{"id":"https://openalex.org/W2099831769","doi":"https://doi.org/10.1084/jem.20141675","title":"Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling","display_name":"Transcellular delivery of vesicular SOCS proteins from macrophages to epithelial cells blunts inflammatory signaling","publication_year":2015,"publication_date":"2015-04-06","ids":{"openalex":"https://openalex.org/W2099831769","doi":"https://doi.org/10.1084/jem.20141675","mag":"2099831769","pmid":"https://pubmed.ncbi.nlm.nih.gov/25847945"},"language":"en","primary_location":{"id":"doi:10.1084/jem.20141675","doi":"https://doi.org/10.1084/jem.20141675","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.20141675","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4419346","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012781356","display_name":"Emilie Bourdonnay","orcid":"https://orcid.org/0000-0002-3579-5478","observed_orcids":["https://orcid.org/0000-0002-3579-5478"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emilie Bourdonnay","raw_affiliation_strings":["Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","institution_ids":[]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078184488","display_name":"Zbigniew Zas\u0142ona","orcid":"https://orcid.org/0000-0003-3361-4140","observed_orcids":["https://orcid.org/0000-0003-3361-4140"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zbigniew Zas\u0142ona","raw_affiliation_strings":["Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","institution_ids":[]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017856278","display_name":"Loka Raghu Kumar Penke","orcid":"https://orcid.org/0000-0002-2780-7950","observed_orcids":["https://orcid.org/0000-0002-2780-7950"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Loka Raghu Kumar Penke","raw_affiliation_strings":["Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","institution_ids":[]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039041145","display_name":"Jennifer M. Speth","orcid":"https://orcid.org/0000-0002-7724-6995","observed_orcids":["https://orcid.org/0000-0002-7724-6995"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer M. Speth","raw_affiliation_strings":["Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","institution_ids":[]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005784693","display_name":"Daniel J. Schneider","orcid":"https://orcid.org/0000-0002-0344-2811","observed_orcids":["https://orcid.org/0000-0002-0344-2811"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel J. Schneider","raw_affiliation_strings":["Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","institution_ids":[]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021482855","display_name":"Sally A. Przybranowski","orcid":"https://orcid.org/0000-0002-3029-0091","observed_orcids":["https://orcid.org/0000-0002-3029-0091"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sally Przybranowski","raw_affiliation_strings":["Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","institution_ids":[]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055543052","display_name":"Joel A. Swanson","orcid":"https://orcid.org/0000-0003-0900-8212","observed_orcids":["https://orcid.org/0000-0003-0900-8212"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Joel A. Swanson","raw_affiliation_strings":["Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","institution_ids":[]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5004123403","display_name":"Peter Mancuso","orcid":"https://orcid.org/0000-0002-2559-7320","observed_orcids":["https://orcid.org/0000-0002-2559-7320"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter Mancuso","raw_affiliation_strings":["Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","institution_ids":[]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007274627","display_name":"Christine M. Freeman","orcid":"https://orcid.org/0000-0003-3548-8133","observed_orcids":["https://orcid.org/0000-0003-3548-8133"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210102099","display_name":"VA Ann Arbor Healthcare System","ror":"https://ror.org/018txrr13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210102099","https://openalex.org/I4210127612"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210122509","display_name":"Ann Arbor VA Medical Center","ror":"https://ror.org/039n0s143","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210102099","https://openalex.org/I4210122509","https://openalex.org/I4210127612"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Christine M. Freeman","raw_affiliation_strings":["Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","Medical Services, Department of Veterans Affairs Health Care System, Ann Arbor, MI 48105 4 and 5","Research Services 4 and 5","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School","Research Services and Medical Services, Department of Veterans Affairs Health Care System, Ann Arbor, MI 48105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","institution_ids":[]},{"raw_affiliation_string":"Medical Services, Department of Veterans Affairs Health Care System, Ann Arbor, MI 48105 4 and 5","institution_ids":["https://openalex.org/I4210102099","https://openalex.org/I4210122509"]},{"raw_affiliation_string":"Research Services 4 and 5","institution_ids":[]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Research Services and Medical Services, Department of Veterans Affairs Health Care System, Ann Arbor, MI 48105","institution_ids":["https://openalex.org/I4210102099"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052110481","display_name":"Jeffrey L. Curtis","orcid":"https://orcid.org/0000-0001-5191-4847","observed_orcids":["https://orcid.org/0000-0001-5191-4847"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210102099","display_name":"VA Ann Arbor Healthcare System","ror":"https://ror.org/018txrr13","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210102099","https://openalex.org/I4210127612"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]},{"id":"https://openalex.org/I4210122509","display_name":"Ann Arbor VA Medical Center","ror":"https://ror.org/039n0s143","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210102099","https://openalex.org/I4210122509","https://openalex.org/I4210127612"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jeffrey L. Curtis","raw_affiliation_strings":["Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","Medical Services, Department of Veterans Affairs Health Care System, Ann Arbor, MI 48105 4 and 5","Research Services 4 and 5","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School","Research Services and Medical Services, Department of Veterans Affairs Health Care System, Ann Arbor, MI 48105"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","institution_ids":[]},{"raw_affiliation_string":"Medical Services, Department of Veterans Affairs Health Care System, Ann Arbor, MI 48105 4 and 5","institution_ids":["https://openalex.org/I4210102099","https://openalex.org/I4210122509"]},{"raw_affiliation_string":"Research Services 4 and 5","institution_ids":[]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Research Services and Medical Services, Department of Veterans Affairs Health Care System, Ann Arbor, MI 48105","institution_ids":["https://openalex.org/I4210102099"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5084604101","display_name":"Marc L. Peters-Golden","orcid":"https://orcid.org/0000-0002-9768-0262","observed_orcids":["https://orcid.org/0000-0002-9768-0262"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]},{"id":"https://openalex.org/I4210114445","display_name":"Michigan Medicine","ror":"https://ror.org/01zcpa714","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210114445"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Marc Peters-Golden","raw_affiliation_strings":["Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Health Sciences, School of Public Health; University of Michigan, Ann Arbor, MI 48109 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315"]},{"raw_affiliation_string":"Department of Microbiology and Immunology, University of Michigan Medical School 1 and 2 ; and 3","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine 1 and 2 ; and 3","institution_ids":[]},{"raw_affiliation_string":"Division of Pulmonary and Critical Care Medicine, Department of Internal Medicine and Department of Microbiology and Immunology, University of Michigan Medical School","institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5084604101"],"corresponding_institution_ids":["https://openalex.org/I27837315","https://openalex.org/I4210114445"],"apc_list":null,"apc_paid":null,"fwci":8.3207,"has_fulltext":false,"cited_by_count":206,"citation_normalized_percentile":{"value":0.98671519,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":89,"max":100},"biblio":{"volume":"212","issue":"5","first_page":"729","last_page":"742"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11503","display_name":"Cytokine Signaling Pathways and Interactions","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12672","display_name":"Phagocytosis and Immune Regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/suppressor-of-cytokine-signaling","display_name":"suppressor of cytokine signaling","score":0.9240000247955322},{"id":"https://openalex.org/keywords/socs1","display_name":"SOCS1","score":0.9700000286102295},{"id":"https://openalex.org/keywords/socs3","display_name":"SOCS3","score":1.0},{"id":"https://openalex.org/keywords/alveolar-macrophages","display_name":"alveolar macrophages","score":0.8610000014305115},{"id":"https://openalex.org/keywords/alveolar-epithelial-cells","display_name":"alveolar epithelial cells","score":0.9459999799728394},{"id":"https://openalex.org/keywords/exosomes","display_name":"exosomes","score":0.8799999952316284},{"id":"https://openalex.org/keywords/microparticles","display_name":"microparticles","score":0.9890000224113464},{"id":"https://openalex.org/keywords/jak-stat-signaling","display_name":"JAK/STAT signaling","score":0.828000009059906},{"id":"https://openalex.org/keywords/stat-activation","display_name":"STAT activation","score":0.843999981880188},{"id":"https://openalex.org/keywords/extracellular-vesicles","display_name":"extracellular vesicles","score":0.6660000085830688},{"id":"https://openalex.org/keywords/cigarette-smoking","display_name":"cigarette smoking","score":0.7549999952316284},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.8859999775886536},{"id":"https://openalex.org/keywords/lung-lining-fluid","display_name":"lung lining fluid","score":0.7720000147819519}],"concepts":[{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.7941538691520691},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.7351593375205994},{"id":"https://openalex.org/C176285220","wikidata":"https://www.wikidata.org/wiki/Q7833830","display_name":"Transcellular","level":2,"score":0.551451563835144},{"id":"https://openalex.org/C20518536","wikidata":"https://www.wikidata.org/wiki/Q6840469","display_name":"Microvesicles","level":4,"score":0.5008056163787842},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.488238126039505},{"id":"https://openalex.org/C60903277","wikidata":"https://www.wikidata.org/wiki/Q2051926","display_name":"Paracellular transport","level":4,"score":0.4815521538257599},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.42636966705322266},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.42503926157951355},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.42075207829475403},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.37678593397140503},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3446230888366699},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.3271099030971527},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.10344067215919495},{"id":"https://openalex.org/C145059251","wikidata":"https://www.wikidata.org/wiki/Q310899","display_name":"microRNA","level":3,"score":0.10273432731628418},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.06605839729309082},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0},{"id":"https://openalex.org/C120882062","wikidata":"https://www.wikidata.org/wiki/Q28352","display_name":"Permeability (electromagnetism)","level":3,"score":0.0},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002461","descriptor_name":"Cell Line, Transformed","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D004847","descriptor_name":"Epithelial Cells","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008264","descriptor_name":"Macrophages","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D011650","descriptor_name":"Pulmonary Alveoli","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017208","descriptor_name":"Rats, Wistar","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050791","descriptor_name":"STAT Transcription Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050791","descriptor_name":"STAT Transcription Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050791","descriptor_name":"STAT Transcription Factors","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D050826","descriptor_name":"Suppressor of Cytokine Signaling Proteins","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D053612","descriptor_name":"Janus Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053612","descriptor_name":"Janus Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D053612","descriptor_name":"Janus Kinases","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D055252","descriptor_name":"Cell-Derived Microparticles","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D055252","descriptor_name":"Cell-Derived Microparticles","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D055252","descriptor_name":"Cell-Derived Microparticles","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D055252","descriptor_name":"Cell-Derived Microparticles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055252","descriptor_name":"Cell-Derived Microparticles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D055252","descriptor_name":"Cell-Derived Microparticles","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1084/jem.20141675","doi":"https://doi.org/10.1084/jem.20141675","is_oa":false,"landing_page_url":"https://doi.org/10.1084/jem.20141675","pdf_url":null,"source":{"id":"https://openalex.org/S22947807","display_name":"The Journal of Experimental Medicine","issn_l":"0022-1007","issn":["0022-1007","1540-9538"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315676","host_organization_name":"Rockefeller University Press","host_organization_lineage":["https://openalex.org/P4310315676"],"host_organization_lineage_names":["Rockefeller University Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Experimental Medicine","raw_type":"journal-article"},{"id":"pmid:25847945","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25847945","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of experimental medicine","raw_type":"Journal Article"},{"id":"pmh:oai:europepmc.org:3605532","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4419346","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4419346","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4419346","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"J Exp Med","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:europepmc.org:3605532","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4419346","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Text"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.8048999905586243,"display_name":"Good health and well-being"}],"sustainable_development_goals_aurora":[{"id":"https://metadata.un.org/sdg/3","score":0.8600000143051147,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1639247322","display_name":"Innate and adaptive immunity in COPD exacerbations","funder_award_id":"5r01hl082480-05","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G1906632938","display_name":null,"funder_award_id":"T32-HL007749","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G2031443463","display_name":null,"funder_award_id":"R56 HL058897","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G4736687069","display_name":null,"funder_award_id":"HL058897","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G5195677771","display_name":null,"funder_award_id":"R01 HL058897","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G557789089","display_name":null,"funder_award_id":"HL-082480","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G6419654210","display_name":"Inducible Renitence in Macrophages","funder_award_id":"R01GM101189","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G6836302297","display_name":null,"funder_award_id":"I01 BX001389","funder_id":"https://openalex.org/F4320306127","funder_display_name":"U.S. Department of Veterans Affairs"},{"id":"https://openalex.org/G6848848125","display_name":"The Regulation of Macropinocytosis","funder_award_id":"R01GM110215","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G7351362432","display_name":null,"funder_award_id":"R01-HL082480","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"},{"id":"https://openalex.org/G9000907063","display_name":"Multidisciplinary Training Program in Lung Disease","funder_award_id":"5t32hl007749-33","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"}],"funders":[{"id":"https://openalex.org/F4320306127","display_name":"U.S. Department of Veterans Affairs","ror":"https://ror.org/05rsv9s98"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":55,"referenced_works":["https://openalex.org/W18788431","https://openalex.org/W63837087","https://openalex.org/W121387658","https://openalex.org/W1525044292","https://openalex.org/W1668039320","https://openalex.org/W1877686344","https://openalex.org/W1964157750","https://openalex.org/W1964827458","https://openalex.org/W1967486091","https://openalex.org/W1969327353","https://openalex.org/W1977269501","https://openalex.org/W1990722057","https://openalex.org/W1995622771","https://openalex.org/W2000825465","https://openalex.org/W2005755533","https://openalex.org/W2009101746","https://openalex.org/W2020539152","https://openalex.org/W2020716763","https://openalex.org/W2021637137","https://openalex.org/W2025067737","https://openalex.org/W2026706842","https://openalex.org/W2028873595","https://openalex.org/W2029335692","https://openalex.org/W2039295539","https://openalex.org/W2048356531","https://openalex.org/W2049817121","https://openalex.org/W2051713330","https://openalex.org/W2065635384","https://openalex.org/W2068738732","https://openalex.org/W2069305891","https://openalex.org/W2075325752","https://openalex.org/W2082973995","https://openalex.org/W2086704388","https://openalex.org/W2089823799","https://openalex.org/W2093442991","https://openalex.org/W2096952947","https://openalex.org/W2100561361","https://openalex.org/W2100927341","https://openalex.org/W2105843214","https://openalex.org/W2111379723","https://openalex.org/W2115933717","https://openalex.org/W2120579640","https://openalex.org/W2121354606","https://openalex.org/W2122467038","https://openalex.org/W2126273548","https://openalex.org/W2141077333","https://openalex.org/W2143041135","https://openalex.org/W2159833023","https://openalex.org/W2161746138","https://openalex.org/W2162159732","https://openalex.org/W2163406329","https://openalex.org/W2169780324","https://openalex.org/W2421220842","https://openalex.org/W2424384909","https://openalex.org/W6600746759"],"related_works":["https://openalex.org/W2071488647","https://openalex.org/W2068634974","https://openalex.org/W2091987168","https://openalex.org/W2707015926","https://openalex.org/W2603412106","https://openalex.org/W2082951676","https://openalex.org/W2011189203","https://openalex.org/W2144856465","https://openalex.org/W2096463688","https://openalex.org/W2186419115"],"abstract_inverted_index":{"JAK-STAT":[0],"signaling":[1],"mediates":[2],"the":[3,16,33,104],"actions":[4],"of":[5,18,61,94,106,116],"numerous":[6],"cytokines":[7],"and":[8,11,45,49,58,67,72,88,91],"growth":[9],"factors,":[10],"its":[12],"endogenous":[13],"brake":[14],"is":[15,65,110],"family":[17],"SOCS":[19,26,75,96],"proteins.":[20],"Consistent":[21],"with":[22],"their":[23],"intracellular":[24],"roles,":[25],"proteins":[27,97],"have":[28],"never":[29],"been":[30],"identified":[31],"in":[32,47,70,73,86],"extracellular":[34],"space.":[35],"Here":[36],"we":[37],"report":[38],"that":[39],"alveolar":[40,55],"macrophages":[41],"can":[42],"secrete":[43],"SOCS1":[44],"-3":[46],"exosomes":[48],"microparticles,":[50],"respectively,":[51],"for":[52,103],"uptake":[53],"by":[54,83],"epithelial":[56],"cells":[57],"subsequent":[59],"inhibition":[60],"STAT":[62],"activation.":[63],"Secretion":[64,90],"tunable":[66],"occurs":[68],"both":[69],"vitro":[71],"vivo.":[74],"secretion":[76],"into":[77],"lung":[78],"lining":[79],"fluid":[80],"was":[81],"diminished":[82],"cigarette":[84],"smoking":[85],"humans":[87],"mice.":[89],"transcellular":[92],"delivery":[93],"vesicular":[95],"thus":[98],"represent":[99],"a":[100],"new":[101],"model":[102],"control":[105],"inflammatory":[107],"signaling,":[108],"which":[109],"subject":[111],"to":[112],"dysregulation":[113],"during":[114],"states":[115],"inflammation.":[117]},"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":11},{"year":2024,"cited_by_count":13},{"year":2023,"cited_by_count":15},{"year":2022,"cited_by_count":20},{"year":2021,"cited_by_count":29},{"year":2020,"cited_by_count":22},{"year":2019,"cited_by_count":23},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":23},{"year":2016,"cited_by_count":16},{"year":2015,"cited_by_count":9},{"year":2014,"cited_by_count":1}],"updated_date":"2026-10-22T18:32:59.640997","created_date":"2025-10-10T00:00:00"}