{"id":"https://openalex.org/W2099868085","doi":"https://doi.org/10.1345/1542-6270(2000)034<0247:mpfarh>2.3.co;2","title":"Management Protocol for Abacavir-Related Hypersensitivity Reaction","display_name":"Management Protocol for Abacavir-Related Hypersensitivity Reaction","publication_year":2000,"publication_date":"2000-02-01","ids":{"openalex":"https://openalex.org/W2099868085","doi":"https://doi.org/10.1345/1542-6270(2000)034<0247:mpfarh>2.3.co;2","mag":"2099868085","pmid":"https://pubmed.ncbi.nlm.nih.gov/10676833"},"language":"en","primary_location":{"id":"doi:10.1345/1542-6270(2000)034<0247:mpfarh>2.3.co;2","doi":"https://doi.org/10.1345/1542-6270(2000)034<0247:mpfarh>2.3.co;2","is_oa":false,"landing_page_url":"https://doi.org/10.1345/1542-6270(2000)034<0247:mpfarh>2.3.co;2","pdf_url":null,"source":{"id":"https://openalex.org/S113426163","display_name":"Annals of Pharmacotherapy","issn_l":"0012-6578","issn":["0012-6578","1060-0280","1542-6270"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Annals of Pharmacotherapy","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5080371674","display_name":"Patrick G. Clay","orcid":"https://orcid.org/0000-0001-8892-3077","observed_orcids":["https://orcid.org/0000-0001-8892-3077"]},"institutions":[{"id":"https://openalex.org/I75421653","display_name":"University of Missouri\u2013Kansas City","ror":"https://ror.org/01w0d5g70","country_code":"US","type":"education","lineage":["https://openalex.org/I75421653"]},{"id":"https://openalex.org/I8692664","display_name":"University of Oklahoma","ror":"https://ror.org/02aqsxs83","country_code":"US","type":"education","lineage":["https://openalex.org/I8692664"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patrick G Clay","raw_affiliation_strings":["Patrick G Clay PharmD, at time of writing, Fellow of Infectious Diseases, College of Pharmacy, University of Oklahoma, Oklahoma City, OK; now, HIV Clinical Specialist, Assistant Professor, Division of Pharmacy Practice, University of Missouri-Kansas City, Kansas City, MO","Patrick G Clay PharmD, at time of writing, Fellow of Infectious Diseases, College of Pharmacy, University of Oklahoma, Oklahoma City, OK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Patrick G Clay PharmD, at time of writing, Fellow of Infectious Diseases, College of Pharmacy, University of Oklahoma, Oklahoma City, OK; now, HIV Clinical Specialist, Assistant Professor, Division of Pharmacy Practice, University of Missouri-Kansas City, Kansas City, MO","institution_ids":["https://openalex.org/I75421653","https://openalex.org/I8692664"]},{"raw_affiliation_string":"Patrick G Clay PharmD, at time of writing, Fellow of Infectious Diseases, College of Pharmacy, University of Oklahoma, Oklahoma City, OK","institution_ids":["https://openalex.org/I8692664"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053255995","display_name":"R. Chris Rathbun","orcid":"https://orcid.org/0000-0002-6033-1624","observed_orcids":["https://orcid.org/0000-0002-6033-1624"]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"R Chris Rathbun","raw_affiliation_strings":["R Chris Rathbun PharmD, Associate Professor, Department of Pharmacy Practice, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"R Chris Rathbun PharmD, Associate Professor, Department of Pharmacy Practice, College of Pharmacy, University of Oklahoma Health Sciences Center, Oklahoma City","institution_ids":["https://openalex.org/I49332381"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5107843639","display_name":"Leonard N. Slater","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I49332381","display_name":"University of Oklahoma Health Sciences Center","ror":"https://ror.org/0457zbj98","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I49332381"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonard N Slater","raw_affiliation_strings":["Leonard N Slater MD, Professor of Medicine, Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Leonard N Slater MD, Professor of Medicine, Department of Medicine, College of Medicine, University of Oklahoma Health Sciences Center","institution_ids":["https://openalex.org/I49332381"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5080371674"],"corresponding_institution_ids":["https://openalex.org/I75421653","https://openalex.org/I8692664"],"apc_list":{"value":4400,"currency":"USD","value_usd":4400},"apc_paid":null,"fwci":3.0838,"has_fulltext":false,"cited_by_count":31,"citation_normalized_percentile":{"value":0.91737308,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"34","issue":"2","first_page":"247","last_page":"249"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11117","display_name":"Drug-Induced Adverse Reactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13970","display_name":"Pharmacy and Medical Practices","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/3004","display_name":"Pharmacology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abacavir","display_name":"abacavir","score":0.9950000047683716},{"id":"https://openalex.org/keywords/hypersensitivity","display_name":"hypersensitivity","score":0.8220000267028809},{"id":"https://openalex.org/keywords/drug-hypersensitivity-management","display_name":"drug hypersensitivity management","score":0.6639999747276306},{"id":"https://openalex.org/keywords/hiv-treatment","display_name":"HIV treatment","score":0.7020000219345093},{"id":"https://openalex.org/keywords/antiretroviral-therapy","display_name":"antiretroviral therapy","score":0.7689999938011169},{"id":"https://openalex.org/keywords/management-protocol","display_name":"management protocol","score":0.7649999856948853},{"id":"https://openalex.org/keywords/patient-education","display_name":"patient education","score":0.5299999713897705}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9303160905838013},{"id":"https://openalex.org/C2779465607","wikidata":"https://www.wikidata.org/wiki/Q304330","display_name":"Abacavir","level":5,"score":0.9236024618148804},{"id":"https://openalex.org/C2780385302","wikidata":"https://www.wikidata.org/wiki/Q367158","display_name":"Protocol (science)","level":3,"score":0.5980318188667297},{"id":"https://openalex.org/C2993280485","wikidata":"https://www.wikidata.org/wiki/Q5958765","display_name":"Hypersensitivity reaction","level":2,"score":0.5753869414329529},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.32966163754463196},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.16262376308441162},{"id":"https://openalex.org/C3013748606","wikidata":"https://www.wikidata.org/wiki/Q15787","display_name":"Human immunodeficiency virus (HIV)","level":2,"score":0.11000242829322815},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.06929683685302734},{"id":"https://openalex.org/C142462285","wikidata":"https://www.wikidata.org/wiki/Q2528140","display_name":"Viral load","level":3,"score":0.05899891257286072},{"id":"https://openalex.org/C2993143319","wikidata":"https://www.wikidata.org/wiki/Q583050","display_name":"Antiretroviral therapy","level":4,"score":0.0},{"id":"https://openalex.org/C204787440","wikidata":"https://www.wikidata.org/wiki/Q188504","display_name":"Alternative medicine","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000075202","descriptor_name":"Contraindications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075202","descriptor_name":"Contraindications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000075202","descriptor_name":"Contraindications","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000099227","descriptor_name":"Abacavir","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D004342","descriptor_name":"Drug Hypersensitivity","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015224","descriptor_name":"Dideoxynucleosides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015224","descriptor_name":"Dideoxynucleosides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015224","descriptor_name":"Dideoxynucleosides","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D015224","descriptor_name":"Dideoxynucleosides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015224","descriptor_name":"Dideoxynucleosides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015224","descriptor_name":"Dideoxynucleosides","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D015658","descriptor_name":"HIV Infections","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false},{"descriptor_ui":"D019380","descriptor_name":"Anti-HIV Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1345/1542-6270(2000)034<0247:mpfarh>2.3.co;2","doi":"https://doi.org/10.1345/1542-6270(2000)034<0247:mpfarh>2.3.co;2","is_oa":false,"landing_page_url":"https://doi.org/10.1345/1542-6270(2000)034<0247:mpfarh>2.3.co;2","pdf_url":null,"source":{"id":"https://openalex.org/S113426163","display_name":"Annals of Pharmacotherapy","issn_l":"0012-6578","issn":["0012-6578","1060-0280","1542-6270"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Annals of Pharmacotherapy","raw_type":"journal-article"},{"id":"doi:10.1345/aph.19107","doi":"https://doi.org/10.1345/aph.19107","is_oa":false,"landing_page_url":"https://doi.org/10.1345/aph.19107","pdf_url":null,"source":{"id":"https://openalex.org/S113426163","display_name":"Annals of Pharmacotherapy","issn_l":"0012-6578","issn":["0012-6578","1060-0280","1542-6270"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Pharmacotherapy","raw_type":"journal-article"},{"id":"pmid:10676833","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/10676833","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Annals of pharmacotherapy","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.6700000166893005,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":6,"referenced_works":["https://openalex.org/W28488281","https://openalex.org/W1993086185","https://openalex.org/W2153102244","https://openalex.org/W2411864025","https://openalex.org/W2414723992","https://openalex.org/W3192549373"],"related_works":["https://openalex.org/W2413165419","https://openalex.org/W4412899915","https://openalex.org/W2147113749","https://openalex.org/W2328602435","https://openalex.org/W1991500836","https://openalex.org/W2091436708","https://openalex.org/W1966005230","https://openalex.org/W2279618556","https://openalex.org/W2084076236","https://openalex.org/W2130470659"],"abstract_inverted_index":{"OBJECTIVE:":[0],"To":[1],"develop":[2],"an":[3],"abacavir":[4,92],"hypersensitivity":[5,81,93],"reaction":[6,94],"management":[7,99],"protocol":[8,61,84],"for":[9,62,70],"the":[10,30,71],"University":[11],"of":[12,73,91],"Oklahoma":[13],"Health":[14],"Sciences":[15],"Center.":[16],"DATA":[17],"SYNTHESIS:":[18],"Conference":[19],"abstracts,":[20],"published":[21],"literature,":[22],"and":[23,32,34,51,54],"manufacturer-provided":[24],"materials":[25],"were":[26,57],"reviewed":[27],"to":[28,35,38,88],"define":[29],"syndrome":[31],"manifestations":[33],"recommend":[36],"steps":[37],"take":[39],"when":[40],"a":[41,60,66,79,86,97],"patient":[42],"develops":[43],"abacavir-related":[44],"reactions.":[45],"RESULTS:":[46],"Initial":[47],"education,":[48],"formalized":[49,98],"contact":[50],"response":[52],"mechanism,":[53],"intervention":[55],"levels":[56],"incorporated":[58],"into":[59],"clinicians.":[63],"CONCLUSIONS:":[64],"Abacavir,":[65],"newly":[67],"approved":[68],"agent":[69],"treatment":[72],"HIV,":[74],"has":[75],"been":[76],"associated":[77],"with":[78],"fatal":[80],"reaction.":[82],"Our":[83],"provides":[85],"mechanism":[87],"minimize":[89],"progression":[90],"by":[95],"providing":[96],"procedure.":[100]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":2}],"updated_date":"2026-10-12T09:40:04.860316","created_date":"2016-06-24T00:00:00"}