{"id":"https://openalex.org/W2100539079","doi":"https://doi.org/10.1124/mol.109.062877","title":"Estrogen Receptor \u03b2 Is a Novel Therapeutic Target for Photoaging","display_name":"Estrogen Receptor \u03b2 Is a Novel Therapeutic Target for Photoaging","publication_year":2010,"publication_date":"2010-01-29","ids":{"openalex":"https://openalex.org/W2100539079","doi":"https://doi.org/10.1124/mol.109.062877","mag":"2100539079","pmid":"https://pubmed.ncbi.nlm.nih.gov/20110405"},"language":"en","primary_location":{"id":"doi:10.1124/mol.109.062877","doi":"https://doi.org/10.1124/mol.109.062877","is_oa":false,"landing_page_url":"https://doi.org/10.1124/mol.109.062877","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5113687664","display_name":"Ken C. N. Chang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ken C.N. Chang","raw_affiliation_strings":["Transcriptional Targets, Tissue Repair, Pfizer Research, Collegeville, PA 19426, USA. changk@wyeth.com"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Transcriptional Targets, Tissue Repair, Pfizer Research, Collegeville, PA 19426, USA. changk@wyeth.com","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101657860","display_name":"Yihe Wang","orcid":"https://orcid.org/0000-0001-9405-8008","observed_orcids":["https://orcid.org/0000-0001-9405-8008"]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yihe Wang","raw_affiliation_strings":["Pfizer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111992701","display_name":"Inn Gyung Oh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I139264467","display_name":"Seoul National University","ror":"https://ror.org/04h9pn542","country_code":"KR","type":"education","lineage":["https://openalex.org/I139264467"]}],"countries":["KR"],"is_corresponding":false,"raw_author_name":"Inn Gyung Oh","raw_affiliation_strings":["Seoul National Univ"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Seoul National Univ","institution_ids":["https://openalex.org/I139264467"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077693041","display_name":"Susan F. Jenkins","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Jenkins","raw_affiliation_strings":["Pfizer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033005779","display_name":"Leonard P. Freedman","orcid":"https://orcid.org/0009-0007-5726-150X","observed_orcids":["https://orcid.org/0009-0007-5726-150X","https://orcid.org/0000-0003-2352-4037"]},"institutions":[{"id":"https://openalex.org/I149251103","display_name":"Thomas Jefferson University","ror":"https://ror.org/00ysqcn41","country_code":"US","type":"education","lineage":["https://openalex.org/I149251103"]},{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard P. Freedman","raw_affiliation_strings":["Pfizer","Thomas Jefferson University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer","institution_ids":["https://openalex.org/I180857899"]},{"raw_affiliation_string":"Thomas Jefferson University","institution_ids":["https://openalex.org/I149251103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110391217","display_name":"Catherine C. Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine C. Thompson","raw_affiliation_strings":["Pfizer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pfizer","institution_ids":["https://openalex.org/I180857899"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056846121","display_name":"Jin Ho Chung","orcid":"https://orcid.org/0000-0002-0582-6392","observed_orcids":["https://orcid.org/0000-0002-0582-6392"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin Ho Chung","raw_affiliation_strings":["Biomedical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Biomedical Sciences","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063183571","display_name":"Sunil Nagpal","orcid":"https://orcid.org/0000-0001-6090-8780","observed_orcids":["https://orcid.org/0000-0001-6090-8780","https://orcid.org/0000-0002-9950-2304"]},"institutions":[{"id":"https://openalex.org/I1285764155","display_name":"Merck & Co., Inc., Rahway, NJ, USA (United States)","ror":"https://ror.org/02891sr49","country_code":"US","type":"company","lineage":["https://openalex.org/I1285764155"]},{"id":"https://openalex.org/I180857899","display_name":"Pfizer (United States)","ror":"https://ror.org/01xdqrp08","country_code":"US","type":"company","lineage":["https://openalex.org/I180857899"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sunil Nagpal","raw_affiliation_strings":["Merck","Pfizer"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Merck","institution_ids":["https://openalex.org/I1285764155"]},{"raw_affiliation_string":"Pfizer","institution_ids":["https://openalex.org/I180857899"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":4,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":5.5208,"has_fulltext":false,"cited_by_count":42,"citation_normalized_percentile":{"value":0.96173237,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":98},"biblio":{"volume":"77","issue":"5","first_page":"744","last_page":"750"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11013","display_name":"Skin Protection and Aging","score":0.9937000274658203,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10756","display_name":"Estrogen and related hormone effects","score":0.004699999932199717,"subfield":{"id":"https://openalex.org/subfields/1310","display_name":"Endocrinology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10771","display_name":"Wound Healing and Treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/estrogen-receptor-beta","display_name":"estrogen receptor beta","score":0.9980000257492065},{"id":"https://openalex.org/keywords/photoaging","display_name":"photoaging","score":0.9909999966621399},{"id":"https://openalex.org/keywords/uv-induced-skin-damage","display_name":"UV-induced skin damage","score":0.7229999899864197},{"id":"https://openalex.org/keywords/erbeta-agonists","display_name":"ER\u03b2 agonists","score":0.6819999814033508},{"id":"https://openalex.org/keywords/dermal-fibroblasts","display_name":"dermal fibroblasts","score":0.8100000023841858},{"id":"https://openalex.org/keywords/keratinocytes","display_name":"keratinocytes","score":0.9980000257492065},{"id":"https://openalex.org/keywords/pro-inflammatory-cytokines","display_name":"inflammatory cytokines","score":0.8820000290870667},{"id":"https://openalex.org/keywords/matrix-metalloproteinases","display_name":"matrix metalloproteinases","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cyclooxygenase-2","display_name":"cyclooxygenase-2","score":0.9980000257492065},{"id":"https://openalex.org/keywords/erbeta-knockout-mice","display_name":"ER\u03b2 knockout mice","score":0.6759999990463257},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C2776960578","wikidata":"https://www.wikidata.org/wiki/Q3705873","display_name":"Photoaging","level":2,"score":0.9261685609817505},{"id":"https://openalex.org/C2777164284","wikidata":"https://www.wikidata.org/wiki/Q277954","display_name":"Estrogen","level":2,"score":0.5700123310089111},{"id":"https://openalex.org/C84606932","wikidata":"https://www.wikidata.org/wiki/Q416496","display_name":"Estrogen receptor","level":4,"score":0.4982173442840576},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4421652853488922},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4360220432281494},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4028926193714142},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.3427552282810211},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.32331836223602295},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.0},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.0}],"mesh":[{"descriptor_ui":"D000375","descriptor_name":"Aging","qualifier_ui":"Q000528","qualifier_name":"radiation effects","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005347","descriptor_name":"Fibroblasts","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008024","descriptor_name":"Ligands","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008812","descriptor_name":"Mice, Hairless","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013472","descriptor_name":"Sunlight","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D014466","descriptor_name":"Ultraviolet Rays","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015595","descriptor_name":"Skin Aging","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016207","descriptor_name":"Cytokines","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020782","descriptor_name":"Matrix Metalloproteinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047629","descriptor_name":"Estrogen Receptor beta","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D047629","descriptor_name":"Estrogen Receptor beta","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D047629","descriptor_name":"Estrogen Receptor beta","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D047629","descriptor_name":"Estrogen Receptor beta","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1124/mol.109.062877","doi":"https://doi.org/10.1124/mol.109.062877","is_oa":false,"landing_page_url":"https://doi.org/10.1124/mol.109.062877","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},{"id":"pmid:20110405","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/20110405","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmacology","raw_type":"Journal Article"},{"id":"pmh:oai:s-space.snu.ac.kr:10371/78361","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/10371/78361","pdf_url":null,"source":{"id":"https://openalex.org/S4306401345","display_name":"Seoul National University Open Repository (Seoul National University)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I139264467","host_organization_name":"Seoul National University","host_organization_lineage":["https://openalex.org/I139264467"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"","raw_type":"Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322557","display_name":"Seoul National University Hospital","ror":"https://ror.org/01z4nnt86"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":36,"referenced_works":["https://openalex.org/W1505090413","https://openalex.org/W1647868114","https://openalex.org/W1824527491","https://openalex.org/W1967004474","https://openalex.org/W1969734058","https://openalex.org/W1973350140","https://openalex.org/W1975847309","https://openalex.org/W1977689541","https://openalex.org/W1980170175","https://openalex.org/W1981397830","https://openalex.org/W1994972521","https://openalex.org/W1996488951","https://openalex.org/W1998866427","https://openalex.org/W2002737481","https://openalex.org/W2006347202","https://openalex.org/W2006407883","https://openalex.org/W2006622019","https://openalex.org/W2012425172","https://openalex.org/W2014455593","https://openalex.org/W2015363725","https://openalex.org/W2015822322","https://openalex.org/W2018837302","https://openalex.org/W2021454655","https://openalex.org/W2036785802","https://openalex.org/W2046951668","https://openalex.org/W2058338331","https://openalex.org/W2061674718","https://openalex.org/W2076086359","https://openalex.org/W2082146838","https://openalex.org/W2097293057","https://openalex.org/W2107277218","https://openalex.org/W2110800997","https://openalex.org/W2142042748","https://openalex.org/W2146525885","https://openalex.org/W2155225555","https://openalex.org/W6642447112"],"related_works":["https://openalex.org/W3029303128","https://openalex.org/W2124477558","https://openalex.org/W2046951668","https://openalex.org/W4391310734","https://openalex.org/W2013101061","https://openalex.org/W1981754237","https://openalex.org/W2113869654","https://openalex.org/W2473385279","https://openalex.org/W2123003537","https://openalex.org/W2061275828"],"abstract_inverted_index":null,"counts_by_year":[{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":1},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":4},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":2},{"year":2014,"cited_by_count":5},{"year":2013,"cited_by_count":4},{"year":2012,"cited_by_count":3}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
