{"id":"https://openalex.org/W2099485194","doi":"https://doi.org/10.1093/molbev/msv135","title":"Molecular Mechanisms and Evolutionary Processes Contributing to Accelerated Divergence of Gene Expression on the Drosophila X Chromosome","display_name":"Molecular Mechanisms and Evolutionary Processes Contributing to Accelerated Divergence of Gene Expression on the Drosophila X Chromosome","publication_year":2015,"publication_date":"2015-06-02","ids":{"openalex":"https://openalex.org/W2099485194","doi":"https://doi.org/10.1093/molbev/msv135","mag":"2099485194","pmid":"https://pubmed.ncbi.nlm.nih.gov/26041937","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4592344"},"language":"en","primary_location":{"id":"doi:10.1093/molbev/msv135","doi":"https://doi.org/10.1093/molbev/msv135","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msv135","pdf_url":"https://academic.oup.com/mbe/article-pdf/32/10/2605/13166187/msv135.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://academic.oup.com/mbe/article-pdf/32/10/2605/13166187/msv135.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5064925364","display_name":"Joseph D. Coolon","orcid":"https://orcid.org/0000-0003-1591-9418","observed_orcids":["https://orcid.org/0000-0003-1591-9418"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Joseph D. Coolon","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, University of Michigan jcoolon@wesleyan.edu wittkopp@umich.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of Michigan jcoolon@wesleyan.edu wittkopp@umich.edu","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5023348687","display_name":"Kraig R. Stevenson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kraig R. Stevenson","raw_affiliation_strings":["Department of Computational Medicine and Bioinformatics, University of Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Computational Medicine and Bioinformatics, University of Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5088627617","display_name":"C. Joel McManus","orcid":"https://orcid.org/0000-0002-6605-2642","observed_orcids":["https://orcid.org/0000-0002-6605-2642"]},"institutions":[{"id":"https://openalex.org/I74973139","display_name":"Carnegie Mellon University","ror":"https://ror.org/05x2bcf33","country_code":"US","type":"education","lineage":["https://openalex.org/I74973139"]},{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"C. Joel McManus","raw_affiliation_strings":["Department of Biological Sciences, Carnegie Mellon University Department of Genetics and Developmental Biology, Institute for Systems Genomics, University of Connecticut Health Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Carnegie Mellon University Department of Genetics and Developmental Biology, Institute for Systems Genomics, University of Connecticut Health Center","institution_ids":["https://openalex.org/I74973139","https://openalex.org/I75929689"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5075058158","display_name":"Bing Yang","orcid":"https://orcid.org/0000-0002-7657-2158","observed_orcids":["https://orcid.org/0000-0002-7657-2158"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Bing Yang","raw_affiliation_strings":["Department of Molecular, Cellular, and Developmental Biology, University of Michigan"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Molecular, Cellular, and Developmental Biology, University of Michigan","institution_ids":["https://openalex.org/I27837315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114376185","display_name":"Brenton R. Graveley","orcid":"https://orcid.org/0000-0001-5777-5892","observed_orcids":["https://orcid.org/0000-0001-5777-5892"]},"institutions":[{"id":"https://openalex.org/I75929689","display_name":"UConn Health","ror":"https://ror.org/02kzs4y22","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I75929689"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brenton R. Graveley","raw_affiliation_strings":["Department of Genetics and Developmental Biology, Institute for Systems Genomics, University of Connecticut Health Center"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Genetics and Developmental Biology, Institute for Systems Genomics, University of Connecticut Health Center","institution_ids":["https://openalex.org/I75929689"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5033807850","display_name":"Patricia Jean Wittkopp","orcid":"https://orcid.org/0000-0001-7619-0048","observed_orcids":["https://orcid.org/0000-0001-7619-0048"]},"institutions":[{"id":"https://openalex.org/I27837315","display_name":"University of Michigan","ror":"https://ror.org/00jmfr291","country_code":"US","type":"education","lineage":["https://openalex.org/I27837315"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Patricia J. Wittkopp","raw_affiliation_strings":["Department of Ecology and Evolutionary Biology, University of Michigan Department of Computational Medicine and Bioinformatics, University of Michigan Department of Molecular, Cellular, and Developmental Biology, University of Michigan jcoolon@wesleyan.edu wittkopp@umich.edu"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ecology and Evolutionary Biology, University of Michigan Department of Computational Medicine and Bioinformatics, University of Michigan Department of Molecular, Cellular, and Developmental Biology, University of Michigan jcoolon@wesleyan.edu wittkopp@umich.edu","institution_ids":["https://openalex.org/I27837315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033807850","https://openalex.org/A5064925364"],"corresponding_institution_ids":["https://openalex.org/I27837315"],"apc_list":{"value":3418,"currency":"USD","value_usd":3418},"apc_paid":null,"fwci":3.4216,"has_fulltext":true,"cited_by_count":39,"citation_normalized_percentile":{"value":0.92862381,"is_in_top_1_percent":false,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":93,"max":99},"biblio":{"volume":"32","issue":"10","first_page":"2605","last_page":"2615"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.6460000276565552,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11077","display_name":"Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities","score":0.6460000276565552,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.1808999925851822,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10434","display_name":"Chromosomal and Genetic Variations","score":0.1298999935388565,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/x-chromosome","display_name":"X chromosome","score":0.7450000047683716},{"id":"https://openalex.org/keywords/gene-expression-divergence","display_name":"gene expression divergence","score":0.824999988079071},{"id":"https://openalex.org/keywords/cis-regulatory-evolution","display_name":"cis-regulatory evolution","score":0.8500000238418579},{"id":"https://openalex.org/keywords/trans-regulatory-variation","display_name":"trans-regulatory variation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/male-biased-genes","display_name":"male-biased genes","score":0.8970000147819519},{"id":"https://openalex.org/keywords/heterogametic-sex","display_name":"heterogametic sex","score":0.6909999847412109},{"id":"https://openalex.org/keywords/positive-selection","display_name":"positive selection","score":0.6940000057220459},{"id":"https://openalex.org/keywords/neutral-evolution","display_name":"neutral evolution","score":0.7860000133514404},{"id":"https://openalex.org/keywords/drosophila","display_name":"Drosophila","score":0.7590000033378601}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.913067102432251},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6907516121864319},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6575573086738586},{"id":"https://openalex.org/C134925867","wikidata":"https://www.wikidata.org/wiki/Q186380","display_name":"Autosome","level":4,"score":0.5504612922668457},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5400081872940063},{"id":"https://openalex.org/C36217612","wikidata":"https://www.wikidata.org/wiki/Q5747181","display_name":"Heterogametic sex","level":4,"score":0.5076016187667847},{"id":"https://openalex.org/C35158069","wikidata":"https://www.wikidata.org/wiki/Q61333","display_name":"X chromosome","level":3,"score":0.49851107597351074},{"id":"https://openalex.org/C207390915","wikidata":"https://www.wikidata.org/wiki/Q1230525","display_name":"Divergence (linguistics)","level":2,"score":0.44524097442626953},{"id":"https://openalex.org/C30481170","wikidata":"https://www.wikidata.org/wiki/Q37748","display_name":"Chromosome","level":3,"score":0.4316169321537018},{"id":"https://openalex.org/C174600577","wikidata":"https://www.wikidata.org/wiki/Q5533491","display_name":"Genome evolution","level":4,"score":0.43022894859313965},{"id":"https://openalex.org/C166393388","wikidata":"https://www.wikidata.org/wiki/Q856529","display_name":"Molecular evolution","level":4,"score":0.4278068542480469},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.42421257495880127},{"id":"https://openalex.org/C7386963","wikidata":"https://www.wikidata.org/wiki/Q3954859","display_name":"Negative selection","level":4,"score":0.42204490303993225},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3598400950431824},{"id":"https://openalex.org/C138885662","wikidata":"https://www.wikidata.org/wiki/Q5891","display_name":"Philosophy","level":0,"score":0.0},{"id":"https://openalex.org/C41895202","wikidata":"https://www.wikidata.org/wiki/Q8162","display_name":"Linguistics","level":1,"score":0.0}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001483","descriptor_name":"Base Sequence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D005075","descriptor_name":"Biological Evolution","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005786","descriptor_name":"Gene Expression Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012045","descriptor_name":"Regulatory Sequences, Nucleic Acid","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014157","descriptor_name":"Transcription Factors","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D014960","descriptor_name":"X Chromosome","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D050172","descriptor_name":"Genes, X-Linked","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1093/molbev/msv135","doi":"https://doi.org/10.1093/molbev/msv135","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msv135","pdf_url":"https://academic.oup.com/mbe/article-pdf/32/10/2605/13166187/msv135.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},{"id":"pmh:oai:europepmc.org:3999868","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4592344","pdf_url":null,"source":{"id":"https://openalex.org/S4306400806","display_name":"Europe PMC (PubMed Central)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1303153112","host_organization_name":"European Bioinformatics Institute","host_organization_lineage":["https://openalex.org/I1303153112"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":null,"raw_type":"Text"},{"id":"pmh:oai:pubmedcentral.nih.gov:4592344","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4592344","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Mol Biol Evol","raw_type":"Text"},{"id":"pmid:26041937","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/26041937","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular biology and evolution","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/molbev/msv135","doi":"https://doi.org/10.1093/molbev/msv135","is_oa":true,"landing_page_url":"https://doi.org/10.1093/molbev/msv135","pdf_url":"https://academic.oup.com/mbe/article-pdf/32/10/2605/13166187/msv135.pdf","source":{"id":"https://openalex.org/S57552105","display_name":"Molecular Biology and Evolution","issn_l":"0737-4038","issn":["0737-4038","1537-1719"],"is_oa":false,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-3","ki-jl-2","medline","norway-2","oarl","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Molecular Biology and Evolution","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G1368339401","display_name":"Evolution of Gene Expression in Yeast","funder_award_id":"R01GM108826","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G1813998119","display_name":"Using next-generation sequencing to understand the evolution of gene regulation","funder_award_id":"F32GM089009","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G319763173","display_name":"The Evolution of Gene Expression: Molecular Mechanisms and Inheritance Patterns Revealed on a Genomic Scale With Next-Generation Sequencing","funder_award_id":"1021398","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"},{"id":"https://openalex.org/G3448066749","display_name":"Trans-Splicing in Drosophila","funder_award_id":"R01GM095296","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G3530300517","display_name":"IGERT: Open Data: Graduate Training for Data Sharing and Reuse in E-Science","funder_award_id":"0903629","funder_id":"https://openalex.org/F4320306076","funder_display_name":"National Science Foundation"}],"funders":[{"id":"https://openalex.org/F4320306076","display_name":"National Science Foundation","ror":"https://ror.org/021nxhr62"},{"id":"https://openalex.org/F4320306151","display_name":"Alfred P. Sloan Foundation","ror":"https://ror.org/052csg198"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2099485194.pdf","grobid_xml":"https://content.openalex.org/works/W2099485194.grobid-xml"},"referenced_works_count":60,"referenced_works":["https://openalex.org/W1833091446","https://openalex.org/W1968376884","https://openalex.org/W1980678014","https://openalex.org/W1983275320","https://openalex.org/W1985558311","https://openalex.org/W1988495007","https://openalex.org/W1994420360","https://openalex.org/W2002604364","https://openalex.org/W2002794144","https://openalex.org/W2011289056","https://openalex.org/W2013955096","https://openalex.org/W2014279841","https://openalex.org/W2015673931","https://openalex.org/W2022651039","https://openalex.org/W2023573993","https://openalex.org/W2057277929","https://openalex.org/W2061661545","https://openalex.org/W2063313162","https://openalex.org/W2067620870","https://openalex.org/W2077751281","https://openalex.org/W2085454778","https://openalex.org/W2090952779","https://openalex.org/W2094248448","https://openalex.org/W2094661511","https://openalex.org/W2098274585","https://openalex.org/W2102982283","https://openalex.org/W2102990813","https://openalex.org/W2103934482","https://openalex.org/W2103999749","https://openalex.org/W2110335151","https://openalex.org/W2117925179","https://openalex.org/W2122152054","https://openalex.org/W2125321608","https://openalex.org/W2126334905","https://openalex.org/W2128016314","https://openalex.org/W2129044180","https://openalex.org/W2133147430","https://openalex.org/W2133710093","https://openalex.org/W2137720693","https://openalex.org/W2138007075","https://openalex.org/W2140603917","https://openalex.org/W2140876173","https://openalex.org/W2144710594","https://openalex.org/W2145726016","https://openalex.org/W2147440110","https://openalex.org/W2151278389","https://openalex.org/W2152579422","https://openalex.org/W2157441401","https://openalex.org/W2161582762","https://openalex.org/W2162205471","https://openalex.org/W2163256056","https://openalex.org/W2164403510","https://openalex.org/W2167120442","https://openalex.org/W2170268763","https://openalex.org/W2170355493","https://openalex.org/W2171269638","https://openalex.org/W2175470937","https://openalex.org/W2315242040","https://openalex.org/W2582743722","https://openalex.org/W4241429633"],"related_works":["https://openalex.org/W7098683245","https://openalex.org/W1980678014","https://openalex.org/W2801700246","https://openalex.org/W1994420360","https://openalex.org/W7099776924","https://openalex.org/W7100203881","https://openalex.org/W833713541","https://openalex.org/W2071666372","https://openalex.org/W2144710594","https://openalex.org/W2026740174"],"abstract_inverted_index":{"In":[0],"species":[1,108],"with":[2,111],"a":[3,51,112,141,188],"heterogametic":[4],"sex,":[5],"population":[6],"genetics":[7],"theory":[8],"predicts":[9],"that":[10,72,136,175,211],"DNA":[11],"sequences":[12,22,78,235],"on":[13,23,79,236,246],"the":[14,70,80,90,170,237,247],"X":[15,81,238,248],"chromosome":[16,82,239,249],"can":[17,31,240],"evolve":[18],"faster":[19],"than":[20,207,221],"comparable":[21],"autosomes.":[24,252],"Both":[25],"neutral":[26,219],"and":[27,65,95,107,149,233],"nonneutral":[28],"evolutionary":[29],"processes":[30,220],"generate":[32],"this":[33,86,121,193],"pattern.":[34],"Complex":[35],"traits":[36],"like":[37],"gene":[38,55],"expression":[39,56,102,145,183,202,244],"are":[40,162],"not":[41],"predicted":[42],"to":[43,98,140,165,180,200,216,242,251],"have":[44],"accelerated":[45,73,228,243],"evolution":[46,75,229],"by":[47,88],"these":[48],"theories,":[49],"yet":[50],"\"faster-X\"":[52],"pattern":[53,87,143],"of":[54,76,93,100,109,114,144,159,184,197,230],"divergence":[57,103,115,146,203,245],"has":[58],"recently":[59],"been":[60],"reported":[61],"for":[62,85,120,192],"both":[63,147,231],"Drosophila":[64,110],"mammals.":[66],"Here,":[67],"we":[68,132],"test":[69],"hypothesis":[71],"adaptive":[74],"cis-regulatory":[77],"is":[83,154,213],"responsible":[84],"comparing":[89,128],"relative":[91,250],"contributions":[92],"cis-":[94],"trans-regulatory":[96,137,198],"changes":[97],"patterns":[99],"faster-X":[101,142,201],"observed":[104],"between":[105,150,208],"strains":[106],"range":[113],"times.":[116],"We":[117,172],"find":[118,134],"support":[119],"hypothesis,":[122],"especially":[123],"among":[124],"male-biased":[125],"genes,":[126,186],"when":[127],"different":[129],"species.":[130,151],"However,":[131],"also":[133],"evidence":[135],"differences":[138],"contribute":[139],"within":[148,206],"This":[152],"contribution":[153,196],"surprising":[155],"because":[156],"trans-acting":[157],"regulators":[158],"X-linked":[160,176,185],"genes":[161],"generally":[163],"assumed":[164],"be":[166],"randomly":[167],"distributed":[168],"throughout":[169],"genome.":[171],"found,":[173],"however,":[174],"transcription":[177],"factors":[178],"appear":[179],"preferentially":[181],"regulate":[182],"providing":[187],"potential":[189],"mechanistic":[190],"explanation":[191],"result.":[194],"The":[195],"variation":[199],"was":[204],"larger":[205],"species,":[209],"suggesting":[210],"it":[212],"more":[214],"likely":[215],"result":[217],"from":[218],"positive":[222],"selection.":[223],"These":[224],"data":[225],"show":[226],"how":[227],"coding":[232],"noncoding":[234],"lead":[241]},"counts_by_year":[{"year":2026,"cited_by_count":1},{"year":2025,"cited_by_count":3},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":7},{"year":2022,"cited_by_count":2},{"year":2021,"cited_by_count":2},{"year":2020,"cited_by_count":3},{"year":2019,"cited_by_count":2},{"year":2018,"cited_by_count":3},{"year":2017,"cited_by_count":5},{"year":2016,"cited_by_count":7}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}