{"id":"https://openalex.org/W2099565829","doi":"https://doi.org/10.3892/ijo.2012.1728","title":"HGF regulates VEGF expression via the c-Met receptor downstream pathways, PI3K/Akt, MAPK and STAT3, in CT26 murine cells","display_name":"HGF regulates VEGF expression via the c-Met receptor downstream pathways, PI3K/Akt, MAPK and STAT3, in CT26 murine cells","publication_year":2012,"publication_date":"2012-12-06","ids":{"openalex":"https://openalex.org/W2099565829","doi":"https://doi.org/10.3892/ijo.2012.1728","mag":"2099565829","pmid":"https://pubmed.ncbi.nlm.nih.gov/23233163"},"language":"en","primary_location":{"id":"doi:10.3892/ijo.2012.1728","doi":"https://doi.org/10.3892/ijo.2012.1728","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2012.1728","pdf_url":"http://www.spandidos-publications.com/10.3892/ijo.2012.1728/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://www.spandidos-publications.com/10.3892/ijo.2012.1728/download","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":null,"display_name":"ATSUSHI MATSUMURA","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"ATSUSHI MATSUMURA","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural                     University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural                     University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010402266","display_name":"Takeshi Kubota","orcid":"https://orcid.org/0000-0002-2246-3028","observed_orcids":["https://orcid.org/0000-0002-2246-3028"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TAKESHI KUBOTA","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023539578","display_name":"\u5b8f\u660e \u5927\u967d","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HIROAKI TAIYOH","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032180784","display_name":"Hitoshi Fujiwara","orcid":"https://orcid.org/0000-0002-6507-4313","observed_orcids":["https://orcid.org/0000-0002-6507-4313"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HITOSHI FUJIWARA","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037713618","display_name":"Kazuma K. Okamoto","orcid":"https://orcid.org/0000-0002-8270-4217","observed_orcids":["https://orcid.org/0000-0002-8270-4217"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KAZUMA OKAMOTO","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026517739","display_name":"Daisuke Ichikawa","orcid":"https://orcid.org/0000-0003-0093-2206","observed_orcids":["https://orcid.org/0000-0003-0093-2206"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"DAISUKE ICHIKAWA","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017095541","display_name":"Atsushi Shiozaki","orcid":"https://orcid.org/0000-0003-3739-160X","observed_orcids":["https://orcid.org/0000-0003-3739-160X"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"ATSUSHI SHIOZAKI","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016157097","display_name":"Shuhei Komatsu","orcid":"https://orcid.org/0000-0001-6074-7614","observed_orcids":["https://orcid.org/0000-0001-6074-7614"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"SHUHEI KOMATSU","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111713442","display_name":"Masayoshi Nakanishi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"MASAYOSHI NAKANISHI","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029668141","display_name":"Yoshiaki Kuriu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YOSHIAKI KURIU","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074854761","display_name":"Yasutoshi Murayama","orcid":"https://orcid.org/0000-0001-5875-1403","observed_orcids":["https://orcid.org/0000-0001-5875-1403"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YASUTOSHI MURAYAMA","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5032001774","display_name":"Hisashi Ikoma","orcid":"https://orcid.org/0000-0002-2647-6854","observed_orcids":["https://orcid.org/0000-0002-2647-6854"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"HISASHI IKOMA","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088052237","display_name":"Toshiya Ochiai","orcid":"https://orcid.org/0000-0002-6564-4048","observed_orcids":["https://orcid.org/0000-0002-6564-4048"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TOSHIYA OCHIAI","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110172506","display_name":"Yukihito Kokuba","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"YUKIHITO KOKUBA","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan","institution_ids":["https://openalex.org/I40677808"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048365478","display_name":"Takahiro Nakamura","orcid":"https://orcid.org/0000-0002-5387-6538","observed_orcids":["https://orcid.org/0000-0002-5387-6538"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4405286179","display_name":"Cancer Research Institute of Kanazawa University","ror":"https://ror.org/01bve4846","country_code":"JP","type":"facility","lineage":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"TAKAHIRO NAKAMURA","raw_affiliation_strings":["Division of Tumor Dynamics and Regulation, Kanazawa University Cancer Research Institute, Kakuma-machi, Ishikawa 920-1192, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Tumor Dynamics and Regulation, Kanazawa University Cancer Research Institute, Kakuma-machi, Ishikawa 920-1192, Japan","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016499405","display_name":"Kunio Matsumoto","orcid":"https://orcid.org/0000-0002-6532-4482","observed_orcids":["https://orcid.org/0000-0002-6532-4482"]},"institutions":[{"id":"https://openalex.org/I10091056","display_name":"Kanazawa University","ror":"https://ror.org/02hwp6a56","country_code":"JP","type":"education","lineage":["https://openalex.org/I10091056"]},{"id":"https://openalex.org/I4405286179","display_name":"Cancer Research Institute of Kanazawa University","ror":"https://ror.org/01bve4846","country_code":"JP","type":"facility","lineage":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"KUNIO MATSUMOTO","raw_affiliation_strings":["Division of Tumor Dynamics and Regulation, Kanazawa University Cancer Research Institute, Kakuma-machi, Ishikawa 920-1192, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Tumor Dynamics and Regulation, Kanazawa University Cancer Research Institute, Kakuma-machi, Ishikawa 920-1192, Japan","institution_ids":["https://openalex.org/I10091056","https://openalex.org/I4405286179"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5041985650","display_name":"Eigo Otsuji","orcid":"https://orcid.org/0000-0002-3260-8155","observed_orcids":["https://orcid.org/0000-0002-3260-8155"]},"institutions":[{"id":"https://openalex.org/I40677808","display_name":"Kyoto Prefectural University of Medicine","ror":"https://ror.org/028vxwa22","country_code":"JP","type":"education","lineage":["https://openalex.org/I40677808","https://openalex.org/I4405285717"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"EIGO OTSUJI","raw_affiliation_strings":["Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Division of Digestive Surgery, Department of Surgery, Kyoto Prefectural University of Medicine, Kamigyo-ku, Kyoto\u00a0602-8566, Japan","institution_ids":["https://openalex.org/I40677808"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":2.5599,"has_fulltext":true,"cited_by_count":94,"citation_normalized_percentile":{"value":0.9075197,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"42","issue":"2","first_page":"535","last_page":"542"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10422","display_name":"Angiogenesis and VEGF in Cancer","score":0.9473000168800354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.01549999974668026,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.01360000018030405,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hepatocyte-growth-factor","display_name":"hepatocyte growth factor","score":0.996999979019165},{"id":"https://openalex.org/keywords/c-met","display_name":"c-Met","score":0.9509999752044678},{"id":"https://openalex.org/keywords/vegf-expression","display_name":"VEGF expression","score":0.8960000276565552},{"id":"https://openalex.org/keywords/hypoxia-inducible-factor-1alpha","display_name":"hypoxia-inducible factor-1\u03b1","score":0.9020000100135803},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8270000219345093},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.9990000128746033},{"id":"https://openalex.org/keywords/stat3","display_name":"STAT3","score":0.7099999785423279},{"id":"https://openalex.org/keywords/ct26-cells","display_name":"CT26 cells","score":0.7760000228881836},{"id":"https://openalex.org/keywords/nk4","display_name":"NK4","score":0.8690000176429749},{"id":"https://openalex.org/keywords/anti-angiogenic-therapy","display_name":"anti-angiogenic therapy","score":0.9229999780654907},{"id":"https://openalex.org/keywords/tumor-angiogenesis","display_name":"tumor angiogenesis","score":0.734000027179718},{"id":"https://openalex.org/keywords/kinase-inhibitors","display_name":"kinase inhibitors","score":0.6200000047683716}],"concepts":[{"id":"https://openalex.org/C75217442","wikidata":"https://www.wikidata.org/wiki/Q423650","display_name":"Protein kinase B","level":3,"score":0.7321819067001343},{"id":"https://openalex.org/C86554907","wikidata":"https://www.wikidata.org/wiki/Q285613","display_name":"PI3K/AKT/mTOR pathway","level":3,"score":0.6344528794288635},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.6217636466026306},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.5992430448532104},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.5923250913619995},{"id":"https://openalex.org/C2776207758","wikidata":"https://www.wikidata.org/wiki/Q5303302","display_name":"Downstream (manufacturing)","level":2,"score":0.5717086791992188},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.5619600415229797},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.5404347777366638},{"id":"https://openalex.org/C2778923194","wikidata":"https://www.wikidata.org/wiki/Q14912019","display_name":"STAT3","level":3,"score":0.5359151363372803},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4977550804615021},{"id":"https://openalex.org/C67082663","wikidata":"https://www.wikidata.org/wiki/Q3523816","display_name":"Molecular medicine","level":4,"score":0.4343792796134949},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.3611224889755249},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.36017298698425293},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.08899688720703125},{"id":"https://openalex.org/C162324750","wikidata":"https://www.wikidata.org/wiki/Q8134","display_name":"Economics","level":0,"score":0.0},{"id":"https://openalex.org/C21547014","wikidata":"https://www.wikidata.org/wiki/Q1423657","display_name":"Operations management","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000230","descriptor_name":"Adenocarcinoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":false},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D003110","descriptor_name":"Colonic Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D017228","descriptor_name":"Hepatocyte Growth Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019859","descriptor_name":"Proto-Oncogene Proteins c-met","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D019869","descriptor_name":"Phosphatidylinositol 3-Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D020935","descriptor_name":"MAP Kinase Signaling System","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000096","qualifier_name":"biosynthesis","is_major_topic":true},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D042461","descriptor_name":"Vascular Endothelial Growth Factor A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D050796","descriptor_name":"STAT3 Transcription Factor","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051058","descriptor_name":"Oncogene Protein v-akt","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051058","descriptor_name":"Oncogene Protein v-akt","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051795","descriptor_name":"Hypoxia-Inducible Factor 1, alpha Subunit","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D058990","descriptor_name":"Molecular Targeted Therapy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":2,"locations":[{"id":"doi:10.3892/ijo.2012.1728","doi":"https://doi.org/10.3892/ijo.2012.1728","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2012.1728","pdf_url":"http://www.spandidos-publications.com/10.3892/ijo.2012.1728/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},{"id":"pmid:23233163","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/23233163","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International journal of oncology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.3892/ijo.2012.1728","doi":"https://doi.org/10.3892/ijo.2012.1728","is_oa":true,"landing_page_url":"https://doi.org/10.3892/ijo.2012.1728","pdf_url":"http://www.spandidos-publications.com/10.3892/ijo.2012.1728/download","source":{"id":"https://openalex.org/S4210208883","display_name":"International Journal of Oncology","issn_l":"1019-6439","issn":["1019-6439","1791-2423"],"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":["dongbi-d","jufo-1","medline","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320412","host_organization_name":"Spandidos Publishing","host_organization_lineage":["https://openalex.org/P4310320412"],"host_organization_lineage_names":["Spandidos Publishing"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"International Journal of Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G751557500","display_name":"Regulation of regeneration, disease and carcinogenesis throughthe ON-OFF conversion of the cMet/HGF receptor.","funder_award_id":"23790327","funder_id":"https://openalex.org/F4320334764","funder_display_name":"Japan Society for the Promotion of Science"}],"funders":[{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2099565829.pdf","grobid_xml":"https://content.openalex.org/works/W2099565829.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1573363574","https://openalex.org/W1605121457","https://openalex.org/W1649526546","https://openalex.org/W1814662736","https://openalex.org/W1884942699","https://openalex.org/W1903437307","https://openalex.org/W1928129824","https://openalex.org/W1959325633","https://openalex.org/W1973966923","https://openalex.org/W1977171839","https://openalex.org/W1977505607","https://openalex.org/W1978506033","https://openalex.org/W1985562847","https://openalex.org/W1992912767","https://openalex.org/W2005782838","https://openalex.org/W2007897471","https://openalex.org/W2007904495","https://openalex.org/W2015344488","https://openalex.org/W2034633555","https://openalex.org/W2035174231","https://openalex.org/W2040024535","https://openalex.org/W2044666189","https://openalex.org/W2044673446","https://openalex.org/W2053298425","https://openalex.org/W2053983684","https://openalex.org/W2054042846","https://openalex.org/W2069216067","https://openalex.org/W2074242691","https://openalex.org/W2091095982","https://openalex.org/W2093014461","https://openalex.org/W2100542906","https://openalex.org/W2104134459","https://openalex.org/W2115785123","https://openalex.org/W2127287125","https://openalex.org/W2136390065","https://openalex.org/W2138896702","https://openalex.org/W2139440398","https://openalex.org/W2143219084","https://openalex.org/W2146277406","https://openalex.org/W2154690224","https://openalex.org/W2157000380","https://openalex.org/W2157959228","https://openalex.org/W6639315028","https://openalex.org/W6640923925","https://openalex.org/W6675659550","https://openalex.org/W6678840981","https://openalex.org/W6683346645"],"related_works":["https://openalex.org/W2119445693","https://openalex.org/W2357336862","https://openalex.org/W2099441764","https://openalex.org/W40801990","https://openalex.org/W2053298425","https://openalex.org/W2053983684","https://openalex.org/W2073621056","https://openalex.org/W2375806360","https://openalex.org/W2032425910","https://openalex.org/W2018951751"],"abstract_inverted_index":{"In":[0,149],"the":[1,6,28,52,55,146,183,210,223],"present":[2],"study,":[3],"we":[4],"assessed":[5],"involvement":[7],"of":[8,43,54,59,118,139,145,217,225],"hepatocyte":[9],"growth":[10,18],"factor":[11,19,24,126],"(HGF)/c-Met":[12],"signalling":[13,232],"with":[14],"vascular":[15],"endothelial":[16],"cell":[17],"(VEGF)":[20],"and":[21,38,41,79,101,164,172,199,213],"hypoxia":[22],"inducible":[23],"(HIF)-1\u03b1":[25],"expression":[26,72,90,134,193,227],"in":[27,47,73,77,80,83,91,137,222,228],"downstream":[29,216],"pathways":[30],"phosphatidylinositol":[31],"3-kinase":[32],"(PI3K)/Akt,":[33],"mitogen-activated":[34],"protein":[35],"kinase":[36,166,184],"(MAPK)":[37],"signal":[39],"transducer":[40],"activator":[42],"transcription":[44,125],"3":[45],"(STAT3)":[46],"CT26":[48,65,75,229],"cells,":[49,141],"to":[50,67,143],"determine":[51],"mechanisms":[53],"potent":[56],"anti-angiogenic":[57,239],"effect":[58],"NK4.":[60],"We":[61],"established":[62],"genetically":[63],"modified":[64],"cells":[66],"produce":[68],"NK4":[69,163],"(CT26-NK4).":[70],"VEGF":[71,100,133,151,226],"subcutaneous":[74],"tumours":[76],"vivo":[78],"culture":[81],"supernatants":[82],"vitro":[84],"was":[85,94,120,135,154,158,179,194,202],"determined":[86],"by":[87,96,107,156,160,165,182,197,204],"ELISA.":[88],"HIF-1\u03b1":[89,102,119,124],"nuclear":[92],"extracts":[93],"evaluated":[95,121],"western":[97],"blot":[98],"analysis.":[99],"mRNA":[103,192],"levels":[104],"were":[105],"examined":[106],"real-time":[108],"reverse":[109],"transcription-polymerase":[110],"chain":[111],"reaction":[112],"(RT-PCR).":[113],"The":[114],"DNA":[115],"binding":[116],"activity":[117,178],"using":[122],"an":[123],"assay":[127],"kit.":[128],"Our":[129],"results":[130],"demonstrated":[131,188],"that":[132,189,209],"reduced":[136],"homografts":[138],"CT26-NK4":[140],"compared":[142],"those":[144],"control":[147],"cells.":[148,230],"vitro,":[150],"expression,":[152],"which":[153],"induced":[155],"HGF,":[157],"inhibited":[159,181,196,203],"anti-HGF":[161],"antibody,":[162],"inhibitors":[167],"(PI3K,":[168],"LY294002;":[169],"MAPK,":[170],"PD98059;":[171],"STAT3,":[173],"Stattic).":[174],"HGF\u2011induced":[175,190],"HIF\u20111\u03b1":[176,191],"transcriptional":[177],"also":[180],"inhibitors.":[185],"Real-time":[186],"RT-PCR":[187],"not":[195],"LY294002":[198],"PD98059,":[200],"but":[201],"Stattic.":[205],"These":[206],"data":[207],"suggest":[208],"PI3K/Akt,":[211],"MAPK":[212],"STAT3":[214],"pathways,":[215],"HGF/c\u2011Met":[218,231],"signalling,":[219],"are":[220],"involved":[221],"regulation":[224],"may":[233],"be":[234],"a":[235],"promising":[236],"target":[237],"for":[238],"strategies.":[240]},"counts_by_year":[{"year":2026,"cited_by_count":4},{"year":2025,"cited_by_count":2},{"year":2024,"cited_by_count":6},{"year":2023,"cited_by_count":5},{"year":2022,"cited_by_count":9},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":8},{"year":2019,"cited_by_count":6},{"year":2018,"cited_by_count":9},{"year":2017,"cited_by_count":9},{"year":2016,"cited_by_count":5},{"year":2015,"cited_by_count":13},{"year":2014,"cited_by_count":6},{"year":2013,"cited_by_count":6}],"updated_date":"2026-11-12T12:28:57.059296","created_date":"2016-06-24T00:00:00"}
