{"id":"https://openalex.org/W2099749095","doi":"https://doi.org/10.1124/mol.113.089821","title":"Novel Small Molecule Inhibitors of TLR7 and TLR9: Mechanism of Action and Efficacy In Vivo","display_name":"Novel Small Molecule Inhibitors of TLR7 and TLR9: Mechanism of Action and Efficacy In Vivo","publication_year":2013,"publication_date":"2013-12-16","ids":{"openalex":"https://openalex.org/W2099749095","doi":"https://doi.org/10.1124/mol.113.089821","mag":"2099749095","pmid":"https://pubmed.ncbi.nlm.nih.gov/24342772"},"language":"en","primary_location":{"id":"doi:10.1124/mol.113.089821","doi":"https://doi.org/10.1124/mol.113.089821","is_oa":false,"landing_page_url":"https://doi.org/10.1124/mol.113.089821","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5024021241","display_name":"Marc S. Lamphier","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Marc Lamphier","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110270343","display_name":"Wanjun Zheng","orcid":"https://orcid.org/0009-0000-7864-3776","observed_orcids":["https://orcid.org/0009-0000-7864-3776"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Wanjun Zheng","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009349672","display_name":"Eicke Latz","orcid":"https://orcid.org/0000-0003-1488-5666","observed_orcids":["https://orcid.org/0000-0003-1488-5666"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Eicke Latz","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081486669","display_name":"Mark R. Spyvee","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Mark Spyvee","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":null,"display_name":"Hans Hansen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Hans Hansen","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086841658","display_name":"Jeffrey Rose","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Jeffrey Rose","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008099148","display_name":"Melinda Genest","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Melinda Genest","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015256862","display_name":"Hua Qian Yang","orcid":"https://orcid.org/0000-0002-9796-5663","observed_orcids":["https://orcid.org/0000-0002-9796-5663"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Hua Yang","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079631431","display_name":"Christina J. Shaffer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Christina Shaffer","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081990902","display_name":"Yan Zhao","orcid":"https://orcid.org/0000-0002-4348-256X","observed_orcids":["https://orcid.org/0000-0002-4348-256X"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Yan Zhao","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052740234","display_name":"Yongchun Shen","orcid":"https://orcid.org/0000-0003-0527-4775","observed_orcids":["https://orcid.org/0000-0003-0527-4775"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Yongchun Shen","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052075123","display_name":"Carrie Liu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Carrie Liu","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056820862","display_name":"Diana Liu","orcid":"https://orcid.org/0000-0002-1559-2622","observed_orcids":["https://orcid.org/0000-0002-1559-2622"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Diana Liu","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046531312","display_name":"Thorsten R. Mempel","orcid":"https://orcid.org/0000-0001-8635-5424","observed_orcids":["https://orcid.org/0000-0001-8635-5424"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Thorsten R. Mempel","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079493001","display_name":"Christopher Rowbottom","orcid":"https://orcid.org/0000-0003-2492-3849","observed_orcids":["https://orcid.org/0000-0003-2492-3849"]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Christopher Rowbottom","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112816907","display_name":"Jesse C. Chow","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Jesse Chow","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5087463666","display_name":"Natalie C. Twine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Natalie C. Twine","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062060750","display_name":"Melvin J. Yu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Melvin Yu","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5108753892","display_name":"Fabian Gusovsky","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Fabian Gusovsky","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5078185837","display_name":"Sally T. Ishizaka","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I135140700","display_name":"University of Bonn","ror":"https://ror.org/041nas322","country_code":"DE","type":"education","lineage":["https://openalex.org/I135140700"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I166722992","display_name":"University of Massachusetts Chan Medical School","ror":"https://ror.org/0464eyp60","country_code":"US","type":"education","lineage":["https://openalex.org/I166722992"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I4210151718","display_name":"Eisai (United States)","ror":"https://ror.org/0469x1750","country_code":"US","type":"company","lineage":["https://openalex.org/I4210151718","https://openalex.org/I55881946"]},{"id":"https://openalex.org/I4210155419","display_name":"Center for Systems Biology","ror":"https://ror.org/05r3dyn47","country_code":"US","type":"facility","lineage":["https://openalex.org/I136199984","https://openalex.org/I4210087915","https://openalex.org/I4210155419","https://openalex.org/I48633490"]}],"countries":["DE","US"],"is_corresponding":false,"raw_author_name":"Sally T. Ishizaka","raw_affiliation_strings":["Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","Institute of Innate Immunity, University of Bonn, Germany (E.L.)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.); Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.); Institute of Innate Immunity, University of Bonn, Germany (E.L.); Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.); and Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I135140700","https://openalex.org/I166722992"]},{"raw_affiliation_string":"Center for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Center for Systems Biology, Harvard Medical School, Charlestown, Massachusetts (T.R.M.)","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210155419"]},{"raw_affiliation_string":"Department of Infectious Diseases and Immunology, University of Massachusetts, Worcester, Massachusetts (E.L.)","institution_ids":["https://openalex.org/I166722992"]},{"raw_affiliation_string":"Eisai, Inc., Andover, Massachusetts (M.L., W.Z., M.S., H.H., J.R., M.G., H.Y., C.S., Y.Z., Y.S., C.L., D.L., C.R., J.C., N.C.T., M.Y., F.G., S.T.I.)","institution_ids":["https://openalex.org/I4210151718"]},{"raw_affiliation_string":"Institute of Innate Immunity, University of Bonn, Germany (E.L.)","institution_ids":["https://openalex.org/I135140700"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":3600,"currency":"USD","value_usd":3600},"apc_paid":null,"fwci":3.5338,"has_fulltext":false,"cited_by_count":147,"citation_normalized_percentile":{"value":0.93167807,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":98,"max":100},"biblio":{"volume":"85","issue":"3","first_page":"429","last_page":"440"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.6929000020027161,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10371","display_name":"Immune Response and Inflammation","score":0.6929000020027161,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10308","display_name":"Systemic Lupus Erythematosus Research","score":0.30469998717308044,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/tlr7","display_name":"TLR7","score":0.628000020980835},{"id":"https://openalex.org/keywords/tlr9","display_name":"TLR9","score":1.0},{"id":"https://openalex.org/keywords/systemic-lupus-erythematosus","display_name":"systemic lupus erythematosus","score":0.9269999861717224},{"id":"https://openalex.org/keywords/cpg-dna","display_name":"CpG DNA","score":0.5699999928474426},{"id":"https://openalex.org/keywords/nucleic-acid-binding","display_name":"nucleic acid binding","score":0.6869999766349792},{"id":"https://openalex.org/keywords/antinuclear-antibodies","display_name":"antinuclear antibodies","score":0.8370000123977661},{"id":"https://openalex.org/keywords/hydroxychloroquine","display_name":"hydroxychloroquine","score":0.902999997138977},{"id":"https://openalex.org/keywords/small-molecule-inhibitors","display_name":"small molecule inhibitors","score":0.5070000290870667},{"id":"https://openalex.org/keywords/plasmacytoid-dendritic-cells","display_name":"plasmacytoid dendritic cells","score":0.8130000233650208},{"id":"https://openalex.org/keywords/b-cells","display_name":"B cells","score":0.5360000133514404}],"concepts":[{"id":"https://openalex.org/C2779138994","wikidata":"https://www.wikidata.org/wiki/Q15332550","display_name":"TLR9","level":5,"score":0.7883208990097046},{"id":"https://openalex.org/C2779836521","wikidata":"https://www.wikidata.org/wiki/Q14914081","display_name":"TLR7","level":5,"score":0.7527273893356323},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5923842787742615},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.5060188174247742},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4899698793888092},{"id":"https://openalex.org/C24107716","wikidata":"https://www.wikidata.org/wiki/Q123619","display_name":"Nucleic acid","level":2,"score":0.4812285900115967},{"id":"https://openalex.org/C552990157","wikidata":"https://www.wikidata.org/wiki/Q7430","display_name":"DNA","level":2,"score":0.4805926978588104},{"id":"https://openalex.org/C2776912625","wikidata":"https://www.wikidata.org/wiki/Q1485","display_name":"Systemic lupus erythematosus","level":3,"score":0.4770088493824005},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4750492572784424},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4551413655281067},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.43969425559043884},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.42202189564704895},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.40045395493507385},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.38923272490501404},{"id":"https://openalex.org/C2776709828","wikidata":"https://www.wikidata.org/wiki/Q408004","display_name":"Toll-like receptor","level":4,"score":0.2188718020915985},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.10556143522262573},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.09971708059310913},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.09484946727752686},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0945202112197876},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.0751657485961914},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.0},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.0},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002352","descriptor_name":"Carrier Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004317","descriptor_name":"Doxorubicin","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D008562","descriptor_name":"Membrane Glycoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013879","descriptor_name":"Thioredoxins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D013879","descriptor_name":"Thioredoxins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D013879","descriptor_name":"Thioredoxins","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D015536","descriptor_name":"Down-Regulation","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017382","descriptor_name":"Reactive Oxygen Species","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D018384","descriptor_name":"Oxidative Stress","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048051","descriptor_name":"p38 Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D048848","descriptor_name":"MAP Kinase Kinase Kinase 5","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D048848","descriptor_name":"MAP Kinase Kinase Kinase 5","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050199","descriptor_name":"Podocytes","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D050199","descriptor_name":"Podocytes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051199","descriptor_name":"Toll-Like Receptor 7","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051199","descriptor_name":"Toll-Like Receptor 7","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051199","descriptor_name":"Toll-Like Receptor 7","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051217","descriptor_name":"Toll-Like Receptor 9","qualifier_ui":"Q000037","qualifier_name":"antagonists & inhibitors","is_major_topic":true},{"descriptor_ui":"D051217","descriptor_name":"Toll-Like Receptor 9","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D051217","descriptor_name":"Toll-Like Receptor 9","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054852","descriptor_name":"Small Molecule Libraries","qualifier_ui":"Q000493","qualifier_name":"pharmacokinetics","is_major_topic":true},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D055372","descriptor_name":"AMP-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1124/mol.113.089821","doi":"https://doi.org/10.1124/mol.113.089821","is_oa":false,"landing_page_url":"https://doi.org/10.1124/mol.113.089821","pdf_url":null,"source":{"id":"https://openalex.org/S62949411","display_name":"Molecular Pharmacology","issn_l":"0026-895X","issn":["0026-895X","1521-0111"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310316283","host_organization_name":"American Society for Pharmacology and Experimental Therapeutics","host_organization_lineage":["https://openalex.org/P4310316283"],"host_organization_lineage_names":["American Society for Pharmacology and Experimental Therapeutics"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Pharmacology","raw_type":"journal-article"},{"id":"pmid:24342772","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/24342772","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular pharmacology","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320307115","display_name":"Bristol-Myers Squibb","ror":"https://ror.org/00gtmwv55"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":31,"referenced_works":["https://openalex.org/W10640494","https://openalex.org/W20089701","https://openalex.org/W99465270","https://openalex.org/W1507468159","https://openalex.org/W1589670817","https://openalex.org/W1962709364","https://openalex.org/W1970291282","https://openalex.org/W1972776583","https://openalex.org/W1972799331","https://openalex.org/W1985477675","https://openalex.org/W1985945544","https://openalex.org/W1990290004","https://openalex.org/W2024116215","https://openalex.org/W2025412364","https://openalex.org/W2044045006","https://openalex.org/W2068975016","https://openalex.org/W2073101936","https://openalex.org/W2077039977","https://openalex.org/W2090772415","https://openalex.org/W2094746130","https://openalex.org/W2096137281","https://openalex.org/W2098920407","https://openalex.org/W2109191041","https://openalex.org/W2118400571","https://openalex.org/W2120111920","https://openalex.org/W2124651203","https://openalex.org/W2134106169","https://openalex.org/W2137059909","https://openalex.org/W2137540618","https://openalex.org/W2166626628","https://openalex.org/W4313342352"],"related_works":["https://openalex.org/W4385605278","https://openalex.org/W1972799331","https://openalex.org/W2096137281","https://openalex.org/W4301510080","https://openalex.org/W2609412714","https://openalex.org/W2015549117","https://openalex.org/W2034233648","https://openalex.org/W2519579918","https://openalex.org/W3013907801","https://openalex.org/W2052528430"],"abstract_inverted_index":null,"counts_by_year":[{"year":2026,"cited_by_count":8},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":8},{"year":2023,"cited_by_count":19},{"year":2022,"cited_by_count":13},{"year":2021,"cited_by_count":19},{"year":2020,"cited_by_count":17},{"year":2019,"cited_by_count":9},{"year":2018,"cited_by_count":11},{"year":2017,"cited_by_count":10},{"year":2016,"cited_by_count":14},{"year":2015,"cited_by_count":10}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
