaccinia,":[41],"cowpox,":[42],"human":[43],"cytomegalovirus,":[44],"herpes":[46],"simplex":[47],"type":[48],"1":[49,138],"virus":[50],"compared":[52],"to":[53,125],"those":[54],"parent":[57,136],"drugs":[58],"((S)-HPMPC,":[59],"2;":[60],"(S)-HPMPA,":[61],"1;":[62],"0.3-35":[64],"\u03bcM);":[65],"there":[66],"was":[67,117],"no":[68],"cytoxicity":[69],"with":[70,95],"KB":[71],"or":[72,121],"HFF":[73],"cells":[74],"at":[75,90],"\u2264100":[76],"\u03bcM.":[77],"The":[78,102],"exhibited":[80],"a":[81,140],"wide":[82],"range":[83],"half-lives":[85],"in":[86,119,139],"rat":[87,120],"intestinal":[88],"homogenate":[89],"pH":[91],"6.5":[92],"(<30-1732":[93],"min)":[94],"differences":[96],"3-10\u00d7":[98],"between":[99],"phostonate":[100],"diastereomers.":[101],"alkylamide":[104],"derivatives":[105],"3":[107],"4":[109],"most":[112],"stable.":[113],"(l)-Tyr-NH-i-Bu":[114],"cHPMPA":[115],"(11)":[116],"converted":[118],"mouse":[122,141],"plasma":[123],"solely":[124],"two":[126],"active":[127],"metabolites":[128],"had":[130],"significantly":[131],"enhanced":[132],"oral":[133],"bioavailability":[134],"drug":[137],"model":[142],"(39%":[143],"<5%).":[145]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":2},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":2},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":4},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":7},{"year":2012,"cited_by_count":2}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
