{"id":"https://openalex.org/W2099627744","doi":"https://doi.org/10.1210/me.2007-0210","title":"Prostaglandin E2 Increases Transforming Growth Factor-\u03b2 Type III Receptor Expression through CCAAT Enhancer-Binding Protein \u03b4 in Osteoblasts","display_name":"Prostaglandin E2 Increases Transforming Growth Factor-\u03b2 Type III Receptor Expression through CCAAT Enhancer-Binding Protein \u03b4 in Osteoblasts","publication_year":2007,"publication_date":"2007-07-18","ids":{"openalex":"https://openalex.org/W2099627744","doi":"https://doi.org/10.1210/me.2007-0210","mag":"2099627744","pmid":"https://pubmed.ncbi.nlm.nih.gov/17636036"},"language":"en","primary_location":{"id":"doi:10.1210/me.2007-0210","doi":"https://doi.org/10.1210/me.2007-0210","is_oa":false,"landing_page_url":"https://doi.org/10.1210/me.2007-0210","pdf_url":null,"source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5108509520","display_name":"Thomas L. McCarthy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas L. McCarthy","raw_affiliation_strings":["Department of Surgery and Section of Plastic Surgery, Yale University School of Medicine, New Haven, Connecticut 06520","Department of Surgery and Section of Plastic Surgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Section of Plastic Surgery, Yale University School of Medicine, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]},{"raw_affiliation_string":"Department of Surgery and Section of Plastic Surgery, Yale University School of Medicine, New Haven, Connecticut 06520, USA","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5002232391","display_name":"Tony H. Pham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tony H. Pham","raw_affiliation_strings":["Department of Surgery and Section of Plastic Surgery, Yale University School of Medicine, New Haven, Connecticut 06520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Section of Plastic Surgery, Yale University School of Medicine, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051283692","display_name":"Bianca I. Knoll","orcid":"https://orcid.org/0000-0002-2372-8219","observed_orcids":["https://orcid.org/0000-0002-2372-8219"]},"institutions":[{"id":"https://openalex.org/I32971472","display_name":"Yale University","ror":"https://ror.org/03v76x132","country_code":"US","type":"education","lineage":["https://openalex.org/I32971472"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bianca I. Knoll","raw_affiliation_strings":["Department of Surgery and Section of Plastic Surgery, Yale University School of Medicine, New Haven, Connecticut 06520"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery and Section of Plastic Surgery, Yale University School of Medicine, New Haven, Connecticut 06520","institution_ids":["https://openalex.org/I32971472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I32971472"],"apc_list":null,"apc_paid":null,"fwci":0.7642,"has_fulltext":false,"cited_by_count":17,"citation_normalized_percentile":{"value":0.66639892,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":96},"biblio":{"volume":"21","issue":"11","first_page":"2713","last_page":"2724"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.6406000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11219","display_name":"Bone Metabolism and Diseases","score":0.6406000256538391,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11501","display_name":"TGF-\u03b2 signaling in diseases","score":0.2401999980211258,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10105","display_name":"Osteoarthritis Treatment and Mechanisms","score":0.02879999950528145,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/prostaglandin-e2","display_name":"prostaglandin E2","score":1.0},{"id":"https://openalex.org/keywords/tgf-beta-type-iii-receptor","display_name":"TGF-beta type III receptor","score":0.9399999976158142},{"id":"https://openalex.org/keywords/c-ebpdelta","display_name":"C/EBP\u03b4","score":0.8410000205039978},{"id":"https://openalex.org/keywords/osteoblasts","display_name":"osteoblasts","score":0.9909999966621399},{"id":"https://openalex.org/keywords/tgf-beta-signaling","display_name":"TGF-beta signaling","score":0.8040000200271606},{"id":"https://openalex.org/keywords/protein-kinase-a","display_name":"protein kinase A","score":0.8379999995231628},{"id":"https://openalex.org/keywords/gene-promoter-activity","display_name":"gene promoter activity","score":0.6840000152587891},{"id":"https://openalex.org/keywords/transcriptional-regulation","display_name":"transcriptional regulation","score":0.7950000166893005},{"id":"https://openalex.org/keywords/bone-regeneration","display_name":"bone regeneration","score":0.9010000228881836},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.8600000143051147},{"id":"https://openalex.org/keywords/trauma-physical-injury","display_name":"trauma (physical injury)","score":0.5090000033378601}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8322104215621948},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.6432279348373413},{"id":"https://openalex.org/C97029542","wikidata":"https://www.wikidata.org/wiki/Q281417","display_name":"Protein kinase A","level":3,"score":0.5695604085922241},{"id":"https://openalex.org/C179716448","wikidata":"https://www.wikidata.org/wiki/Q2508056","display_name":"CAAT box","level":5,"score":0.5600247383117676},{"id":"https://openalex.org/C149240914","wikidata":"https://www.wikidata.org/wiki/Q907967","display_name":"Ccaat-enhancer-binding proteins","level":5,"score":0.5304450392723083},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.4668389558792114},{"id":"https://openalex.org/C195794163","wikidata":"https://www.wikidata.org/wiki/Q420877","display_name":"Protein kinase C","level":3,"score":0.45696064829826355},{"id":"https://openalex.org/C2778229498","wikidata":"https://www.wikidata.org/wiki/Q24785672","display_name":"Transforming growth factor beta","level":3,"score":0.45341500639915466},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.416908860206604},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.4133342504501343},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.40204840898513794},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.35117876529693604},{"id":"https://openalex.org/C101762097","wikidata":"https://www.wikidata.org/wiki/Q224093","display_name":"Promoter","level":4,"score":0.32105302810668945},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.22539696097373962},{"id":"https://openalex.org/C94966510","wikidata":"https://www.wikidata.org/wiki/Q2252764","display_name":"DNA-binding protein","level":4,"score":0.20226231217384338},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.09772038459777832}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005799","descriptor_name":"Genes, Dominant","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007249","descriptor_name":"Inflammation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010006","descriptor_name":"Osteoblasts","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011401","descriptor_name":"Promoter Regions, Genetic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011493","descriptor_name":"Protein Kinase C","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011509","descriptor_name":"Proteoglycans","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015232","descriptor_name":"Dinoprostone","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017207","descriptor_name":"Rats, Sprague-Dawley","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017868","descriptor_name":"Cyclic AMP-Dependent Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018125","descriptor_name":"Receptors, Transforming Growth Factor beta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051381","descriptor_name":"Rats","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051743","descriptor_name":"CCAAT-Enhancer-Binding Protein-delta","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051743","descriptor_name":"CCAAT-Enhancer-Binding Protein-delta","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.1210/me.2007-0210","doi":"https://doi.org/10.1210/me.2007-0210","is_oa":false,"landing_page_url":"https://doi.org/10.1210/me.2007-0210","pdf_url":null,"source":{"id":"https://openalex.org/S57449756","display_name":"Molecular Endocrinology","issn_l":"0888-8809","issn":["0888-8809","1944-9917"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","poland-100"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Endocrinology","raw_type":"journal-article"},{"id":"pmid:17636036","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/17636036","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular endocrinology (Baltimore, Md.)","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1104295822","display_name":null,"funder_award_id":"AR-39201","funder_id":"https://openalex.org/F4320337362","funder_display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases"}],"funders":[{"id":"https://openalex.org/F4320337362","display_name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","ror":"https://ror.org/006zn3t30"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":76,"referenced_works":["https://openalex.org/W40584579","https://openalex.org/W1505418565","https://openalex.org/W1511960757","https://openalex.org/W1528585209","https://openalex.org/W1542464099","https://openalex.org/W1550813715","https://openalex.org/W1578080358","https://openalex.org/W1647782814","https://openalex.org/W1726024662","https://openalex.org/W1849805128","https://openalex.org/W1965084403","https://openalex.org/W1969619516","https://openalex.org/W1971510126","https://openalex.org/W1976229592","https://openalex.org/W1978146894","https://openalex.org/W1981406615","https://openalex.org/W1981828273","https://openalex.org/W1982496667","https://openalex.org/W1983655894","https://openalex.org/W1997135900","https://openalex.org/W1997337512","https://openalex.org/W1998926980","https://openalex.org/W1999480813","https://openalex.org/W2002773456","https://openalex.org/W2008888011","https://openalex.org/W2010488399","https://openalex.org/W2010707218","https://openalex.org/W2014065455","https://openalex.org/W2017292651","https://openalex.org/W2019937507","https://openalex.org/W2024184251","https://openalex.org/W2025480920","https://openalex.org/W2025718047","https://openalex.org/W2027577008","https://openalex.org/W2029515001","https://openalex.org/W2032672821","https://openalex.org/W2039125372","https://openalex.org/W2046390517","https://openalex.org/W2049476520","https://openalex.org/W2049530394","https://openalex.org/W2050183943","https://openalex.org/W2058226743","https://openalex.org/W2059211912","https://openalex.org/W2062790057","https://openalex.org/W2064418281","https://openalex.org/W2083043675","https://openalex.org/W2087268612","https://openalex.org/W2087523011","https://openalex.org/W2089938880","https://openalex.org/W2089938893","https://openalex.org/W2091724639","https://openalex.org/W2094654701","https://openalex.org/W2103093283","https://openalex.org/W2103262900","https://openalex.org/W2107556307","https://openalex.org/W2110901553","https://openalex.org/W2111949892","https://openalex.org/W2115269733","https://openalex.org/W2115393190","https://openalex.org/W2133004102","https://openalex.org/W2134372312","https://openalex.org/W2134678935","https://openalex.org/W2136856538","https://openalex.org/W2139440574","https://openalex.org/W2159774995","https://openalex.org/W2160048807","https://openalex.org/W2161560274","https://openalex.org/W2165054460","https://openalex.org/W2339597308","https://openalex.org/W2351016679","https://openalex.org/W4238258283","https://openalex.org/W4255366786","https://openalex.org/W4301110686","https://openalex.org/W4301444516","https://openalex.org/W4322701621","https://openalex.org/W7214228041"],"related_works":["https://openalex.org/W2077084676","https://openalex.org/W2015022333","https://openalex.org/W2059668536","https://openalex.org/W2062497599","https://openalex.org/W2035195746","https://openalex.org/W2026862825","https://openalex.org/W1998953382","https://openalex.org/W2162606702","https://openalex.org/W4236378788","https://openalex.org/W1975272915"],"abstract_inverted_index":{"Variations":[0],"in":[1,22,42,66,231],"individual":[2],"TGF-beta":[3,8],"receptors":[4],"(TbetaRs)":[5],"may":[6],"modify":[7],"activity":[9,83,144,185],"and":[10,75,78,113,130,183,191,230],"significantly":[11],"alter":[12],"its":[13],"effects":[14],"on":[15,36,63,141,201],"connective":[16],"tissue":[17],"growth":[18,46],"or":[19,41,60,220],"repair.":[20,246],"Differences":[21],"the":[23,92,120,178,240],"amount":[24],"of":[25,91,139,177,205,214,237,244],"TbetaR":[26,64],"type":[27],"III":[28],"(TbetaRIII)":[29],"relative":[30],"to":[31,44,172,188,192],"signal":[32],"transducing":[33],"TbetaRI":[34],"occur":[35,217],"bone":[37,245],"cells":[38],"during":[39,57,239],"differentiation":[40],"response":[43],"other":[45],"regulators.":[47],"Here":[48],"we":[49],"investigated":[50],"prostaglandin":[51],"(PG)":[52],"E2,":[53],"a":[54,85,148,173],"potent":[55],"effector":[56],"trauma,":[58],"inflammation,":[59],"mechanical":[61],"load,":[62],"expression":[65,77,118,229],"primary":[67],"osteoblast-enriched":[68],"cultures.":[69],"PGE2":[70,96,140,161,215],"rapidly":[71],"increased":[72,163],"TbetaRIII":[73,80,121,142,180,202,228],"mRNA":[74],"protein":[76,107,125,158,168],"enhanced":[79,116],"gene":[81,117,122],"promoter":[82,143,181,184],"through":[84,100,119,223],"discrete":[86],"region":[87],"within":[88],"0.4":[89],"kb":[90],"transcription":[93],"start":[94],"site.":[95],"alters":[97],"osteoblast":[98],"function":[99],"multiple":[101],"signal-inducing":[102],"pathways.":[103],"In":[104,196,210],"this":[105,232],"regard,":[106],"kinase":[108,126,159],"A":[109],"(PKA)":[110],"activators,":[111,128],"PGE1":[112],"forskolin,":[114],"also":[115],"promoter,":[123],"whereas":[124],"C":[127],"PGF2alpha":[129],"phorbol":[131],"myristate":[132],"acetate,":[133],"did":[134],"not.":[135],"The":[136],"stimulatory":[137],"effect":[138,200],"was":[145,186],"suppressed":[146],"by":[147,155],"dominant":[149,156],"negative":[150,157],"PKA-regulatory":[151],"subunit,":[152],"but":[153],"not":[154],"C.":[160],"specifically":[162],"nuclear":[164],"factor":[165],"CCAAT":[166],"enhancer-binding":[167],"delta":[169],"(C/EBPdelta)":[170],"binding":[171],"half-binding":[174],"site":[175],"upstream":[176],"basal":[179],"region,":[182],"sensitive":[187],"C/EBPdelta":[189,194],"overexpression":[190],"dominant-negative":[193],"competition.":[195],"parallel":[197],"with":[198,218],"their":[199],"expression,":[203],"activators":[204],"PKA":[206],"decreased":[207],"TGF-beta-induced":[208],"activity.":[209],"summary,":[211],"high":[212],"levels":[213],"that":[216],"inflammation":[219],"trauma":[221],"may,":[222],"PKA-activated":[224],"C/EBPdelta,":[225],"preferentially":[226],"increase":[227],"way":[233],"delay":[234],"TGF-beta-dependent":[235],"activation":[236],"osteoblasts":[238],"early":[241],"stabilization":[242],"phase":[243]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":1},{"year":2017,"cited_by_count":2},{"year":2015,"cited_by_count":1},{"year":2014,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":1}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
