{"id":"https://openalex.org/W2099411381","doi":"https://doi.org/10.1128/mbio.01631-14","title":"Metagenome-Wide Association of Microbial Determinants of Host Phenotype in Drosophila melanogaster","display_name":"Metagenome-Wide Association of Microbial Determinants of Host Phenotype in Drosophila melanogaster","publication_year":2014,"publication_date":"2014-10-01","ids":{"openalex":"https://openalex.org/W2099411381","doi":"https://doi.org/10.1128/mbio.01631-14","mag":"2099411381","pmid":"https://pubmed.ncbi.nlm.nih.gov/25271286","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/4196228"},"language":"en","primary_location":{"id":"doi:10.1128/mbio.01631-14","doi":"https://doi.org/10.1128/mbio.01631-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.01631-14","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},"volume":null,"type":"article","indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1128/mbio.01631-14","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070939603","display_name":"John M. Chaston","orcid":"https://orcid.org/0000-0002-2625-6413","observed_orcids":["https://orcid.org/0000-0002-2625-6413"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"John M. Chaston","raw_affiliation_strings":["Department of Entomology, Cornell University, Ithaca, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Entomology, Cornell University, Ithaca, New York, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5071652506","display_name":"Peter D. Newell","orcid":"https://orcid.org/0000-0002-0959-5907","observed_orcids":["https://orcid.org/0000-0002-0959-5907"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Peter D. Newell","raw_affiliation_strings":["Department of Entomology, Cornell University, Ithaca, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Entomology, Cornell University, Ithaca, New York, USA","institution_ids":["https://openalex.org/I205783295"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5050851681","display_name":"Angela E. Douglas","orcid":"https://orcid.org/0000-0001-5212-6826","observed_orcids":["https://orcid.org/0000-0001-5212-6826"]},"institutions":[{"id":"https://openalex.org/I205783295","display_name":"Cornell University","ror":"https://ror.org/05bnh6r87","country_code":"US","type":"education","lineage":["https://openalex.org/I205783295"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Angela E. Douglas","raw_affiliation_strings":["Department of Entomology, Cornell University, Ithaca, New York, USA","Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Entomology, Cornell University, Ithaca, New York, USA","institution_ids":["https://openalex.org/I205783295"]},{"raw_affiliation_string":"Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, USA","institution_ids":["https://openalex.org/I205783295"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5070939603"],"corresponding_institution_ids":["https://openalex.org/I205783295"],"apc_list":{"value":3900,"currency":"USD","value_usd":3900},"apc_paid":{"value":3900,"currency":"USD","value_usd":3900},"fwci":12.926,"has_fulltext":false,"cited_by_count":138,"citation_normalized_percentile":{"value":0.99192166,"is_in_top_1_percent":true,"is_in_top_10_percent":true},"cited_by_percentile_year":{"min":96,"max":100},"biblio":{"volume":"5","issue":"5","first_page":"e01631","last_page":"14"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12134","display_name":"Insect symbiosis and bacterial influences","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12134","display_name":"Insect symbiosis and bacterial influences","score":0.8842999935150146,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10066","display_name":"Gut microbiota and health","score":0.08749999850988388,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10120","display_name":"Bacterial Genetics and Biotechnology","score":0.003700000001117587,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.7960000038146973},{"id":"https://openalex.org/keywords/host-microbe-interactions","display_name":"host-microbe interactions","score":0.9399999976158142},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.9319999814033508},{"id":"https://openalex.org/keywords/development-time","display_name":"development time","score":0.7940000295639038},{"id":"https://openalex.org/keywords/triglyceride-content","display_name":"triglyceride content","score":0.9940000176429749},{"id":"https://openalex.org/keywords/gluconate-dehydrogenase","display_name":"gluconate dehydrogenase","score":0.8769999742507935},{"id":"https://openalex.org/keywords/host-nutritional-status","display_name":"host nutritional status","score":0.8370000123977661},{"id":"https://openalex.org/keywords/high-fat-diet","display_name":"high-fat diet","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8464083075523376},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6361473798751831},{"id":"https://openalex.org/C15151743","wikidata":"https://www.wikidata.org/wiki/Q903778","display_name":"Metagenomics","level":3,"score":0.6245118379592896},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.6133349537849426},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6088641285896301},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.5946719646453857},{"id":"https://openalex.org/C126831891","wikidata":"https://www.wikidata.org/wiki/Q221673","display_name":"Host (biology)","level":2,"score":0.5906583666801453},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5696004033088684},{"id":"https://openalex.org/C28693550","wikidata":"https://www.wikidata.org/wiki/Q7835335","display_name":"Transposon mutagenesis","level":5,"score":0.44264286756515503},{"id":"https://openalex.org/C81941488","wikidata":"https://www.wikidata.org/wiki/Q853421","display_name":"Quantitative trait locus","level":3,"score":0.4204102158546448},{"id":"https://openalex.org/C141231307","wikidata":"https://www.wikidata.org/wiki/Q7020","display_name":"Genome","level":3,"score":0.3275836408138275},{"id":"https://openalex.org/C4918238","wikidata":"https://www.wikidata.org/wiki/Q121438","display_name":"Transposable element","level":4,"score":0.27104175090789795}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001419","descriptor_name":"Bacteria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D003001","descriptor_name":"Cloning, Molecular","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004269","descriptor_name":"DNA, Bacterial","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004331","descriptor_name":"Drosophila melanogaster","qualifier_ui":"Q000382","qualifier_name":"microbiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005798","descriptor_name":"Genes, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D007778","descriptor_name":"Lactobacillus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D007778","descriptor_name":"Lactobacillus","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D010641","descriptor_name":"Phenotype","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010802","descriptor_name":"Phylogeny","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012336","descriptor_name":"RNA, Ribosomal, 16S","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014280","descriptor_name":"Triglycerides","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014644","descriptor_name":"Genetic Variation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015964","descriptor_name":"Gene Expression Regulation, Bacterial","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016947","descriptor_name":"Acetobacteraceae","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016947","descriptor_name":"Acetobacteraceae","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D017422","descriptor_name":"Sequence Analysis, DNA","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D020560","descriptor_name":"Proteobacteria","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020560","descriptor_name":"Proteobacteria","qualifier_ui":"Q000302","qualifier_name":"isolation & purification","is_major_topic":false},{"descriptor_ui":"D054884","descriptor_name":"Host-Pathogen Interactions","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054892","descriptor_name":"Metagenome","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D064307","descriptor_name":"Microbiota","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":6,"locations":[{"id":"doi:10.1128/mbio.01631-14","doi":"https://doi.org/10.1128/mbio.01631-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.01631-14","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:4196228","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4196228","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"Text"},{"id":"pmid:25271286","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/25271286","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"Journal Article"},{"id":"pmh:oai:CiteSeerX.psu:10.1.1.784.7348","doi":null,"is_oa":false,"landing_page_url":"http://citeseerx.ist.psu.edu/viewdoc/summary?doi=10.1.1.784.7348","pdf_url":null,"source":null,"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"ftp://ftp.ncbi.nlm.nih.gov/pub/pmc/ef/0d/mBio.01631-14.PMC4196228.pdf","raw_type":"text"},{"id":"pmh:oai:doaj.org/article:74e0baf607d44dcaa520d53b99d45cee","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/74e0baf607d44dcaa520d53b99d45cee","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mBio, Vol 5, Iss 5 (2014)","raw_type":"article"},{"id":"pmh:oai:doaj.org/article:eff6f21f60ba48009aaeaf1793bc2027","doi":null,"is_oa":true,"landing_page_url":"https://doaj.org/article/eff6f21f60ba48009aaeaf1793bc2027","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-sa","license_id":"https://openalex.org/licenses/cc-by-sa","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"mBio, Vol 5, Iss 5 (2014)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1128/mbio.01631-14","doi":"https://doi.org/10.1128/mbio.01631-14","is_oa":true,"landing_page_url":"https://doi.org/10.1128/mbio.01631-14","pdf_url":null,"source":{"id":"https://openalex.org/S4210201176","display_name":"mBio","issn_l":"2150-7511","issn":["2150-7511","2161-2129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320263","host_organization_name":"American Society for Microbiology","host_organization_lineage":["https://openalex.org/P4310320263"],"host_organization_lineage_names":["American Society for Microbiology"],"type":"journal"},"license":"cc-by-nc-sa","license_id":"https://openalex.org/licenses/cc-by-nc-sa","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"mBio","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Zero hunger","id":"https://metadata.un.org/sdg/2","score":0.5666999816894531}],"study_designs":[],"awards":[{"id":"https://openalex.org/G4955936338","display_name":"Investigation of microbial factors required for integrated functions of the Droso","funder_award_id":"F32GM099374","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"},{"id":"https://openalex.org/G8456436009","display_name":"Integrating the Metabolic Function and Population Dynamics of Gut Microbiota for Host Nutritional Health","funder_award_id":"R01GM095372","funder_id":"https://openalex.org/F4320337354","funder_display_name":"National Institute of General Medical Sciences"}],"funders":[{"id":"https://openalex.org/F4320306114","display_name":"U.S. Department of Agriculture","ror":"https://ror.org/01na82s61"},{"id":"https://openalex.org/F4320310094","display_name":"University of Washington","ror":"https://ror.org/00cvxb145"},{"id":"https://openalex.org/F4320310400","display_name":"Dartmouth College","ror":"https://ror.org/049s0rh22"},{"id":"https://openalex.org/F4320323830","display_name":"Universit\u00e9 de Gen\u00e8ve","ror":"https://ror.org/01swzsf04"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332818","display_name":"Audrey and Theodor Geisel School of Medicine at Dartmouth","ror":"https://ror.org/049s0rh22"},{"id":"https://openalex.org/F4320337354","display_name":"National Institute of General Medical Sciences","ror":"https://ror.org/04q48ey07"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":59,"referenced_works":["https://openalex.org/W1485044783","https://openalex.org/W1842639876","https://openalex.org/W1920510593","https://openalex.org/W1963890672","https://openalex.org/W1964244234","https://openalex.org/W1970635130","https://openalex.org/W1975431864","https://openalex.org/W1977027195","https://openalex.org/W1981500982","https://openalex.org/W1986150323","https://openalex.org/W2004548026","https://openalex.org/W2007636825","https://openalex.org/W2008856488","https://openalex.org/W2010508535","https://openalex.org/W2019703934","https://openalex.org/W2027039519","https://openalex.org/W2031442063","https://openalex.org/W2033384876","https://openalex.org/W2047123551","https://openalex.org/W2063856799","https://openalex.org/W2071841602","https://openalex.org/W2082966250","https://openalex.org/W2086335460","https://openalex.org/W2088209062","https://openalex.org/W2088732289","https://openalex.org/W2089693716","https://openalex.org/W2105293638","https://openalex.org/W2112024369","https://openalex.org/W2117029190","https://openalex.org/W2117613892","https://openalex.org/W2122600131","https://openalex.org/W2125452584","https://openalex.org/W2128769815","https://openalex.org/W2129736385","https://openalex.org/W2132815101","https://openalex.org/W2132926880","https://openalex.org/W2135621733","https://openalex.org/W2137150469","https://openalex.org/W2138122982","https://openalex.org/W2143335572","https://openalex.org/W2143544846","https://openalex.org/W2144694815","https://openalex.org/W2146356256","https://openalex.org/W2149573313","https://openalex.org/W2151409320","https://openalex.org/W2151945971","https://openalex.org/W2154780969","https://openalex.org/W2157765869","https://openalex.org/W2158849915","https://openalex.org/W2159267296","https://openalex.org/W2160969485","https://openalex.org/W2161478038","https://openalex.org/W2163023998","https://openalex.org/W2166674630","https://openalex.org/W2167163043","https://openalex.org/W2169276813","https://openalex.org/W2409549369","https://openalex.org/W2582743722","https://openalex.org/W3086315876"],"related_works":["https://openalex.org/W7009450009","https://openalex.org/W2033591591","https://openalex.org/W2224802932","https://openalex.org/W4289334028","https://openalex.org/W7097020974","https://openalex.org/W2498581231","https://openalex.org/W4411930426","https://openalex.org/W2154780969","https://openalex.org/W7099838354","https://openalex.org/W1998465679"],"abstract_inverted_index":{"UNLABELLED:":[0],"Animal-associated":[1],"bacteria":[2,74,171,276,377],"(microbiota)":[3],"affect":[4,141,230],"host":[5,17,34,58,87,142,214,231,252,309,355,407],"behaviors":[6],"and":[7,38,80,254,370],"physiological":[8],"traits.":[9],"To":[10,151,271,311],"identify":[11,287],"bacterial":[12,51,91,206,249,289,302,322,337,348],"genetic":[13],"determinants":[14,250],"of":[15,49,55,72,85,113,124,155,212,236,245,251,266,280,320,334,393],"microbiota-responsive":[16,33],"traits,":[18,35],"we":[19,30,68,159,284,315,343],"employed":[20],"a":[21,125,164,175,267,399],"metagenome-wide":[22],"association":[23],"(MGWA)":[24],"approach":[25],"in":[26,42,163,191,354,367],"two":[27,32],"steps.":[28],"First,":[29],"measured":[31],"development":[36,119],"time":[37],"triglyceride":[39],"(TAG)":[40],"content,":[41,144],"Drosophila":[43,183,325],"melanogaster":[44],"flies":[45,219,327],"monoassociated":[46,98],"with":[47,89,99,170,196,350],"each":[48,319],"41":[50,321],"strains.":[52,224],"The":[53,94,332],"effects":[54,112],"monoassociation":[56],"on":[57,118],"traits":[59,253],"were":[60,220,339,364],"not":[61],"confined":[62],"to":[63,140,187,222,286,380,390,401],"particular":[64],"taxonomic":[65],"groups.":[66],"Second,":[67],"clustered":[69],"protein-coding":[70],"sequences":[71],"the":[73,83,86,90,103,122,132,153,156,188,197,209,213,243,263,278,288,301,335,368,375,382,391],"by":[75],"sequence":[76],"similarity":[77],"de":[78],"novo":[79],"statistically":[81,345],"associated":[82],"magnitude":[84],"trait":[88],"gene":[92,203],"contents.":[93],"animals":[95],"had":[96],"been":[97],"genome-sequenced":[100],"bacteria,":[101],"so":[102,342],"metagenome":[104],"content":[105,211],"was":[106,216,378],"unambiguous.":[107],"This":[108,296],"analysis":[109],"showed":[110],"significant":[111],"pyrroloquinoline":[114],"quinone":[115],"biosynthesis":[116],"genes":[117,138,162,290,349,359,373,404],"time,":[120],"confirming":[121],"results":[123],"published":[126],"transposon":[127],"mutagenesis":[128],"screen,":[129],"thereby":[130],"validating":[131],"MGWA;":[133],"it":[134],"also":[135],"identified":[136],"multiple":[137],"predicted":[139,176],"TAG":[143,184,189],"including":[145],"extracellular":[146],"glucose":[147,200,207,210,362],"oxidation":[148,201],"pathway":[149,202],"components.":[150],"test":[152],"validity":[154],"statistical":[157],"associations,":[158],"expressed":[160,174],"candidate":[161],"strain":[165],"that":[166,172,199,228,291,360],"lacks":[167],"them.":[168],"Monoassociation":[169],"ectopically":[173],"oxidoreductase":[177],"or":[178],"gluconate":[179],"dehydrogenase":[180],"conferred":[181],"reduced":[182,217],"contents":[185,190],"relative":[186],"empty":[192],"vector":[193],"controls.":[194],"Consistent":[195],"prediction":[198],"expression":[204],"increased":[205],"utilization,":[208],"diet":[215],"when":[218],"exposed":[221],"these":[223,240,293,372],"Our":[225,386],"findings":[226,241],"indicate":[227],"microbiota":[229,261],"nutritional":[232,264],"status":[233,265],"through":[234],"modulation":[235],"nutrient":[237],"acquisition.":[238],"Together,":[239],"demonstrate":[242],"utility":[244],"MGWA":[246],"for":[247,406],"identifying":[248],"provide":[255],"mechanistic":[256],"insight":[257],"into":[258,374],"how":[259,273,317],"gut":[260,275,376],"modulate":[262],"model":[268],"host.":[269],"IMPORTANCE:":[270],"understand":[272],"certain":[274],"promote":[277,361],"health":[279],"their":[281],"animal":[282],"hosts,":[283],"need":[285],"drive":[292],"beneficial":[294],"relationships.":[295],"task":[297],"is":[298,388],"challenging":[299],"because":[300],"communities":[303],"can":[304],"vary":[305],"widely":[306],"among":[307],"different":[308],"individuals.":[310],"overcome":[312],"this":[313],"difficulty,":[314],"quantified":[316],"well":[318],"species":[323],"protected":[324],"fruit":[326],"from":[328],"high":[329],"fat":[330,356,384],"content.":[331,357,385],"genomes":[333],"chosen":[336],"strains":[338],"previously":[340],"sequenced,":[341],"could":[344],"associate":[346],"specific":[347],"bacterially":[351],"mediated":[352],"reduction":[353],"Bacterial":[358],"utilization":[363],"strongly":[365],"represented":[366],"association,":[369],"introducing":[371],"sufficient":[379],"lower":[381],"animal's":[383],"method":[387],"applicable":[389],"study":[392],"many":[394],"other":[395],"host-microbe":[396],"interactions":[397],"as":[398],"way":[400],"uncover":[402],"microbial":[403],"important":[405],"health.":[408]},"counts_by_year":[{"year":2026,"cited_by_count":2},{"year":2025,"cited_by_count":10},{"year":2024,"cited_by_count":4},{"year":2023,"cited_by_count":6},{"year":2022,"cited_by_count":10},{"year":2021,"cited_by_count":20},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":23},{"year":2018,"cited_by_count":16},{"year":2017,"cited_by_count":16},{"year":2016,"cited_by_count":10},{"year":2015,"cited_by_count":9}],"updated_date":"2026-10-31T12:09:11.096373","created_date":"2016-06-24T00:00:00"}
