{"id":"https://openalex.org/W209983235","doi":"https://doi.org/10.3760/cma.j.issn.1001-9030.2011.12.015","title":"Dynamic changes of the expression of hypoxia inducible factor-1a and the target genes miR-210, vascular endothelial growth factor in the kidney after ischemic-reperfusion injury","display_name":"Dynamic changes of the expression of hypoxia inducible factor-1a and the target genes miR-210, vascular endothelial growth factor in the kidney after ischemic-reperfusion injury","publication_year":2011,"publication_date":"2011-01-01","ids":{"openalex":"https://openalex.org/W209983235","doi":"https://doi.org/10.3760/cma.j.issn.1001-9030.2011.12.015","mag":"209983235"},"language":"en","primary_location":{"id":"mag:209983235","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/91364X/201112/40048338.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541219","display_name":"\u4e2d\u534e\u5b9e\u9a8c\u5916\u79d1\u6742\u5fd7","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u5b9e\u9a8c\u5916\u79d1\u6742\u5fd7","raw_type":null},"volume":null,"type":"article","is_traditional":true,"indexed_in":[],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5002177019","display_name":"\u674e\u8d3a","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u674e\u8d3a","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027902467","display_name":"\u6c6a\u6cf1","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u6c6a\u6cf1","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073712681","display_name":"Liu Hua Fen","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Liu Hua Fen","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002718497","display_name":"\u5a04\u8fdc\u857e","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5a04\u8fdc\u857e","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057373442","display_name":"Jun Deng","orcid":"https://orcid.org/0009-0009-0028-6372","observed_orcids":["https://orcid.org/0009-0009-0028-6372"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Deng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5005348635","display_name":"\u5d14\u82cf\u840d","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"\u5d14\u82cf\u840d","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":1,"citation_normalized_percentile":{"value":0.02303015,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":88,"max":93},"biblio":{"volume":"28","issue":"12","first_page":"2074","last_page":"2076"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.9854000210762024,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0013000000035390258,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12067","display_name":"Renal and Vascular Pathologies","score":0.0012000000569969416,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/renal-ischemia-reperfusion-injury","display_name":"renal ischemia-reperfusion injury","score":0.9240000247955322},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.9380000233650208},{"id":"https://openalex.org/keywords/mir-210","display_name":"miR-210","score":0.9950000047683716},{"id":"https://openalex.org/keywords/vascular-endothelial-growth-factor","display_name":"vascular endothelial growth factor","score":0.9990000128746033},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.7329999804496765},{"id":"https://openalex.org/keywords/renal-hypoxia","display_name":"renal hypoxia","score":0.7490000128746033},{"id":"https://openalex.org/keywords/microrna","display_name":"microRNA","score":0.4189999997615814},{"id":"https://openalex.org/keywords/renal-function-markers","display_name":"renal function markers","score":0.44200000166893005},{"id":"https://openalex.org/keywords/creatinine","display_name":"creatinine","score":0.6119999885559082},{"id":"https://openalex.org/keywords/urea-nitrogen","display_name":"urea nitrogen","score":0.8980000019073486},{"id":"https://openalex.org/keywords/gene-expression-changes","display_name":"gene expression changes","score":0.5329999923706055},{"id":"https://openalex.org/keywords/mouse-model","display_name":"mouse model","score":0.5669999718666077},{"id":"https://openalex.org/keywords/hif-1-target-genes","display_name":"HIF-1 target genes","score":0.6489999890327454}],"concepts":[{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.3749406635761261}],"mesh":[],"locations_count":2,"locations":[{"id":"mag:209983235","doi":null,"is_oa":false,"landing_page_url":"http://www.cqvip.com/QK/91364X/201112/40048338.html","pdf_url":null,"source":{"id":"https://openalex.org/S4306541219","display_name":"\u4e2d\u534e\u5b9e\u9a8c\u5916\u79d1\u6742\u5fd7","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"\u4e2d\u534e\u5b9e\u9a8c\u5916\u79d1\u6742\u5fd7","raw_type":null},{"id":"mag:3029200635","doi":"https://doi.org/10.3760/cma.j.issn.1001-9030.2011.12.015","is_oa":false,"landing_page_url":"http://rs.yiigle.com/CN42121320112812/476261.htm","pdf_url":null,"source":{"id":"https://openalex.org/S2764660617","display_name":"Zhonghua shiyan waike zazhi","issn_l":"1001-9030","issn":["1001-9030"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/P4320800525","host_organization_name":"Chinese Medical Association","host_organization_lineage":["https://openalex.org/P4320800525"],"host_organization_lineage_names":["Chinese Medical Association"],"type":"journal"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":"Zhonghua shiyan waike zazhi","raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9476000070571899,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3029200635","https://openalex.org/W3030057961","https://openalex.org/W1008570456","https://openalex.org/W2235111581","https://openalex.org/W3032712964","https://openalex.org/W2291273660","https://openalex.org/W1513075819","https://openalex.org/W846240766","https://openalex.org/W1006181030","https://openalex.org/W3031566321"],"abstract_inverted_index":{"\u76ee\u7684\u89c2\u5bdf\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u540e\u5c0f\u9f20\u80be\u810f\u7f3a\u6c27\u8bf1\u5bfc\u56e0\u5b50\uff08HIF\uff09-1a\u53ca\u5176\u9776\u57fa\u56e0miR-210\u3001\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\u7684\u8868\u8fbe\u53d8\u5316\uff0c\u63a2\u8ba8\u3002\u80be\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u540e\u8840\u7ba1\u65b0\u751f\u7684\u8c03\u63a7\u673a\u5236\u3002\u65b9\u6cd5\u5c0620\u53ea\u6210\u5e74BALB\uff0fC\u7cfb\u96c4\u6027\u5c0f\u9f20\u968f\u673a\u5206\u4e3a\u5047\u624b\u672f\uff08Sham\uff09\u7ec4\u3001\u80be\u7f3a\u8840\u518d\u704c\u6ce8\uff08IR\uff094h\u30011d\u30013d\u7ec4\uff0c\u6bcf\u7ec45\u53ea\u3002\u5404\u7ec4\u5206\u522b\u5728IR4h\u30011d\u30013d\u540e\u6536\u96c6\u8840\u6e05\u68c0\u6d4b\u808c\u9150\uff08Cr\uff09\u548c\u5c3f\u7d20\u6c2e\uff08BUN\uff09\u7684\u6c34\u5e73\uff0c\u53d6\u80be\u7ec4\u7ec7\u6807\u672c\u91c7\u7528\u5b9e\u65f6\u5b9a\u91cf\u9006\u8f6c\u5f55-\u805a\u5408\u9176\u94fe\u53cd\u5e94\uff08RT\u2014PCR\uff09\u68c0\u6d4bHIF-1amRNA\u3001miR-210\u3001\u8840\u7ba1\u5185\u76ae\u751f\u957f\u56e0\u5b50\uff08VEGF\uff09mRNA\u7684\u8868\u8fbe\u53d8\u5316\uff0c\u91c7\u7528Westernblot\u68c0\u6d4bHIF-1a\u86cb\u767d\u7684\u8868\u8fbe\u53d8\u5316\u3002\u7ed3\u679cCr\u3001BUN\u548cHIF-1amRNA\u5728IR4h\u30011d\u7ec4\u8868\u8fbe\u6c34\u5e73\u5747\u660e\u663e\u9ad8\u4e8eSham\u7ec4\uff0c\u5206\u522b\u4e3a\uff0840\uff0e20\u00b13\uff0e50\uff09\u3001\uff0890\uff0e00\u00b13\uff0e81\uff09umol\uff0fL\u3001\uff0816\uff0e88\u00b11\uff0e31\uff09\u3001\uff0838\uff0e86\u00b15\uff0e11\uff09mmol\uff0fL\uff0c\uff084\uff0e57\u00b10\uff0e52\uff09\u3001\uff083\uff0e15\u00b10\uff0e46\uff09\u500d\uff08P\u30080\uff0e05\uff09\uff1bVEGFmRNA\u3001miR-210\u548cHIF\u20141a\u86cb\u767d\u5728IR4h\u30011d\u30013d\u7ec4\u8868\u8fbe\u6c34\u5e73\u5747\u660e\u663e\u9ad8\u4e8eSham\u7ec4\uff0c\u5206\u522b\u4e3a[\uff084\uff0e33\u00b10\uff0e22\uff09\u3001\uff083\uff0e35\u00b10\uff0e22\uff09\u3001\uff082\uff0e51\u00b10\uff0e20\uff09\u500d\uff0c\uff081\uff0e29\u00b10\uff0e06\uff09\u3001\uff082\uff0e55\u00b10\uff0e15\uff09\u3001\uff081\uff0e80\u00b10\uff0e13\uff09\u500d\uff0c\uff081\uff0e54\u00b10\uff0e08\uff09\u3001\uff083\uff0e08\u00b10\uff0e23\uff09\u3001\uff081\uff0e69\u00b10\uff0e08\uff09\u500d\uff0cP\u30080\uff0e05]\u3002\u7ed3\u8bba\u80be\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u660e\u663e\u5f71\u54cdHIF\u20141a\u53ca\u5176\u9776\u57fa\u56e0miR-210\u3001VEGF\u7684\u8868\u8fbe\uff0c\u8be5\u8868\u8fbe\u53d8\u5316\u53ef\u80fd\u4e0e\u80be\u7f3a\u8840\u518d\u704c\u6ce8\u635f\u4f24\u8840\u7ba1\u65b0\u751f\u7684\u8c03\u63a7\u6709\u5173\u3002":[0]},"counts_by_year":[{"year":2015,"cited_by_count":1}],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2016-06-24T00:00:00"}