{"id":"https://openalex.org/W2099888147","doi":"https://doi.org/10.5326/jaaha-ms-6145","title":"Comparison of High-Dose Intermittent and Low-Dose Continuous Oral Artemisinin in Dogs With Naturally Occurring Tumors","display_name":"Comparison of High-Dose Intermittent and Low-Dose Continuous Oral Artemisinin in Dogs With Naturally Occurring Tumors","publication_year":2014,"publication_date":"2014-01-01","ids":{"openalex":"https://openalex.org/W2099888147","doi":"https://doi.org/10.5326/jaaha-ms-6145","mag":"2099888147","pmid":"https://pubmed.ncbi.nlm.nih.gov/25251432"},"language":"en","primary_location":{"id":"doi:10.5326/jaaha-ms-6145","doi":"https://doi.org/10.5326/jaaha-ms-6145","is_oa":false,"landing_page_url":"https://doi.org/10.5326/jaaha-ms-6145","pdf_url":null,"source":{"id":"https://openalex.org/S59244838","display_name":"Journal of the American Animal Hospital Association","issn_l":"0587-2871","issn":["0587-2871","1547-3317"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4324309660","host_organization_name":"American Animal Hospital Association","host_organization_lineage":["https://openalex.org/P4324309660"],"host_organization_lineage_names":["American Animal Hospital Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Animal Hospital Association","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5067997379","display_name":"Kenji Hosoya","orcid":"https://orcid.org/0000-0001-9208-3736","observed_orcids":["https://orcid.org/0000-0001-9208-3736"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kenji Hosoya","raw_affiliation_strings":["Departments of Veterinary Clinical Sciences and Veterinary Biosciences (K.H., C.C., C.L., W.K.) and Division of Pharmaceutics, College of Pharmacy (M.P., J.D.), The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Veterinary Clinical Sciences and Veterinary Biosciences (K.H., C.C., C.L., W.K.) and Division of Pharmaceutics, College of Pharmacy (M.P., J.D.), The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008443429","display_name":"C. Guillermo Couto","orcid":"https://orcid.org/0000-0003-2983-8272","observed_orcids":["https://orcid.org/0000-0003-2983-8272"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Guillermo Couto","raw_affiliation_strings":["Departments of Veterinary Clinical Sciences and Veterinary Biosciences (K.H., C.C., C.L., W.K.) and Division of Pharmaceutics, College of Pharmacy (M.P., J.D.), The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Veterinary Clinical Sciences and Veterinary Biosciences (K.H., C.C., C.L., W.K.) and Division of Pharmaceutics, College of Pharmacy (M.P., J.D.), The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021474295","display_name":"Cheryl A. London","orcid":"https://orcid.org/0000-0001-8563-1490","observed_orcids":["https://orcid.org/0000-0001-8563-1490"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Cheryl A. London","raw_affiliation_strings":["Departments of Veterinary Clinical Sciences and Veterinary Biosciences (K.H., C.C., C.L., W.K.) and Division of Pharmaceutics, College of Pharmacy (M.P., J.D.), The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Veterinary Clinical Sciences and Veterinary Biosciences (K.H., C.C., C.L., W.K.) and Division of Pharmaceutics, College of Pharmacy (M.P., J.D.), The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5043559536","display_name":"William C. Kisseberth","orcid":"https://orcid.org/0000-0002-5991-147X","observed_orcids":["https://orcid.org/0000-0002-5991-147X"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"William C. Kisseberth","raw_affiliation_strings":["Departments of Veterinary Clinical Sciences and Veterinary Biosciences (K.H., C.C., C.L., W.K.) and Division of Pharmaceutics, College of Pharmacy (M.P., J.D.), The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Veterinary Clinical Sciences and Veterinary Biosciences (K.H., C.C., C.L., W.K.) and Division of Pharmaceutics, College of Pharmacy (M.P., J.D.), The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5066257150","display_name":"Mitch A. Phelps","orcid":"https://orcid.org/0000-0002-1615-5280","observed_orcids":["https://orcid.org/0000-0002-1615-5280"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mitchell A. Phelps","raw_affiliation_strings":["Departments of Veterinary Clinical Sciences and Veterinary Biosciences (K.H., C.C., C.L., W.K.) and Division of Pharmaceutics, College of Pharmacy (M.P., J.D.), The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Veterinary Clinical Sciences and Veterinary Biosciences (K.H., C.C., C.L., W.K.) and Division of Pharmaceutics, College of Pharmacy (M.P., J.D.), The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5002243266","display_name":"James T. Dalton","orcid":"https://orcid.org/0000-0002-3915-7326","observed_orcids":["https://orcid.org/0000-0002-3915-7326"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"James T. Dalton","raw_affiliation_strings":["Departments of Veterinary Clinical Sciences and Veterinary Biosciences (K.H., C.C., C.L., W.K.) and Division of Pharmaceutics, College of Pharmacy (M.P., J.D.), The Ohio State University, Columbus, OH"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Veterinary Clinical Sciences and Veterinary Biosciences (K.H., C.C., C.L., W.K.) and Division of Pharmaceutics, College of Pharmacy (M.P., J.D.), The Ohio State University, Columbus, OH","institution_ids":["https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I52357470"],"apc_list":null,"apc_paid":null,"fwci":1.5056,"has_fulltext":false,"cited_by_count":18,"citation_normalized_percentile":{"value":0.82118863,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"50","issue":"6","first_page":"390","last_page":"395"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11149","display_name":"Veterinary Oncology Research","score":0.8496000170707703,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11905","display_name":"Veterinary Pharmacology and Anesthesia","score":0.10779999941587448,"subfield":{"id":"https://openalex.org/subfields/3404","display_name":"Small Animals"},"field":{"id":"https://openalex.org/fields/34","display_name":"Veterinary"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11547","display_name":"Sesquiterpenes and Asteraceae Studies","score":0.003599999938160181,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/artemisinin","display_name":"artemisinin","score":0.9940000176429749},{"id":"https://openalex.org/keywords/dogs","display_name":"dogs","score":0.5630000233650208},{"id":"https://openalex.org/keywords/oral-administration","display_name":"oral administration","score":0.5149999856948853},{"id":"https://openalex.org/keywords/dosing-regimen","display_name":"dosing regimen","score":0.6970000267028809},{"id":"https://openalex.org/keywords/clinical-toxicity","display_name":"clinical toxicity","score":0.7099999785423279},{"id":"https://openalex.org/keywords/hematological-adverse-events","display_name":"hematologic adverse events","score":0.8180000185966492},{"id":"https://openalex.org/keywords/anorexia","display_name":"anorexia","score":0.8209999799728394},{"id":"https://openalex.org/keywords/dihydroartemisinin","display_name":"dihydroartemisinin","score":0.9610000252723694},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.4569999873638153},{"id":"https://openalex.org/keywords/parenteral-administration","display_name":"parenteral administration","score":0.7889999747276306}],"concepts":[{"id":"https://openalex.org/C2776120307","wikidata":"https://www.wikidata.org/wiki/Q426921","display_name":"Artemisinin","level":4,"score":0.9452607035636902},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6316923499107361},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.407989501953125},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.11885178089141846},{"id":"https://openalex.org/C2778048844","wikidata":"https://www.wikidata.org/wiki/Q12156","display_name":"Malaria","level":2,"score":0.10469266772270203},{"id":"https://openalex.org/C2778371730","wikidata":"https://www.wikidata.org/wiki/Q311383","display_name":"Plasmodium falciparum","level":3,"score":0.0658872127532959}],"mesh":[{"descriptor_ui":"D000284","descriptor_name":"Administration, Oral","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000855","descriptor_name":"Anorexia","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D000855","descriptor_name":"Anorexia","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D000890","descriptor_name":"Anti-Infective Agents","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D001682","descriptor_name":"Biological Availability","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002853","descriptor_name":"Chromatography, Liquid","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D004283","descriptor_name":"Dog Diseases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004285","descriptor_name":"Dogs","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004305","descriptor_name":"Dose-Response Relationship, Drug","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004334","descriptor_name":"Drug Administration Schedule","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007408","descriptor_name":"Intestinal Absorption","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008401","descriptor_name":"Gas Chromatography-Mass Spectrometry","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009369","descriptor_name":"Neoplasms","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":true},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000008","qualifier_name":"administration & dosage","is_major_topic":true},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":false},{"descriptor_ui":"D037621","descriptor_name":"Artemisinins","qualifier_ui":"Q000633","qualifier_name":"toxicity","is_major_topic":false},{"descriptor_ui":"D053609","descriptor_name":"Lethargy","qualifier_ui":"Q000139","qualifier_name":"chemically induced","is_major_topic":false},{"descriptor_ui":"D053609","descriptor_name":"Lethargy","qualifier_ui":"Q000662","qualifier_name":"veterinary","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.5326/jaaha-ms-6145","doi":"https://doi.org/10.5326/jaaha-ms-6145","is_oa":false,"landing_page_url":"https://doi.org/10.5326/jaaha-ms-6145","pdf_url":null,"source":{"id":"https://openalex.org/S59244838","display_name":"Journal of the American Animal Hospital Association","issn_l":"0587-2871","issn":["0587-2871","1547-3317"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-1","medline","norway-1","poland-40","russia-white-list-2"],"host_organization":"https://openalex.org/P4324309660","host_organization_name":"American Animal Hospital Association","host_organization_lineage":["https://openalex.org/P4324309660"],"host_organization_lineage_names":["American Animal Hospital Association"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Animal Hospital Association","raw_type":"journal-article"},{"id":"pmid:25251432","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25251432","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of the American Animal Hospital Association","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.98580002784729,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":32,"referenced_works":["https://openalex.org/W41589304","https://openalex.org/W644330819","https://openalex.org/W1964095666","https://openalex.org/W1966533879","https://openalex.org/W1972596256","https://openalex.org/W1980882114","https://openalex.org/W1985777650","https://openalex.org/W1995521183","https://openalex.org/W1995685700","https://openalex.org/W2003242915","https://openalex.org/W2005476873","https://openalex.org/W2007805709","https://openalex.org/W2010459983","https://openalex.org/W2013090067","https://openalex.org/W2033721665","https://openalex.org/W2034746905","https://openalex.org/W2039265647","https://openalex.org/W2040450077","https://openalex.org/W2044811771","https://openalex.org/W2055031325","https://openalex.org/W2062432591","https://openalex.org/W2065807726","https://openalex.org/W2078500738","https://openalex.org/W2096787650","https://openalex.org/W2112526465","https://openalex.org/W2131216414","https://openalex.org/W2141575693","https://openalex.org/W2162079763","https://openalex.org/W2163154965","https://openalex.org/W2166363384","https://openalex.org/W2184709802","https://openalex.org/W4235987765"],"related_works":["https://openalex.org/W6958290117","https://openalex.org/W2002245126","https://openalex.org/W2003242915","https://openalex.org/W7073826866","https://openalex.org/W2058689045","https://openalex.org/W2080816163","https://openalex.org/W2620003140","https://openalex.org/W4391340133","https://openalex.org/W149661692","https://openalex.org/W2012214908"],"abstract_inverted_index":{"To":[0],"evaluate":[1],"the":[2,69,72,95,128,145,151],"clinical":[3,65],"toxicity":[4],"and":[5,25,67,76,85,110,119,148,160],"activity":[6],"of":[7,40,50,71,83,98,108,144,150],"orally":[8],"administered":[9],"artemisinin":[10,51,84,99,109],"in":[11,100,103,124,142,157,166,170],"dogs":[12,18,102,167],"with":[13],"spontaneous":[14],"tumors,":[15],"24":[16,33],"client-owned":[17],"were":[19,61,87,112],"randomly":[20],"divided":[21],"into":[22],"two":[23,129],"groups":[24],"received":[26],"either":[27],"low-continuous":[28],"dose":[29,97],"(3":[30],"mg/kg":[31,42],"q":[32,43,47],"hr)":[34],"or":[35],"high-dose":[36,152,161],"intermittent":[37],"(three":[38],"doses":[39],"45":[41],"6":[44],"hr":[45],"repeated":[46],"1":[48],"wk)":[49],"per":[52],"os.":[53],"Treatment":[54],"was":[55,121,137,140],"continued":[56],"for":[57,64,74,178],"21":[58],"days.":[59],"Dogs":[60],"evaluated":[62],"weekly":[63],"effect":[66],"at":[68,115],"end":[70],"treatment":[73],"hematologic":[75],"biochemical":[77],"adverse":[78,135],"events.":[79],"Whole":[80],"blood":[81,125],"concentrations":[82,107],"dihydroartemisinin":[86,111],"measured":[88],"by":[89],"liquid":[90],"chromatography/tandem":[91],"mass":[92],"spectrometry":[93],"after":[94],"first":[96],"three":[101],"each":[104],"group.":[105,153],"Blood":[106],"<0.1":[113],"\u03bcM":[114],"all":[116],"time":[117],"points,":[118],"there":[120],"no":[122],"difference":[123],"concentration":[126],"between":[127],"dosing":[130],"groups.":[131],"The":[132],"most":[133],"frequent":[134],"event":[136],"anorexia,":[138],"which":[139],"observed":[141],"11%":[143],"low-dose":[146,158],"group":[147],"29%":[149],"Oral":[154],"artemisinin,":[155],"both":[156],"continuous":[159],"intermittent,":[162],"is":[163],"well":[164],"tolerated":[165],"but":[168],"results":[169],"low":[171],"bioavailability.":[172],"Parenteral":[173],"administration":[174],"should":[175],"be":[176],"considered":[177],"future":[179],"studies.":[180]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":2},{"year":2023,"cited_by_count":3},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":2},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
