{"id":"https://openalex.org/W2099576352","doi":"https://doi.org/10.1002/path.1711740105","title":"Human non\u2010small cell lung cancer: P53 protein accumulation is an early event and persists during metastatic progression","display_name":"Human non\u2010small cell lung cancer: P53 protein accumulation is an early event and persists during metastatic progression","publication_year":1994,"publication_date":"1994-09-01","ids":{"openalex":"https://openalex.org/W2099576352","doi":"https://doi.org/10.1002/path.1711740105","mag":"2099576352","pmid":"https://pubmed.ncbi.nlm.nih.gov/7965400"},"language":"en","primary_location":{"id":"doi:10.1002/path.1711740105","doi":"https://doi.org/10.1002/path.1711740105","is_oa":false,"landing_page_url":"https://doi.org/10.1002/path.1711740105","pdf_url":null,"source":{"id":"https://openalex.org/S4394736614","display_name":"The Journal of Pathology","issn_l":"0022-3417","issn":["0022-3417","1096-9896"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pathology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5017474339","display_name":"Gabriella Fontanini","orcid":"https://orcid.org/0000-0003-1957-2052","observed_orcids":["https://orcid.org/0000-0003-1957-2052"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Gabriella Fontanini","raw_affiliation_strings":["Institute of Pathology, University of Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5105413697","display_name":"Silvana Vignati","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Silvana Vignati","raw_affiliation_strings":["Institute of Pathology, University of Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5080085202","display_name":"Daniela Bigini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Daniela Bigini","raw_affiliation_strings":["Institute of Pathology, University of Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5060902293","display_name":"Fulvio Basolo","orcid":"https://orcid.org/0000-0003-1657-5020","observed_orcids":["https://orcid.org/0000-0003-1657-5020"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Fulvio Basolo","raw_affiliation_strings":["Institute of Pathology, University of Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113766773","display_name":"Raffaele Pingitore","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Raffaele Pingitore","raw_affiliation_strings":["Institute of Pathology, University of Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019570497","display_name":"Generoso Bevilacqua","orcid":"https://orcid.org/0000-0001-8857-2609","observed_orcids":["https://orcid.org/0000-0001-8857-2609","https://orcid.org/0000-0002-7298-6185"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Generoso Bevilacqua","raw_affiliation_strings":["Institute of Pathology, University of Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute of Pathology, University of Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107521322","display_name":"Giorgio R. Merlo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I860889466","display_name":"Friedrich Miescher Institute","ror":"https://ror.org/01bmjkv45","country_code":"CH","type":"facility","lineage":["https://openalex.org/I860889466"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Giorgio R. Merlo","raw_affiliation_strings":["Friedrich Miescher Institute, Basel, Switzerland"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Friedrich Miescher Institute, Basel, Switzerland","institution_ids":["https://openalex.org/I860889466"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101072499","display_name":"Alessandro Ribechini","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alessandro Ribecchini","raw_affiliation_strings":["Service of Thoracic Surgery, University of Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Thoracic Surgery, University of Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5076801056","display_name":"Carlo Alberto Angeletti","orcid":"https://orcid.org/0000-0002-7420-3201","observed_orcids":["https://orcid.org/0000-0002-7420-3201"]},"institutions":[{"id":"https://openalex.org/I108290504","display_name":"University of Pisa","ror":"https://ror.org/03ad39j10","country_code":"IT","type":"education","lineage":["https://openalex.org/I108290504"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carlo Alberto Angeletti","raw_affiliation_strings":["Service of Thoracic Surgery, University of Pisa, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Service of Thoracic Surgery, University of Pisa, Italy","institution_ids":["https://openalex.org/I108290504"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017474339"],"corresponding_institution_ids":["https://openalex.org/I108290504"],"apc_list":{"value":5450,"currency":"USD","value_usd":5450},"apc_paid":null,"fwci":2.7992,"has_fulltext":false,"cited_by_count":53,"citation_normalized_percentile":{"value":0.91911207,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":88,"max":95},"biblio":{"volume":"174","issue":"1","first_page":"23","last_page":"31"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10583","display_name":"Cancer-related Molecular Pathways","score":0.9564999938011169,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.03669999912381172,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/p53-accumulation","display_name":"p53 accumulation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.9660000205039978},{"id":"https://openalex.org/keywords/tp53-mutation","display_name":"TP53 mutation","score":0.765999972820282},{"id":"https://openalex.org/keywords/tumor-suppressor-genes","display_name":"tumor suppressor","score":0.7630000114440918},{"id":"https://openalex.org/keywords/metastatic-progression","display_name":"metastatic progression","score":0.6899999976158142},{"id":"https://openalex.org/keywords/proliferating-cell-nuclear-antigen","display_name":"proliferating cell nuclear antigen","score":0.9070000052452087},{"id":"https://openalex.org/keywords/pcna","display_name":"PCNA","score":0.5680000185966492},{"id":"https://openalex.org/keywords/carcinoma-in-situ","display_name":"carcinoma in situ","score":0.6869999766349792},{"id":"https://openalex.org/keywords/squamous-metaplasia","display_name":"squamous metaplasia","score":0.8130000233650208},{"id":"https://openalex.org/keywords/bronchial-dysplasia","display_name":"bronchial dysplasia","score":0.8059999942779541},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.6039999723434448},{"id":"https://openalex.org/keywords/preinvasive-lesions","display_name":"preinvasive lesions","score":0.578000009059906}],"concepts":[{"id":"https://openalex.org/C34688535","wikidata":"https://www.wikidata.org/wiki/Q418732","display_name":"Proliferating cell nuclear antigen","level":3,"score":0.8505600690841675},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.6713226437568665},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6575515270233154},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.5492215752601624},{"id":"https://openalex.org/C2777661416","wikidata":"https://www.wikidata.org/wiki/Q1035645","display_name":"Carcinoma in situ","level":3,"score":0.5052137970924377},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.479576051235199},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.4794794023036957},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.46467477083206177},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4537206292152405},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.4415481388568878},{"id":"https://openalex.org/C2778264664","wikidata":"https://www.wikidata.org/wiki/Q422445","display_name":"Tumor suppressor gene","level":4,"score":0.4233663082122803},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.20086181163787842},{"id":"https://openalex.org/C555283112","wikidata":"https://www.wikidata.org/wiki/Q1637543","display_name":"Carcinogenesis","level":3,"score":0.19747677445411682},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000951","descriptor_name":"Antigens, Neoplasm","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false},{"descriptor_ui":"D001980","descriptor_name":"Bronchi","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002278","descriptor_name":"Carcinoma in Situ","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000556","qualifier_name":"secondary","is_major_topic":false},{"descriptor_ui":"D002289","descriptor_name":"Carcinoma, Non-Small-Cell Lung","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006965","descriptor_name":"Hyperplasia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D007124","descriptor_name":"Immunoenzyme Techniques","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008175","descriptor_name":"Lung Neoplasms","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D008679","descriptor_name":"Metaplasia","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D009361","descriptor_name":"Neoplasm Invasiveness","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009363","descriptor_name":"Neoplasm Proteins","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D011230","descriptor_name":"Precancerous Conditions","qualifier_ui":"Q000737","qualifier_name":"chemistry","is_major_topic":true},{"descriptor_ui":"D016159","descriptor_name":"Tumor Suppressor Protein p53","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D018450","descriptor_name":"Disease Progression","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018809","descriptor_name":"Proliferating Cell Nuclear Antigen","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/path.1711740105","doi":"https://doi.org/10.1002/path.1711740105","is_oa":false,"landing_page_url":"https://doi.org/10.1002/path.1711740105","pdf_url":null,"source":{"id":"https://openalex.org/S4394736614","display_name":"The Journal of Pathology","issn_l":"0022-3417","issn":["0022-3417","1096-9896"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of Pathology","raw_type":"journal-article"},{"id":"pmid:7965400","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/7965400","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The Journal of pathology","raw_type":"Journal Article"},{"id":"pmh:oai:arpi.unipi.it:11568/174505","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/11568/174505","pdf_url":null,"source":{"id":"https://openalex.org/S4377196265","display_name":"CINECA IRIS Institutial research information system (University of Pisa)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I108290504","host_organization_name":"University of Pisa","host_organization_lineage":["https://openalex.org/I108290504"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"},{"id":"pmh:oai:iris.unito.it:2318/87311","doi":null,"is_oa":false,"landing_page_url":"http://hdl.handle.net/2318/87311","pdf_url":null,"source":{"id":"https://openalex.org/S4306400637","display_name":"Institutional Research Information System University of Turin (University of Turin)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I55143463","host_organization_name":"University of Turin","host_organization_lineage":["https://openalex.org/I55143463"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":50,"referenced_works":["https://openalex.org/W24457209","https://openalex.org/W36785195","https://openalex.org/W89974406","https://openalex.org/W602470663","https://openalex.org/W1499849678","https://openalex.org/W1546247763","https://openalex.org/W1674633125","https://openalex.org/W1844300134","https://openalex.org/W1875257387","https://openalex.org/W1922148398","https://openalex.org/W1927337580","https://openalex.org/W1947531295","https://openalex.org/W1959371471","https://openalex.org/W1963556079","https://openalex.org/W1967304777","https://openalex.org/W1982619204","https://openalex.org/W1982805891","https://openalex.org/W1984277231","https://openalex.org/W1986685145","https://openalex.org/W2001962665","https://openalex.org/W2004074465","https://openalex.org/W2008301561","https://openalex.org/W2012053348","https://openalex.org/W2015519364","https://openalex.org/W2025348241","https://openalex.org/W2042316019","https://openalex.org/W2060937867","https://openalex.org/W2078833455","https://openalex.org/W2085172497","https://openalex.org/W2088098884","https://openalex.org/W2090157013","https://openalex.org/W2091151265","https://openalex.org/W2105327099","https://openalex.org/W2108402398","https://openalex.org/W2130153603","https://openalex.org/W2146642286","https://openalex.org/W2163501463","https://openalex.org/W2165314624","https://openalex.org/W2170166931","https://openalex.org/W2170494099","https://openalex.org/W2313655951","https://openalex.org/W2412452782","https://openalex.org/W2413828262","https://openalex.org/W2414523248","https://openalex.org/W2460549767","https://openalex.org/W2615716036","https://openalex.org/W2992642388","https://openalex.org/W4231423721","https://openalex.org/W4322384837","https://openalex.org/W6603701329"],"related_works":["https://openalex.org/W2414523248","https://openalex.org/W1535790825","https://openalex.org/W2376373111","https://openalex.org/W2363644609","https://openalex.org/W2087230077","https://openalex.org/W1963997965","https://openalex.org/W4232745546","https://openalex.org/W2058597600","https://openalex.org/W1541722509","https://openalex.org/W2165314624"],"abstract_inverted_index":{"Mutations":[0],"in":[1,17,77,83,98,120,146,157,173,196],"the":[2,11,28,45,115,121,124,128,158,166],"p53":[3,12,61,73,107,118,153,200],"tumour":[4,105],"suppressor":[5],"gene,":[6],"with":[7],"consequent":[8],"accumulation":[9],"of":[10,30,51,66,89,96,117,127,132,135,162,189],"protein,":[13],"are":[14],"frequently":[15],"observed":[16,195,206],"non-small":[18],"cell":[19,68],"lung":[20],"cancer":[21,37],"(NSCLC).":[22],"Little":[23],"is":[24,168],"known,":[25],"however,":[26],"about":[27],"timing":[29],"their":[31,34],"appearance":[32],"or":[33],"maintenance":[35],"through":[36],"progression":[38,171],"and":[39,48,57,63,79,93,123,138,164,178,212],"metastatic":[40,58,179],"spread.":[41,180],"We":[42],"have":[43],"examined":[44],"normal":[46,78],"epithelium":[47],"a":[49,111],"panel":[50],"bronchial":[52],"lesions,":[53,59],"including":[54],"dysplastic,":[55],"neoplastic,":[56],"for":[60,64,207],"immunoreactivity":[62,74,193],"expression":[65,119,182,209],"proliferating":[67],"nuclear":[69],"antigen":[70],"(PCNA).":[71],"No":[72],"was":[75,110,194,205],"found":[76],"hyperplastic":[80],"epithelium,":[81],"nor":[82],"squamous":[84],"metaplastic":[85],"lesions.":[86,214],"Twenty":[87],"out":[88,95,131],"30":[90],"invasive":[91,104,125,176,213],"tumours":[92,137,197],"13":[94],"17":[97],"situ":[99,174],"carcinomas":[100],"adjacent":[101],"to":[102,175,186],"an":[103],"showed":[106],"immunoreactivity.":[108],"There":[109],"strict":[112],"correlation":[113],"between":[114,210],"level":[116],"non-invasive":[122],"components":[126],"tumours.":[129],"Five":[130],"eight":[133],"pairs":[134],"primary":[136],"matching":[139],"metastases":[140],"expressed":[141],"p53,":[142],"at":[143],"identical":[144],"levels":[145],"both":[147],"compartments.":[148],"These":[149],"data":[150],"indicate":[151],"that":[152,165],"overexpression":[154],"can":[155],"occur":[156],"earliest":[159],"recognized":[160],"phase":[161],"NSCLC":[163],"alteration":[167],"maintained":[169],"during":[170],"from":[172,184],"carcinoma":[177],"PCNA":[181,192,208],"increased":[183],"early":[185],"advanced":[187],"phases":[188],"NSCLC.":[190],"High":[191],"expressing":[198],"high":[199],"levels.":[201],"A":[202],"significant":[203],"association":[204],"preinvasive":[211]},"counts_by_year":[{"year":2019,"cited_by_count":1},{"year":2016,"cited_by_count":1},{"year":2013,"cited_by_count":1},{"year":2012,"cited_by_count":2}],"updated_date":"2026-11-04T10:54:05.112534","created_date":"2016-06-24T00:00:00"}
