{"id":"https://openalex.org/W2099712428","doi":"https://doi.org/10.1152/ajpcell.00555.2006","title":"Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic \u03b2-cell: a computational approach","display_name":"Regulation of cAMP dynamics by Ca2+ and G protein-coupled receptors in the pancreatic \u03b2-cell: a computational approach","publication_year":2007,"publication_date":"2007-10-11","ids":{"openalex":"https://openalex.org/W2099712428","doi":"https://doi.org/10.1152/ajpcell.00555.2006","mag":"2099712428","pmid":"https://pubmed.ncbi.nlm.nih.gov/17928534"},"language":"en","primary_location":{"id":"doi:10.1152/ajpcell.00555.2006","doi":"https://doi.org/10.1152/ajpcell.00555.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.00555.2006","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5045927870","display_name":"Leonid E. Fridlyand","orcid":"https://orcid.org/0000-0003-4424-9986","observed_orcids":["https://orcid.org/0000-0003-4424-9986"]},"institutions":[{"id":"https://openalex.org/I40347166","display_name":"University of Chicago","ror":"https://ror.org/024mw5h28","country_code":"US","type":"education","lineage":["https://openalex.org/I40347166"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Leonid E. Fridlyand","raw_affiliation_strings":["Department of Medicine, The University of Chicago, Chicago, IL 60637, USA. lfridlia@medicine.bsd.uchicago.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, The University of Chicago, Chicago, IL 60637, USA. lfridlia@medicine.bsd.uchicago.edu","institution_ids":["https://openalex.org/I40347166"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036238941","display_name":"Mark C. Harbeck","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mark C. Harbeck","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103817299","display_name":"Michael Wm. Roe","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Michael W. Roe","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5073002116","display_name":"Louis H. Philipson","orcid":"https://orcid.org/0000-0002-2208-3607","observed_orcids":["https://orcid.org/0000-0002-2208-3607"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Louis H. Philipson","raw_affiliation_strings":[""],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":4.5495,"has_fulltext":false,"cited_by_count":67,"citation_normalized_percentile":{"value":0.94945095,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":87,"max":99},"biblio":{"volume":"293","issue":"6","first_page":"C1924","last_page":"C1933"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10839","display_name":"Pancreatic function and diabetes","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12434","display_name":"Phosphodiesterase function and regulation","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13415","display_name":"Calcium signaling and nucleotide metabolism","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1314","display_name":"Physiology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/camp-oscillations","display_name":"cAMP oscillations","score":0.9419999718666077},{"id":"https://openalex.org/keywords/pancreatic-beta-cells","display_name":"pancreatic beta cells","score":0.8629999756813049},{"id":"https://openalex.org/keywords/calcium-oscillations","display_name":"calcium oscillations","score":0.9070000052452087},{"id":"https://openalex.org/keywords/glp-1-receptor","display_name":"GLP-1 receptor","score":0.7829999923706055},{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8330000042915344},{"id":"https://openalex.org/keywords/adenylate-cyclase","display_name":"adenylate cyclase","score":0.9300000071525574},{"id":"https://openalex.org/keywords/phosphodiesterase","display_name":"phosphodiesterase","score":0.9380000233650208},{"id":"https://openalex.org/keywords/calmodulin","display_name":"calmodulin","score":0.9520000219345093},{"id":"https://openalex.org/keywords/membrane-potential","display_name":"membrane potential","score":0.7289999723434448},{"id":"https://openalex.org/keywords/tetraethylammonium","display_name":"tetraethylammonium","score":0.8650000095367432},{"id":"https://openalex.org/keywords/glucose","display_name":"glucose","score":0.7229999899864197},{"id":"https://openalex.org/keywords/insulin-secretion","display_name":"insulin secretion","score":0.796999990940094},{"id":"https://openalex.org/keywords/min6-cells","display_name":"MIN6 cells","score":0.8579999804496765},{"id":"https://openalex.org/keywords/mathematical-model","display_name":"mathematical model","score":0.6970000267028809}],"concepts":[{"id":"https://openalex.org/C2779178603","wikidata":"https://www.wikidata.org/wiki/Q356257","display_name":"Adenylyl cyclase","level":3,"score":0.607444167137146},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.5551971197128296},{"id":"https://openalex.org/C62826618","wikidata":"https://www.wikidata.org/wiki/Q424304","display_name":"Phosphodiesterase","level":3,"score":0.5293156504631042},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5087507367134094},{"id":"https://openalex.org/C519063684","wikidata":"https://www.wikidata.org/wiki/Q706","display_name":"Calcium","level":2,"score":0.48296183347702026},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.46497583389282227},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.443525105714798},{"id":"https://openalex.org/C29688787","wikidata":"https://www.wikidata.org/wiki/Q409145","display_name":"Calmodulin","level":3,"score":0.4360886812210083},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.43213289976119995},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.430163711309433},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4267573356628418},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.36307328939437866},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.21672573685646057},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.08642280101776123},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000242","descriptor_name":"Cyclic AMP","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000262","descriptor_name":"Adenylyl Cyclases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002118","descriptor_name":"Calcium","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003593","descriptor_name":"Cytoplasm","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005947","descriptor_name":"Glucose","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D007527","descriptor_name":"Isoenzymes","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D010727","descriptor_name":"Phosphoric Diester Hydrolases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019204","descriptor_name":"GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019295","descriptor_name":"Computational Biology","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020013","descriptor_name":"Calcium Signaling","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":true},{"descriptor_ui":"D050417","descriptor_name":"Insulin-Secreting Cells","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D052216","descriptor_name":"Glucagon-Like Peptide 1","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D054795","descriptor_name":"Incretins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1152/ajpcell.00555.2006","doi":"https://doi.org/10.1152/ajpcell.00555.2006","is_oa":false,"landing_page_url":"https://doi.org/10.1152/ajpcell.00555.2006","pdf_url":null,"source":{"id":"https://openalex.org/S62704344","display_name":"American Journal of Physiology-Cell Physiology","issn_l":"0363-6143","issn":["0363-6143","1522-1563"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-d","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320261","host_organization_name":"American Physical Society","host_organization_lineage":["https://openalex.org/P4310320261"],"host_organization_lineage_names":["American Physical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American Journal of Physiology-Cell Physiology","raw_type":"journal-article"},{"id":"pmid:17928534","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17928534","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"American journal of physiology. Cell physiology","raw_type":"Journal Article"},{"id":"mag:2183703649","doi":null,"is_oa":false,"landing_page_url":"https://www.upstate.edu/endo/pdf/researchlab/regulation_camp.pdf","pdf_url":null,"source":null,"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":null}],"best_oa_location":null,"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.46810001134872437,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G2807054497","display_name":null,"funder_award_id":"DK 20595","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"},{"id":"https://openalex.org/G6423859823","display_name":null,"funder_award_id":"DK48495","funder_id":"https://openalex.org/F4320337357","funder_display_name":"National Institute of Diabetes and Digestive and Kidney Diseases"}],"funders":[{"id":"https://openalex.org/F4320337357","display_name":"National Institute of Diabetes and Digestive and Kidney Diseases","ror":"https://ror.org/00adh9b73"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1602447595","https://openalex.org/W1750957464","https://openalex.org/W1970389825","https://openalex.org/W1970866361","https://openalex.org/W1971166172","https://openalex.org/W1971748110","https://openalex.org/W1975636291","https://openalex.org/W1976805952","https://openalex.org/W1979314178","https://openalex.org/W1986308935","https://openalex.org/W2000569688","https://openalex.org/W2002939114","https://openalex.org/W2009770052","https://openalex.org/W2014716037","https://openalex.org/W2014866096","https://openalex.org/W2015256748","https://openalex.org/W2016242736","https://openalex.org/W2023556678","https://openalex.org/W2055054551","https://openalex.org/W2059831521","https://openalex.org/W2066399874","https://openalex.org/W2077118054","https://openalex.org/W2083049815","https://openalex.org/W2088508581","https://openalex.org/W2094632981","https://openalex.org/W2097135764","https://openalex.org/W2105100736","https://openalex.org/W2113303890","https://openalex.org/W2120552228","https://openalex.org/W2121760611","https://openalex.org/W2122675719","https://openalex.org/W2123482247","https://openalex.org/W2125853346","https://openalex.org/W2133404293","https://openalex.org/W2135600268","https://openalex.org/W2136460746","https://openalex.org/W2146927479","https://openalex.org/W2155394194","https://openalex.org/W2157551948","https://openalex.org/W2161546239","https://openalex.org/W2162685663","https://openalex.org/W2167324760"],"related_works":["https://openalex.org/W2113763892","https://openalex.org/W2320065712","https://openalex.org/W2106657141","https://openalex.org/W2023556678","https://openalex.org/W2090606796","https://openalex.org/W3175612749","https://openalex.org/W2041272927","https://openalex.org/W7032978067","https://openalex.org/W1564500789","https://openalex.org/W2264779148"],"abstract_inverted_index":{"In":[0,145],"this":[1],"report":[2],"we":[3],"describe":[4],"a":[5,42,51,171],"mathematical":[6],"model":[7,95,130,166],"for":[8,170,174],"the":[9,71,94,107,193],"regulation":[10],"of":[11,73,182,195],"cAMP":[12,26,45,56,98,116,127,137,151,185,200],"dynamics":[13,201],"in":[14,31,37,64,106,139,162,180,192,202],"pancreatic":[15,32],"beta-cells.":[16,33,204],"Incretin":[17],"hormones":[18],"such":[19],"as":[20],"glucagon-like":[21],"peptide":[22],"1":[23],"(GLP-1)":[24],"increase":[25],"and":[27,47,67,77,89,118,150,159,177,184,197],"augment":[28],"insulin":[29],"secretion":[30],"Imaging":[34],"experiments":[35],"performed":[36],"MIN6":[38,203],"insulinoma":[39],"cells":[40],"expressing":[41],"genetically":[43],"encoded":[44],"biosensor":[46],"loaded":[48],"with":[49,80,93,141],"fura-2,":[50],"calcium":[52,75],"indicator,":[53],"showed":[54],"that":[55,97,132],"oscillations":[57,99,105,111,121,138,152],"are":[58,100],"differentially":[59],"regulated":[60],"by":[61],"periodic":[62],"changes":[63,161],"membrane":[65,163],"potential":[66],"GLP-1.":[68],"We":[69],"modeled":[70],"interplay":[72],"intracellular":[74],"(Ca(2+))":[76],"its":[78],"interaction":[79],"calmodulin,":[81],"G":[82],"protein-coupled":[83],"receptor":[84,134],"activation,":[85],"adenylyl":[86],"cyclases":[87],"(AC),":[88],"phosphodiesterases":[90],"(PDE).":[91],"Simulations":[92],"demonstrate":[96],"coupled":[101],"to":[102],"cytoplasmic":[103,142],"Ca(2+)":[104,110,120,143,149,183],"beta-cell.":[108],"Slow":[109],"(<1":[112],"min(-1))":[113,123],"produce":[114],"low-frequency":[115],"oscillations,":[117],"faster":[119],"(>3-4":[122],"entrain":[124],"high-frequency,":[125],"low-amplitude":[126],"oscillations.":[128,144],"The":[129,165],"predicts":[131],"GLP-1":[133,198],"agonists":[135],"induce":[136],"phase":[140],"contrast,":[146],"observed":[147],"antiphasic":[148],"can":[153],"be":[154],"simulated":[155],"following":[156],"combined":[157],"glucose":[158],"tetraethylammonium-induced":[160],"potential.":[164],"provides":[167],"additional":[168],"evidence":[169],"pivotal":[172],"role":[173],"Ca(2+)-dependent":[175],"AC":[176],"PDE":[178],"activation":[179],"coupling":[181],"signals.":[186],"Our":[187],"results":[188],"reveal":[189],"important":[190],"differences":[191],"effects":[194],"glucose/TEA":[196],"on":[199]},"counts_by_year":[{"year":2024,"cited_by_count":2},{"year":2022,"cited_by_count":1},{"year":2021,"cited_by_count":1},{"year":2020,"cited_by_count":1},{"year":2019,"cited_by_count":1},{"year":2017,"cited_by_count":3},{"year":2016,"cited_by_count":2},{"year":2015,"cited_by_count":6},{"year":2014,"cited_by_count":10},{"year":2013,"cited_by_count":2},{"year":2012,"cited_by_count":7}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}
