{"id":"https://openalex.org/W2099353036","doi":"https://doi.org/10.1101/gad.1022203","title":"Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation","display_name":"Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation","publication_year":2003,"publication_date":"2003-01-15","ids":{"openalex":"https://openalex.org/W2099353036","doi":"https://doi.org/10.1101/gad.1022203","mag":"2099353036","pmid":"https://pubmed.ncbi.nlm.nih.gov/12533515","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/195976"},"language":"en","primary_location":{"id":"doi:10.1101/gad.1022203","doi":"https://doi.org/10.1101/gad.1022203","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.1022203","pdf_url":"http://genesdev.cshlp.org/content/17/2/295.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & Development","raw_type":"journal-article"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"http://genesdev.cshlp.org/content/17/2/295.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5041654210","display_name":"Raymond Habas","orcid":"https://orcid.org/0000-0003-4804-4128","observed_orcids":["https://orcid.org/0000-0003-4804-4128"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Raymond Habas","raw_affiliation_strings":["Laboratory of Molecular Genetics, National Institutes of Child Health and Human Development, Bethesda, Maryland 20892-2790, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Institutes of Child Health and Human Development, Bethesda, Maryland 20892-2790, USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064390918","display_name":"Igor B. Dawid","orcid":"https://orcid.org/0000-0003-0579-5693","observed_orcids":["https://orcid.org/0000-0003-0579-5693"]},"institutions":[{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Igor B. Dawid","raw_affiliation_strings":["Laboratory of Molecular Genetics, National Institutes of Child Health and Human Development, Bethesda, Maryland 20892-2790,\n                           USA;\n                           2Division of Neuroscience, Children's Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115,\n                           USA","Laboratory of Molecular Genetics, National Institutes of Child Health and Human Development, Bethesda, Maryland 20892-2790, USA;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Institutes of Child Health and Human Development, Bethesda, Maryland 20892-2790,\n                           USA;\n                           2Division of Neuroscience, Children's Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115,\n                           USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I136199984","https://openalex.org/I4210144228"]},{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Institutes of Child Health and Human Development, Bethesda, Maryland 20892-2790, USA;","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000021060","display_name":"Xi He","orcid":"https://orcid.org/0000-0002-8093-7981","observed_orcids":["https://orcid.org/0000-0002-8093-7981"]},"institutions":[{"id":"https://openalex.org/I1288882113","display_name":"Boston Children's Hospital","ror":"https://ror.org/00dvg7y05","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1288882113"]},{"id":"https://openalex.org/I1299303238","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88","country_code":"US","type":"government","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210144228","display_name":"Eunice Kennedy Shriver National Institute of Child Health and Human Development","ror":"https://ror.org/04byxyr05","country_code":"US","type":"facility","lineage":["https://openalex.org/I1299022934","https://openalex.org/I1299303238","https://openalex.org/I4210144228"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Xi He","raw_affiliation_strings":["Laboratory of Molecular Genetics, National Institutes of Child Health and Human Development, Bethesda, Maryland 20892-2790,\n                           USA;\n                           2Division of Neuroscience, Children's Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115,\n                           USA","Division of Neuroscience, Children's Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Molecular Genetics, National Institutes of Child Health and Human Development, Bethesda, Maryland 20892-2790,\n                           USA;\n                           2Division of Neuroscience, Children's Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115,\n                           USA","institution_ids":["https://openalex.org/I1299303238","https://openalex.org/I136199984","https://openalex.org/I4210144228"]},{"raw_affiliation_string":"Division of Neuroscience, Children's Hospital, Department of Neurology, Harvard Medical School, Boston, Massachusetts 02115, USA","institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I136199984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5000021060"],"corresponding_institution_ids":["https://openalex.org/I1288882113","https://openalex.org/I1299303238","https://openalex.org/I136199984","https://openalex.org/I4210144228"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":612,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"2","first_page":"295","last_page":"309"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10929","display_name":"Wnt/\u03b2-catenin signaling in development and cancer","score":0.9765999913215637,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10268","display_name":"Developmental Biology and Gene Regulation","score":0.014399999752640724,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10169","display_name":"Protein Kinase Regulation and GTPase Signaling","score":0.0035000001080334187,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/wnt-frizzled-signaling","display_name":"Wnt/Frizzled signaling","score":0.9909999966621399},{"id":"https://openalex.org/keywords/rac","display_name":"Rac","score":0.4490000009536743},{"id":"https://openalex.org/keywords/rho-gtpases","display_name":"Rho GTPases","score":0.9390000104904175},{"id":"https://openalex.org/keywords/dishevelled","display_name":"Dishevelled","score":0.828000009059906},{"id":"https://openalex.org/keywords/jun-n-terminal-kinase","display_name":"Jun N-terminal kinase","score":0.8769999742507935},{"id":"https://openalex.org/keywords/cell-polarity","display_name":"cell polarity","score":0.8690000176429749},{"id":"https://openalex.org/keywords/cell-migration","display_name":"cell migration","score":0.6809999942779541},{"id":"https://openalex.org/keywords/cytoskeleton-regulation","display_name":"cytoskeleton regulation","score":0.8489999771118164},{"id":"https://openalex.org/keywords/xenopus-embryo","display_name":"Xenopus embryo","score":0.75},{"id":"https://openalex.org/keywords/beta-catenin-signaling","display_name":"\u03b2-catenin signaling","score":0.8730000257492065}],"concepts":[{"id":"https://openalex.org/C137620995","wikidata":"https://www.wikidata.org/wiki/Q155769","display_name":"Wnt signaling pathway","level":3,"score":0.8843688368797302},{"id":"https://openalex.org/C129536746","wikidata":"https://www.wikidata.org/wiki/Q1141026","display_name":"Gastrulation","level":4,"score":0.8671836853027344},{"id":"https://openalex.org/C2775928862","wikidata":"https://www.wikidata.org/wiki/Q5282208","display_name":"Dishevelled","level":5,"score":0.8315600156784058},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.8046784400939941},{"id":"https://openalex.org/C107300179","wikidata":"https://www.wikidata.org/wiki/Q41797887","display_name":"Frizzled","level":4,"score":0.8008090257644653},{"id":"https://openalex.org/C2779535977","wikidata":"https://www.wikidata.org/wiki/Q1342298","display_name":"Xenopus","level":3,"score":0.7863800525665283},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7801011800765991},{"id":"https://openalex.org/C182819311","wikidata":"https://www.wikidata.org/wiki/Q18028670","display_name":"LRP5","level":4,"score":0.5615048408508301},{"id":"https://openalex.org/C49353375","wikidata":"https://www.wikidata.org/wiki/Q189100","display_name":"Cell polarity","level":3,"score":0.49397188425064087},{"id":"https://openalex.org/C2780915607","wikidata":"https://www.wikidata.org/wiki/Q323438","display_name":"Mesoderm","level":4,"score":0.486944317817688},{"id":"https://openalex.org/C170320316","wikidata":"https://www.wikidata.org/wiki/Q18028667","display_name":"LRP6","level":4,"score":0.467121422290802},{"id":"https://openalex.org/C2779324961","wikidata":"https://www.wikidata.org/wiki/Q1634046","display_name":"Beta-catenin","level":4,"score":0.4324050843715668},{"id":"https://openalex.org/C192586883","wikidata":"https://www.wikidata.org/wiki/Q5166400","display_name":"Convergent extension","level":5,"score":0.41324174404144287},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3595881462097168},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.15576747059822083},{"id":"https://openalex.org/C196843134","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryo","level":2,"score":0.14733517169952393},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.13092634081840515},{"id":"https://openalex.org/C87073359","wikidata":"https://www.wikidata.org/wiki/Q33196","display_name":"Embryogenesis","level":3,"score":0.0979124903678894},{"id":"https://openalex.org/C145103041","wikidata":"https://www.wikidata.org/wiki/Q1151519","display_name":"Embryonic stem cell","level":3,"score":0.09013459086418152},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.05295315384864807}],"mesh":[{"descriptor_ui":"D000072261","descriptor_name":"Dishevelled Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002460","descriptor_name":"Cell Line","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D004330","descriptor_name":"Drosophila","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D005775","descriptor_name":"Gastrula","qualifier_ui":"Q000166","qualifier_name":"cytology","is_major_topic":true},{"descriptor_ui":"D005775","descriptor_name":"Gastrula","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008954","descriptor_name":"Models, Biological","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D010750","descriptor_name":"Phosphoproteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011506","descriptor_name":"Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D011518","descriptor_name":"Proto-Oncogene Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D012313","descriptor_name":"RNA","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":"Q000196","qualifier_name":"embryology","is_major_topic":true},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014981","descriptor_name":"Xenopus","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D015398","descriptor_name":"Signal Transduction","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D016764","descriptor_name":"Cell Polarity","qualifier_ui":"Q000502","qualifier_name":"physiology","is_major_topic":false},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020741","descriptor_name":"rho GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020744","descriptor_name":"rac GTP-Binding Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D020744","descriptor_name":"rac GTP-Binding Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D020928","descriptor_name":"Mitogen-Activated Protein Kinases","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D029721","descriptor_name":"Drosophila Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029867","descriptor_name":"Xenopus Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D029961","descriptor_name":"Zebrafish Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D048031","descriptor_name":"JNK Mitogen-Activated Protein Kinases","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D048868","descriptor_name":"Adaptor Proteins, Signal Transducing","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051153","descriptor_name":"Wnt Proteins","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D051157","descriptor_name":"Frizzled Receptors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1101/gad.1022203","doi":"https://doi.org/10.1101/gad.1022203","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.1022203","pdf_url":"http://genesdev.cshlp.org/content/17/2/295.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & Development","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:195976","doi":null,"is_oa":true,"landing_page_url":"https://www.ncbi.nlm.nih.gov/pmc/articles/195976","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes Dev","raw_type":"Text"},{"id":"pmid:12533515","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/12533515","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & development","raw_type":"Comparative Study"}],"best_oa_location":{"id":"doi:10.1101/gad.1022203","doi":"https://doi.org/10.1101/gad.1022203","is_oa":true,"landing_page_url":"https://doi.org/10.1101/gad.1022203","pdf_url":"http://genesdev.cshlp.org/content/17/2/295.full.pdf","source":{"id":"https://openalex.org/S168778273","display_name":"Genes & Development","issn_l":"0890-9369","issn":["0890-9369","1549-5477"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","doyens","jufo-3","ki-jl-2","medline","norway-2","poland-200","russia-white-list-1"],"host_organization":"https://openalex.org/P4310315909","host_organization_name":"Cold Spring Harbor Laboratory Press","host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genes & Development","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[{"id":"https://openalex.org/G9000885930","display_name":"Developmental Neurology","funder_award_id":"T32NS007473","funder_id":"https://openalex.org/F4320337359","funder_display_name":"National Institute of Neurological Disorders and Stroke"}],"funders":[{"id":"https://openalex.org/F4320306078","display_name":"U.S. Department of Defense","ror":"https://ror.org/0447fe631"},{"id":"https://openalex.org/F4320306159","display_name":"W. M. Keck Foundation","ror":"https://ror.org/000dswa46"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320337359","display_name":"National Institute of Neurological Disorders and Stroke","ror":"https://ror.org/01s5ya894"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W2099353036.pdf","grobid_xml":"https://content.openalex.org/works/W2099353036.grobid-xml"},"referenced_works_count":71,"referenced_works":["https://openalex.org/W154439523","https://openalex.org/W1504655784","https://openalex.org/W1545602072","https://openalex.org/W1554135744","https://openalex.org/W1583486328","https://openalex.org/W1611720630","https://openalex.org/W1625983242","https://openalex.org/W1635607892","https://openalex.org/W1664587663","https://openalex.org/W1752721376","https://openalex.org/W1896260333","https://openalex.org/W1964743891","https://openalex.org/W1965927965","https://openalex.org/W1966529319","https://openalex.org/W1967062108","https://openalex.org/W1968137237","https://openalex.org/W1974313494","https://openalex.org/W1974712344","https://openalex.org/W1978379357","https://openalex.org/W1996788021","https://openalex.org/W2003286575","https://openalex.org/W2006671195","https://openalex.org/W2010451082","https://openalex.org/W2021803477","https://openalex.org/W2022798578","https://openalex.org/W2027356109","https://openalex.org/W2027919192","https://openalex.org/W2042584344","https://openalex.org/W2044764655","https://openalex.org/W2054974461","https://openalex.org/W2055181868","https://openalex.org/W2055349760","https://openalex.org/W2055557491","https://openalex.org/W2059954649","https://openalex.org/W2061482218","https://openalex.org/W2066164607","https://openalex.org/W2070548790","https://openalex.org/W2071397057","https://openalex.org/W2078637309","https://openalex.org/W2080145523","https://openalex.org/W2080372560","https://openalex.org/W2082978552","https://openalex.org/W2083061238","https://openalex.org/W2084060837","https://openalex.org/W2092117239","https://openalex.org/W2096791952","https://openalex.org/W2097315204","https://openalex.org/W2110887378","https://openalex.org/W2113786860","https://openalex.org/W2114618350","https://openalex.org/W2115351454","https://openalex.org/W2120983879","https://openalex.org/W2123073901","https://openalex.org/W2125545718","https://openalex.org/W2127251425","https://openalex.org/W2130172628","https://openalex.org/W2133172561","https://openalex.org/W2136790681","https://openalex.org/W2141108067","https://openalex.org/W2144917440","https://openalex.org/W2146916662","https://openalex.org/W2148450224","https://openalex.org/W2150589615","https://openalex.org/W2153182714","https://openalex.org/W2154655439","https://openalex.org/W2162049443","https://openalex.org/W2164964874","https://openalex.org/W2165061154","https://openalex.org/W2219887549","https://openalex.org/W2341480989","https://openalex.org/W2397921565"],"related_works":["https://openalex.org/W1587518404","https://openalex.org/W2150589615","https://openalex.org/W4211218482","https://openalex.org/W2408700124","https://openalex.org/W2027015740","https://openalex.org/W2043502133","https://openalex.org/W1987158639","https://openalex.org/W7019387359","https://openalex.org/W2034810258","https://openalex.org/W2158673376"],"abstract_inverted_index":{"Wnt/Frizzled":[0],"(Fz)":[1],"signaling":[2,44,125],"controls":[3],"cell":[4,129],"polarity/movements":[5],"during":[6,133],"vertebrate":[7,31,134],"gastrulation":[8,102],"via":[9],"incompletely":[10],"defined":[11],"mechanisms.":[12],"We":[13,113],"demonstrated":[14],"previously":[15],"that":[16,36,115],"Wnt/Fz":[17,43,57,67,105,124],"activation":[18,58,68,106,117],"of":[19,25,54,59,63,69,80,89,97,107,118],"Rho,":[20],"a":[21,76,83],"GTPase":[22,50],"and":[23,40,47,51,65,120,131],"regulator":[24,53],"cytoskeletal":[26,55],"architecture,":[27],"is":[28,61,126],"essential":[29],"for":[30,128],"gastrulation.":[32,135],"Here":[33],"we":[34],"report":[35],"in":[37],"mammalian":[38],"cells":[39],"Xenopus":[41,101],"embryos,":[42],"coactivates":[45],"Rho":[46,64,109,121],"Rac,":[48],"another":[49],"distinct":[52],"architecture.":[56],"Rac":[60,87,98,119],"independent":[62,88],"mediates":[66],"Jun":[70],"N-terminal":[71],"kinase":[72],"(JNK).":[73],"Dishevelled":[74],"(Dvl),":[75],"cytoplasmic":[77],"protein":[78],"downstream":[79],"Fz,":[81],"forms":[82],"Wnt-induced":[84,91],"complex":[85],"with":[86],"the":[90,108],"Dvl-Rho":[92],"complex.":[93],"Depletion":[94],"or":[95,110],"inhibition":[96],"function":[99],"perturbs":[100],"without":[103],"affecting":[104],"beta-catenin":[111],"pathway.":[112],"propose":[114],"parallel":[116],"pathways":[122],"by":[123],"required":[127],"polarity":[130],"movements":[132]},"counts_by_year":[{"year":2026,"cited_by_count":9},{"year":2025,"cited_by_count":9},{"year":2024,"cited_by_count":9},{"year":2023,"cited_by_count":9},{"year":2022,"cited_by_count":22},{"year":2021,"cited_by_count":24},{"year":2020,"cited_by_count":12},{"year":2019,"cited_by_count":15},{"year":2018,"cited_by_count":13},{"year":2017,"cited_by_count":22},{"year":2016,"cited_by_count":17},{"year":2015,"cited_by_count":27},{"year":2014,"cited_by_count":28},{"year":2013,"cited_by_count":22},{"year":2012,"cited_by_count":36}],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2016-06-24T00:00:00"}