{"id":"https://openalex.org/W2099823634","doi":"https://doi.org/10.1191/0961203305lu2136oa","title":"Block and tackle: CTLA4Ig takes on lupus","display_name":"Block and tackle: CTLA4Ig takes on lupus","publication_year":2005,"publication_date":"2005-02-28","ids":{"openalex":"https://openalex.org/W2099823634","doi":"https://doi.org/10.1191/0961203305lu2136oa","mag":"2099823634","pmid":"https://pubmed.ncbi.nlm.nih.gov/15807196"},"language":"en","primary_location":{"id":"doi:10.1191/0961203305lu2136oa","doi":"https://doi.org/10.1191/0961203305lu2136oa","is_oa":false,"landing_page_url":"https://doi.org/10.1191/0961203305lu2136oa","pdf_url":null,"source":{"id":"https://openalex.org/S115920904","display_name":"Lupus","issn_l":"0961-2033","issn":["0961-2033","1477-0962"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lupus","raw_type":"journal-article"},"volume":null,"type":"review","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072875873","display_name":"Anne Davidson","orcid":"https://orcid.org/0000-0002-4081-6464","observed_orcids":["https://orcid.org/0000-0002-4081-6464"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"A Davidson","raw_affiliation_strings":["Departments of Medicine and Microbiology, Columbia University, New York,                         NY, USA,","Department of Medicine, Columbia University, New York, NY, USA. ad2247@columbia.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Microbiology, Columbia University, New York,                         NY, USA,","institution_ids":["https://openalex.org/I78577930"]},{"raw_affiliation_string":"Department of Medicine, Columbia University, New York, NY, USA. ad2247@columbia.edu","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089808423","display_name":"Betty Diamond","orcid":"https://orcid.org/0000-0002-3250-3804","observed_orcids":["https://orcid.org/0000-0002-3250-3804"]},"institutions":[{"id":"https://openalex.org/I78577930","display_name":"Columbia University","ror":"https://ror.org/00hj8s172","country_code":"US","type":"education","lineage":["https://openalex.org/I78577930"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"B Diamond","raw_affiliation_strings":["Departments of Medicine and Microbiology, Columbia University, New York, NY, USA,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Departments of Medicine and Microbiology, Columbia University, New York, NY, USA,","institution_ids":["https://openalex.org/I78577930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054643514","display_name":"David Wofsy","orcid":"https://orcid.org/0000-0001-8350-3428","observed_orcids":["https://orcid.org/0000-0001-8350-3428"]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Wofsy","raw_affiliation_strings":["Department of Veterans Affairs Medical Center and the University of California, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Medical Center and the University of California, San Francisco, CA, USA","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080133980","display_name":"David Daikh","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1315708478","display_name":"San Francisco VA Medical Center","ror":"https://ror.org/049peqw80","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1315708478","https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210125474","https://openalex.org/I4210143381"]},{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"D Daikh","raw_affiliation_strings":["Department of Veterans Affairs Medical Center and the University of California, San Francisco, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Veterans Affairs Medical Center and the University of California, San Francisco, CA, USA","institution_ids":["https://openalex.org/I1315708478","https://openalex.org/I180670191"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":4150,"currency":"USD","value_usd":4150},"apc_paid":null,"fwci":1.759,"has_fulltext":false,"cited_by_count":68,"citation_normalized_percentile":{"value":0.84383562,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":97},"biblio":{"volume":"14","issue":"3","first_page":"197","last_page":"203"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11330","display_name":"Systemic Sclerosis and Related Diseases","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/abatacept","display_name":"abatacept","score":0.9919999837875366},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9909999966621399},{"id":"https://openalex.org/keywords/cd28-b7-costimulation","display_name":"CD28/B7 costimulation","score":0.8679999709129333},{"id":"https://openalex.org/keywords/costimulation-blockade","display_name":"costimulation blockade","score":0.7200000286102295},{"id":"https://openalex.org/keywords/lupus-nephritis","display_name":"lupus nephritis","score":0.8199999928474426},{"id":"https://openalex.org/keywords/cyclophosphamide","display_name":"cyclophosphamide","score":0.878000020980835},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.5109999775886536},{"id":"https://openalex.org/keywords/murine-lupus-model","display_name":"murine lupus model","score":0.7789999842643738},{"id":"https://openalex.org/keywords/immunomodulation","display_name":"immunomodulation","score":0.5709999799728394}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8627645969390869},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.757125973701477},{"id":"https://openalex.org/C2779912601","wikidata":"https://www.wikidata.org/wiki/Q1621830","display_name":"Lupus nephritis","level":3,"score":0.6832283735275269},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.6782911419868469},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.582905650138855},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.5400031805038452},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.46497416496276855},{"id":"https://openalex.org/C2777058396","wikidata":"https://www.wikidata.org/wiki/Q401402","display_name":"Nephritis","level":2,"score":0.4494034945964813},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.442179411649704},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.43144524097442627},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.20539873838424683},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.15259766578674316},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.12554669380187988},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.11164861917495728}],"mesh":[{"descriptor_ui":"D000069594","descriptor_name":"Abatacept","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001402","descriptor_name":"B-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D008180","descriptor_name":"Lupus Erythematosus, Systemic","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D018796","descriptor_name":"Immunoconjugates","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1191/0961203305lu2136oa","doi":"https://doi.org/10.1191/0961203305lu2136oa","is_oa":false,"landing_page_url":"https://doi.org/10.1191/0961203305lu2136oa","pdf_url":null,"source":{"id":"https://openalex.org/S115920904","display_name":"Lupus","issn_l":"0961-2033","issn":["0961-2033","1477-0962"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320017","host_organization_name":"SAGE Publishing","host_organization_lineage":["https://openalex.org/P4310320017"],"host_organization_lineage_names":["SAGE Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lupus","raw_type":"journal-article"},{"id":"pmid:15807196","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/15807196","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Lupus","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":80,"referenced_works":["https://openalex.org/W1485596855","https://openalex.org/W1489480103","https://openalex.org/W1507979065","https://openalex.org/W1517758150","https://openalex.org/W1519521580","https://openalex.org/W1525199620","https://openalex.org/W1597159169","https://openalex.org/W1647115901","https://openalex.org/W1656960246","https://openalex.org/W1668298676","https://openalex.org/W1819078819","https://openalex.org/W1907308479","https://openalex.org/W1971637301","https://openalex.org/W1971782694","https://openalex.org/W1972388670","https://openalex.org/W1975249184","https://openalex.org/W1975929837","https://openalex.org/W1976945431","https://openalex.org/W1977218118","https://openalex.org/W1984049620","https://openalex.org/W1989175805","https://openalex.org/W1989436604","https://openalex.org/W1994478925","https://openalex.org/W1997146705","https://openalex.org/W2006554521","https://openalex.org/W2008182583","https://openalex.org/W2008304542","https://openalex.org/W2010542727","https://openalex.org/W2014081699","https://openalex.org/W2015085911","https://openalex.org/W2017051726","https://openalex.org/W2024081009","https://openalex.org/W2032028786","https://openalex.org/W2033202090","https://openalex.org/W2037374883","https://openalex.org/W2037920661","https://openalex.org/W2038390458","https://openalex.org/W2042736763","https://openalex.org/W2045932062","https://openalex.org/W2046739604","https://openalex.org/W2047427464","https://openalex.org/W2048073154","https://openalex.org/W2059557874","https://openalex.org/W2062443745","https://openalex.org/W2064718671","https://openalex.org/W2075819066","https://openalex.org/W2075964378","https://openalex.org/W2077043104","https://openalex.org/W2077389439","https://openalex.org/W2077903396","https://openalex.org/W2079676235","https://openalex.org/W2085332498","https://openalex.org/W2087757222","https://openalex.org/W2087976968","https://openalex.org/W2089563009","https://openalex.org/W2094526738","https://openalex.org/W2095013915","https://openalex.org/W2096370504","https://openalex.org/W2098004457","https://openalex.org/W2100117872","https://openalex.org/W2100764147","https://openalex.org/W2112082484","https://openalex.org/W2118637098","https://openalex.org/W2121498145","https://openalex.org/W2127882613","https://openalex.org/W2131136878","https://openalex.org/W2135271976","https://openalex.org/W2136408524","https://openalex.org/W2137096190","https://openalex.org/W2137386490","https://openalex.org/W2140460887","https://openalex.org/W2143212200","https://openalex.org/W2154055388","https://openalex.org/W2155086276","https://openalex.org/W2162856391","https://openalex.org/W2167234191","https://openalex.org/W2168931543","https://openalex.org/W2171026458","https://openalex.org/W2416254123","https://openalex.org/W4313333829"],"related_works":["https://openalex.org/W2037775378","https://openalex.org/W2066054693","https://openalex.org/W1501881726","https://openalex.org/W2155086276","https://openalex.org/W2994382439","https://openalex.org/W2477929749","https://openalex.org/W2008304542","https://openalex.org/W1525199620","https://openalex.org/W2162055377","https://openalex.org/W2156131100"],"abstract_inverted_index":{"Blockade":[0],"of":[1,13,24,47,59,61,89],"antigen":[2],"nonspecific":[3],"costimulatory":[4,27],"signals":[5],"is":[6],"a":[7,99],"promising":[8],"approach":[9],"for":[10,98],"the":[11,25,56,86,96],"treatment":[12],"autoimmune":[14,69],"diseases":[15],"including":[16],"systemic":[17],"lupus":[18],"erythematosus":[19],"(SLE).":[20],"CTLA4Ig,":[21],"an":[22],"antagonist":[23],"CD28/B7":[26],"interaction,":[28],"effectively":[29],"prevents":[30],"SLE":[31,49,93,103],"onset":[32],"in":[33,40,64,68,91,102],"several":[34],"murine":[35,92],"models":[36,71,94],"and,":[37],"when":[38],"used":[39],"combination":[41],"with":[42],"cyclophosphamide,":[43],"can":[44],"induce":[45],"remission":[46],"active":[48],"nephritis.":[50],"In":[51],"this":[52],"review":[53],"we":[54],"describe":[55],"known":[57],"mechanisms":[58],"action":[60],"CTLA4Ig":[62,90],"both":[63],"normal":[65],"immunity":[66],"and":[67,72,95],"disease":[70],"address":[73],"issues":[74],"about":[75],"its":[76],"activity":[77],"that":[78],"still":[79],"need":[80],"to":[81],"be":[82],"resolved.":[83],"We":[84],"discuss":[85],"preclinical":[87],"use":[88],"rationale":[97],"clinical":[100],"trial":[101],"patients.":[104]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2024,"cited_by_count":1},{"year":2020,"cited_by_count":2},{"year":2015,"cited_by_count":3},{"year":2014,"cited_by_count":2},{"year":2013,"cited_by_count":3},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
