{"id":"https://openalex.org/W2099498317","doi":"https://doi.org/10.1002/dneu.22330","title":"Aryl hydrocarbon receptor deletion in cerebellar granule neuron precursors impairs neurogenesis","display_name":"Aryl hydrocarbon receptor deletion in cerebellar granule neuron precursors impairs neurogenesis","publication_year":2015,"publication_date":"2015-08-03","ids":{"openalex":"https://openalex.org/W2099498317","doi":"https://doi.org/10.1002/dneu.22330","mag":"2099498317","pmid":"https://pubmed.ncbi.nlm.nih.gov/26243376"},"language":"en","primary_location":{"id":"doi:10.1002/dneu.22330","doi":"https://doi.org/10.1002/dneu.22330","is_oa":false,"landing_page_url":"https://doi.org/10.1002/dneu.22330","pdf_url":null,"source":{"id":"https://openalex.org/S73400187","display_name":"Developmental Neurobiology","issn_l":"1932-8451","issn":["1932-8451","1932-846X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Neurobiology","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4740276","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5057101465","display_name":"Daniel P. Dever","orcid":"https://orcid.org/0000-0001-5966-4803","observed_orcids":["https://orcid.org/0000-0001-5966-4803"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Daniel P. Dever","raw_affiliation_strings":["Department of Environmental Medicine University of Rochester School of Medicine and Dentistry Rochester New York 14642","Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine University of Rochester School of Medicine and Dentistry Rochester New York 14642","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090830844","display_name":"Zachariah O. Adham","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zachariah O. Adham","raw_affiliation_strings":["Department of Environmental Medicine University of Rochester School of Medicine and Dentistry Rochester New York 14642","Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine University of Rochester School of Medicine and Dentistry Rochester New York 14642","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018626779","display_name":"Bryan D. Thompson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bryan Thompson","raw_affiliation_strings":["Department of Environmental Medicine University of Rochester School of Medicine and Dentistry Rochester New York 14642","Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine University of Rochester School of Medicine and Dentistry Rochester New York 14642","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012289692","display_name":"Matthieu Genestine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Matthieu Genestine","raw_affiliation_strings":["Department of Neuroscience and Cell Biology Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey Piscataway New Jersey 08854","Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, Piscataway, New Jersey, 08854"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Cell Biology Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey Piscataway New Jersey 08854","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, Piscataway, New Jersey, 08854","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090727156","display_name":"Jonathan D. Cherry","orcid":"https://orcid.org/0000-0002-1257-981X","observed_orcids":["https://orcid.org/0000-0002-1257-981X"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jonathan Cherry","raw_affiliation_strings":["Department of Pathology and Laboratory Medicine University of Rochester School of Medicine and Dentistry Rochester New York 14642","Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine University of Rochester School of Medicine and Dentistry Rochester New York 14642","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York 14642","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073516027","display_name":"John A. Olschowka","orcid":"https://orcid.org/0000-0002-8478-7773","observed_orcids":["https://orcid.org/0000-0002-8478-7773"]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"John A. Olschowka","raw_affiliation_strings":["Department of Neurobiology and Anatomy University of Rochester School of Medicine and Dentistry Rochester New York 14642","Department of Neurobiology and Anatomy; University of Rochester School of Medicine and Dentistry; Rochester New York 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurobiology and Anatomy University of Rochester School of Medicine and Dentistry Rochester New York 14642","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Neurobiology and Anatomy; University of Rochester School of Medicine and Dentistry; Rochester New York 14642","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077746312","display_name":"Emanuel M. DiCicco-Bloom","orcid":"https://orcid.org/0000-0001-5091-1046","observed_orcids":["https://orcid.org/0000-0001-5091-1046"]},"institutions":[{"id":"https://openalex.org/I102322142","display_name":"Rutgers, The State University of New Jersey","ror":"https://ror.org/05vt9qd57","country_code":"US","type":"education","lineage":["https://openalex.org/I102322142"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emanuel DiCicco\u2010Bloom","raw_affiliation_strings":["Department of Neuroscience and Cell Biology Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey Piscataway New Jersey 08854","Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, Piscataway, New Jersey, 08854"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neuroscience and Cell Biology Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey Piscataway New Jersey 08854","institution_ids":["https://openalex.org/I102322142"]},{"raw_affiliation_string":"Department of Neuroscience and Cell Biology, Robert Wood Johnson Medical School, Rutgers, the State University of New Jersey, Piscataway, New Jersey, 08854","institution_ids":["https://openalex.org/I102322142"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042600788","display_name":"Lisa A. Opanashuk","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I28792581","display_name":"University of Rochester Medicine","ror":"https://ror.org/00trqv719","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"id":"https://openalex.org/I5388228","display_name":"University of Rochester","ror":"https://ror.org/022kthw22","country_code":"US","type":"education","lineage":["https://openalex.org/I5388228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lisa A. Opanashuk","raw_affiliation_strings":["Department of Environmental Medicine University of Rochester School of Medicine and Dentistry Rochester New York 14642","Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Environmental Medicine University of Rochester School of Medicine and Dentistry Rochester New York 14642","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]},{"raw_affiliation_string":"Department of Environmental Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, 14642","institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5057101465"],"corresponding_institution_ids":["https://openalex.org/I28792581","https://openalex.org/I5388228"],"apc_list":{"value":4550,"currency":"USD","value_usd":4550},"apc_paid":null,"fwci":1.4298,"has_fulltext":false,"cited_by_count":56,"citation_normalized_percentile":{"value":0.78545927,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":{"min":89,"max":99},"biblio":{"volume":"76","issue":"5","first_page":"533","last_page":"550"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10608","display_name":"Neurogenesis and neuroplasticity mechanisms","score":0.9980000257492065,"subfield":{"id":"https://openalex.org/subfields/2806","display_name":"Developmental Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10122","display_name":"Toxic Organic Pollutants Impact","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2307","display_name":"Health, Toxicology and Mutagenesis"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/aryl-hydrocarbon-receptor","display_name":"aryl hydrocarbon receptor","score":1.0},{"id":"https://openalex.org/keywords/cerebellar-granule-neuron-precursors","display_name":"cerebellar granule neuron precursors","score":0.9750000238418579},{"id":"https://openalex.org/keywords/conditional-knockout","display_name":"conditional knockout","score":0.5450000166893005},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.7519999742507935},{"id":"https://openalex.org/keywords/neuronal-differentiation","display_name":"neuronal differentiation","score":0.8090000152587891},{"id":"https://openalex.org/keywords/neurite-outgrowth","display_name":"neurite outgrowth","score":0.8970000147819519},{"id":"https://openalex.org/keywords/cerebellar-dysgenesis","display_name":"cerebellar dysgenesis","score":0.8169999718666077},{"id":"https://openalex.org/keywords/dioxin-toxicity","display_name":"dioxin toxicity","score":0.6650000214576721}],"concepts":[{"id":"https://openalex.org/C4746552","wikidata":"https://www.wikidata.org/wiki/Q1456827","display_name":"Neurogenesis","level":2,"score":0.874398946762085},{"id":"https://openalex.org/C33594762","wikidata":"https://www.wikidata.org/wiki/Q155750","display_name":"Aryl hydrocarbon receptor","level":4,"score":0.8474614024162292},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7651894092559814},{"id":"https://openalex.org/C2778888523","wikidata":"https://www.wikidata.org/wiki/Q1777753","display_name":"Granule cell","level":4,"score":0.7354971170425415},{"id":"https://openalex.org/C45815257","wikidata":"https://www.wikidata.org/wiki/Q109984923","display_name":"Aryl hydrocarbon receptor nuclear translocator","level":5,"score":0.6657875180244446},{"id":"https://openalex.org/C164659718","wikidata":"https://www.wikidata.org/wiki/Q5159266","display_name":"Conditional gene knockout","level":4,"score":0.5518999099731445},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.530181884765625},{"id":"https://openalex.org/C113246987","wikidata":"https://www.wikidata.org/wiki/Q1534415","display_name":"Neurite","level":3,"score":0.5232692956924438},{"id":"https://openalex.org/C2779652256","wikidata":"https://www.wikidata.org/wiki/Q130983","display_name":"Cerebellum","level":2,"score":0.5192582607269287},{"id":"https://openalex.org/C86339819","wikidata":"https://www.wikidata.org/wiki/Q407384","display_name":"Transcription factor","level":3,"score":0.45130667090415955},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.37730470299720764},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.35052192211151123},{"id":"https://openalex.org/C529278444","wikidata":"https://www.wikidata.org/wiki/Q47273","display_name":"Central nervous system","level":2,"score":0.26973891258239746},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.14628124237060547},{"id":"https://openalex.org/C2776464000","wikidata":"https://www.wikidata.org/wiki/Q545787","display_name":"Dentate gyrus","level":3,"score":0.11440008878707886},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.07742723822593689},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.07256418466567993},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.0},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002452","descriptor_name":"Cell Count","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002478","descriptor_name":"Cells, Cultured","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000254","qualifier_name":"growth & development","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D002531","descriptor_name":"Cerebellum","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D009474","descriptor_name":"Neurons","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011963","descriptor_name":"Receptors, GABA-A","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D016501","descriptor_name":"Neurites","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018336","descriptor_name":"Receptors, Aryl Hydrocarbon","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018345","descriptor_name":"Mice, Knockout","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Transcription Factors","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Transcription Factors","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000172","qualifier_name":"deficiency","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Transcription Factors","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Transcription Factors","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D051792","descriptor_name":"Basic Helix-Loop-Helix Proteins","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D055495","descriptor_name":"Neurogenesis","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D058953","descriptor_name":"Neural Stem Cells","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1002/dneu.22330","doi":"https://doi.org/10.1002/dneu.22330","is_oa":false,"landing_page_url":"https://doi.org/10.1002/dneu.22330","pdf_url":null,"source":{"id":"https://openalex.org/S73400187","display_name":"Developmental Neurobiology","issn_l":"1932-8451","issn":["1932-8451","1932-846X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental Neurobiology","raw_type":"journal-article"},{"id":"pmid:26243376","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26243376","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Developmental neurobiology","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4740276","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4740276","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dev Neurobiol","raw_type":"Text"}],"best_oa_location":{"id":"pmh:oai:pubmedcentral.nih.gov:4740276","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4740276","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Dev Neurobiol","raw_type":"Text"},"sustainable_development_goals":[{"score":0.800000011920929,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"sustainable_development_goals_aurora":[{"score":0.41999998688697815,"display_name":"Life on land","id":"https://metadata.un.org/sdg/15"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1081269979","display_name":null,"funder_award_id":"T32ES007026","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G1862412751","display_name":null,"funder_award_id":"T32-ES07026","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G469873995","display_name":null,"funder_award_id":"P30 ES0 1247","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G550616590","display_name":null,"funder_award_id":"R01-ES016357","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"},{"id":"https://openalex.org/G9000122455","display_name":null,"funder_award_id":"T32-ES07026","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000150136","display_name":null,"funder_award_id":"R01 ES016357","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000271661","display_name":null,"funder_award_id":"R01 ES016357, P30 ES01247","funder_id":"https://openalex.org/F4320332161","funder_display_name":"National Institutes of Health"},{"id":"https://openalex.org/G9000888856","display_name":"Environmental Agents as Modulators of Disease Processes","funder_award_id":"P30ES001247","funder_id":"https://openalex.org/F4320337361","funder_display_name":"National Institute of Environmental Health Sciences"}],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337361","display_name":"National Institute of Environmental Health Sciences","ror":"https://ror.org/00j4k1h63"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":64,"referenced_works":["https://openalex.org/W142203824","https://openalex.org/W1490879656","https://openalex.org/W1528440616","https://openalex.org/W1935479846","https://openalex.org/W1935643746","https://openalex.org/W1963687870","https://openalex.org/W1969754449","https://openalex.org/W1970864607","https://openalex.org/W1972668098","https://openalex.org/W1977779461","https://openalex.org/W1979379615","https://openalex.org/W1984421966","https://openalex.org/W1994624028","https://openalex.org/W1997905438","https://openalex.org/W1998928723","https://openalex.org/W2001142544","https://openalex.org/W2001193776","https://openalex.org/W2013346975","https://openalex.org/W2020792897","https://openalex.org/W2022512766","https://openalex.org/W2023067699","https://openalex.org/W2025980626","https://openalex.org/W2032635061","https://openalex.org/W2042657989","https://openalex.org/W2052208984","https://openalex.org/W2054702856","https://openalex.org/W2058457184","https://openalex.org/W2061920760","https://openalex.org/W2068059460","https://openalex.org/W2070386728","https://openalex.org/W2071224279","https://openalex.org/W2071435286","https://openalex.org/W2074172315","https://openalex.org/W2079082362","https://openalex.org/W2090922420","https://openalex.org/W2090939833","https://openalex.org/W2093069537","https://openalex.org/W2093396000","https://openalex.org/W2094611185","https://openalex.org/W2099035230","https://openalex.org/W2100193266","https://openalex.org/W2101516334","https://openalex.org/W2104010513","https://openalex.org/W2104499380","https://openalex.org/W2107229728","https://openalex.org/W2110496051","https://openalex.org/W2110767180","https://openalex.org/W2111197864","https://openalex.org/W2115153534","https://openalex.org/W2116481437","https://openalex.org/W2118366155","https://openalex.org/W2122922916","https://openalex.org/W2124009292","https://openalex.org/W2128152788","https://openalex.org/W2135996597","https://openalex.org/W2137279272","https://openalex.org/W2137751635","https://openalex.org/W2141078839","https://openalex.org/W2144062280","https://openalex.org/W2144458244","https://openalex.org/W2146008657","https://openalex.org/W2154532970","https://openalex.org/W2156319617","https://openalex.org/W2321956648"],"related_works":["https://openalex.org/W2394599053","https://openalex.org/W2116231282","https://openalex.org/W2002396362","https://openalex.org/W2378346785","https://openalex.org/W2060058885","https://openalex.org/W2049881818","https://openalex.org/W1981300446","https://openalex.org/W2060065906","https://openalex.org/W2087122683","https://openalex.org/W2137671292"],"abstract_inverted_index":{"The":[0],"aryl":[1],"hydrocarbon":[2],"receptor":[3,158],"(AhR)":[4],"is":[5],"a":[6,72,77,170],"ligand-activated":[7],"member":[8],"of":[9,20,31,196,212],"the":[10,18,29,35,60,124,193,210],"basic-helix-loop-helix/PER-ARNT-SIM(PAS)":[11],"transcription":[12],"factor":[13],"superfamily":[14],"that":[15,26,43,166],"also":[16],"mediates":[17],"toxicity":[19],"2,3,7,8-tetrachlorodibenzo-p-dioxin":[21],"(TCDD).":[22],"Increasing":[23],"evidence":[24],"suggests":[25],"AhR":[27,45,50,67,79,87,135,167,197],"influences":[28],"development":[30,70],"many":[32],"tissues,":[33],"including":[34,147],"central":[36],"nervous":[37],"system.":[38],"Our":[39,163],"previous":[40],"studies":[41,187],"suggest":[42,165],"sustained":[44],"activation":[46],"by":[47,106,180],"TCDD":[48],"and/or":[49],"deletion":[51,80,88,161],"disrupts":[52],"cerebellar":[53,200,216],"granule":[54,120,126,174,201],"neuron":[55,121,175],"precursor":[56],"(GNP)":[57],"development.":[58],"In":[59],"current":[61],"study,":[62],"to":[63],"determine":[64],"whether":[65],"endogenous":[66],"controls":[68],"GNP":[69,183],"in":[71,89,93,102,109,123,134,150,156,160,172,215],"cell-autonomous":[73],"manner,":[74],"we":[75],"created":[76],"GNP-specific":[78],"mouse,":[81],"AhR(fx/fx)":[82],"/Math1(CRE/+)":[83],"(AhR":[84],"CKO).":[85],"Selective":[86],"GNPs":[90,99],"produced":[91],"abnormalities":[92],"proliferation":[94],"and":[95,113,130,153,177,204],"differentiation.":[96],"Specifically,":[97],"fewer":[98],"were":[100,132],"engaged":[101],"S-phase,":[103],"as":[104],"demonstrated":[105],"\u223c25%":[107],"reductions":[108],"thymidine":[110],"(in":[111,115],"vitro)":[112],"Bromodeoxyuridine":[114],"vivo)":[116],"incorporation.":[117],"Furthermore,":[118],"total":[119],"numbers":[122],"internal":[125],"layer":[127],"at":[128],"PND21":[129],"PND60":[131],"diminished":[133],"conditional":[136],"knockout":[137],"(CKO)":[138],"mice":[139],"compared":[140],"with":[141],"controls.":[142],"Conversely,":[143],"differentiation":[144],"was":[145],"enhanced,":[146],"\u223c40%":[148],"increase":[149,155],"neurite":[151],"outgrowth":[152],"50%":[154],"GABAR\u03b16":[157],"expression":[159],"mutants.":[162],"results":[164],"activity":[168],"plays":[169],"role":[171],"regulating":[173],"number":[176],"differentiation,":[178],"possibly":[179],"coordinating":[181],"this":[182],"developmental":[184],"transition.":[185],"These":[186],"provide":[188],"novel":[189],"insights":[190],"for":[191,209],"understanding":[192],"normal":[194],"roles":[195],"signaling":[198],"during":[199],"cell":[202],"neurogenesis":[203],"may":[205],"have":[206],"important":[207],"implications":[208],"effects":[211],"environmental":[213],"factors":[214],"dysgenesis.":[217]},"counts_by_year":[{"year":2026,"cited_by_count":3},{"year":2025,"cited_by_count":6},{"year":2024,"cited_by_count":1},{"year":2023,"cited_by_count":12},{"year":2022,"cited_by_count":6},{"year":2021,"cited_by_count":6},{"year":2020,"cited_by_count":7},{"year":2019,"cited_by_count":3},{"year":2018,"cited_by_count":4},{"year":2017,"cited_by_count":7},{"year":2016,"cited_by_count":1}],"updated_date":"2026-10-24T09:50:30.924529","created_date":"2016-06-24T00:00:00"}
